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The map label for this gene is yclK [H]

Identifier: 170756067

GI number: 170756067

Start: 3859067

End: 3860476

Strand: Reverse

Name: yclK [H]

Synonym: CLD_0941

Alternate gene names: 170756067

Gene position: 3860476-3859067 (Counterclockwise)

Preceding gene: 170755568

Following gene: 170754796

Centisome position: 97.53

GC content: 29.01

Gene sequence:

>1410_bases
ATGAAAAAAGGCTTATTTGCTAAACTTGTAGCTACATTTACCATAATAATATCTGTAAGCTTTATAATTATAGCAACATT
TTTATCTTATTGGTTTGAGAGTTACTATTTTGATCAAAGGAAAAATCAACTTTTTACAGAATCACAGTTTGTAGGCAATG
CAGCAGTTAGATATATAGAAGGAAGCATATCATCTGAAAGAATTAATGAAGTAATAAACTATATCAGCAATTATTTATCT
GTAAATATATGGATTACTGATAAGTATGGATATGTTTATGCCGTATCTAATCCCAAGCATAAAAATTTAGTAGGAGTACA
GGTTTTAACTGATGAATTAGAAGAATTAAGAAGAGGAAACAATTTGGAAAATAAAGGACAGTACAAATCAGCCTTTTCAA
CCCCTGTACATACTTTTGAAGTGCCTATTTTTCACAAGGGAGTATTTAGTGGAGCTATAATAATGCATACATCTATAAAT
GAAATAAAAGATCCATTAAAAAAAGTTTATAATATAATCTGGATATCAGCTATTTTTGCTATAATAATATCCTGCATAGT
AATATATTATTTTTCTCAAAGGATAATTATAAGACCACTTGCGCAAATTAATTATGTAGCTGATAAGATATCTAAAGGAG
AGGTCGGCAAGAGAGTAGATATAGAATCAGATGATGAGATTGGAGCTTTAGCATCTTCCTTTAACTCTATGGCAGAGTCT
ATAGAACAGGTAGAGAGCAATAGAAGATTATTTATTTCAAATGTTTCCCATGAAATAAGATCTCCTATTACATCAATAAA
AGGGTTTATCGGTGGAATTTTAGACGGAATAGTTCCAGAGGAAAAGCAAAATTATTATTTGAAATTAACCTATGAAGAAA
TTCAAAGGCTTACAAGACTTATAAATGATTTATTAGACCTATCTGCCATTGAAGAAGGCCATTTAAAATTAAATTTAGAG
GAAATAGATTTAAATGAGATTATAAGAGCTAGCGTAATAAAATTTGAAACAAAAATAAGAGATAAAAAACTAAAGGTCAA
TGTAAGCTTAGAAGATGACAAAGTATATGTTGTTGCTGATAAAGATAGATTAACACAGGTTGTAATAAATGTATTAGACA
ATGCGATTAAATATGCTAATGAGGGTGGAAATGTAAAATTAAATACAAAAATCAAAGGAAGCAAAGTTATAGTTTCTATA
TTTAATGATGGACCAGTTATATCTGATGAAGATATAAAACATATATGGGACAGATTTTATAAAGCAGATAAAGCTAGATC
ATCTAAAGTTAGTACTGGACTAGGGTTATCTATTGTAAGAAGTATTTTAACACAACACGGGGAAGATATTTGGGTTAATA
ATAGTCCAGAAGGAGGGGTAACTTTTAATTTTACCATAAAGAGAGCATAA

Upstream 100 bases:

>100_bases
AGATGTTCACATAAAAAGATTAAGAGAAAAACTAGAAGGAGGACCTAATTGGGAAATAGAAACTGTTTGGGGTGTAGGTT
ACAAATTTGAGGTGAAATAA

Downstream 100 bases:

>100_bases
TTATTAAATTTAAACTAAAGAGCGGAGGTTGAACATGGGTAGAGATAATTTAAATAATATTGAAGAGAATGGTTTAAATG
CTGAACCATATGGTGAAATA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MKKGLFAKLVATFTIIISVSFIIIATFLSYWFESYYFDQRKNQLFTESQFVGNAAVRYIEGSISSERINEVINYISNYLS
VNIWITDKYGYVYAVSNPKHKNLVGVQVLTDELEELRRGNNLENKGQYKSAFSTPVHTFEVPIFHKGVFSGAIIMHTSIN
EIKDPLKKVYNIIWISAIFAIIISCIVIYYFSQRIIIRPLAQINYVADKISKGEVGKRVDIESDDEIGALASSFNSMAES
IEQVESNRRLFISNVSHEIRSPITSIKGFIGGILDGIVPEEKQNYYLKLTYEEIQRLTRLINDLLDLSAIEEGHLKLNLE
EIDLNEIIRASVIKFETKIRDKKLKVNVSLEDDKVYVVADKDRLTQVVINVLDNAIKYANEGGNVKLNTKIKGSKVIVSI
FNDGPVISDEDIKHIWDRFYKADKARSSKVSTGLGLSIVRSILTQHGEDIWVNNSPEGGVTFNFTIKRA

Sequences:

>Translated_469_residues
MKKGLFAKLVATFTIIISVSFIIIATFLSYWFESYYFDQRKNQLFTESQFVGNAAVRYIEGSISSERINEVINYISNYLS
VNIWITDKYGYVYAVSNPKHKNLVGVQVLTDELEELRRGNNLENKGQYKSAFSTPVHTFEVPIFHKGVFSGAIIMHTSIN
EIKDPLKKVYNIIWISAIFAIIISCIVIYYFSQRIIIRPLAQINYVADKISKGEVGKRVDIESDDEIGALASSFNSMAES
IEQVESNRRLFISNVSHEIRSPITSIKGFIGGILDGIVPEEKQNYYLKLTYEEIQRLTRLINDLLDLSAIEEGHLKLNLE
EIDLNEIIRASVIKFETKIRDKKLKVNVSLEDDKVYVVADKDRLTQVVINVLDNAIKYANEGGNVKLNTKIKGSKVIVSI
FNDGPVISDEDIKHIWDRFYKADKARSSKVSTGLGLSIVRSILTQHGEDIWVNNSPEGGVTFNFTIKRA
>Mature_469_residues
MKKGLFAKLVATFTIIISVSFIIIATFLSYWFESYYFDQRKNQLFTESQFVGNAAVRYIEGSISSERINEVINYISNYLS
VNIWITDKYGYVYAVSNPKHKNLVGVQVLTDELEELRRGNNLENKGQYKSAFSTPVHTFEVPIFHKGVFSGAIIMHTSIN
EIKDPLKKVYNIIWISAIFAIIISCIVIYYFSQRIIIRPLAQINYVADKISKGEVGKRVDIESDDEIGALASSFNSMAES
IEQVESNRRLFISNVSHEIRSPITSIKGFIGGILDGIVPEEKQNYYLKLTYEEIQRLTRLINDLLDLSAIEEGHLKLNLE
EIDLNEIIRASVIKFETKIRDKKLKVNVSLEDDKVYVVADKDRLTQVVINVLDNAIKYANEGGNVKLNTKIKGSKVIVSI
FNDGPVISDEDIKHIWDRFYKADKARSSKVSTGLGLSIVRSILTQHGEDIWVNNSPEGGVTFNFTIKRA

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=272, Percent_Identity=30.1470588235294, Blast_Score=151, Evalue=9e-38,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=30.9012875536481, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=27.5423728813559, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1790346, Length=269, Percent_Identity=27.1375464684015, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87082128, Length=299, Percent_Identity=24.0802675585284, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1787894, Length=307, Percent_Identity=24.1042345276873, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1789808, Length=283, Percent_Identity=25.7950530035336, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1786783, Length=289, Percent_Identity=25.9515570934256, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788713, Length=223, Percent_Identity=27.8026905829596, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790861, Length=306, Percent_Identity=25.4901960784314, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1789149, Length=350, Percent_Identity=27.1428571428571, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790436, Length=214, Percent_Identity=28.0373831775701, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=26.6666666666667, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789403, Length=293, Percent_Identity=26.2798634812287, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788549, Length=250, Percent_Identity=26.4, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI87081816, Length=386, Percent_Identity=20.2072538860104, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI48994928, Length=237, Percent_Identity=25.3164556962025, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788279, Length=277, Percent_Identity=23.4657039711191, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790551, Length=291, Percent_Identity=21.3058419243986, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53222; Mature: 53222

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGLFAKLVATFTIIISVSFIIIATFLSYWFESYYFDQRKNQLFTESQFVGNAAVRYIE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSISSERINEVINYISNYLSVNIWITDKYGYVYAVSNPKHKNLVGVQVLTDELEELRRGN
CCCCHHHHHHHHHHHHHHEEEEEEEEECCCEEEEECCCCCCCEEEHHHHHHHHHHHHCCC
NLENKGQYKSAFSTPVHTFEVPIFHKGVFSGAIIMHTSINEIKDPLKKVYNIIWISAIFA
CCCCCCCHHHHHCCCCEEEECCCEECHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
IIISCIVIYYFSQRIIIRPLAQINYVADKISKGEVGKRVDIESDDEIGALASSFNSMAES
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
IEQVESNRRLFISNVSHEIRSPITSIKGFIGGILDGIVPEEKQNYYLKLTYEEIQRLTRL
HHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHH
INDLLDLSAIEEGHLKLNLEEIDLNEIIRASVIKFETKIRDKKLKVNVSLEDDKVYVVAD
HHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCEEEEEEC
KDRLTQVVINVLDNAIKYANEGGNVKLNTKIKGSKVIVSIFNDGPVISDEDIKHIWDRFY
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHH
KADKARSSKVSTGLGLSIVRSILTQHGEDIWVNNSPEGGVTFNFTIKRA
HHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEECC
>Mature Secondary Structure
MKKGLFAKLVATFTIIISVSFIIIATFLSYWFESYYFDQRKNQLFTESQFVGNAAVRYIE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSISSERINEVINYISNYLSVNIWITDKYGYVYAVSNPKHKNLVGVQVLTDELEELRRGN
CCCCHHHHHHHHHHHHHHEEEEEEEEECCCEEEEECCCCCCCEEEHHHHHHHHHHHHCCC
NLENKGQYKSAFSTPVHTFEVPIFHKGVFSGAIIMHTSINEIKDPLKKVYNIIWISAIFA
CCCCCCCHHHHHCCCCEEEECCCEECHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
IIISCIVIYYFSQRIIIRPLAQINYVADKISKGEVGKRVDIESDDEIGALASSFNSMAES
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
IEQVESNRRLFISNVSHEIRSPITSIKGFIGGILDGIVPEEKQNYYLKLTYEEIQRLTRL
HHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHH
INDLLDLSAIEEGHLKLNLEEIDLNEIIRASVIKFETKIRDKKLKVNVSLEDDKVYVVAD
HHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCEEEEEEC
KDRLTQVVINVLDNAIKYANEGGNVKLNTKIKGSKVIVSIFNDGPVISDEDIKHIWDRFY
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHH
KADKARSSKVSTGLGLSIVRSILTQHGEDIWVNNSPEGGVTFNFTIKRA
HHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]