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The map label for this gene is ykoH [H]

Identifier: 170755916

GI number: 170755916

Start: 2506290

End: 2507540

Strand: Reverse

Name: ykoH [H]

Synonym: CLD_2251

Alternate gene names: 170755916

Gene position: 2507540-2506290 (Counterclockwise)

Preceding gene: 170754689

Following gene: 170757333

Centisome position: 63.35

GC content: 29.26

Gene sequence:

>1251_bases
ATGAGTAGAAAAAATAAAACAAAAAATGTTATATCTATTGCAATAAAATTAAACTCTGTTTTTGTAAGAAGTTTATTTTT
AAAGTTTCTTATCCTTGATATATGCATAATTGCTGGATTTATTGGAGTTTGGTGTATTGAAAATGAAATAAATTTTTATG
GTGAGATCGTAAGAAATGCTCAAAGGTCATTTGAATTTTATCCTATAGAAGCAGCAAATTATAAAGTCATTTGGGATAAT
GGAAAGGTTATGATAAAAGAGGCTAGCACTTTTTTAAACCTTCTTATAAAAGTAATTAGCGCTATTGGAATTATAGAAGG
AATAATGCTATTAATGCAAATGATATTTGGTACTGCAAAAAATAGAAGGATTTTAAAACCACTTAATGAAATAGCAGAAG
CTGCAAGTAGGCTTAGTGATATGGCTTTTGATGAGCAAAAATTTCAAAGTCTTGAGGATGCTATATCTAAAATAAGTCCT
GCTATATCTGATGAAAGAATTCATATTAAAGATAGTGAACTTCAGGGTTTAGAGGAAGCAATTAATAACCTATTAGATAG
AATGAGAGATTCTTATAGGCAACAAGCAAGATTTGTTTCAGATGCATCCCATGAACTTAGAACTCCTATATCTGTAATTC
AAGGGTATGCCAATATGTTAGATCGTTGGGGAAAAGATGATGAAGAAGTATTAGAGGAATCTATTGCAGCTATAAAGAGT
GAATCAGAAAATATGAAAAACTTAGTAGAACAGTTATTATTTTTAGCCAGGGGTATTAATGGTAAAACTCAACTTAAGGT
TATGGGGTTTTCACTTAATGATATGATGAAAGAAGTTTTAGAAGAATCTAAGATGATAGATAAAGATCATATATATAGAT
ATATAGATTCAGAAAATATAAATGTTTATGGTGATATATCATTACTCAAACAAACAGCTAGAATATTAATAGAAAATGCA
GCAAAGTATACAGATAAAGGTGAAGATATAATACTAAGAACAGGGAAAAATAATAAAAATGAGCCGTATTTTTCTATTCA
AGATAATGGAATAGGAATGGATGAGAATGATGTATTACACATGTTTGAACGTTTTTTCAGAGCTGATACTGCAAGAGTTA
GAAAAAATGGTGGTACAGGGCTAGGTCTTTCCATTGCTAAATGGATTATTGACAGTCATAAAGGATATTTTAGCGTTTTA
AGTAGGAAAGAAATAGGTACAAGAATAACTGTTTTTTTACCTAAAAGATAG

Upstream 100 bases:

>100_bases
GTTATAGATGTTTATATAAGGTTTTTGAGAACAAAAATAGATGATGCTTTTAAGGTTAAAATAATAACTACAGTTCGTGG
TGTAGGATACGTAATTAAAG

Downstream 100 bases:

>100_bases
CAAAATATAGTGAAACAAGCAACTTAAGCATAAGACAGTAATCATCTCCTGTCTTATGCTTAAATGCTATGGCTTAATAT
CCACTGCTTTATGTCATCTT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSRKNKTKNVISIAIKLNSVFVRSLFLKFLILDICIIAGFIGVWCIENEINFYGEIVRNAQRSFEFYPIEAANYKVIWDN
GKVMIKEASTFLNLLIKVISAIGIIEGIMLLMQMIFGTAKNRRILKPLNEIAEAASRLSDMAFDEQKFQSLEDAISKISP
AISDERIHIKDSELQGLEEAINNLLDRMRDSYRQQARFVSDASHELRTPISVIQGYANMLDRWGKDDEEVLEESIAAIKS
ESENMKNLVEQLLFLARGINGKTQLKVMGFSLNDMMKEVLEESKMIDKDHIYRYIDSENINVYGDISLLKQTARILIENA
AKYTDKGEDIILRTGKNNKNEPYFSIQDNGIGMDENDVLHMFERFFRADTARVRKNGGTGLGLSIAKWIIDSHKGYFSVL
SRKEIGTRITVFLPKR

Sequences:

>Translated_416_residues
MSRKNKTKNVISIAIKLNSVFVRSLFLKFLILDICIIAGFIGVWCIENEINFYGEIVRNAQRSFEFYPIEAANYKVIWDN
GKVMIKEASTFLNLLIKVISAIGIIEGIMLLMQMIFGTAKNRRILKPLNEIAEAASRLSDMAFDEQKFQSLEDAISKISP
AISDERIHIKDSELQGLEEAINNLLDRMRDSYRQQARFVSDASHELRTPISVIQGYANMLDRWGKDDEEVLEESIAAIKS
ESENMKNLVEQLLFLARGINGKTQLKVMGFSLNDMMKEVLEESKMIDKDHIYRYIDSENINVYGDISLLKQTARILIENA
AKYTDKGEDIILRTGKNNKNEPYFSIQDNGIGMDENDVLHMFERFFRADTARVRKNGGTGLGLSIAKWIIDSHKGYFSVL
SRKEIGTRITVFLPKR
>Mature_415_residues
SRKNKTKNVISIAIKLNSVFVRSLFLKFLILDICIIAGFIGVWCIENEINFYGEIVRNAQRSFEFYPIEAANYKVIWDNG
KVMIKEASTFLNLLIKVISAIGIIEGIMLLMQMIFGTAKNRRILKPLNEIAEAASRLSDMAFDEQKFQSLEDAISKISPA
ISDERIHIKDSELQGLEEAINNLLDRMRDSYRQQARFVSDASHELRTPISVIQGYANMLDRWGKDDEEVLEESIAAIKSE
SENMKNLVEQLLFLARGINGKTQLKVMGFSLNDMMKEVLEESKMIDKDHIYRYIDSENINVYGDISLLKQTARILIENAA
KYTDKGEDIILRTGKNNKNEPYFSIQDNGIGMDENDVLHMFERFFRADTARVRKNGGTGLGLSIAKWIIDSHKGYFSVLS
RKEIGTRITVFLPKR

Specific function: Probable member of the two-component regulatory system ykoH/ykoG. Potentially phosphorylates ykoG [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=30.4545454545455, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1786783, Length=244, Percent_Identity=29.0983606557377, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790551, Length=322, Percent_Identity=27.0186335403727, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1788393, Length=296, Percent_Identity=25, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790346, Length=235, Percent_Identity=28.5106382978723, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1789149, Length=265, Percent_Identity=27.9245283018868, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788549, Length=266, Percent_Identity=25.5639097744361, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788279, Length=246, Percent_Identity=28.4552845528455, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI145693157, Length=244, Percent_Identity=26.2295081967213, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1789808, Length=245, Percent_Identity=25.3061224489796, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788713, Length=229, Percent_Identity=27.0742358078603, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789403, Length=307, Percent_Identity=25.7328990228013, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787894, Length=273, Percent_Identity=25.2747252747253, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786912, Length=228, Percent_Identity=26.7543859649123, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87081816, Length=365, Percent_Identity=24.1095890410959, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790861, Length=216, Percent_Identity=25.462962962963, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87082128, Length=295, Percent_Identity=24.406779661017, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI48994928, Length=233, Percent_Identity=22.7467811158798, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47550; Mature: 47418

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKNKTKNVISIAIKLNSVFVRSLFLKFLILDICIIAGFIGVWCIENEINFYGEIVRNA
CCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QRSFEFYPIEAANYKVIWDNGKVMIKEASTFLNLLIKVISAIGIIEGIMLLMQMIFGTAK
HHCCEEEEECCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NRRILKPLNEIAEAASRLSDMAFDEQKFQSLEDAISKISPAISDERIHIKDSELQGLEEA
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHH
INNLLDRMRDSYRQQARFVSDASHELRTPISVIQGYANMLDRWGKDDEEVLEESIAAIKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
ESENMKNLVEQLLFLARGINGKTQLKVMGFSLNDMMKEVLEESKMIDKDHIYRYIDSENI
CHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCC
NVYGDISLLKQTARILIENAAKYTDKGEDIILRTGKNNKNEPYFSIQDNGIGMDENDVLH
EEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHH
MFERFFRADTARVRKNGGTGLGLSIAKWIIDSHKGYFSVLSRKEIGTRITVFLPKR
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCC
>Mature Secondary Structure 
SRKNKTKNVISIAIKLNSVFVRSLFLKFLILDICIIAGFIGVWCIENEINFYGEIVRNA
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QRSFEFYPIEAANYKVIWDNGKVMIKEASTFLNLLIKVISAIGIIEGIMLLMQMIFGTAK
HHCCEEEEECCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NRRILKPLNEIAEAASRLSDMAFDEQKFQSLEDAISKISPAISDERIHIKDSELQGLEEA
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHH
INNLLDRMRDSYRQQARFVSDASHELRTPISVIQGYANMLDRWGKDDEEVLEESIAAIKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
ESENMKNLVEQLLFLARGINGKTQLKVMGFSLNDMMKEVLEESKMIDKDHIYRYIDSENI
CHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCC
NVYGDISLLKQTARILIENAAKYTDKGEDIILRTGKNNKNEPYFSIQDNGIGMDENDVLH
EEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHH
MFERFFRADTARVRKNGGTGLGLSIAKWIIDSHKGYFSVLSRKEIGTRITVFLPKR
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]