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The map label for this gene is leuS

Identifier: 170755878

GI number: 170755878

Start: 224418

End: 226859

Strand: Reverse

Name: leuS

Synonym: CLD_0594

Alternate gene names: 170755878

Gene position: 226859-224418 (Counterclockwise)

Preceding gene: 170756429

Following gene: 170754361

Centisome position: 5.73

GC content: 31.16

Gene sequence:

>2442_bases
ATGGGAAACTATAGTACTAAAATCGACGAGAAATGGCAAAAAAAATGGGAAGAAAACTCTCTATACAAATTTAATAATAA
AAATTTAGATAAAAAATTATATGTACTTGAAATGTTTTCTTATCCATCAGGTAGTAAATTACATGCAGGACACTGGTTTA
ACTATGGACCTGTAGACTCTTGGGCAAGATTTAAAAGAATGCAAGGTTACAATGTTTTTCAACCTATGGGGTTTGATGCT
TTTGGTCTTCCAGCTGAAAACTATGCAATAAAAACTGGTATACATCCAAAGGATTCTACCTTTAAAAATATTGAAACTAT
GGAAACTCAATTAAAAGCCATGGGTGCCATGTTCAACTGGGAAAATGAAGTTATAACTTGTTCACCAGACTACTATAAAT
GGACTCAATGGTTATTTTTAAAACTTTACGAAAAAGGTTTAGCTTATAAAAAGAAAGCACCTGTAAATTGGTGCCCAAGT
TGTAATACTGTTCTTGCTAATGAACAGGTTTTAGATGGAAAATGTGAAAGATGTGATAGCAATGTTGATAAAAAAAATCT
AGAGCAATGGTTCTTAAAGATAACTGACTATGCTGATGAATTATTAGAAAAACTCGATGAATTAGATTGGCCTGAAAAAA
CTAAGGCTATGCAAAAACACTGGATTGGAAAATCTGTAGGTGCTGAAGTTACATTTAATGTAGCAGATTCAGACTTGAGC
TTTAATGTATTTACTACAAGGGTAGATACTTTATTTGGAGTTACTTATGTAGTTTTAGCTCCTGAAAATGATTTAGTAGA
TAAGCTAACTACTCCTGAAAACAAAGCTGAAGTTGAATCATATAAAACTCAAGCTAAAAATCAATCTGATATAGAAAGAC
AATCTATAACTCGAGAAAAAACTGGTGTATTCTCAGGCTCTTATGCCATAAATCCTATAAACGGTAAAGAAGTACCTATA
TGGATAGGAGATTATGTATTAAATACCTATGGAACAGGTTGTGTAATGGCAGTTCCTGCCCATGATGAAAGAGATTTCGC
TTTTGCTACTAAATATAACCTTCCTATAGAAAGAGTTATAGAAGGCGGTGATTCTCTCCCTTATACAGAATATGGCAAAA
TGGTTAATAGTGGAGAATTCGATGGTTTATTTGGAAATAAAGCTAAAGAAGCTGTAATTTCTAAGTTAGAGTCTATGAAT
CTTGGTAGAAAGAAAATAAATTATAGATTAAGAGATTGGCTTGTATCAAGACAAAGATATTGGGGGGCACCTATTCCTAT
AATTTATTGTGAAAAATGTGGTACAGTAGAAGTTCCTATAGAACAGCTTCCTGTAGAACTACCATATAATGTAGAATTCT
CTCCAGATGGGAAATCACCTTTAGGTAAATGTGATGACTTTATAAATACAACTTGCCCAAAATGTGGTGGTCCAGCAAAA
AGAGAAGCAGACACATTAGATACCTTTGTATGTTCTTCTTGGTACTATTTAAGATATCCAGATAATAATAACGAAAAAGA
TGCTTTTAATCCTGAATTAATAAATAAAATGCTTCCAGTTGATAAATATGTTGGCGGTCCTGAACACGCTTGTATGCATC
TTTTATATGCTAGATTTATAACTAAAGCTTTAAGAGATATGGGGTATCTAAACTTTGATGAACCATTCTTATCTCTTACT
CATCAAGGATTAATATTAGGACCTGATGGCTTAAAAATGAGTAAATCAAAAGGAAATACTATATCTCCTGATGATTATAT
AAAAGAATTCGGTGCAGATGTATTTAGAATGTATTTAATGTTTGGATTTGATTATACAGAAGGCGGCGCTTGGAGTGACG
ATGCTATAAAATCCATAGGTAAATTTGTAGACAGAGTAGAAAGAATATTAGAAAATGCTAGAGAAGAAATAAAAAATTCT
AAAGATAATAAATCTACTATGGATAAAGATGAGAAAGAATTAAACTACGTAAGGCATCATAGCATTAAATCTATAACTGA
AGATATAGATAAAATGCAGTTCAATACTTCCATAGCAAGATTAATGGAATTTACAAATGCTCTATCTAAATATCTTGGTA
GTGATACTCTTAGGAATGCTTCATTCTTGAGAGAAAGTATAATTGACTTTATAACATTATTAGCACCTTTTGCTCCTCAT
TTTGCTGAAGAACAATGGGAACTTATAGGCATTAATTCTTCCATTTTCAATGAAAAATGGCCTGAATTTGACCCTAAAGC
CCTAATAAAAGATGAAGTTGAAATAGCCGTACAAGTAAATGGAAAAATAAGAGCTAAAATAAATATATCTACTAGTTCAT
CAGAAGATGAAATAAAAGAATCAGCATTAAACAATGATGATATTAAAAATTCTATAGGCGATAAAGAGATTAAAAAAGTT
ATAGTAATAAAAAATAGATTAGTTAATATAGTTGCTAAATAA

Upstream 100 bases:

>100_bases
TTAGGAGATGAAGGTTTTTTTATTTTATATAAAAATATTTAATTATTATTTTAAATTTTATTTATAAATAATAGTTAATG
AAATAGATAGGAGGATTTTT

Downstream 100 bases:

>100_bases
AATTAAAAAGGCTGTCTGAAGATAAAAATAGATTTAATTTTAACCCGTAAATATAGAAAATACATTTATAAGGCACTTCA
TTTTGCTAAGAAGTTCTAAA

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS [H]

Number of amino acids: Translated: 813; Mature: 812

Protein sequence:

>813_residues
MGNYSTKIDEKWQKKWEENSLYKFNNKNLDKKLYVLEMFSYPSGSKLHAGHWFNYGPVDSWARFKRMQGYNVFQPMGFDA
FGLPAENYAIKTGIHPKDSTFKNIETMETQLKAMGAMFNWENEVITCSPDYYKWTQWLFLKLYEKGLAYKKKAPVNWCPS
CNTVLANEQVLDGKCERCDSNVDKKNLEQWFLKITDYADELLEKLDELDWPEKTKAMQKHWIGKSVGAEVTFNVADSDLS
FNVFTTRVDTLFGVTYVVLAPENDLVDKLTTPENKAEVESYKTQAKNQSDIERQSITREKTGVFSGSYAINPINGKEVPI
WIGDYVLNTYGTGCVMAVPAHDERDFAFATKYNLPIERVIEGGDSLPYTEYGKMVNSGEFDGLFGNKAKEAVISKLESMN
LGRKKINYRLRDWLVSRQRYWGAPIPIIYCEKCGTVEVPIEQLPVELPYNVEFSPDGKSPLGKCDDFINTTCPKCGGPAK
READTLDTFVCSSWYYLRYPDNNNEKDAFNPELINKMLPVDKYVGGPEHACMHLLYARFITKALRDMGYLNFDEPFLSLT
HQGLILGPDGLKMSKSKGNTISPDDYIKEFGADVFRMYLMFGFDYTEGGAWSDDAIKSIGKFVDRVERILENAREEIKNS
KDNKSTMDKDEKELNYVRHHSIKSITEDIDKMQFNTSIARLMEFTNALSKYLGSDTLRNASFLRESIIDFITLLAPFAPH
FAEEQWELIGINSSIFNEKWPEFDPKALIKDEVEIAVQVNGKIRAKINISTSSSEDEIKESALNNDDIKNSIGDKEIKKV
IVIKNRLVNIVAK

Sequences:

>Translated_813_residues
MGNYSTKIDEKWQKKWEENSLYKFNNKNLDKKLYVLEMFSYPSGSKLHAGHWFNYGPVDSWARFKRMQGYNVFQPMGFDA
FGLPAENYAIKTGIHPKDSTFKNIETMETQLKAMGAMFNWENEVITCSPDYYKWTQWLFLKLYEKGLAYKKKAPVNWCPS
CNTVLANEQVLDGKCERCDSNVDKKNLEQWFLKITDYADELLEKLDELDWPEKTKAMQKHWIGKSVGAEVTFNVADSDLS
FNVFTTRVDTLFGVTYVVLAPENDLVDKLTTPENKAEVESYKTQAKNQSDIERQSITREKTGVFSGSYAINPINGKEVPI
WIGDYVLNTYGTGCVMAVPAHDERDFAFATKYNLPIERVIEGGDSLPYTEYGKMVNSGEFDGLFGNKAKEAVISKLESMN
LGRKKINYRLRDWLVSRQRYWGAPIPIIYCEKCGTVEVPIEQLPVELPYNVEFSPDGKSPLGKCDDFINTTCPKCGGPAK
READTLDTFVCSSWYYLRYPDNNNEKDAFNPELINKMLPVDKYVGGPEHACMHLLYARFITKALRDMGYLNFDEPFLSLT
HQGLILGPDGLKMSKSKGNTISPDDYIKEFGADVFRMYLMFGFDYTEGGAWSDDAIKSIGKFVDRVERILENAREEIKNS
KDNKSTMDKDEKELNYVRHHSIKSITEDIDKMQFNTSIARLMEFTNALSKYLGSDTLRNASFLRESIIDFITLLAPFAPH
FAEEQWELIGINSSIFNEKWPEFDPKALIKDEVEIAVQVNGKIRAKINISTSSSEDEIKESALNNDDIKNSIGDKEIKKV
IVIKNRLVNIVAK
>Mature_812_residues
GNYSTKIDEKWQKKWEENSLYKFNNKNLDKKLYVLEMFSYPSGSKLHAGHWFNYGPVDSWARFKRMQGYNVFQPMGFDAF
GLPAENYAIKTGIHPKDSTFKNIETMETQLKAMGAMFNWENEVITCSPDYYKWTQWLFLKLYEKGLAYKKKAPVNWCPSC
NTVLANEQVLDGKCERCDSNVDKKNLEQWFLKITDYADELLEKLDELDWPEKTKAMQKHWIGKSVGAEVTFNVADSDLSF
NVFTTRVDTLFGVTYVVLAPENDLVDKLTTPENKAEVESYKTQAKNQSDIERQSITREKTGVFSGSYAINPINGKEVPIW
IGDYVLNTYGTGCVMAVPAHDERDFAFATKYNLPIERVIEGGDSLPYTEYGKMVNSGEFDGLFGNKAKEAVISKLESMNL
GRKKINYRLRDWLVSRQRYWGAPIPIIYCEKCGTVEVPIEQLPVELPYNVEFSPDGKSPLGKCDDFINTTCPKCGGPAKR
EADTLDTFVCSSWYYLRYPDNNNEKDAFNPELINKMLPVDKYVGGPEHACMHLLYARFITKALRDMGYLNFDEPFLSLTH
QGLILGPDGLKMSKSKGNTISPDDYIKEFGADVFRMYLMFGFDYTEGGAWSDDAIKSIGKFVDRVERILENAREEIKNSK
DNKSTMDKDEKELNYVRHHSIKSITEDIDKMQFNTSIARLMEFTNALSKYLGSDTLRNASFLRESIIDFITLLAPFAPHF
AEEQWELIGINSSIFNEKWPEFDPKALIKDEVEIAVQVNGKIRAKINISTSSSEDEIKESALNNDDIKNSIGDKEIKKVI
VIKNRLVNIVAK

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7661872, Length=870, Percent_Identity=33.5632183908046, Blast_Score=472, Evalue=1e-133,
Organism=Escherichia coli, GI1786861, Length=858, Percent_Identity=40.7925407925408, Blast_Score=648, Evalue=0.0,
Organism=Escherichia coli, GI2367096, Length=309, Percent_Identity=26.2135922330097, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71997510, Length=808, Percent_Identity=29.0841584158416, Blast_Score=313, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI71997517, Length=803, Percent_Identity=28.6425902864259, Blast_Score=311, Evalue=7e-85,
Organism=Caenorhabditis elegans, GI212645227, Length=323, Percent_Identity=29.1021671826625, Blast_Score=126, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6323414, Length=876, Percent_Identity=36.4155251141553, Blast_Score=511, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6321531, Length=374, Percent_Identity=23.7967914438503, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI21355409, Length=859, Percent_Identity=32.8288707799767, Blast_Score=416, Evalue=1e-116,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008 [H]

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1 [H]

EC number: =6.1.1.4 [H]

Molecular weight: Translated: 93010; Mature: 92879

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNYSTKIDEKWQKKWEENSLYKFNNKNLDKKLYVLEMFSYPSGSKLHAGHWFNYGPVDS
CCCCCCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEECCCCCCCEECCCCCCCCCHHH
WARFKRMQGYNVFQPMGFDAFGLPAENYAIKTGIHPKDSTFKNIETMETQLKAMGAMFNW
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCC
ENEVITCSPDYYKWTQWLFLKLYEKGLAYKKKAPVNWCPSCNTVLANEQVLDGKCERCDS
CCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCHHHCCHHHHHCC
NVDKKNLEQWFLKITDYADELLEKLDELDWPEKTKAMQKHWIGKSVGAEVTFNVADSDLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCE
FNVFTTRVDTLFGVTYVVLAPENDLVDKLTTPENKAEVESYKTQAKNQSDIERQSITREK
EEEHHHHHHHHHCCEEEEECCCCHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
TGVFSGSYAINPINGKEVPIWIGDYVLNTYGTGCVMAVPAHDERDFAFATKYNLPIERVI
HCCCCCCEEECCCCCCEEEEEEHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCHHHHH
EGGDSLPYTEYGKMVNSGEFDGLFGNKAKEAVISKLESMNLGRKKINYRLRDWLVSRQRY
CCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
WGAPIPIIYCEKCGTVEVPIEQLPVELPYNVEFSPDGKSPLGKCDDFINTTCPKCGGPAK
CCCCCCEEEECCCCCEECCHHHCCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCCCCCCC
READTLDTFVCSSWYYLRYPDNNNEKDAFNPELINKMLPVDKYVGGPEHACMHLLYARFI
CCHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHCCHHHHCCCHHHHHHHHHHHHHH
TKALRDMGYLNFDEPFLSLTHQGLILGPDGLKMSKSKGNTISPDDYIKEFGADVFRMYLM
HHHHHHCCCCCCCCHHHHHCCCCEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHH
FGFDYTEGGAWSDDAIKSIGKFVDRVERILENAREEIKNSKDNKSTMDKDEKELNYVRHH
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHH
SIKSITEDIDKMQFNTSIARLMEFTNALSKYLGSDTLRNASFLRESIIDFITLLAPFAPH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCHH
FAEEQWELIGINSSIFNEKWPEFDPKALIKDEVEIAVQVNGKIRAKINISTSSSEDEIKE
HHCCCEEEEECCHHHHCCCCCCCCCHHHHCCCEEEEEEECCEEEEEEEECCCCCHHHHHH
SALNNDDIKNSIGDKEIKKVIVIKNRLVNIVAK
HHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GNYSTKIDEKWQKKWEENSLYKFNNKNLDKKLYVLEMFSYPSGSKLHAGHWFNYGPVDS
CCCCCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEECCCCCCCEECCCCCCCCCHHH
WARFKRMQGYNVFQPMGFDAFGLPAENYAIKTGIHPKDSTFKNIETMETQLKAMGAMFNW
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCC
ENEVITCSPDYYKWTQWLFLKLYEKGLAYKKKAPVNWCPSCNTVLANEQVLDGKCERCDS
CCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCHHHCCHHHHHCC
NVDKKNLEQWFLKITDYADELLEKLDELDWPEKTKAMQKHWIGKSVGAEVTFNVADSDLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCE
FNVFTTRVDTLFGVTYVVLAPENDLVDKLTTPENKAEVESYKTQAKNQSDIERQSITREK
EEEHHHHHHHHHCCEEEEECCCCHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
TGVFSGSYAINPINGKEVPIWIGDYVLNTYGTGCVMAVPAHDERDFAFATKYNLPIERVI
HCCCCCCEEECCCCCCEEEEEEHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCHHHHH
EGGDSLPYTEYGKMVNSGEFDGLFGNKAKEAVISKLESMNLGRKKINYRLRDWLVSRQRY
CCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
WGAPIPIIYCEKCGTVEVPIEQLPVELPYNVEFSPDGKSPLGKCDDFINTTCPKCGGPAK
CCCCCCEEEECCCCCEECCHHHCCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCCCCCCC
READTLDTFVCSSWYYLRYPDNNNEKDAFNPELINKMLPVDKYVGGPEHACMHLLYARFI
CCHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHCCHHHHCCCHHHHHHHHHHHHHH
TKALRDMGYLNFDEPFLSLTHQGLILGPDGLKMSKSKGNTISPDDYIKEFGADVFRMYLM
HHHHHHCCCCCCCCHHHHHCCCCEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHH
FGFDYTEGGAWSDDAIKSIGKFVDRVERILENAREEIKNSKDNKSTMDKDEKELNYVRHH
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHH
SIKSITEDIDKMQFNTSIARLMEFTNALSKYLGSDTLRNASFLRESIIDFITLLAPFAPH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCHH
FAEEQWELIGINSSIFNEKWPEFDPKALIKDEVEIAVQVNGKIRAKINISTSSSEDEIKE
HHCCCEEEEECCHHHHCCCCCCCCCHHHHCCCEEEEEEECCEEEEEEEECCCCCHHHHHH
SALNNDDIKNSIGDKEIKKVIVIKNRLVNIVAK
HHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA