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The map label for this gene is pepD

Identifier: 170755724

GI number: 170755724

Start: 2428919

End: 2430367

Strand: Reverse

Name: pepD

Synonym: CLD_2343

Alternate gene names: 170755724

Gene position: 2430367-2428919 (Counterclockwise)

Preceding gene: 170757596

Following gene: 170754713

Centisome position: 61.4

GC content: 30.71

Gene sequence:

>1449_bases
ATGATGGAAGTATTAAGTAATTTAGAGCCTAAATCAGTATTTCATTTTTTTGAGGAATTAACTAAAATACCACATGGATC
AAGAAATGAAAAAGAGATTAGTGATTTTTTAGTTAGCTTTGCCAAGGAAAGAAATTTAGAAGTATGTCAAGATAAGGCCT
TAAATGTAATAATTAAGAAGCCTGGCACAAAGGGATATGAAAATGCACCAACTGTAATAATACAAGGTCATATGGATATG
GTTTGTGAAAAGTTAAAAGATGTAGATCATGATTTTGAAAAAGATCCATTAAAATTAAGAATAGAAGATGACTATATTTA
TGCTACGGGTACAACATTAGGTGGAGATGATGGTATTGCTATAGCTTATGGACTCGCAATATTAGATTCAAAGGATATAG
ATCATCCACCAATAGAATTTGTTGCTACAAGTAATGAAGAAGATGGCATGGAAGGAGCTTTTGCATTAGACACTAAAAAT
TTAAAGGGTAAAATGCTTATAAATATAGATGGAGAAGAGGATGGTGTATTCATAATAAGCTGCGCAGGGGGAATTACAGC
TACTACAAAAATAAAAGTAGAGTCAGAAAAATGCGAAAAGGAAGCTATTAAAATAAGAGTAGTAGGTTTAAATGGTGGAC
ATTCTGGAATGGAAATTGTTAAACAAAGAGGAAATGCAAATAAATTAATGGGTAGACTTTTATATATTTTAAGCAAGTAC
ATTGATTTTAATATTGCACATATAGAAGGTGGAACAAAAGATAATGCTATACCTAGAGAGTGCAGTGCCCTAATAACTTT
GGATAAAAATAAAATAGAAGAAGTTAAAGAAATCTTAAGTAAAGTTCAGGAGAATTTAAAAGCTGAATATAGAGTACAAG
ATCCTTCAGTGGAAATAAAAGTTGAGAGCTCAAATAAAGTAGACAAGCATTTCAGTAAAACAAATACACAATCAATTATT
AGATTTTTAACATCAGTTCCAGATGGAGTACAATCTATGAGTCAAGACATAAAAGGTCTTGTAGAGAGTAGCTTAAATAC
TGCAATAATAAATACAAAAGAAGATGAAGTTGAGATTATATCTTCTATAAGAAGTTCTGTTTATAGCAGAAAATCTGAAA
TAGCAGATAAGATTGAAGCTTTAGCAGAGGCCGTTGATGCTACTGTTAAAAGAGAATCAGAATATCCAGGTTGGGAATAC
GATAAGGATTCTAAAATAAGAGATATATCTGTTTTAGCTTACAAAAACTTATTTGGCGTAGAACCAGCTATAACAGCTAT
TCATGCAGGCCTTGAATGTGGTTTATTTAAAGAAACTATGAAAGATACAGATATGATTAGCTTTGGACCAGATATAATAG
ATGTTCATACCGCTAATGAGCATTTAAAAATATCTTCAGTTGAAAAATATTGGGCGCTTCTAAAAGAAATATTAAAAAAC
ATTAAATAG

Upstream 100 bases:

>100_bases
TGAATTTTATATTTAAAATGTAAATTTGTGGTTCGAATCATATTTATAATTTTTTATTTGTTGTATTAAACAATATATTA
ATGAATTTTAGGAGGGTTAT

Downstream 100 bases:

>100_bases
ATACTTTAATGTAAATAGTTGGAAAATTGATTTCTTAGTTAACTATAAGTTTATGTTAATCATAAGAAATCAATTTCCTT
ATACTCGAATTCTACAATAG

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MMEVLSNLEPKSVFHFFEELTKIPHGSRNEKEISDFLVSFAKERNLEVCQDKALNVIIKKPGTKGYENAPTVIIQGHMDM
VCEKLKDVDHDFEKDPLKLRIEDDYIYATGTTLGGDDGIAIAYGLAILDSKDIDHPPIEFVATSNEEDGMEGAFALDTKN
LKGKMLINIDGEEDGVFIISCAGGITATTKIKVESEKCEKEAIKIRVVGLNGGHSGMEIVKQRGNANKLMGRLLYILSKY
IDFNIAHIEGGTKDNAIPRECSALITLDKNKIEEVKEILSKVQENLKAEYRVQDPSVEIKVESSNKVDKHFSKTNTQSII
RFLTSVPDGVQSMSQDIKGLVESSLNTAIINTKEDEVEIISSIRSSVYSRKSEIADKIEALAEAVDATVKRESEYPGWEY
DKDSKIRDISVLAYKNLFGVEPAITAIHAGLECGLFKETMKDTDMISFGPDIIDVHTANEHLKISSVEKYWALLKEILKN
IK

Sequences:

>Translated_482_residues
MMEVLSNLEPKSVFHFFEELTKIPHGSRNEKEISDFLVSFAKERNLEVCQDKALNVIIKKPGTKGYENAPTVIIQGHMDM
VCEKLKDVDHDFEKDPLKLRIEDDYIYATGTTLGGDDGIAIAYGLAILDSKDIDHPPIEFVATSNEEDGMEGAFALDTKN
LKGKMLINIDGEEDGVFIISCAGGITATTKIKVESEKCEKEAIKIRVVGLNGGHSGMEIVKQRGNANKLMGRLLYILSKY
IDFNIAHIEGGTKDNAIPRECSALITLDKNKIEEVKEILSKVQENLKAEYRVQDPSVEIKVESSNKVDKHFSKTNTQSII
RFLTSVPDGVQSMSQDIKGLVESSLNTAIINTKEDEVEIISSIRSSVYSRKSEIADKIEALAEAVDATVKRESEYPGWEY
DKDSKIRDISVLAYKNLFGVEPAITAIHAGLECGLFKETMKDTDMISFGPDIIDVHTANEHLKISSVEKYWALLKEILKN
IK
>Mature_482_residues
MMEVLSNLEPKSVFHFFEELTKIPHGSRNEKEISDFLVSFAKERNLEVCQDKALNVIIKKPGTKGYENAPTVIIQGHMDM
VCEKLKDVDHDFEKDPLKLRIEDDYIYATGTTLGGDDGIAIAYGLAILDSKDIDHPPIEFVATSNEEDGMEGAFALDTKN
LKGKMLINIDGEEDGVFIISCAGGITATTKIKVESEKCEKEAIKIRVVGLNGGHSGMEIVKQRGNANKLMGRLLYILSKY
IDFNIAHIEGGTKDNAIPRECSALITLDKNKIEEVKEILSKVQENLKAEYRVQDPSVEIKVESSNKVDKHFSKTNTQSII
RFLTSVPDGVQSMSQDIKGLVESSLNTAIINTKEDEVEIISSIRSSVYSRKSEIADKIEALAEAVDATVKRESEYPGWEY
DKDSKIRDISVLAYKNLFGVEPAITAIHAGLECGLFKETMKDTDMISFGPDIIDVHTANEHLKISSVEKYWALLKEILKN
IK

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=482, Percent_Identity=38.1742738589212, Blast_Score=354, Evalue=7e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 53654; Mature: 53654

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEVLSNLEPKSVFHFFEELTKIPHGSRNEKEISDFLVSFAKERNLEVCQDKALNVIIKK
CCCHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEC
PGTKGYENAPTVIIQGHMDMVCEKLKDVDHDFEKDPLKLRIEDDYIYATGTTLGGDDGIA
CCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCEEEEEECCEEEEECCCCCCCCCEE
IAYGLAILDSKDIDHPPIEFVATSNEEDGMEGAFALDTKNLKGKMLINIDGEEDGVFIIS
HHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCEEEEE
CAGGITATTKIKVESEKCEKEAIKIRVVGLNGGHSGMEIVKQRGNANKLMGRLLYILSKY
ECCCCEEEEEEEECHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
IDFNIAHIEGGTKDNAIPRECSALITLDKNKIEEVKEILSKVQENLKAEYRVQDPSVEIK
HCCEEEEECCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEE
VESSNKVDKHFSKTNTQSIIRFLTSVPDGVQSMSQDIKGLVESSLNTAIINTKEDEVEII
ECCCCCHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHH
SSIRSSVYSRKSEIADKIEALAEAVDATVKRESEYPGWEYDKDSKIRDISVLAYKNLFGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEHEEHHHHCCC
EPAITAIHAGLECGLFKETMKDTDMISFGPDIIDVHTANEHLKISSVEKYWALLKEILKN
CHHHHHHHCCCHHHHHHHHHCCCCCEECCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHH
IK
CC
>Mature Secondary Structure
MMEVLSNLEPKSVFHFFEELTKIPHGSRNEKEISDFLVSFAKERNLEVCQDKALNVIIKK
CCCHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEC
PGTKGYENAPTVIIQGHMDMVCEKLKDVDHDFEKDPLKLRIEDDYIYATGTTLGGDDGIA
CCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCEEEEEECCEEEEECCCCCCCCCEE
IAYGLAILDSKDIDHPPIEFVATSNEEDGMEGAFALDTKNLKGKMLINIDGEEDGVFIIS
HHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCEEEEE
CAGGITATTKIKVESEKCEKEAIKIRVVGLNGGHSGMEIVKQRGNANKLMGRLLYILSKY
ECCCCEEEEEEEECHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
IDFNIAHIEGGTKDNAIPRECSALITLDKNKIEEVKEILSKVQENLKAEYRVQDPSVEIK
HCCEEEEECCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEE
VESSNKVDKHFSKTNTQSIIRFLTSVPDGVQSMSQDIKGLVESSLNTAIINTKEDEVEII
ECCCCCHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHH
SSIRSSVYSRKSEIADKIEALAEAVDATVKRESEYPGWEYDKDSKIRDISVLAYKNLFGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEHEEHHHHCCC
EPAITAIHAGLECGLFKETMKDTDMISFGPDIIDVHTANEHLKISSVEKYWALLKEILKN
CHHHHHHHCCCHHHHHHHHHCCCCCEECCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHH
IK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]