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The map label for this gene is lon

Identifier: 170755581

GI number: 170755581

Start: 3504686

End: 3507007

Strand: Reverse

Name: lon

Synonym: CLD_1303

Alternate gene names: 170755581

Gene position: 3507007-3504686 (Counterclockwise)

Preceding gene: 170756440

Following gene: 170757263

Centisome position: 88.6

GC content: 29.84

Gene sequence:

>2322_bases
ATGAAAGAAAACTTAGAAGTTCTTCCTTTAATTCCATTGAGAGGAATAATTATATTTCCATATATGATTTTACATTTTGA
TGTAGGTAGAGAAAAATCTATTTTAGCTTTAGAAGAAGCTATGGAAAATGAACAAAAAATATTTTTATCTGCTCAAAAAG
AGGCTGAAACAGAAGAACCAATTGTAGAAGACATATATGATATAGGAACTATATGTGAAATAAAACAAATACTAAAATTG
CCAGGAGATACAGTTAGAGTTTTAGTGGAAGGAAAAACTAGAGGTAGAATAGTTAATTATTTAGAAGAAGAACCATTTTT
AAAAGTAGAGATAGAAGAGATAGAAGATAATCAATATGAAGATGATAAGGAAGTGGATGCTCTTATAAGATTAGTAAAAA
CTAATTTTGATGAGTATATTAAGCTTTCAGGTGATTCATCTTCAGATTTAACTGTAGGAGTAGAAGATTTAGAAGAACCA
GGTAGAATAGCAGATGTTATAGGTTCATACATAAATATAAATCAAGAAGAAAAACAAGAGCTCATAGGAATTATTGATTC
TAAAGAGAGATTAGAAAGAATATTAATCATTATAAATGAAGAGATAGAAATACTAAAAATTGAAAGAAAAATAGGAATTA
AAGTAAAGAACAAAATAGACAAAGTGCAAAAGGAATATTATCTAAAAGAACAATTAAAGGCTATACAAGAGGAGCTAGGG
GAAGACGAGGAAGATAAAAAAGAAATAAATTTATATAAAGAGAAAATAAATAAAGCAAAGCTTCCTAAAGAAGTAAAAGA
AAAAGCTATATATGAATTAGATAGGCTAAAAAATTCTGGTAATTTCTCTGCAGAGGGGGGAGTTATTAGGACTTATTTAG
ACTGGATATTATCATTACCGTGGAATAAAGATACTAAAGATAATCTAGATATAAAAAAAGCTAGAGAGATATTGGATAAA
GAGCATTATGGATTAAAAGATGTAAAAGATAGAATAATAGAATATTTAGCAGTAAGAAAAGTCAGTAAAACCCTAAAAGG
GCCTATATTATGTTTAGTAGGGCCACCAGGGGTGGGAAAGACATCTATAGCCAAGTCTATAGCACATTCTTTAAATAGGA
ATTTTGTAAGAATGTCTTTAGGTGGAGTAAGAGATGAAGCAGAAATAAGGGGTCATAGAAAAACTTATGTAGGAGCAATA
CCAGGAAGAGTAATTTATGGTATGAAGCAAGCGAAATCTAAAAATCCATTATTTTTACTTGATGAAATAGATAAAATGAG
TAATGATTTTAGAGGGGATCCAGCAGACGCGTTATTAGAGGTTCTAGATGCAGAACAAAATGCTACTTTTAGAGATCACT
ATTTAGAATTAGATTTTGATTTATCTAAAGTACTATTTATAACTACTGCAAATACTTTAAGTACAATACCTGGTCCATTG
TTAGACAGAATGGAAGTTATAGAAGTATCTGGATATACTTCAGAAGAAAAGTTTTATATAGCTAAAAATCATCTTATTCC
TAAAAAATTAAAAGAGCATAATATGGAAGATGGGAAAATTACTTTTTCTAATTCCTCTATATATTATATTATAGATAATT
ATACTCGTGAATCAGGAGTCAGAGGATTAGAAAGAAAAATATCCTCTATTATAAGAAAGTCTATAACAGAAATGATCGAA
AAAAATAAGGATACAACCAACGTTACAATAAATCATGTTAAGAAGTATTTAGGACCAGAAGTATTTTCCTATGAAAAAGC
AGATAAAGAGGATAAAATCGGTGTGGTAACAGGCTTAGCTTGGACTGCTTATGGTGGAGATACTCTACCTATAGAGGTTA
CTGCTATGGATGGTAATGGTAAGTTGCAGCTTACAGGAAAATTAGGAGAAGTTATGGTAGAGTCTGCGAAAGCAGGATAT
AGTTATGTAAGATCAAATGCTAGCAAATATGAAATAGATACTGATTTTTATAAAAATAAGGATATTCATATACATGTACC
AGAAGGAGCAGTGCCAAAAGACGGTCCTTCAGCAGGAGTAACTATGATAACTGCATTAATTTCAGCTTTAGGTGGTAAAA
GAGTTAAGCATAATGTGGCTATGACAGGAGAAATTACATTGACAGGAAGGGTACTACCTATTGGTGGATTAAAAGAAAAG
TCATTAGCAGCCTATAGGGCTGGAATAGATACAATAATAATTCCTAAAGCTAATGAAAAAGATTTAAGAAATATTCCTAA
AACTGTAAAGAATAAAATTGATTTTATTGTAGCTGATAGAATAGAAAAGGTTCTTGATAATGCTTTAATAAAAGAACAAT
AA

Upstream 100 bases:

>100_bases
AATAACCTTATAATAACTATTTGAAAAAAAGTATTTTTATAGGTATAATATATTAGTCTAGCTATATGTAAAGCTAAATT
TATCAAAGCGAGGGAGATAT

Downstream 100 bases:

>100_bases
TGGAGAGATTAAGTATGGAAATGGAAATAAAAAAAGCAGAATTTGTAATATCAGCAGTGAAGAAAACTCAATATCCTGAG
GATGGTAGACCAGAAGTTGC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 773; Mature: 773

Protein sequence:

>773_residues
MKENLEVLPLIPLRGIIIFPYMILHFDVGREKSILALEEAMENEQKIFLSAQKEAETEEPIVEDIYDIGTICEIKQILKL
PGDTVRVLVEGKTRGRIVNYLEEEPFLKVEIEEIEDNQYEDDKEVDALIRLVKTNFDEYIKLSGDSSSDLTVGVEDLEEP
GRIADVIGSYININQEEKQELIGIIDSKERLERILIIINEEIEILKIERKIGIKVKNKIDKVQKEYYLKEQLKAIQEELG
EDEEDKKEINLYKEKINKAKLPKEVKEKAIYELDRLKNSGNFSAEGGVIRTYLDWILSLPWNKDTKDNLDIKKAREILDK
EHYGLKDVKDRIIEYLAVRKVSKTLKGPILCLVGPPGVGKTSIAKSIAHSLNRNFVRMSLGGVRDEAEIRGHRKTYVGAI
PGRVIYGMKQAKSKNPLFLLDEIDKMSNDFRGDPADALLEVLDAEQNATFRDHYLELDFDLSKVLFITTANTLSTIPGPL
LDRMEVIEVSGYTSEEKFYIAKNHLIPKKLKEHNMEDGKITFSNSSIYYIIDNYTRESGVRGLERKISSIIRKSITEMIE
KNKDTTNVTINHVKKYLGPEVFSYEKADKEDKIGVVTGLAWTAYGGDTLPIEVTAMDGNGKLQLTGKLGEVMVESAKAGY
SYVRSNASKYEIDTDFYKNKDIHIHVPEGAVPKDGPSAGVTMITALISALGGKRVKHNVAMTGEITLTGRVLPIGGLKEK
SLAAYRAGIDTIIIPKANEKDLRNIPKTVKNKIDFIVADRIEKVLDNALIKEQ

Sequences:

>Translated_773_residues
MKENLEVLPLIPLRGIIIFPYMILHFDVGREKSILALEEAMENEQKIFLSAQKEAETEEPIVEDIYDIGTICEIKQILKL
PGDTVRVLVEGKTRGRIVNYLEEEPFLKVEIEEIEDNQYEDDKEVDALIRLVKTNFDEYIKLSGDSSSDLTVGVEDLEEP
GRIADVIGSYININQEEKQELIGIIDSKERLERILIIINEEIEILKIERKIGIKVKNKIDKVQKEYYLKEQLKAIQEELG
EDEEDKKEINLYKEKINKAKLPKEVKEKAIYELDRLKNSGNFSAEGGVIRTYLDWILSLPWNKDTKDNLDIKKAREILDK
EHYGLKDVKDRIIEYLAVRKVSKTLKGPILCLVGPPGVGKTSIAKSIAHSLNRNFVRMSLGGVRDEAEIRGHRKTYVGAI
PGRVIYGMKQAKSKNPLFLLDEIDKMSNDFRGDPADALLEVLDAEQNATFRDHYLELDFDLSKVLFITTANTLSTIPGPL
LDRMEVIEVSGYTSEEKFYIAKNHLIPKKLKEHNMEDGKITFSNSSIYYIIDNYTRESGVRGLERKISSIIRKSITEMIE
KNKDTTNVTINHVKKYLGPEVFSYEKADKEDKIGVVTGLAWTAYGGDTLPIEVTAMDGNGKLQLTGKLGEVMVESAKAGY
SYVRSNASKYEIDTDFYKNKDIHIHVPEGAVPKDGPSAGVTMITALISALGGKRVKHNVAMTGEITLTGRVLPIGGLKEK
SLAAYRAGIDTIIIPKANEKDLRNIPKTVKNKIDFIVADRIEKVLDNALIKEQ
>Mature_773_residues
MKENLEVLPLIPLRGIIIFPYMILHFDVGREKSILALEEAMENEQKIFLSAQKEAETEEPIVEDIYDIGTICEIKQILKL
PGDTVRVLVEGKTRGRIVNYLEEEPFLKVEIEEIEDNQYEDDKEVDALIRLVKTNFDEYIKLSGDSSSDLTVGVEDLEEP
GRIADVIGSYININQEEKQELIGIIDSKERLERILIIINEEIEILKIERKIGIKVKNKIDKVQKEYYLKEQLKAIQEELG
EDEEDKKEINLYKEKINKAKLPKEVKEKAIYELDRLKNSGNFSAEGGVIRTYLDWILSLPWNKDTKDNLDIKKAREILDK
EHYGLKDVKDRIIEYLAVRKVSKTLKGPILCLVGPPGVGKTSIAKSIAHSLNRNFVRMSLGGVRDEAEIRGHRKTYVGAI
PGRVIYGMKQAKSKNPLFLLDEIDKMSNDFRGDPADALLEVLDAEQNATFRDHYLELDFDLSKVLFITTANTLSTIPGPL
LDRMEVIEVSGYTSEEKFYIAKNHLIPKKLKEHNMEDGKITFSNSSIYYIIDNYTRESGVRGLERKISSIIRKSITEMIE
KNKDTTNVTINHVKKYLGPEVFSYEKADKEDKIGVVTGLAWTAYGGDTLPIEVTAMDGNGKLQLTGKLGEVMVESAKAGY
SYVRSNASKYEIDTDFYKNKDIHIHVPEGAVPKDGPSAGVTMITALISALGGKRVKHNVAMTGEITLTGRVLPIGGLKEK
SLAAYRAGIDTIIIPKANEKDLRNIPKTVKNKIDFIVADRIEKVLDNALIKEQ

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=836, Percent_Identity=37.0813397129187, Blast_Score=558, Evalue=1e-159,
Organism=Homo sapiens, GI31377667, Length=762, Percent_Identity=40.0262467191601, Blast_Score=554, Evalue=1e-157,
Organism=Escherichia coli, GI1786643, Length=767, Percent_Identity=51.238591916558, Blast_Score=781, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=647, Percent_Identity=40.8037094281298, Blast_Score=482, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17556486, Length=535, Percent_Identity=41.3084112149533, Blast_Score=438, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319449, Length=691, Percent_Identity=42.1128798842258, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24666867, Length=677, Percent_Identity=41.8020679468242, Blast_Score=534, Evalue=1e-151,
Organism=Drosophila melanogaster, GI221513036, Length=677, Percent_Identity=41.8020679468242, Blast_Score=534, Evalue=1e-151,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87346; Mature: 87346

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKENLEVLPLIPLRGIIIFPYMILHFDVGREKSILALEEAMENEQKIFLSAQKEAETEEP
CCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
IVEDIYDIGTICEIKQILKLPGDTVRVLVEGKTRGRIVNYLEEEPFLKVEIEEIEDNQYE
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCCCEEEEEEEECCCCCCC
DDKEVDALIRLVKTNFDEYIKLSGDSSSDLTVGVEDLEEPGRIADVIGSYININQEEKQE
CHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEHHHHCCCCHHHHHHHHHHCCCHHHHHH
LIGIIDSKERLERILIIINEEIEILKIERKIGIKVKNKIDKVQKEYYLKEQLKAIQEELG
HHHHCCCHHHHCEEEEEECCCEEEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
EDEEDKKEINLYKEKINKAKLPKEVKEKAIYELDRLKNSGNFSAEGGVIRTYLDWILSLP
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCC
WNKDTKDNLDIKKAREILDKEHYGLKDVKDRIIEYLAVRKVSKTLKGPILCLVGPPGVGK
CCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCH
TSIAKSIAHSLNRNFVRMSLGGVRDEAEIRGHRKTYVGAIPGRVIYGMKQAKSKNPLFLL
HHHHHHHHHHHCCCEEEEECCCCCCHHHHCCCCCEEEECCCCHHHHCHHHCCCCCCEEEE
DEIDKMSNDFRGDPADALLEVLDAEQNATFRDHYLELDFDLSKVLFITTANTLSTIPGPL
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHEEEEECCCEEEEEEEECCHHHHCCCHH
LDRMEVIEVSGYTSEEKFYIAKNHLIPKKLKEHNMEDGKITFSNSSIYYIIDNYTRESGV
HCCCCEEEECCCCCCCEEEEECCCCCHHHHHHCCCCCCEEEEECCEEEEEEECCCHHHHH
RGLERKISSIIRKSITEMIEKNKDTTNVTINHVKKYLGPEVFSYEKADKEDKIGVVTGLA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHCCHHCCCCCCCCCCCCEEEEEEE
WTAYGGDTLPIEVTAMDGNGKLQLTGKLGEVMVESAKAGYSYVRSNASKYEIDTDFYKNK
EEECCCCEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEECCHHHCCC
DIHIHVPEGAVPKDGPSAGVTMITALISALGGKRVKHNVAMTGEITLTGRVLPIGGLKEK
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCEEEEEEEEEEEEEEECCCCCHH
SLAAYRAGIDTIIIPKANEKDLRNIPKTVKNKIDFIVADRIEKVLDNALIKEQ
HHHHHHCCCCEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKENLEVLPLIPLRGIIIFPYMILHFDVGREKSILALEEAMENEQKIFLSAQKEAETEEP
CCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
IVEDIYDIGTICEIKQILKLPGDTVRVLVEGKTRGRIVNYLEEEPFLKVEIEEIEDNQYE
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCCCEEEEEEEECCCCCCC
DDKEVDALIRLVKTNFDEYIKLSGDSSSDLTVGVEDLEEPGRIADVIGSYININQEEKQE
CHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEHHHHCCCCHHHHHHHHHHCCCHHHHHH
LIGIIDSKERLERILIIINEEIEILKIERKIGIKVKNKIDKVQKEYYLKEQLKAIQEELG
HHHHCCCHHHHCEEEEEECCCEEEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
EDEEDKKEINLYKEKINKAKLPKEVKEKAIYELDRLKNSGNFSAEGGVIRTYLDWILSLP
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCC
WNKDTKDNLDIKKAREILDKEHYGLKDVKDRIIEYLAVRKVSKTLKGPILCLVGPPGVGK
CCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCH
TSIAKSIAHSLNRNFVRMSLGGVRDEAEIRGHRKTYVGAIPGRVIYGMKQAKSKNPLFLL
HHHHHHHHHHHCCCEEEEECCCCCCHHHHCCCCCEEEECCCCHHHHCHHHCCCCCCEEEE
DEIDKMSNDFRGDPADALLEVLDAEQNATFRDHYLELDFDLSKVLFITTANTLSTIPGPL
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHEEEEECCCEEEEEEEECCHHHHCCCHH
LDRMEVIEVSGYTSEEKFYIAKNHLIPKKLKEHNMEDGKITFSNSSIYYIIDNYTRESGV
HCCCCEEEECCCCCCCEEEEECCCCCHHHHHHCCCCCCEEEEECCEEEEEEECCCHHHHH
RGLERKISSIIRKSITEMIEKNKDTTNVTINHVKKYLGPEVFSYEKADKEDKIGVVTGLA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHCCHHCCCCCCCCCCCCEEEEEEE
WTAYGGDTLPIEVTAMDGNGKLQLTGKLGEVMVESAKAGYSYVRSNASKYEIDTDFYKNK
EEECCCCEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEECCHHHCCC
DIHIHVPEGAVPKDGPSAGVTMITALISALGGKRVKHNVAMTGEITLTGRVLPIGGLKEK
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCEEEEEEEEEEEEEEECCCCCHH
SLAAYRAGIDTIIIPKANEKDLRNIPKTVKNKIDFIVADRIEKVLDNALIKEQ
HHHHHHCCCCEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]