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The map label for this gene is disA

Identifier: 170755550

GI number: 170755550

Start: 3806700

End: 3807761

Strand: Reverse

Name: disA

Synonym: CLD_0994

Alternate gene names: 170755550

Gene position: 3807761-3806700 (Counterclockwise)

Preceding gene: 170757152

Following gene: 170757652

Centisome position: 96.2

GC content: 30.23

Gene sequence:

>1062_bases
GTGAGAATAGAAAAAGATAAAGAATTAATGAATATACTTAAAATAATGGCCCCAGGAACACCCCTAAGAGAGGGGTTAGA
GAATATATTAAGAGCTAAAACCGGTGGATTATTAATTCTAGGGGATAGTGACCAGATATTAAAGTTAGTAGACGGTGGAT
TTAAAATTAATTCGGAATATAGTCCATCTTATGTTTATGAATTAGCTAAAATGGATGGTTCAATTGTGTTAAGCAGCGAT
TTAAAGAAGATATTATGTGCTAATGCTCAACTAATACCAGATTCATCTATACCTACTTTTGAAACAGGAACAAGACATAG
AACTGCTGATAGAGTAGCAAAACAAACAGGGGCTATAGTAATAGCTATTTCTCAAAGGAGAAATATAATAACTGTTTATA
AGGGTGGAATAAAGTATGTATTAAGAGATAGTAGCATAATATTGGCAAGAGCTAATCAGGCTCTGCAAACTTTAGAAAAG
TATGTAGCTGTTTTAGACAGAGTAGTAAATAATTTAAATATACTAGAATTTAAGGATATAGCAACTTTATTTGATGTAGT
AACTGCTATTCAAAGATCCGAAATGGTTATGAGAATAGTTAGTGAAATAGAAAGATATATATGTGAATTAGGTAATGAAG
GAAGACTAATTGATATGCAATTAAGTGAATTAATAAAAAGTGTAGAAGAAGATGGTATTCTGCTTATAAGAGACTATTGT
AGAAGTAATATGGAATATGAAGATATATACAAACAGATACAAGGACTTTCATCAGAAGAACTTTTAAATTTAGATGGATT
ATCAAAAATTATAGGATATACAGGAGTACCTTTGGTAGATACACTTATTTCACCTCGAGGATATAGGATGATTAATAAAA
TACCGAGGATACCAAGTAATGTAATAGAAAATTTAGTAGCTAATTTTAATCAATTAAAATGTGTAATGGAAGCATCCTAT
GAGCAATTAGATAATGTAGAAGGGATTGGAGAAGCTAGAGCTAAAGCTATAAAAAACGGATTAAGAAGACTTAGAGAACA
AATAATGCTAGATAAAGTATAG

Upstream 100 bases:

>100_bases
TAAAGACAAAATTTCTGTTAAAAATAATGTTAACCTAATTGGTATATCTTCTTTAAGAGAAGGTATTAATAAAGTATTTT
AATTGTGTAGGGTGAGAGAA

Downstream 100 bases:

>100_bases
CACAAAGTATTTTAATACTTTGTGCTATACTTTATCTCATACTATATTTGCCTAATGTATTTATCTTATTATACTCTTTT
AACAATATATCATATAAGTT

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEYSPSYVYELAKMDGSIVLSSD
LKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIVIAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEK
YVAVLDRVVNNLNILEFKDIATLFDVVTAIQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYC
RSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSNVIENLVANFNQLKCVMEASY
EQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV

Sequences:

>Translated_353_residues
MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEYSPSYVYELAKMDGSIVLSSD
LKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIVIAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEK
YVAVLDRVVNNLNILEFKDIATLFDVVTAIQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYC
RSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSNVIENLVANFNQLKCVMEASY
EQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV
>Mature_353_residues
MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEYSPSYVYELAKMDGSIVLSSD
LKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIVIAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEK
YVAVLDRVVNNLNILEFKDIATLFDVVTAIQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYC
RSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSNVIENLVANFNQLKCVMEASY
EQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV

Specific function: Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, disA pauses at

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DISA_CLOB1 (A7FZ95)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001385824.1
- ProteinModelPortal:   A7FZ95
- SMR:   A7FZ95
- STRING:   A7FZ95
- GeneID:   5395285
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_3567
- eggNOG:   COG1623
- HOGENOM:   HBG292471
- OMA:   ISVSQSM
- ProtClustDB:   PRK13482
- BioCyc:   CBOT441770:CLB_3567-MONOMER
- HAMAP:   MF_01438
- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR003583
- InterPro:   IPR010994
- SMART:   SM00278

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N; SSF47781 RuvA_2_like

EC number: NA

Molecular weight: Translated: 39656; Mature: 39656

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEY
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCEEECCCC
SPSYVYELAKMDGSIVLSSDLKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIV
CHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEE
IAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEKYVAVLDRVVNNLNILEFKDI
EEEECCCCEEEEEECCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ATLFDVVTAIQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCEEEEEHHH
RSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSN
CCCCCHHHHHHHHHCCCHHHHHCCCHHHHHHCCCCCHHHHHHHCCCCHHHHHHCCCCHHH
VIENLVANFNQLKCVMEASYEQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEY
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCEEECCCC
SPSYVYELAKMDGSIVLSSDLKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIV
CHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEE
IAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEKYVAVLDRVVNNLNILEFKDI
EEEECCCCEEEEEECCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ATLFDVVTAIQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCEEEEEHHH
RSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSN
CCCCCHHHHHHHHHCCCHHHHHCCCHHHHHHCCCCCHHHHHHHCCCCHHHHHHCCCCHHH
VIENLVANFNQLKCVMEASYEQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA