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The map label for this gene is iscS

Identifier: 170755483

GI number: 170755483

Start: 2737848

End: 2739041

Strand: Reverse

Name: iscS

Synonym: CLD_1997

Alternate gene names: 170755483

Gene position: 2739041-2737848 (Counterclockwise)

Preceding gene: 170756317

Following gene: 170754548

Centisome position: 69.2

GC content: 31.24

Gene sequence:

>1194_bases
ATGAATAAACAAGTTTATATGGATTATTCAGCTACTACTTATACAAAACCAGAGGTATTAGAAGAAATGCTTCCATTTTT
TACTGAAAATTTTGGAAATCCATCTTCTTTATATTCTTTCTCAGATAAAACTAAAAAAGCTGTAAATCTAGCAAGAGAAA
GAGTATCAAAGGCATTAAATGCAGAAAAAAATGAGATATTCTTTACAAGTGGTGGCTCAGAAGCAGATAACTGGGCCCTA
AAAGGAATAGCTTATGCTAATAAAAAGAAGGGAAATCATATAATCACCACTAAGATAGAACATCATGCTATATTACATAC
GGCACAATTCTTAGAAAAAGAAGGCTTCAAAGTAACTTATCTTCCAGTAGATGAGGAGGGCTTTGTAAGTGTAGAGGATA
TAAAAAATGCTATAACAGATGAAACTATCCTAGTTTCTGTAATGTTTGCTAACAACGAAATAGGAACTATAGAACCAATA
AAAGAAATAGGAGAATTATGTAAGGAAAAAAATATTTATTTCCATACAGATGCAGTTCAAGCTATAGGTCATGTAGATAT
AGATGTAAAAGATATGAATATAGATTTGCTATCTATGTCTGCTCATAAATTTTATGGACCTAAAGGAGTAGGTGCTCTAT
ATATAAAAAATGGAGTTAAAATACAAAACTTAATTCATGGTGGAGGACAAGAAAGAGGTAAAAGGGCTAGCACAGAAGAC
ACAGCTGGAATAGTAGGGCTTGGTAAGGCCATAGAATTAGCTATGGAAAATATGCCTGAAGAAAATAAAAAATTAGCTAG
TTTAAGAGGAAAGCTAATAAAAGAAGTTGAAAAAAGAATACCTGAAGTAAAATTAAATGGACCTAGAGATATGAGCAAAA
GATTATCTAATAATGTTAATATTAGCTTTATAGGTATTGAAGGAGAAACTTTATTGTTAGATTTAGATATGAATGGCATA
TTTGGATCTACAGGAAGTGCTTGTGCTTCAGCATCTTTAGACCCATCCCATGTACTTTTATCTATAGGATTGCCACATGA
AGTTGCTCATGGTTCTTTAAGATTAAGCTTAGGAGCTAAGAATACAGAAGAAGATATAGATTATGTATTAGAAGTACTTC
CTAAAATAATAAAACAAAGAAGAGAAATGTCACCACTTTGGGAAGATTATATGAAAAACAAGGAGGAAAAATAA

Upstream 100 bases:

>100_bases
ATAAAGGAAAGTCTAGATAATATAATGGAATCAACTACCTTACAAGATATGGTAGAAGACTATAAGAAAATAAATTCACC
AATTAAAAGGAGTGAAAATA

Downstream 100 bases:

>100_bases
TATGTATACAGAAAAGGTAATGGATCATTTTAGAAATCCTAGAAATGTAGGGGAAATAGAAGATGCTAATGGTATAGGTG
AAGTAGGAAACGCTAAATGT

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MNKQVYMDYSATTYTKPEVLEEMLPFFTENFGNPSSLYSFSDKTKKAVNLARERVSKALNAEKNEIFFTSGGSEADNWAL
KGIAYANKKKGNHIITTKIEHHAILHTAQFLEKEGFKVTYLPVDEEGFVSVEDIKNAITDETILVSVMFANNEIGTIEPI
KEIGELCKEKNIYFHTDAVQAIGHVDIDVKDMNIDLLSMSAHKFYGPKGVGALYIKNGVKIQNLIHGGGQERGKRASTED
TAGIVGLGKAIELAMENMPEENKKLASLRGKLIKEVEKRIPEVKLNGPRDMSKRLSNNVNISFIGIEGETLLLDLDMNGI
FGSTGSACASASLDPSHVLLSIGLPHEVAHGSLRLSLGAKNTEEDIDYVLEVLPKIIKQRREMSPLWEDYMKNKEEK

Sequences:

>Translated_397_residues
MNKQVYMDYSATTYTKPEVLEEMLPFFTENFGNPSSLYSFSDKTKKAVNLARERVSKALNAEKNEIFFTSGGSEADNWAL
KGIAYANKKKGNHIITTKIEHHAILHTAQFLEKEGFKVTYLPVDEEGFVSVEDIKNAITDETILVSVMFANNEIGTIEPI
KEIGELCKEKNIYFHTDAVQAIGHVDIDVKDMNIDLLSMSAHKFYGPKGVGALYIKNGVKIQNLIHGGGQERGKRASTED
TAGIVGLGKAIELAMENMPEENKKLASLRGKLIKEVEKRIPEVKLNGPRDMSKRLSNNVNISFIGIEGETLLLDLDMNGI
FGSTGSACASASLDPSHVLLSIGLPHEVAHGSLRLSLGAKNTEEDIDYVLEVLPKIIKQRREMSPLWEDYMKNKEEK
>Mature_397_residues
MNKQVYMDYSATTYTKPEVLEEMLPFFTENFGNPSSLYSFSDKTKKAVNLARERVSKALNAEKNEIFFTSGGSEADNWAL
KGIAYANKKKGNHIITTKIEHHAILHTAQFLEKEGFKVTYLPVDEEGFVSVEDIKNAITDETILVSVMFANNEIGTIEPI
KEIGELCKEKNIYFHTDAVQAIGHVDIDVKDMNIDLLSMSAHKFYGPKGVGALYIKNGVKIQNLIHGGGQERGKRASTED
TAGIVGLGKAIELAMENMPEENKKLASLRGKLIKEVEKRIPEVKLNGPRDMSKRLSNNVNISFIGIEGETLLLDLDMNGI
FGSTGSACASASLDPSHVLLSIGLPHEVAHGSLRLSLGAKNTEEDIDYVLEVLPKIIKQRREMSPLWEDYMKNKEEK

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=389, Percent_Identity=44.987146529563, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI156713448, Length=414, Percent_Identity=36.7149758454106, Blast_Score=242, Evalue=5e-64,
Organism=Escherichia coli, GI48994898, Length=395, Percent_Identity=46.0759493670886, Blast_Score=352, Evalue=2e-98,
Organism=Escherichia coli, GI1787970, Length=396, Percent_Identity=25, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1789175, Length=394, Percent_Identity=24.6192893401015, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25143064, Length=390, Percent_Identity=45.3846153846154, Blast_Score=350, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI17533177, Length=330, Percent_Identity=32.4242424242424, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319831, Length=390, Percent_Identity=45.8974358974359, Blast_Score=342, Evalue=4e-95,
Organism=Drosophila melanogaster, GI20129463, Length=389, Percent_Identity=44.7300771208226, Blast_Score=343, Evalue=8e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44078; Mature: 44078

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00595 AA_TRANSFER_CLASS_5 ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQVYMDYSATTYTKPEVLEEMLPFFTENFGNPSSLYSFSDKTKKAVNLARERVSKALN
CCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHC
AEKNEIFFTSGGSEADNWALKGIAYANKKKGNHIITTKIEHHAILHTAQFLEKEGFKVTY
CCCCEEEEECCCCCCCCCEEEEEEECCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCEEEE
LPVDEEGFVSVEDIKNAITDETILVSVMFANNEIGTIEPIKEIGELCKEKNIYFHTDAVQ
EECCCCCCEEHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEHHHH
AIGHVDIDVKDMNIDLLSMSAHKFYGPKGVGALYIKNGVKIQNLIHGGGQERGKRASTED
HHCCCEEEEEECCEEEEEECHHHCCCCCCCCEEEEECCCEEEHHHCCCCHHCCCCCCCCC
TAGIVGLGKAIELAMENMPEENKKLASLRGKLIKEVEKRIPEVKLNGPRDMSKRLSNNVN
CCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCCCCC
ISFIGIEGETLLLDLDMNGIFGSTGSACASASLDPSHVLLSIGLPHEVAHGSLRLSLGAK
EEEEEECCCEEEEEECCCCCCCCCCCHHHCCCCCCCCEEEEECCCHHHCCCEEEEEECCC
NTEEDIDYVLEVLPKIIKQRREMSPLWEDYMKNKEEK
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MNKQVYMDYSATTYTKPEVLEEMLPFFTENFGNPSSLYSFSDKTKKAVNLARERVSKALN
CCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHC
AEKNEIFFTSGGSEADNWALKGIAYANKKKGNHIITTKIEHHAILHTAQFLEKEGFKVTY
CCCCEEEEECCCCCCCCCEEEEEEECCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCEEEE
LPVDEEGFVSVEDIKNAITDETILVSVMFANNEIGTIEPIKEIGELCKEKNIYFHTDAVQ
EECCCCCCEEHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEHHHH
AIGHVDIDVKDMNIDLLSMSAHKFYGPKGVGALYIKNGVKIQNLIHGGGQERGKRASTED
HHCCCEEEEEECCEEEEEECHHHCCCCCCCCEEEEECCCEEEHHHCCCCHHCCCCCCCCC
TAGIVGLGKAIELAMENMPEENKKLASLRGKLIKEVEKRIPEVKLNGPRDMSKRLSNNVN
CCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCCCCC
ISFIGIEGETLLLDLDMNGIFGSTGSACASASLDPSHVLLSIGLPHEVAHGSLRLSLGAK
EEEEEECCCEEEEEECCCCCCCCCCCHHHCCCCCCCCEEEEECCCHHHCCCEEEEEECCC
NTEEDIDYVLEVLPKIIKQRREMSPLWEDYMKNKEEK
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA