Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 170755478

GI number: 170755478

Start: 3908206

End: 3909153

Strand: Reverse

Name: serA [H]

Synonym: CLD_0893

Alternate gene names: 170755478

Gene position: 3909153-3908206 (Counterclockwise)

Preceding gene: 170755123

Following gene: 170756044

Centisome position: 98.76

GC content: 25.11

Gene sequence:

>948_bases
ATGAGCATAAAAGCATTATTTACTTATAATTATGGTAAAGAAAGCATGAAAAAAATAGAAAATCTAGGTTATGATATAAC
TATAATAAATGAAAAAGAAATAAAATATAAAGATCAGATTAAAGATATGGAAGTTTTGGTTTGTTATAATCCTTTTAGCA
CTTTAGATATATCTCTTATGAAAAACTTAAAATGGATACAACTTTCAAGCACAGGTGTAGATCAAGTACCTAAGGACATT
GTTTTAAAAAATAATGTTATAGTTACTAATAATAATGGAGGATATTCTATACCAATAGCAGAATGGATTGTTTTAAAGAC
ATTAGAACTTTTAAAAAATAGTAAGGAATTTTATAAAAAACAAGAGAATAAGATTTGGAAACTAGATACCAGTTTATTAG
AGCTATGTGGAAAAACTATAGGATTTATAGGAACTGGAAGCATTGCAAAAGAGACAGCTAAAAGATTTTCAGGCTTTAAT
GTTAATATATTAGGAGTTAATACCAAAGGAAGAGATGTAGAGTATTTTAATAAATGCTATTCTAAAGATAATATAAAAGA
AATGGTTTCAAAGAGTGATATTATAATATTAAGTATACCTTATACCAAAGAAACAGAAAATTTAGTAGATGAAAATGTAT
TAAACAGTATGAAGAATGGAGCATTATTTATAAATATATCAAGGGGTTCTATTGTAGATGAGATAAAACTTATAGAAAAT
TTAAAACTAGGAAAAATAAAAGGAGCAGCATTGGATGTATTTGAAGAAGAGCCTTTATTTAGAGATAATCCTATTTGGGA
ATTGGATAATGCTATAATAACTCCTCATAATTCTTGGATTTCCGAAAAAAGAAATATTAGAAGATTTGATATAATATACG
AAAACTTAAAAAATTATAAAGAGGGAACGGAATTAAAAAGCGTTGTTAATATGAATAAAGGTTATTAA

Upstream 100 bases:

>100_bases
AGTAAATATAAATAGTGATTTGATTGAATTTTCAATATATTAATGATAAAATCAAAATTAACTTTAAATTATTAAAAGTA
AAAGAGGGAGAAGGATAGTA

Downstream 100 bases:

>100_bases
AATTAAAGGTATAATTAAAGGTGATTTTATGAATGAAAGAAAGCTTAGGATATTTTATGAAGTAGCAGAAAAGCTTAATA
TGACAGAAGTGGCAGAAAAG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MSIKALFTYNYGKESMKKIENLGYDITIINEKEIKYKDQIKDMEVLVCYNPFSTLDISLMKNLKWIQLSSTGVDQVPKDI
VLKNNVIVTNNNGGYSIPIAEWIVLKTLELLKNSKEFYKKQENKIWKLDTSLLELCGKTIGFIGTGSIAKETAKRFSGFN
VNILGVNTKGRDVEYFNKCYSKDNIKEMVSKSDIIILSIPYTKETENLVDENVLNSMKNGALFINISRGSIVDEIKLIEN
LKLGKIKGAALDVFEEEPLFRDNPIWELDNAIITPHNSWISEKRNIRRFDIIYENLKNYKEGTELKSVVNMNKGY

Sequences:

>Translated_315_residues
MSIKALFTYNYGKESMKKIENLGYDITIINEKEIKYKDQIKDMEVLVCYNPFSTLDISLMKNLKWIQLSSTGVDQVPKDI
VLKNNVIVTNNNGGYSIPIAEWIVLKTLELLKNSKEFYKKQENKIWKLDTSLLELCGKTIGFIGTGSIAKETAKRFSGFN
VNILGVNTKGRDVEYFNKCYSKDNIKEMVSKSDIIILSIPYTKETENLVDENVLNSMKNGALFINISRGSIVDEIKLIEN
LKLGKIKGAALDVFEEEPLFRDNPIWELDNAIITPHNSWISEKRNIRRFDIIYENLKNYKEGTELKSVVNMNKGY
>Mature_314_residues
SIKALFTYNYGKESMKKIENLGYDITIINEKEIKYKDQIKDMEVLVCYNPFSTLDISLMKNLKWIQLSSTGVDQVPKDIV
LKNNVIVTNNNGGYSIPIAEWIVLKTLELLKNSKEFYKKQENKIWKLDTSLLELCGKTIGFIGTGSIAKETAKRFSGFNV
NILGVNTKGRDVEYFNKCYSKDNIKEMVSKSDIIILSIPYTKETENLVDENVLNSMKNGALFINISRGSIVDEIKLIENL
KLGKIKGAALDVFEEEPLFRDNPIWELDNAIITPHNSWISEKRNIRRFDIIYENLKNYKEGTELKSVVNMNKGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=255, Percent_Identity=27.843137254902, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI6912396, Length=233, Percent_Identity=31.3304721030043, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI4557497, Length=165, Percent_Identity=32.1212121212121, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI61743967, Length=165, Percent_Identity=32.1212121212121, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI145580578, Length=165, Percent_Identity=29.6969696969697, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4557499, Length=165, Percent_Identity=29.6969696969697, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI145580575, Length=241, Percent_Identity=25.7261410788382, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI87082289, Length=258, Percent_Identity=27.5193798449612, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1789279, Length=228, Percent_Identity=29.3859649122807, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI87081824, Length=219, Percent_Identity=24.6575342465753, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787645, Length=328, Percent_Identity=24.0853658536585, Blast_Score=81, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=248, Percent_Identity=30.241935483871, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25147481, Length=155, Percent_Identity=30.9677419354839, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320925, Length=229, Percent_Identity=29.6943231441048, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322116, Length=229, Percent_Identity=28.82096069869, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324964, Length=329, Percent_Identity=24.0121580547112, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=163, Percent_Identity=28.8343558282209, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=202, Percent_Identity=25.2475247524752, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574286, Length=244, Percent_Identity=28.6885245901639, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45552429, Length=224, Percent_Identity=30.3571428571429, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19921140, Length=236, Percent_Identity=28.3898305084746, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585514, Length=224, Percent_Identity=30.3571428571429, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28574282, Length=224, Percent_Identity=30.3571428571429, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28574284, Length=224, Percent_Identity=30.3571428571429, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45551003, Length=224, Percent_Identity=30.3571428571429, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28571528, Length=141, Percent_Identity=34.0425531914894, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24585516, Length=320, Percent_Identity=23.75, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24646446, Length=152, Percent_Identity=30.2631578947368, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646448, Length=152, Percent_Identity=30.2631578947368, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646452, Length=152, Percent_Identity=30.2631578947368, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646450, Length=152, Percent_Identity=30.2631578947368, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI62472511, Length=187, Percent_Identity=26.2032085561497, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 36140; Mature: 36009

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKALFTYNYGKESMKKIENLGYDITIINEKEIKYKDQIKDMEVLVCYNPFSTLDISLM
CCEEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCHHHCCCCEEEEEEECCCCHHHHHHH
KNLKWIQLSSTGVDQVPKDIVLKNNVIVTNNNGGYSIPIAEWIVLKTLELLKNSKEFYKK
CCCEEEEEECCCHHHCCHHHEEECCEEEECCCCCEECHHHHHHHHHHHHHHHCCHHHHHH
QENKIWKLDTSLLELCGKTIGFIGTGSIAKETAKRFSGFNVNILGVNTKGRDVEYFNKCY
HCCCEEEECHHHHHHHHHHHCEEECCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHC
SKDNIKEMVSKSDIIILSIPYTKETENLVDENVLNSMKNGALFINISRGSIVDEIKLIEN
CCCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHC
LKLGKIKGAALDVFEEEPLFRDNPIWELDNAIITPHNSWISEKRNIRRFDIIYENLKNYK
CCCCCCCCCEEEHHCCCCCCCCCCCEECCCCEECCCCHHHHHHCCCHHHHHHHHHHHHHH
EGTELKSVVNMNKGY
CHHHHHHHHHCCCCC
>Mature Secondary Structure 
SIKALFTYNYGKESMKKIENLGYDITIINEKEIKYKDQIKDMEVLVCYNPFSTLDISLM
CEEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCHHHCCCCEEEEEEECCCCHHHHHHH
KNLKWIQLSSTGVDQVPKDIVLKNNVIVTNNNGGYSIPIAEWIVLKTLELLKNSKEFYKK
CCCEEEEEECCCHHHCCHHHEEECCEEEECCCCCEECHHHHHHHHHHHHHHHCCHHHHHH
QENKIWKLDTSLLELCGKTIGFIGTGSIAKETAKRFSGFNVNILGVNTKGRDVEYFNKCY
HCCCEEEECHHHHHHHHHHHCEEECCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHC
SKDNIKEMVSKSDIIILSIPYTKETENLVDENVLNSMKNGALFINISRGSIVDEIKLIEN
CCCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHC
LKLGKIKGAALDVFEEEPLFRDNPIWELDNAIITPHNSWISEKRNIRRFDIIYENLKNYK
CCCCCCCCCEEEHHCCCCCCCCCCCEECCCCEECCCCHHHHHHCCCHHHHHHHHHHHHHH
EGTELKSVVNMNKGY
CHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]