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The map label for this gene is lexA [H]

Identifier: 170755273

GI number: 170755273

Start: 1028613

End: 1030208

Strand: Direct

Name: lexA [H]

Synonym: CLD_3650

Alternate gene names: 170755273

Gene position: 1028613-1030208 (Clockwise)

Preceding gene: 170754225

Following gene: 170756288

Centisome position: 25.99

GC content: 27.01

Gene sequence:

>1596_bases
ATGAAGCTAGAAAGTGGACAAAATAGAATAGCTAAAAGTAAACATTTAGGATACGGATTATTAAGAGGATCAGAAGGTAC
TGGAAAAACTACTGCAGCTATATATAGAGGTATTTATTTAAGAAATCAATATTGTATGTATGATAAAGATAAAGTATTAA
TACTATCAAAGAATGAAGAAAATTTAAACTATATTAAGAACATATATGATGAGGCAGAAAAAACAGGAGGTCAATACATT
ACTTTGTTTTCATATATTGAAGACAAGCTATATTTTAGTGTTATATATAAAATTATAAACAAGTATTTTTGGGAGTACAT
AGAAAATAACAATCTACAATGTAAAATAGCAAGTGAAGAAGAAAAACTGGCTATAGTTGAAGAATGTATAAGTAATGTAA
AGGATGAATACAAAAATTTAAAATATATAGACATAAAATATAGCAAATTCTTTTTAGAAGAAATACAATGGACGAAAGAT
TGTATGTATTATGAACTAGAGGAATATAAAAAAGCAGATAGAATAGGTAGAAAAGCAAAAAAAGGTGAAGGACCTCAAAG
AATTATAAAAAACTCAAAAATTAGAGAAGCAGTATTTAAAATTATGCTTTTATATAATGAAAAATTAAAGGATAAAAATT
TGGTAGACTACAGTGATGTAGTATCTATGTCCTTAAAAGAAGCTTCTAAAAATAAAGAAAATAAATTTAATCACATAATA
GTAGATGAGGCACAAAATTTTACTAAACTAGAATTAAAATTTATAGAAGCTTTAGGAAGAAAAAATATATATTCAAGCAT
ACTATTTATTGCAGATAAAGAGGAAAGTTCAAATCCTAAGGGATGGATAACTAAGGGACGGAAATTAAATAATCTTCAAT
TAGGGTTTGAATTTAAAAGATTTAATCTAAATAAAAAAATATCTATTAATCTGAAAGAAAATATAGATGATTGCAATCTT
AAAAGGAAAGTTTCAAATATTGATACAAAAAATGAAGATGTTTCTAATATAGGTAATGCTAATTCAGAAGATAAGGTTTT
AGATAAAAACATTAAAAATGAATGGCATAAAGATAAGGTGAACTATAATATGGATAAGTTTGAATATGTAGATATGAAAC
ACAGAAGATCTTATGAATTTTCTAGAGGTTTAGGTAGTAATGAAGAAATTATTGTAGAAGATCAAGGAAGCAAAGAAGAG
TACAAAGAGGATGAGCTAACAAAACTCCCAGTATTTAATGATATAGCGGCAGGAGAACCTATACTTATGAATCCTTGTGT
AGAAGGAGAATTTAATATACCTAAATATTGGGTAAGGGGTATGAAAAATTGCTTCATATTAAAAGTAAAAGGGGATAGTA
TGATAGGTGCTAATATAGAAGATGGAGATCATGTGGTAATAAAGAGGCAGCAAATGGCTGAAAATAAAGATATAGTAGCT
GTTAACTTAGAGGGGAGCGCAACCCTTAAAAGGTTATTAATAAAAAAATCTGGAGCAGTACTTATTCCAGAAAATAAAAA
ATATAAACCGATTGAAATACGAGAAGAAGGCGCAAGTATTATAGGGATAGCAGTAGGAATAATAAAAGGAAAATAG

Upstream 100 bases:

>100_bases
TGCAATGGCATTGCTATTATAATAATTAAAATTTTGGCTAAAGTATAAGGTGTTATATATAATGTTTTAGGGTAAAGAAT
TAGATAAGGAGGTGAAAAAA

Downstream 100 bases:

>100_bases
CAATATATAATTATTGAACTGTCTTATATTTGTTATAATATAATAAATATAAGGCAGTTTTTTGTTAATATGCTTTTAAA
AAAAGAAAAGATTATGTTTA

Product: putative LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MKLESGQNRIAKSKHLGYGLLRGSEGTGKTTAAIYRGIYLRNQYCMYDKDKVLILSKNEENLNYIKNIYDEAEKTGGQYI
TLFSYIEDKLYFSVIYKIINKYFWEYIENNNLQCKIASEEEKLAIVEECISNVKDEYKNLKYIDIKYSKFFLEEIQWTKD
CMYYELEEYKKADRIGRKAKKGEGPQRIIKNSKIREAVFKIMLLYNEKLKDKNLVDYSDVVSMSLKEASKNKENKFNHII
VDEAQNFTKLELKFIEALGRKNIYSSILFIADKEESSNPKGWITKGRKLNNLQLGFEFKRFNLNKKISINLKENIDDCNL
KRKVSNIDTKNEDVSNIGNANSEDKVLDKNIKNEWHKDKVNYNMDKFEYVDMKHRRSYEFSRGLGSNEEIIVEDQGSKEE
YKEDELTKLPVFNDIAAGEPILMNPCVEGEFNIPKYWVRGMKNCFILKVKGDSMIGANIEDGDHVVIKRQQMAENKDIVA
VNLEGSATLKRLLIKKSGAVLIPENKKYKPIEIREEGASIIGIAVGIIKGK

Sequences:

>Translated_531_residues
MKLESGQNRIAKSKHLGYGLLRGSEGTGKTTAAIYRGIYLRNQYCMYDKDKVLILSKNEENLNYIKNIYDEAEKTGGQYI
TLFSYIEDKLYFSVIYKIINKYFWEYIENNNLQCKIASEEEKLAIVEECISNVKDEYKNLKYIDIKYSKFFLEEIQWTKD
CMYYELEEYKKADRIGRKAKKGEGPQRIIKNSKIREAVFKIMLLYNEKLKDKNLVDYSDVVSMSLKEASKNKENKFNHII
VDEAQNFTKLELKFIEALGRKNIYSSILFIADKEESSNPKGWITKGRKLNNLQLGFEFKRFNLNKKISINLKENIDDCNL
KRKVSNIDTKNEDVSNIGNANSEDKVLDKNIKNEWHKDKVNYNMDKFEYVDMKHRRSYEFSRGLGSNEEIIVEDQGSKEE
YKEDELTKLPVFNDIAAGEPILMNPCVEGEFNIPKYWVRGMKNCFILKVKGDSMIGANIEDGDHVVIKRQQMAENKDIVA
VNLEGSATLKRLLIKKSGAVLIPENKKYKPIEIREEGASIIGIAVGIIKGK
>Mature_531_residues
MKLESGQNRIAKSKHLGYGLLRGSEGTGKTTAAIYRGIYLRNQYCMYDKDKVLILSKNEENLNYIKNIYDEAEKTGGQYI
TLFSYIEDKLYFSVIYKIINKYFWEYIENNNLQCKIASEEEKLAIVEECISNVKDEYKNLKYIDIKYSKFFLEEIQWTKD
CMYYELEEYKKADRIGRKAKKGEGPQRIIKNSKIREAVFKIMLLYNEKLKDKNLVDYSDVVSMSLKEASKNKENKFNHII
VDEAQNFTKLELKFIEALGRKNIYSSILFIADKEESSNPKGWITKGRKLNNLQLGFEFKRFNLNKKISINLKENIDDCNL
KRKVSNIDTKNEDVSNIGNANSEDKVLDKNIKNEWHKDKVNYNMDKFEYVDMKHRRSYEFSRGLGSNEEIIVEDQGSKEE
YKEDELTKLPVFNDIAAGEPILMNPCVEGEFNIPKYWVRGMKNCFILKVKGDSMIGANIEDGDHVVIKRQQMAENKDIVA
VNLEGSATLKRLLIKKSGAVLIPENKKYKPIEIREEGASIIGIAVGIIKGK

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=131, Percent_Identity=34.3511450381679, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787431, Length=128, Percent_Identity=28.90625, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 61615; Mature: 61615

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLESGQNRIAKSKHLGYGLLRGSEGTGKTTAAIYRGIYLRNQYCMYDKDKVLILSKNEE
CCCCCCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHEEECCEEEECCCEEEEEECCCC
NLNYIKNIYDEAEKTGGQYITLFSYIEDKLYFSVIYKIINKYFWEYIENNNLQCKIASEE
HHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
EKLAIVEECISNVKDEYKNLKYIDIKYSKFFLEEIQWTKDCMYYELEEYKKADRIGRKAK
HHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KGEGPQRIIKNSKIREAVFKIMLLYNEKLKDKNLVDYSDVVSMSLKEASKNKENKFNHII
CCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEE
VDEAQNFTKLELKFIEALGRKNIYSSILFIADKEESSNPKGWITKGRKLNNLQLGFEFKR
EECCCCCHHHHHHHHHHHCCCCHHEEEEEEEECCCCCCCCCEEECCCEECCEEEEEEEEE
FNLNKKISINLKENIDDCNLKRKVSNIDTKNEDVSNIGNANSEDKVLDKNIKNEWHKDKV
ECCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCC
NYNMDKFEYVDMKHRRSYEFSRGLGSNEEIIVEDQGSKEEYKEDELTKLPVFNDIAAGEP
CCCCCCEEEECHHHHCCCHHHCCCCCCCEEEEECCCCHHHHCCCCCEECCCCCCCCCCCC
ILMNPCVEGEFNIPKYWVRGMKNCFILKVKGDSMIGANIEDGDHVVIKRQQMAENKDIVA
EEECCCCCCCCCCCHHHHCCCCCEEEEEECCCCEEECCCCCCCEEEEEEHHHCCCCCEEE
VNLEGSATLKRLLIKKSGAVLIPENKKYKPIEIREEGASIIGIAVGIIKGK
EECCCHHHHHHHHHHCCCCEEECCCCCCCCEEEECCCCEEEEEEEEEEECC
>Mature Secondary Structure
MKLESGQNRIAKSKHLGYGLLRGSEGTGKTTAAIYRGIYLRNQYCMYDKDKVLILSKNEE
CCCCCCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHEEECCEEEECCCEEEEEECCCC
NLNYIKNIYDEAEKTGGQYITLFSYIEDKLYFSVIYKIINKYFWEYIENNNLQCKIASEE
HHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
EKLAIVEECISNVKDEYKNLKYIDIKYSKFFLEEIQWTKDCMYYELEEYKKADRIGRKAK
HHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KGEGPQRIIKNSKIREAVFKIMLLYNEKLKDKNLVDYSDVVSMSLKEASKNKENKFNHII
CCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEE
VDEAQNFTKLELKFIEALGRKNIYSSILFIADKEESSNPKGWITKGRKLNNLQLGFEFKR
EECCCCCHHHHHHHHHHHCCCCHHEEEEEEEECCCCCCCCCEEECCCEECCEEEEEEEEE
FNLNKKISINLKENIDDCNLKRKVSNIDTKNEDVSNIGNANSEDKVLDKNIKNEWHKDKV
ECCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCC
NYNMDKFEYVDMKHRRSYEFSRGLGSNEEIIVEDQGSKEEYKEDELTKLPVFNDIAAGEP
CCCCCCEEEECHHHHCCCHHHCCCCCCCEEEEECCCCHHHHCCCCCEECCCCCCCCCCCC
ILMNPCVEGEFNIPKYWVRGMKNCFILKVKGDSMIGANIEDGDHVVIKRQQMAENKDIVA
EEECCCCCCCCCCCHHHHCCCCCEEEEEECCCCEEECCCCCCCEEEEEEHHHCCCCCEEE
VNLEGSATLKRLLIKKSGAVLIPENKKYKPIEIREEGASIIGIAVGIIKGK
EECCCHHHHHHHHHHCCCCEEECCCCCCCCEEEECCCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA