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The map label for this gene is lytC [H]

Identifier: 170754963

GI number: 170754963

Start: 461297

End: 462385

Strand: Direct

Name: lytC [H]

Synonym: CLD_0377

Alternate gene names: 170754963

Gene position: 461297-462385 (Clockwise)

Preceding gene: 170755719

Following gene: 170755070

Centisome position: 11.65

GC content: 33.98

Gene sequence:

>1089_bases
ATGTTAAAGAAAAATAAAAAAATTCTTTCGGTTATAACTGCTACTTTAGTAATGGCAATAGGAATTTCTTTCACTAATGT
ACAAGCAGCTTCTATAAAAAGAATGAATGGAAGTAATAGAATAGATACAGCTAACAAAACAGCAAAAGAAATATTCCAAA
AATCAGAAGCGGTTATTTTAGTAAATGGTACGGGCTATGCAGATGCAGTAAGCTCAGCACCACTTTCAAAATTATTAAAT
GCTCCAATACTTTTAACTGAAAATAAGGGCGCATTAGAATCAGATGTATTAAAAACTATAAATGACTTACAAAACGTTAA
AAAAATATATATAGTTGGTGGTACTGGAGTTGTATCTACAACTATGGAAAATTCATTAAAGAGCAAGGGATTCCAAGTTA
TACGTTACGATGGACAGAAATATGGAGACAAAACAAGATATGGAACTAACGCTAGAGTGGCAGAAGAAATATTAAAATTA
AGTCCTAAATCAAAGACAGGGATTCTGGTAAATGGACAAGATGGATATGCAGATGCATTATCTGTAGCTTCAGTAGCAGC
AACCAATGGTTATCCAGTATTATTTGGAAACACTCAGAATGTACCAAATGTAATAAAAAATAATATAATATCAAAAAACA
AATTACAGATTCTTGCGGTAGGTGGTAGCGGAGTGTTGCCTTCTTCTGTGGTTAGCTCTGTAAGTGGTAAAAAGATAACT
TCAGATGCTCAATCTAAAAACAGATTTCAAACTAATCTAGCCGTGCTAGAATATTTTAAAGGTAAAGGCGGCTTAGATTT
TAGTAATGTATATATAGCAGCAGGAGGACAAGCCGGAAAAGCTGGACAAAGTCAATTTGCAGATGCTCTAGTAGCTTCAG
CAGCAGCAGCTAAAACAGGCTCACCATTAGTTCTAAGTGGATTGGGAGCAGGTACAACAGAAATAGCTAATGCGGAAAAA
TTTGTTGAAACTAATATAGAGGACGAGGGTAACTTAGTTATTGTTGGAGGAAAAGCTTCAGTATCCGAGTCAGTGGAACA
AAAATTAGATGAAAAAGTAGGAGATTTTAGAATATTAGATGTATTTTAG

Upstream 100 bases:

>100_bases
AACAAAAGATTTTGTACGAATATTATATAGAACGTGCAAATAAGAATTAATTTAGTATATAATCATAAATATAGAAAATT
ATATAAATGGAGGAGAACTA

Downstream 100 bases:

>100_bases
AAAAGAGTACAGAGTATAGAGTATAGAGTATAGAAAAAAGAGTTAAGTAAATAAATTTACTTAACTCTTTTATTTAATGA
TCAATAATTAATTAGCAATG

Product: amidase domain-containing protein

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MLKKNKKILSVITATLVMAIGISFTNVQAASIKRMNGSNRIDTANKTAKEIFQKSEAVILVNGTGYADAVSSAPLSKLLN
APILLTENKGALESDVLKTINDLQNVKKIYIVGGTGVVSTTMENSLKSKGFQVIRYDGQKYGDKTRYGTNARVAEEILKL
SPKSKTGILVNGQDGYADALSVASVAATNGYPVLFGNTQNVPNVIKNNIISKNKLQILAVGGSGVLPSSVVSSVSGKKIT
SDAQSKNRFQTNLAVLEYFKGKGGLDFSNVYIAAGGQAGKAGQSQFADALVASAAAAKTGSPLVLSGLGAGTTEIANAEK
FVETNIEDEGNLVIVGGKASVSESVEQKLDEKVGDFRILDVF

Sequences:

>Translated_362_residues
MLKKNKKILSVITATLVMAIGISFTNVQAASIKRMNGSNRIDTANKTAKEIFQKSEAVILVNGTGYADAVSSAPLSKLLN
APILLTENKGALESDVLKTINDLQNVKKIYIVGGTGVVSTTMENSLKSKGFQVIRYDGQKYGDKTRYGTNARVAEEILKL
SPKSKTGILVNGQDGYADALSVASVAATNGYPVLFGNTQNVPNVIKNNIISKNKLQILAVGGSGVLPSSVVSSVSGKKIT
SDAQSKNRFQTNLAVLEYFKGKGGLDFSNVYIAAGGQAGKAGQSQFADALVASAAAAKTGSPLVLSGLGAGTTEIANAEK
FVETNIEDEGNLVIVGGKASVSESVEQKLDEKVGDFRILDVF
>Mature_362_residues
MLKKNKKILSVITATLVMAIGISFTNVQAASIKRMNGSNRIDTANKTAKEIFQKSEAVILVNGTGYADAVSSAPLSKLLN
APILLTENKGALESDVLKTINDLQNVKKIYIVGGTGVVSTTMENSLKSKGFQVIRYDGQKYGDKTRYGTNARVAEEILKL
SPKSKTGILVNGQDGYADALSVASVAATNGYPVLFGNTQNVPNVIKNNIISKNKLQILAVGGSGVLPSSVVSSVSGKKIT
SDAQSKNRFQTNLAVLEYFKGKGGLDFSNVYIAAGGQAGKAGQSQFADALVASAAAAKTGSPLVLSGLGAGTTEIANAEK
FVETNIEDEGNLVIVGGKASVSESVEQKLDEKVGDFRILDVF

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 37903; Mature: 37903

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKNKKILSVITATLVMAIGISFTNVQAASIKRMNGSNRIDTANKTAKEIFQKSEAVIL
CCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHEECCCCCCCCCCHHHHHHHHHCCCEEEE
VNGTGYADAVSSAPLSKLLNAPILLTENKGALESDVLKTINDLQNVKKIYIVGGTGVVST
EECCCCHHHHHCCHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCHHHH
TMENSLKSKGFQVIRYDGQKYGDKTRYGTNARVAEEILKLSPKSKTGILVNGQDGYADAL
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHH
SVASVAATNGYPVLFGNTQNVPNVIKNNIISKNKLQILAVGGSGVLPSSVVSSVSGKKIT
HHHHHHCCCCEEEEECCCCCCHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHCCCCEEC
SDAQSKNRFQTNLAVLEYFKGKGGLDFSNVYIAAGGQAGKAGQSQFADALVASAAAAKTG
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCC
SPLVLSGLGAGTTEIANAEKFVETNIEDEGNLVIVGGKASVSESVEQKLDEKVGDFRILD
CCEEEECCCCCCHHHHCHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEE
VF
EC
>Mature Secondary Structure
MLKKNKKILSVITATLVMAIGISFTNVQAASIKRMNGSNRIDTANKTAKEIFQKSEAVIL
CCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHEECCCCCCCCCCHHHHHHHHHCCCEEEE
VNGTGYADAVSSAPLSKLLNAPILLTENKGALESDVLKTINDLQNVKKIYIVGGTGVVST
EECCCCHHHHHCCHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCHHHH
TMENSLKSKGFQVIRYDGQKYGDKTRYGTNARVAEEILKLSPKSKTGILVNGQDGYADAL
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHH
SVASVAATNGYPVLFGNTQNVPNVIKNNIISKNKLQILAVGGSGVLPSSVVSSVSGKKIT
HHHHHHCCCCEEEEECCCCCCHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHCCCCEEC
SDAQSKNRFQTNLAVLEYFKGKGGLDFSNVYIAAGGQAGKAGQSQFADALVASAAAAKTG
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCC
SPLVLSGLGAGTTEIANAEKFVETNIEDEGNLVIVGGKASVSESVEQKLDEKVGDFRILD
CCEEEECCCCCCHHHHCHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEE
VF
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]