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The map label for this gene is gcvT

Identifier: 170754781

GI number: 170754781

Start: 817557

End: 818669

Strand: Direct

Name: gcvT

Synonym: CLD_0070

Alternate gene names: 170754781

Gene position: 817557-818669 (Clockwise)

Preceding gene: 170756940

Following gene: 170754700

Centisome position: 20.65

GC content: 30.55

Gene sequence:

>1113_bases
ATGGAAGATTTAAAAGTTACGCCTTTAAGAGGGGTGTATGAAGAGTATGGCGGTAAAATTGTAGATTTTGCAGGATATGA
ACTTCCAACACAATTTAAAGGTTTTTTACATGAGCATCATACAGTAAGAGAAAAGGCAGGTCTTTTTGATGTTTCTCATA
TGGGAGAAGTTATGGTAACAGGAAAAGATGCTGGAAAATTCATTCAATACTTGATGACTAATGACATAAATATTCTTAAA
GATAATGAGGTTTTGTACACATTTATGTGCAATGAAGATGGTGGAGTGATAGATGATTTATTGGTTTACAAATTTGCAGA
GAATGAGTTTTTCTTAGTTATTAATGCAAGTAATAAGGATAAAGATGTTAAGTGGATAATGGATCATAAAGGGGATTTTG
ATGTTGAAATTGTTGATGAATCAGATAGTATTGCTCAACTTGCATTACAAGGACCCTTGGCAGAAGAAATACTTCAAAAA
ATAGTAGATATAGATTTACAAGAAATAAAATTCTTTAAACTTAAAAGAGATGTTTTAGTTAATGGGAAAAAATGCTTAGT
ATCAAGAACCGGTTATACTGGAGAAGATGGTTTTGAAATTTATTGTAAACCAGAGGATGCAAAAGGACTATGGCATGCTA
TATTAAATGCAGGAAAAGAAGAAGGTGTACAGCCAATAGGATTAGGTGCTAGGGATACTTTAAGATTTGAAGCTAGTCTT
CTTTTATATGGAAATGAAATGGATGAAACAATTACACCATTAGAAGTAGGTATGGGATTCTTTGTAAAATTAAAAGTTGA
AGAAGATTTTATAGGAAAAGATGCTTTAATAAAACAAAAAGCAGAAGGCGTAACTAGAAAATTGGTAGGATTTGAGCTTT
TAGATAAGGGAATTCCGAGGCATGGTTATGAGGTTATTAAAGATGGAAAAGTTATAGGACATGTTACAACTGGATATAAA
TCTCCTACATTAAACAAAGCAATTGGATTAGCTTTAGTAGAAGAACAATATTCTAAAATAGGAACAGAGTTTAATATAAA
AGTTAGAAAAAAAGAATTAAAAGCTGTTGCTATAGATAAGAGATTCTATACTAAAAAAACAAAAACTAAATAA

Upstream 100 bases:

>100_bases
AACCTTACAACTTGGGTTTACACTAAATCATTTTCATAATTTTATTAAAACATATATATAAATATTTATGGGTAAATAAT
TTTAATTGGGGGTAAAACAC

Downstream 100 bases:

>100_bases
TATGTAGAATAATAAATTAACTGTTAATTTGTAGAGTATATTTTGATGTATATAAATTTACACTAATGCTTAGTTCTTAT
GTTAAAAGCATTGTCAATAA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MEDLKVTPLRGVYEEYGGKIVDFAGYELPTQFKGFLHEHHTVREKAGLFDVSHMGEVMVTGKDAGKFIQYLMTNDINILK
DNEVLYTFMCNEDGGVIDDLLVYKFAENEFFLVINASNKDKDVKWIMDHKGDFDVEIVDESDSIAQLALQGPLAEEILQK
IVDIDLQEIKFFKLKRDVLVNGKKCLVSRTGYTGEDGFEIYCKPEDAKGLWHAILNAGKEEGVQPIGLGARDTLRFEASL
LLYGNEMDETITPLEVGMGFFVKLKVEEDFIGKDALIKQKAEGVTRKLVGFELLDKGIPRHGYEVIKDGKVIGHVTTGYK
SPTLNKAIGLALVEEQYSKIGTEFNIKVRKKELKAVAIDKRFYTKKTKTK

Sequences:

>Translated_370_residues
MEDLKVTPLRGVYEEYGGKIVDFAGYELPTQFKGFLHEHHTVREKAGLFDVSHMGEVMVTGKDAGKFIQYLMTNDINILK
DNEVLYTFMCNEDGGVIDDLLVYKFAENEFFLVINASNKDKDVKWIMDHKGDFDVEIVDESDSIAQLALQGPLAEEILQK
IVDIDLQEIKFFKLKRDVLVNGKKCLVSRTGYTGEDGFEIYCKPEDAKGLWHAILNAGKEEGVQPIGLGARDTLRFEASL
LLYGNEMDETITPLEVGMGFFVKLKVEEDFIGKDALIKQKAEGVTRKLVGFELLDKGIPRHGYEVIKDGKVIGHVTTGYK
SPTLNKAIGLALVEEQYSKIGTEFNIKVRKKELKAVAIDKRFYTKKTKTK
>Mature_370_residues
MEDLKVTPLRGVYEEYGGKIVDFAGYELPTQFKGFLHEHHTVREKAGLFDVSHMGEVMVTGKDAGKFIQYLMTNDINILK
DNEVLYTFMCNEDGGVIDDLLVYKFAENEFFLVINASNKDKDVKWIMDHKGDFDVEIVDESDSIAQLALQGPLAEEILQK
IVDIDLQEIKFFKLKRDVLVNGKKCLVSRTGYTGEDGFEIYCKPEDAKGLWHAILNAGKEEGVQPIGLGARDTLRFEASL
LLYGNEMDETITPLEVGMGFFVKLKVEEDFIGKDALIKQKAEGVTRKLVGFELLDKGIPRHGYEVIKDGKVIGHVTTGYK
SPTLNKAIGLALVEEQYSKIGTEFNIKVRKKELKAVAIDKRFYTKKTKTK

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=382, Percent_Identity=36.1256544502618, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI257796258, Length=359, Percent_Identity=36.2116991643454, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI24797151, Length=345, Percent_Identity=32.7536231884058, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI257796254, Length=375, Percent_Identity=33.3333333333333, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI257796256, Length=324, Percent_Identity=35.1851851851852, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI197927446, Length=325, Percent_Identity=27.6923076923077, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI21361378, Length=325, Percent_Identity=27.6923076923077, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI194306651, Length=374, Percent_Identity=25.1336898395722, Blast_Score=115, Evalue=6e-26,
Organism=Escherichia coli, GI1789272, Length=369, Percent_Identity=39.2953929539295, Blast_Score=242, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17560118, Length=352, Percent_Identity=38.9204545454545, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI32563613, Length=327, Percent_Identity=27.5229357798165, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71994045, Length=331, Percent_Identity=27.190332326284, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71994052, Length=331, Percent_Identity=27.190332326284, Blast_Score=118, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6320222, Length=372, Percent_Identity=36.0215053763441, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI20129441, Length=360, Percent_Identity=34.4444444444444, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI28571104, Length=286, Percent_Identity=28.6713286713287, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI20130091, Length=316, Percent_Identity=24.3670886075949, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 41724; Mature: 41724

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDLKVTPLRGVYEEYGGKIVDFAGYELPTQFKGFLHEHHTVREKAGLFDVSHMGEVMVT
CCCCCCCCCHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCEEEE
GKDAGKFIQYLMTNDINILKDNEVLYTFMCNEDGGVIDDLLVYKFAENEFFLVINASNKD
CCCHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCCHHHHHEEEEECCCEEEEEECCCCC
KDVKWIMDHKGDFDVEIVDESDSIAQLALQGPLAEEILQKIVDIDLQEIKFFKLKRDVLV
CCEEEEECCCCCCCEEEECCCCCHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHEEHHHHC
NGKKCLVSRTGYTGEDGFEIYCKPEDAKGLWHAILNAGKEEGVQPIGLGARDTLRFEASL
CCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCHHHCCCEECCCCCCEEEEEEEE
LLYGNEMDETITPLEVGMGFFVKLKVEEDFIGKDALIKQKAEGVTRKLVGFELLDKGIPR
EEECCCCCCCCCHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
HGYEVIKDGKVIGHVTTGYKSPTLNKAIGLALVEEQYSKIGTEFNIKVRKKELKAVAIDK
CCHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEEEEECH
RFYTKKTKTK
HHHCCCCCCC
>Mature Secondary Structure
MEDLKVTPLRGVYEEYGGKIVDFAGYELPTQFKGFLHEHHTVREKAGLFDVSHMGEVMVT
CCCCCCCCCHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCEEEE
GKDAGKFIQYLMTNDINILKDNEVLYTFMCNEDGGVIDDLLVYKFAENEFFLVINASNKD
CCCHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCCHHHHHEEEEECCCEEEEEECCCCC
KDVKWIMDHKGDFDVEIVDESDSIAQLALQGPLAEEILQKIVDIDLQEIKFFKLKRDVLV
CCEEEEECCCCCCCEEEECCCCCHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHEEHHHHC
NGKKCLVSRTGYTGEDGFEIYCKPEDAKGLWHAILNAGKEEGVQPIGLGARDTLRFEASL
CCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCHHHCCCEECCCCCCEEEEEEEE
LLYGNEMDETITPLEVGMGFFVKLKVEEDFIGKDALIKQKAEGVTRKLVGFELLDKGIPR
EEECCCCCCCCCHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
HGYEVIKDGKVIGHVTTGYKSPTLNKAIGLALVEEQYSKIGTEFNIKVRKKELKAVAIDK
CCHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEEEEECH
RFYTKKTKTK
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA