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The map label for this gene is serS

Identifier: 170754762

GI number: 170754762

Start: 629175

End: 630452

Strand: Direct

Name: serS

Synonym: CLD_0238

Alternate gene names: 170754762

Gene position: 629175-630452 (Clockwise)

Preceding gene: 170757855

Following gene: 170755743

Centisome position: 15.9

GC content: 34.12

Gene sequence:

>1278_bases
ATGTTAGATTTAAAATTTGTAAGAGAAAATCCAGAAGTTGTTAAGGAAAACATAAGGAAAAAATTTCAGCATAATAAGCT
GGAGTTAGTAGATAAAGTAATCGCTCTAGATGCTGAACTCAGAAATATAAAGCCAGAAGCAGATAATTTAAGAGCTATGA
GAAATAAGATTTCAAAACAAATCGGTGGATTAATGGCTCAGGGAAAAAAAGGAGAAGCAGAAGAACTAAAGAAACAGGTT
ACAGTAGCCTCAGATCATTTAGCTGAGTTAGAAAAAAGAGAAAGCGAACTGGAAGAAAAAATAAAAAAAATTATGATTAC
TATTCCAAATATTATTGATCCAAGTGTTCCTATTGGTAAAGATGATAGCGAAAATGTGGAAATTCAACGATATGGTGAAC
CAGTTGTGCCAGATTTCCAGGTTCCTTATCATACTGAAATTATGGAGAAATTTAATGGAATTGATTTGGATAGTGCTAGA
AAAGTTGCTGGTAATGGTTTTTATTATTTGATGGGAGATATTGCTAGACTACATTCTGCAGTGATTTCTTATGCTAGAGA
CTTTATGATTAACCGTGGTTTTACATATTGTATTCCACCTTTTATGATTCGTAGTGAAGTTGTGACTGGTGTTATGAGCT
TTGCAGAAATGGATTCTATGATGTATAAAATAGAAGGTGAAGATTTATATTTGATCGGAACCAGTGAACATTCTATGATT
GGTAAATTCATTGATACAATATCACCAGAAACTTCTTTGCCACAAACATTAACTAGTTACTCACCTTGCTTTAGAAAGGA
AAAAGGAGCTCATGGTATTGAAGAAAGAGGAGTATATAGAATTCATCAATTTGAAAAGCAGGAAATGATTGTTGTATGTA
GACCGGAAGATAGTGTAATGTGGTATGATAAGCTATGGCAAAATACAGTAGATTTTTTTCGCTCTTTAGATATTCCCGTA
AGAACTTTGGAATGCTGTTCTGGTGACTTGGCAGATTTAAAAGTAAAATCAGTTGATGTAGAAGCTTGGTCCCCTAGACA
GAAAAAATACTTCGAGGTAGGAAGTTGTTCTAATTTAGGTGATGCACAAGCACGCCGTCTTAAAATTCGTGTAGCTGGTG
AGAATGGCAAATACTTTGCGCACACATTAAACAATACCGTAGTTGCACCTCCAAGAATGCTAATTGCTTTTTTAGAGAAC
AACTTAAATGAAGATGGCTCTGTCAATATTCCAGTTCCATTACAGCCATATATGGGTGGAATGACTGTCATTAAATAA

Upstream 100 bases:

>100_bases
CGCGGATACTTCCGTCCCATATTTATATATGAGATGGGAGTTTTTTATTTTATGGTTTCAAAATTATAATATTATTTATA
TTTATGTAGGAGGAAAAACT

Downstream 100 bases:

>100_bases
TTAATATTTGTTTTTTCTTAGAATATATGGTTCCAAATTAAACTTAATAAACGCTGCAGGAATGATATGGAATATGAGAA
AATTATATCCTAATAGCTTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLDLKFVRENPEVVKENIRKKFQHNKLELVDKVIALDAELRNIKPEADNLRAMRNKISKQIGGLMAQGKKGEAEELKKQV
TVASDHLAELEKRESELEEKIKKIMITIPNIIDPSVPIGKDDSENVEIQRYGEPVVPDFQVPYHTEIMEKFNGIDLDSAR
KVAGNGFYYLMGDIARLHSAVISYARDFMINRGFTYCIPPFMIRSEVVTGVMSFAEMDSMMYKIEGEDLYLIGTSEHSMI
GKFIDTISPETSLPQTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCRPEDSVMWYDKLWQNTVDFFRSLDIPV
RTLECCSGDLADLKVKSVDVEAWSPRQKKYFEVGSCSNLGDAQARRLKIRVAGENGKYFAHTLNNTVVAPPRMLIAFLEN
NLNEDGSVNIPVPLQPYMGGMTVIK

Sequences:

>Translated_425_residues
MLDLKFVRENPEVVKENIRKKFQHNKLELVDKVIALDAELRNIKPEADNLRAMRNKISKQIGGLMAQGKKGEAEELKKQV
TVASDHLAELEKRESELEEKIKKIMITIPNIIDPSVPIGKDDSENVEIQRYGEPVVPDFQVPYHTEIMEKFNGIDLDSAR
KVAGNGFYYLMGDIARLHSAVISYARDFMINRGFTYCIPPFMIRSEVVTGVMSFAEMDSMMYKIEGEDLYLIGTSEHSMI
GKFIDTISPETSLPQTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCRPEDSVMWYDKLWQNTVDFFRSLDIPV
RTLECCSGDLADLKVKSVDVEAWSPRQKKYFEVGSCSNLGDAQARRLKIRVAGENGKYFAHTLNNTVVAPPRMLIAFLEN
NLNEDGSVNIPVPLQPYMGGMTVIK
>Mature_425_residues
MLDLKFVRENPEVVKENIRKKFQHNKLELVDKVIALDAELRNIKPEADNLRAMRNKISKQIGGLMAQGKKGEAEELKKQV
TVASDHLAELEKRESELEEKIKKIMITIPNIIDPSVPIGKDDSENVEIQRYGEPVVPDFQVPYHTEIMEKFNGIDLDSAR
KVAGNGFYYLMGDIARLHSAVISYARDFMINRGFTYCIPPFMIRSEVVTGVMSFAEMDSMMYKIEGEDLYLIGTSEHSMI
GKFIDTISPETSLPQTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCRPEDSVMWYDKLWQNTVDFFRSLDIPV
RTLECCSGDLADLKVKSVDVEAWSPRQKKYFEVGSCSNLGDAQARRLKIRVAGENGKYFAHTLNNTVVAPPRMLIAFLEN
NLNEDGSVNIPVPLQPYMGGMTVIK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=469, Percent_Identity=31.1300639658849, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI8923421, Length=400, Percent_Identity=32.75, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI225579074, Length=404, Percent_Identity=32.1782178217822, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1787120, Length=435, Percent_Identity=32.6436781609195, Blast_Score=249, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17539260, Length=470, Percent_Identity=32.1276595744681, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17542084, Length=331, Percent_Identity=30.8157099697885, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6320226, Length=445, Percent_Identity=33.2584269662921, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6321799, Length=416, Percent_Identity=30.7692307692308, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24581334, Length=467, Percent_Identity=32.3340471092077, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI17737985, Length=333, Percent_Identity=32.1321321321321, Blast_Score=162, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48359; Mature: 48359

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLKFVRENPEVVKENIRKKFQHNKLELVDKVIALDAELRNIKPEADNLRAMRNKISKQ
CCCCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IGGLMAQGKKGEAEELKKQVTVASDHLAELEKRESELEEKIKKIMITIPNIIDPSVPIGK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DDSENVEIQRYGEPVVPDFQVPYHTEIMEKFNGIDLDSARKVAGNGFYYLMGDIARLHSA
CCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCEEEEHHHHHHHHHH
VISYARDFMINRGFTYCIPPFMIRSEVVTGVMSFAEMDSMMYKIEGEDLYLIGTSEHSMI
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEECCCHHHH
GKFIDTISPETSLPQTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCRPEDSVM
HHHHHHCCCCCCCCHHHHHCCHHHHHCCCCCCCHHCCCHHHHHCCCCCEEEEECCCCCEE
WYDKLWQNTVDFFRSLDIPVRTLECCSGDLADLKVKSVDVEAWSPRQKKYFEVGSCSNLG
HHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHCEEEEEECCCCCCCHHHEEECCCCCCCC
DAQARRLKIRVAGENGKYFAHTLNNTVVAPPRMLIAFLENNLNEDGSVNIPVPLQPYMGG
CCCEEEEEEEEECCCCCEEEEECCCCEECCHHHHHHHHHHCCCCCCCEECCCCCCCCCCC
MTVIK
EEECC
>Mature Secondary Structure
MLDLKFVRENPEVVKENIRKKFQHNKLELVDKVIALDAELRNIKPEADNLRAMRNKISKQ
CCCCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IGGLMAQGKKGEAEELKKQVTVASDHLAELEKRESELEEKIKKIMITIPNIIDPSVPIGK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DDSENVEIQRYGEPVVPDFQVPYHTEIMEKFNGIDLDSARKVAGNGFYYLMGDIARLHSA
CCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCEEEEHHHHHHHHHH
VISYARDFMINRGFTYCIPPFMIRSEVVTGVMSFAEMDSMMYKIEGEDLYLIGTSEHSMI
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEECCCHHHH
GKFIDTISPETSLPQTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCRPEDSVM
HHHHHHCCCCCCCCHHHHHCCHHHHHCCCCCCCHHCCCHHHHHCCCCCEEEEECCCCCEE
WYDKLWQNTVDFFRSLDIPVRTLECCSGDLADLKVKSVDVEAWSPRQKKYFEVGSCSNLG
HHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHCEEEEEECCCCCCCHHHEEECCCCCCCC
DAQARRLKIRVAGENGKYFAHTLNNTVVAPPRMLIAFLENNLNEDGSVNIPVPLQPYMGG
CCCEEEEEEEEECCCCCEEEEECCCCEECCHHHHHHHHHHCCCCCCCEECCCCCCCCCCC
MTVIK
EEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA