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The map label for this gene is clpP

Identifier: 170754567

GI number: 170754567

Start: 3510261

End: 3510845

Strand: Reverse

Name: clpP

Synonym: CLD_1300

Alternate gene names: 170754567

Gene position: 3510845-3510261 (Counterclockwise)

Preceding gene: 170755085

Following gene: 170756735

Centisome position: 88.7

GC content: 32.48

Gene sequence:

>585_bases
ATGAGTTTAGTACCTGTAGTTGTAGAGCAAACTAATAGAGGGGAAAGATCTTACGATATTTATTCTAGGTTATTAAAGGA
CAGAATAATAATGTTAAGTGAAGAGGTTAATGACACAACTGCTAGTTTAATAGTAGCACAATTATTATTTTTAGAAGCCG
AGGATCCAGATAAAGATATACATCTATATATTAATAGTCCAGGAGGTTCTATAACTTCTGGGATGGCAATATATGATACA
ATGCAATATATAAAACCAGATGTTTCTACTATATGTGTAGGAATGGCAGCATCTATGGGAGCATTTCTTCTTGCAGCTGG
TGCAAAGGGAAAAAGATATGCATTACCTAATAGTGAAGTTATGATACATCAACCACTAGGTGGATTCAGAGGTCAAGCAA
CAGATATAGGAATACATGCTGAAAGAATTCTAAAAATGAAGAAAAAATTAAATACTATACTAAGTGATAGAACAGGAAAG
CCATTAGAACAAGTAGAGCTTGACACAGAGAGAGATCATTTCTTAAGTGCAGAAGAAGCTAAAGAATATGGTTTAATTGA
TGAAGTTATTGATAAAAAGAAATAA

Upstream 100 bases:

>100_bases
ATAGTTGCCAGGATATATTTTCTGGCAACTAAGTTTTAATAATTATAAATATCACATAGGTATCATTAGTATCTTATTTT
TATAGAAGGAGGAGATATAT

Downstream 100 bases:

>100_bases
CCTTTAGTGAGGTGTAGAAATGTCTAAATTAGATGAAAAAAAACAGTTGAAATGTTCATTCTGCGGCAAGACACAAGATC
AAGTAAGACGACTTATAGCA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MSLVPVVVEQTNRGERSYDIYSRLLKDRIIMLSEEVNDTTASLIVAQLLFLEAEDPDKDIHLYINSPGGSITSGMAIYDT
MQYIKPDVSTICVGMAASMGAFLLAAGAKGKRYALPNSEVMIHQPLGGFRGQATDIGIHAERILKMKKKLNTILSDRTGK
PLEQVELDTERDHFLSAEEAKEYGLIDEVIDKKK

Sequences:

>Translated_194_residues
MSLVPVVVEQTNRGERSYDIYSRLLKDRIIMLSEEVNDTTASLIVAQLLFLEAEDPDKDIHLYINSPGGSITSGMAIYDT
MQYIKPDVSTICVGMAASMGAFLLAAGAKGKRYALPNSEVMIHQPLGGFRGQATDIGIHAERILKMKKKLNTILSDRTGK
PLEQVELDTERDHFLSAEEAKEYGLIDEVIDKKK
>Mature_193_residues
SLVPVVVEQTNRGERSYDIYSRLLKDRIIMLSEEVNDTTASLIVAQLLFLEAEDPDKDIHLYINSPGGSITSGMAIYDTM
QYIKPDVSTICVGMAASMGAFLLAAGAKGKRYALPNSEVMIHQPLGGFRGQATDIGIHAERILKMKKKLNTILSDRTGKP
LEQVELDTERDHFLSAEEAKEYGLIDEVIDKKK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=57.3684210526316, Blast_Score=240, Evalue=5e-64,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=69.5876288659794, Blast_Score=293, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=52.6881720430108, Blast_Score=213, Evalue=4e-56,
Organism=Drosophila melanogaster, GI20129427, Length=191, Percent_Identity=58.6387434554974, Blast_Score=244, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_CLOB1 (A7FYI2)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001385555.1
- ProteinModelPortal:   A7FYI2
- SMR:   A7FYI2
- STRING:   A7FYI2
- MEROPS:   S14.001
- GeneID:   5395494
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_3268
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   KFGLVDN
- ProtClustDB:   PRK00277
- BioCyc:   CBOT441770:CLB_3268-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21503; Mature: 21372

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVPVVVEQTNRGERSYDIYSRLLKDRIIMLSEEVNDTTASLIVAQLLFLEAEDPDKDI
CCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEE
HLYINSPGGSITSGMAIYDTMQYIKPDVSTICVGMAASMGAFLLAAGAKGKRYALPNSEV
EEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCE
MIHQPLGGFRGQATDIGIHAERILKMKKKLNTILSDRTGKPLEQVELDTERDHFLSAEEA
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHCCHHHH
KEYGLIDEVIDKKK
HHCCCHHHHHCCCC
>Mature Secondary Structure 
SLVPVVVEQTNRGERSYDIYSRLLKDRIIMLSEEVNDTTASLIVAQLLFLEAEDPDKDI
CCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEE
HLYINSPGGSITSGMAIYDTMQYIKPDVSTICVGMAASMGAFLLAAGAKGKRYALPNSEV
EEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCE
MIHQPLGGFRGQATDIGIHAERILKMKKKLNTILSDRTGKPLEQVELDTERDHFLSAEEA
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHCCHHHH
KEYGLIDEVIDKKK
HHCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA