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The map label for this gene is ribAB

Identifier: 170754528

GI number: 170754528

Start: 3094331

End: 3095536

Strand: Reverse

Name: ribAB

Synonym: CLD_1678

Alternate gene names: 170754528

Gene position: 3095536-3094331 (Counterclockwise)

Preceding gene: 170756551

Following gene: 170755111

Centisome position: 78.2

GC content: 31.67

Gene sequence:

>1206_bases
ATGAGTTATAAATTTAATACTATAGAAGAGGCAATAGAGGATATAAAAGATGGAAAGATTATTGTAGTTGTAGATGATGA
GGATAGAGAAAACGAGGGAGATCTTTTAATGGCAGCAGAAAAAATTACTCCAGAGTCTATAAATTTTATGGCTAAAGAGG
GAAGAGGGCTTATATGTACTCCCGTAAAAAAATCTAGATTAGAGGAATTAGAAATATGCCAAATGGTACATAAAAATAAA
GATAATTTTGGTACCGCTTTTACTGTATCAGTAGATGCAGTAGATACATCTACTGGAATATCTGCATTTGATAGAGCATT
TACAGTATCAAAAATAGTAGATCTAAATTCAAAACCAGAGGATTTTTTAAAGCCAGGCCATGTATTTCCTTTAGCTGCTA
AAGATGGAGGAGTTTTAGTTAGAGCAGGTCATACAGAAGCAGCAGTAGATATGGCAAGATTATCAGGCTTTTCTGAGGTA
GGAGTTATATGTGAAATAATGAATGAGGACGGAACTATGGCAAGAGTGCCACAGCTTATGGAATTTGTAAAAAAACATAA
TCTAAAAATAATAACTATAGCAGATTTAATTGAATATAGAAGTAAAGAAGAAAAACTAATAAAGGCTTTAGAACCAGTAA
AACTTCCCTCTAAATATGGAAATTTTACTGCTATAGGTTATGAAAATTTAATAACTGGAGAAGAACATATAGCTTTAATA
AAAGGAGATGTAAAAGGAGAAGATCCAGTACTTGTTAGAGTACATTCAGAATGTTTAACAGGAGATGTATTCGGTTCTTT
AAGATGCGATTGTGGTGAGCAAATAGCTAAAGCTCTTATGAAAATAGAAGAAGAAGGGAAAGGAGTTTTAGTTTATATGA
GACAGGAAGGAAGAGGAATAGGTTTATTAAATAAACTAAAGGCATATGCTCTTCAAGATGAAGGTATGGATACTATAGAA
GCAAATTTAGCTTTAGGATTCCCAGAGGACTTAAGAGATTATGGCATAGGAGCTCAAATATTAAAGGATTTAGGGATTAA
AAATATTAAACTTATGACTAATAATCCTAAAAAAATATCAGGACTTTCAGGTTATGGTATAAAAATAGTAGATAGGGTTC
CTATAGATATGGGCTGTAAAAAAGAAAATCGTAATTATTTAAGAACTAAGAAAGATAAAATGGGACACTTGATAGACATA
ATGTAG

Upstream 100 bases:

>100_bases
TGCTATATATACATCTCATAGGTTACAGGTAGGGCACTATATTCAATAAATTGTGTAAAATTTTTCAGTAAATCTAAAAA
TATATTTAGGGGGAATTTTC

Downstream 100 bases:

>100_bases
ATAAATTAATAAAAGATTAGGGGGAAATAAAATGAAAATATATGAAGGTAAATTAACAGCAGAAGGTTTAAAGGTAGGAA
TAATAGTTTCAAGATTCAAT

Product: bifunctional riboflavin biosynthesis protein RibAB

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSYKFNTIEEAIEDIKDGKIIVVVDDEDRENEGDLLMAAEKITPESINFMAKEGRGLICTPVKKSRLEELEICQMVHKNK
DNFGTAFTVSVDAVDTSTGISAFDRAFTVSKIVDLNSKPEDFLKPGHVFPLAAKDGGVLVRAGHTEAAVDMARLSGFSEV
GVICEIMNEDGTMARVPQLMEFVKKHNLKIITIADLIEYRSKEEKLIKALEPVKLPSKYGNFTAIGYENLITGEEHIALI
KGDVKGEDPVLVRVHSECLTGDVFGSLRCDCGEQIAKALMKIEEEGKGVLVYMRQEGRGIGLLNKLKAYALQDEGMDTIE
ANLALGFPEDLRDYGIGAQILKDLGIKNIKLMTNNPKKISGLSGYGIKIVDRVPIDMGCKKENRNYLRTKKDKMGHLIDI
M

Sequences:

>Translated_401_residues
MSYKFNTIEEAIEDIKDGKIIVVVDDEDRENEGDLLMAAEKITPESINFMAKEGRGLICTPVKKSRLEELEICQMVHKNK
DNFGTAFTVSVDAVDTSTGISAFDRAFTVSKIVDLNSKPEDFLKPGHVFPLAAKDGGVLVRAGHTEAAVDMARLSGFSEV
GVICEIMNEDGTMARVPQLMEFVKKHNLKIITIADLIEYRSKEEKLIKALEPVKLPSKYGNFTAIGYENLITGEEHIALI
KGDVKGEDPVLVRVHSECLTGDVFGSLRCDCGEQIAKALMKIEEEGKGVLVYMRQEGRGIGLLNKLKAYALQDEGMDTIE
ANLALGFPEDLRDYGIGAQILKDLGIKNIKLMTNNPKKISGLSGYGIKIVDRVPIDMGCKKENRNYLRTKKDKMGHLIDI
M
>Mature_400_residues
SYKFNTIEEAIEDIKDGKIIVVVDDEDRENEGDLLMAAEKITPESINFMAKEGRGLICTPVKKSRLEELEICQMVHKNKD
NFGTAFTVSVDAVDTSTGISAFDRAFTVSKIVDLNSKPEDFLKPGHVFPLAAKDGGVLVRAGHTEAAVDMARLSGFSEVG
VICEIMNEDGTMARVPQLMEFVKKHNLKIITIADLIEYRSKEEKLIKALEPVKLPSKYGNFTAIGYENLITGEEHIALIK
GDVKGEDPVLVRVHSECLTGDVFGSLRCDCGEQIAKALMKIEEEGKGVLVYMRQEGRGIGLLNKLKAYALQDEGMDTIEA
NLALGFPEDLRDYGIGAQILKDLGIKNIKLMTNNPKKISGLSGYGIKIVDRVPIDMGCKKENRNYLRTKKDKMGHLIDIM

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=54.9222797927461, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1789420, Length=202, Percent_Identity=44.5544554455446, Blast_Score=203, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320695, Length=207, Percent_Identity=43.9613526570048, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319438, Length=173, Percent_Identity=49.7109826589595, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44345; Mature: 44214

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYKFNTIEEAIEDIKDGKIIVVVDDEDRENEGDLLMAAEKITPESINFMAKEGRGLICT
CCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEC
PVKKSRLEELEICQMVHKNKDNFGTAFTVSVDAVDTSTGISAFDRAFTVSKIVDLNSKPE
CCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCH
DFLKPGHVFPLAAKDGGVLVRAGHTEAAVDMARLSGFSEVGVICEIMNEDGTMARVPQLM
HHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCHHCEEEEEECCCCCHHHHHHHH
EFVKKHNLKIITIADLIEYRSKEEKLIKALEPVKLPSKYGNFTAIGYENLITGEEHIALI
HHHHHCCCEEEEHHHHHHHCCHHHHHHHHHCCCCCCCCCCCEEEECHHHHCCCCCEEEEE
KGDVKGEDPVLVRVHSECLTGDVFGSLRCDCGEQIAKALMKIEEEGKGVLVYMRQEGRGI
ECCCCCCCCEEEEEECCHHCCHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
GLLNKLKAYALQDEGMDTIEANLALGFPEDLRDYGIGAQILKDLGIKNIKLMTNNPKKIS
CHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHCCCHHHHHHHCCCCEEEEEECCCCCCC
GLSGYGIKIVDRVPIDMGCKKENRNYLRTKKDKMGHLIDIM
CCCCCCEEEEEECCCCCCCCCCCCCHHHCCHHHCCCEEECC
>Mature Secondary Structure 
SYKFNTIEEAIEDIKDGKIIVVVDDEDRENEGDLLMAAEKITPESINFMAKEGRGLICT
CCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEC
PVKKSRLEELEICQMVHKNKDNFGTAFTVSVDAVDTSTGISAFDRAFTVSKIVDLNSKPE
CCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCH
DFLKPGHVFPLAAKDGGVLVRAGHTEAAVDMARLSGFSEVGVICEIMNEDGTMARVPQLM
HHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCHHCEEEEEECCCCCHHHHHHHH
EFVKKHNLKIITIADLIEYRSKEEKLIKALEPVKLPSKYGNFTAIGYENLITGEEHIALI
HHHHHCCCEEEEHHHHHHHCCHHHHHHHHHCCCCCCCCCCCEEEECHHHHCCCCCEEEEE
KGDVKGEDPVLVRVHSECLTGDVFGSLRCDCGEQIAKALMKIEEEGKGVLVYMRQEGRGI
ECCCCCCCCEEEEEECCHHCCHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
GLLNKLKAYALQDEGMDTIEANLALGFPEDLRDYGIGAQILKDLGIKNIKLMTNNPKKIS
CHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHCCCHHHHHHHCCCCEEEEEECCCCCCC
GLSGYGIKIVDRVPIDMGCKKENRNYLRTKKDKMGHLIDIM
CCCCCCEEEEEECCCCCCCCCCCCCHHHCCHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA