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The map label for this gene is neuA [H]

Identifier: 170754454

GI number: 170754454

Start: 2891690

End: 2892400

Strand: Reverse

Name: neuA [H]

Synonym: CLD_1850

Alternate gene names: 170754454

Gene position: 2892400-2891690 (Counterclockwise)

Preceding gene: 170757000

Following gene: 170757334

Centisome position: 73.07

GC content: 36.01

Gene sequence:

>711_bases
GTGATAAATAATAAAAGTGTTCTCTCAATAATACCTGCAAGGGGCGGATCTAAAGAGGTTCCAAGAAAAAATATAAAAAA
TTTGAACGGCAAGCCGCTTATTGCATACTCCATAGAAGAAGCTAGGAAAAGCAAGTATATTGACAGAACAGTGGTTTCTA
CTGAAGATGTAGAGATAGCAAAAGTAAGCCAAAAGTTCGGTGCAGAGGTGCCGTGTTTAAGACCGTTGGAACTGTCAAGG
GATGATTCTCCCACAATAGATTGCGTTATTCATATGCTAAACTGGTTAAGGGAGGAGCAAAATTACATTCCAGACTATGT
GTGCTTGCTTCAATGTACATCACCGTTAAGAACATATGAGGACATTGACGGTACCATTGAAAAAGCTTTAACTTCAAATT
TTGACGGAGCAGTTTCAGTTTGTGAAGCAGAAGTAAATCCGTATTGGACTAATGTTTTTGATGAAGACAAGTTGAAGTAT
TTTTTGGAAGAAGGTAAGCAGATTACAAGGAGGCAGGACCTGCCTAGAGTATATAGAATCAATGGTTCAGTTTATGTAAT
AAAAACAGAGATTCTACTTGATGAAGAAGTTTTAGAGCCAAGCAATATTACAGGATTCATTATGAGAAACAAGAAATCCT
TGGATATTGATGATAATGAAGACTTTATGTTAGCTGATTTATTAATTAAGAACAAAGGTGATGCAAAATGA

Upstream 100 bases:

>100_bases
ATAAGAGATTACTGGATGGATATAGGCAGGATAGAAGATTACTACAAAGCAAATGAAGATGTGTATGACTTAATAGCTTG
TGAGAAATTAGGTGATGAAA

Downstream 100 bases:

>100_bases
GAATTGTGTATATTGGAGTTGTAGAATTCAGCCATATATGTTTGGAAGAAATCATAAAAAATAAGGGAGAGGTTGTAGGG
GTATTAACTAAAAAGCGATC

Product: acylneuraminate cytidylyltransferase

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase; CMP-sialic acid synthase [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MINNKSVLSIIPARGGSKEVPRKNIKNLNGKPLIAYSIEEARKSKYIDRTVVSTEDVEIAKVSQKFGAEVPCLRPLELSR
DDSPTIDCVIHMLNWLREEQNYIPDYVCLLQCTSPLRTYEDIDGTIEKALTSNFDGAVSVCEAEVNPYWTNVFDEDKLKY
FLEEGKQITRRQDLPRVYRINGSVYVIKTEILLDEEVLEPSNITGFIMRNKKSLDIDDNEDFMLADLLIKNKGDAK

Sequences:

>Translated_236_residues
MINNKSVLSIIPARGGSKEVPRKNIKNLNGKPLIAYSIEEARKSKYIDRTVVSTEDVEIAKVSQKFGAEVPCLRPLELSR
DDSPTIDCVIHMLNWLREEQNYIPDYVCLLQCTSPLRTYEDIDGTIEKALTSNFDGAVSVCEAEVNPYWTNVFDEDKLKY
FLEEGKQITRRQDLPRVYRINGSVYVIKTEILLDEEVLEPSNITGFIMRNKKSLDIDDNEDFMLADLLIKNKGDAK
>Mature_236_residues
MINNKSVLSIIPARGGSKEVPRKNIKNLNGKPLIAYSIEEARKSKYIDRTVVSTEDVEIAKVSQKFGAEVPCLRPLELSR
DDSPTIDCVIHMLNWLREEQNYIPDYVCLLQCTSPLRTYEDIDGTIEKALTSNFDGAVSVCEAEVNPYWTNVFDEDKLKY
FLEEGKQITRRQDLPRVYRINGSVYVIKTEILLDEEVLEPSNITGFIMRNKKSLDIDDNEDFMLADLLIKNKGDAK

Specific function: Activates Kdo (A Required 8-Carbon Sugar) For Incorporation Into Bacterial Lipopolysaccharide In Gram-Negative Bacteria (By Similarity). [C]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=223, Percent_Identity=32.7354260089686, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 26955; Mature: 26955

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINNKSVLSIIPARGGSKEVPRKNIKNLNGKPLIAYSIEEARKSKYIDRTVVSTEDVEIA
CCCCCCEEEEEECCCCCCCCCHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCHHH
KVSQKFGAEVPCLRPLELSRDDSPTIDCVIHMLNWLREEQNYIPDYVCLLQCTSPLRTYE
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHH
DIDGTIEKALTSNFDGAVSVCEAEVNPYWTNVFDEDKLKYFLEEGKQITRRQDLPRVYRI
HHHHHHHHHHHCCCCCCEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEE
NGSVYVIKTEILLDEEVLEPSNITGFIMRNKKSLDIDDNEDFMLADLLIKNKGDAK
CCEEEEEEEEEEECHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEECCCCCCC
>Mature Secondary Structure
MINNKSVLSIIPARGGSKEVPRKNIKNLNGKPLIAYSIEEARKSKYIDRTVVSTEDVEIA
CCCCCCEEEEEECCCCCCCCCHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCHHH
KVSQKFGAEVPCLRPLELSRDDSPTIDCVIHMLNWLREEQNYIPDYVCLLQCTSPLRTYE
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHH
DIDGTIEKALTSNFDGAVSVCEAEVNPYWTNVFDEDKLKYFLEEGKQITRRQDLPRVYRI
HHHHHHHHHHHCCCCCCEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEE
NGSVYVIKTEILLDEEVLEPSNITGFIMRNKKSLDIDDNEDFMLADLLIKNKGDAK
CCEEEEEEEEEEECHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]