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The map label for this gene is uraA [H]

Identifier: 170754342

GI number: 170754342

Start: 1641169

End: 1642512

Strand: Direct

Name: uraA [H]

Synonym: CLD_3072

Alternate gene names: 170754342

Gene position: 1641169-1642512 (Clockwise)

Preceding gene: 170755225

Following gene: 170757676

Centisome position: 41.46

GC content: 34.67

Gene sequence:

>1344_bases
ATGAAAAAATATGTAGACGTAAATGAAAAATTACCTATCTTAAAAACCATACCTTTAAGCTTTCAACATTTATTTGCAAT
GGTGGGAGCCACTATACTAGTTCCAATGCTTACAGGTATGAGTCCTTCTATTGCATTGTTTGGAAGCGGTGTAGGAACAC
TTCTTTATGTACTTTGTACAAAAGCAAAGCTACCAGCTTATATAGGATCATCTTTTGCATTCATAGGTCCTATGACAGTA
GCATCAGCAGCTTATGGACCAAATGCCATGTTATCTGGAATAATAGCTGCAGGTTTAATTTATATATTAGTAGCAGCTAT
AATAAGTTTTACAGGAACAGATTGGCTAAATAAAGTATTACCACCAATTGTAGTTGGTTCCGTTGTAATAGTAATAGGTT
TAGGATTAGCGGGAGTAGCAATAAATTGGGCAGGTCTTAATTCTAATTTTATGGTAGATTCCATGCAAAGCGTACCAAGA
TGGGCATGGATTACGGTTTCAATAATAACCTTAGGAATAGGAATACTTGGAACTATGTATTTCAAAGGATTCTTAGGAGT
GATACCAATCCTTATAGCAATGATATGTGGATATATTTCAGCATTAGCCCTAGGGGTTATATCTCAGGAAACTTTAACTC
AAATAGCAAGTGCGCCTTTATTTCAGCTTCCACCATTTATGAAACCAGAGTTTAACATAAACGCCATGGTATTAATGGCA
CCAGTAGCTTTTGTAACCTTAGCAGAACATATTGGACATGTTTATGTAACAAATAATGTAGTAGGAAAAGACTTTACAAA
AGACCCTGGCCTTCATAGATCTATACTAGGAGATGGAGTGGCTACTCTACTAGCAGGATTCATAGGTGGACCTCCTAACA
CAACTTATGGAGAAAATATTGGAGTTATGGCTATAACTAAAGTATACAGCGTATGGGTAATTATAGGAGCTGCAATAATA
GCTATTATACTTTCCTTTATAGGACCTGTAGCAACATTAATAGCTACTATACCAATGCCAGTAATGGGCGGAGTGAGTAT
ACTTTTATTTGGAATAATAGCTTCCTCAGGTTTTAGAGTATTTGTAGAGGATAAAGTAGATTTTAGCAAAAAGAGAAACT
TAATAATATCCTCTGTAATAATAGTATTAGGAATAGGTGGAGCTGCAGTAAAATTTAAGTTAGCAGGATCAGAGGTAGAA
ATAGCAGGAGTTGCATTAGCAACACTAGTAGGAATAATATTAAATCTAATACTTCCAAAAGAAAGTAGAACGGAAGAAGA
GGATAATAAAGAAGAAAATCTTAAAGAAGAGTTCATTAAACCTATAGAAAAAAATGTGGGTTAA

Upstream 100 bases:

>100_bases
TCAGTACATTTAAAAGAACTTGATGGACAAGATTCCATTAAAATATTTGAAAAATAGCGTCTTTTAAAATAGTCCAGAGA
GACTAAAAGGGGGAAATAAT

Downstream 100 bases:

>100_bases
AAGATTTAATGTATCATACCTTTTAAAGGTTAAGAATTAAAACAAAAAGTATTTTTAGTCAATAAATAGCTATAAAGAAT
AAAGAATACTAATATTTGTG

Product: uracil permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MKKYVDVNEKLPILKTIPLSFQHLFAMVGATILVPMLTGMSPSIALFGSGVGTLLYVLCTKAKLPAYIGSSFAFIGPMTV
ASAAYGPNAMLSGIIAAGLIYILVAAIISFTGTDWLNKVLPPIVVGSVVIVIGLGLAGVAINWAGLNSNFMVDSMQSVPR
WAWITVSIITLGIGILGTMYFKGFLGVIPILIAMICGYISALALGVISQETLTQIASAPLFQLPPFMKPEFNINAMVLMA
PVAFVTLAEHIGHVYVTNNVVGKDFTKDPGLHRSILGDGVATLLAGFIGGPPNTTYGENIGVMAITKVYSVWVIIGAAII
AIILSFIGPVATLIATIPMPVMGGVSILLFGIIASSGFRVFVEDKVDFSKKRNLIISSVIIVLGIGGAAVKFKLAGSEVE
IAGVALATLVGIILNLILPKESRTEEEDNKEENLKEEFIKPIEKNVG

Sequences:

>Translated_447_residues
MKKYVDVNEKLPILKTIPLSFQHLFAMVGATILVPMLTGMSPSIALFGSGVGTLLYVLCTKAKLPAYIGSSFAFIGPMTV
ASAAYGPNAMLSGIIAAGLIYILVAAIISFTGTDWLNKVLPPIVVGSVVIVIGLGLAGVAINWAGLNSNFMVDSMQSVPR
WAWITVSIITLGIGILGTMYFKGFLGVIPILIAMICGYISALALGVISQETLTQIASAPLFQLPPFMKPEFNINAMVLMA
PVAFVTLAEHIGHVYVTNNVVGKDFTKDPGLHRSILGDGVATLLAGFIGGPPNTTYGENIGVMAITKVYSVWVIIGAAII
AIILSFIGPVATLIATIPMPVMGGVSILLFGIIASSGFRVFVEDKVDFSKKRNLIISSVIIVLGIGGAAVKFKLAGSEVE
IAGVALATLVGIILNLILPKESRTEEEDNKEENLKEEFIKPIEKNVG
>Mature_447_residues
MKKYVDVNEKLPILKTIPLSFQHLFAMVGATILVPMLTGMSPSIALFGSGVGTLLYVLCTKAKLPAYIGSSFAFIGPMTV
ASAAYGPNAMLSGIIAAGLIYILVAAIISFTGTDWLNKVLPPIVVGSVVIVIGLGLAGVAINWAGLNSNFMVDSMQSVPR
WAWITVSIITLGIGILGTMYFKGFLGVIPILIAMICGYISALALGVISQETLTQIASAPLFQLPPFMKPEFNINAMVLMA
PVAFVTLAEHIGHVYVTNNVVGKDFTKDPGLHRSILGDGVATLLAGFIGGPPNTTYGENIGVMAITKVYSVWVIIGAAII
AIILSFIGPVATLIATIPMPVMGGVSILLFGIIASSGFRVFVEDKVDFSKKRNLIISSVIIVLGIGGAAVKFKLAGSEVE
IAGVALATLVGIILNLILPKESRTEEEDNKEENLKEEFIKPIEKNVG

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788843, Length=434, Percent_Identity=47.926267281106, Blast_Score=380, Evalue=1e-107,
Organism=Escherichia coli, GI87081818, Length=427, Percent_Identity=38.4074941451991, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI87082181, Length=469, Percent_Identity=26.4392324093817, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790087, Length=447, Percent_Identity=25.7270693512304, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082178, Length=402, Percent_Identity=25.1243781094527, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17558856, Length=457, Percent_Identity=25.8205689277899, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17542262, Length=179, Percent_Identity=27.9329608938547, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21356175, Length=428, Percent_Identity=24.0654205607477, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 47120; Mature: 47120

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYVDVNEKLPILKTIPLSFQHLFAMVGATILVPMLTGMSPSIALFGSGVGTLLYVLCT
CCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHH
KAKLPAYIGSSFAFIGPMTVASAAYGPNAMLSGIIAAGLIYILVAAIISFTGTDWLNKVL
CCCCCHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
PPIVVGSVVIVIGLGLAGVAINWAGLNSNFMVDSMQSVPRWAWITVSIITLGIGILGTMY
HHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
FKGFLGVIPILIAMICGYISALALGVISQETLTQIASAPLFQLPPFMKPEFNINAMVLMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
PVAFVTLAEHIGHVYVTNNVVGKDFTKDPGLHRSILGDGVATLLAGFIGGPPNTTYGENI
HHHHHHHHHHHCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GVMAITKVYSVWVIIGAAIIAIILSFIGPVATLIATIPMPVMGGVSILLFGIIASSGFRV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEE
FVEDKVDFSKKRNLIISSVIIVLGIGGAAVKFKLAGSEVEIAGVALATLVGIILNLILPK
EEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHCCC
ESRTEEEDNKEENLKEEFIKPIEKNVG
CCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKYVDVNEKLPILKTIPLSFQHLFAMVGATILVPMLTGMSPSIALFGSGVGTLLYVLCT
CCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHH
KAKLPAYIGSSFAFIGPMTVASAAYGPNAMLSGIIAAGLIYILVAAIISFTGTDWLNKVL
CCCCCHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
PPIVVGSVVIVIGLGLAGVAINWAGLNSNFMVDSMQSVPRWAWITVSIITLGIGILGTMY
HHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
FKGFLGVIPILIAMICGYISALALGVISQETLTQIASAPLFQLPPFMKPEFNINAMVLMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
PVAFVTLAEHIGHVYVTNNVVGKDFTKDPGLHRSILGDGVATLLAGFIGGPPNTTYGENI
HHHHHHHHHHHCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GVMAITKVYSVWVIIGAAIIAIILSFIGPVATLIATIPMPVMGGVSILLFGIIASSGFRV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEE
FVEDKVDFSKKRNLIISSVIIVLGIGGAAVKFKLAGSEVEIAGVALATLVGIILNLILPK
EEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHCCC
ESRTEEEDNKEENLKEEFIKPIEKNVG
CCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]