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The map label for this gene is icd [H]

Identifier: 170752132

GI number: 170752132

Start: 6073713

End: 6074927

Strand: Reverse

Name: icd [H]

Synonym: Mrad2831_5765

Alternate gene names: 170752132

Gene position: 6074927-6073713 (Counterclockwise)

Preceding gene: 170752134

Following gene: 170752128

Centisome position: 99.95

GC content: 64.69

Gene sequence:

>1215_bases
ATGGCGAAGATCAAGGTAGCGAACCCCGTCGTCGAGCTCGACGGCGACGAGATGACCCGGATCATCTGGGCCGAGATCAA
GAACAAGCTCATCCACCCCTATCTCGACGTCGACCTCGAGTACTACGACCTCGGCGTCGAGCACCGGGACGCCACCAACG
ACAAGGTGACGGTGGACGCCGCCGAGGCGATCAAGCGCCACGGCGTCGGCGTGAAGTGCGCCACCATCACCCCCGACGAG
CAGCGGGTGCAGGAATTCGGTCTCAAGGAGATGTGGCGCTCGCCCAACGGCACGATCCGCAACATCCTGGGCGGCGTGAT
CTTCCGCGAGCCGATCATCTGCAAGAACGTGCCCCGCCTCGTGCCCGGCTGGACGCAGCCCTTCGTGATCGGCCGCCACG
CCTACGGCGACCAGTACCGCGCCACGGACTTCAAGGTGCCCGGCAAGGGACGCCTGACCATCAAGTTCGAGGGCGATGAC
GGCACGGTCATCGAGAAGGAGGTGTTCAAGTTCCCCGAGGCCGGCGTCGCCATGTCGATGTACAACCTCGACCAGTCGAT
CATCGACTTCGCCCGCGCCTCGATGAACTACGGCCTCGCGCGCAAGTACCCGGTCTACCTGTCGACCAAGAACACCATCC
TCAAGGCCTATGACGGCCGCTTCAAGGACCTGTTCCAGAAGGTCTACGAGGACGAGTTCGAGGCCAAGTTCAAGGCGCTC
GGTATCACCTACGAGCACCGTCTGATCGACGACATGGTGGCCTCGTGCCTGAAGTGGTCGGGCGGCTACGTCTGGGCCTG
CAAGAACTACGACGGCGACGTGCAGTCGGACACGGCCGCGCAGGGCTTCGGCTCGCTCGGCCTGATGACCTCGGTGCTGA
TGACGCCGGACGGCCGGACCGTGGAGGCCGAGGCCGCCCACGGCACCGTCACCCGCCATTACCGCGAGCACCAGAAGGGC
CGCGAGACGTCGACCAACTCGATAGCGTCGATCTTCGCCTGGACCCGGGGCCTGTCGCACCGCGCCAAGCTCGACGGCAA
CGACGATCTGGCGAAGTTCTCCGCCACCCTGGAGAAGGTCTGCGTCGACACGGTCGAGGCCGGCTACATGACCAAGGATC
TCGCCCTCCTCGTCGGGCCGGACCAGAAGTGGCTCTCGACCACCGGCTTCCTCGACAAGGTCGATCAGAACCTGAAAACC
GCGATGGGCGTCTGA

Upstream 100 bases:

>100_bases
GGGGCGATTCCGGCCCGGGGCGCCCCACAGGTCTCCCGGGACAACGACCGCACGGCCCTTGCATGCCGTGCGCGGGGACA
ACGCGGGAAGGCAGCGGTCC

Downstream 100 bases:

>100_bases
GGCATTAGCCACAACGTGGAGAACGGCGGGCGTCCTACGGGACGCCCGCCGTTCCCGTATCCGACTGCCGCCGGCGCCTC
AGGCGCCGCTCGCGCGGTCC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MAKIKVANPVVELDGDEMTRIIWAEIKNKLIHPYLDVDLEYYDLGVEHRDATNDKVTVDAAEAIKRHGVGVKCATITPDE
QRVQEFGLKEMWRSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPFVIGRHAYGDQYRATDFKVPGKGRLTIKFEGDD
GTVIEKEVFKFPEAGVAMSMYNLDQSIIDFARASMNYGLARKYPVYLSTKNTILKAYDGRFKDLFQKVYEDEFEAKFKAL
GITYEHRLIDDMVASCLKWSGGYVWACKNYDGDVQSDTAAQGFGSLGLMTSVLMTPDGRTVEAEAAHGTVTRHYREHQKG
RETSTNSIASIFAWTRGLSHRAKLDGNDDLAKFSATLEKVCVDTVEAGYMTKDLALLVGPDQKWLSTTGFLDKVDQNLKT
AMGV

Sequences:

>Translated_404_residues
MAKIKVANPVVELDGDEMTRIIWAEIKNKLIHPYLDVDLEYYDLGVEHRDATNDKVTVDAAEAIKRHGVGVKCATITPDE
QRVQEFGLKEMWRSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPFVIGRHAYGDQYRATDFKVPGKGRLTIKFEGDD
GTVIEKEVFKFPEAGVAMSMYNLDQSIIDFARASMNYGLARKYPVYLSTKNTILKAYDGRFKDLFQKVYEDEFEAKFKAL
GITYEHRLIDDMVASCLKWSGGYVWACKNYDGDVQSDTAAQGFGSLGLMTSVLMTPDGRTVEAEAAHGTVTRHYREHQKG
RETSTNSIASIFAWTRGLSHRAKLDGNDDLAKFSATLEKVCVDTVEAGYMTKDLALLVGPDQKWLSTTGFLDKVDQNLKT
AMGV
>Mature_403_residues
AKIKVANPVVELDGDEMTRIIWAEIKNKLIHPYLDVDLEYYDLGVEHRDATNDKVTVDAAEAIKRHGVGVKCATITPDEQ
RVQEFGLKEMWRSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPFVIGRHAYGDQYRATDFKVPGKGRLTIKFEGDDG
TVIEKEVFKFPEAGVAMSMYNLDQSIIDFARASMNYGLARKYPVYLSTKNTILKAYDGRFKDLFQKVYEDEFEAKFKALG
ITYEHRLIDDMVASCLKWSGGYVWACKNYDGDVQSDTAAQGFGSLGLMTSVLMTPDGRTVEAEAAHGTVTRHYREHQKGR
ETSTNSIASIFAWTRGLSHRAKLDGNDDLAKFSATLEKVCVDTVEAGYMTKDLALLVGPDQKWLSTTGFLDKVDQNLKTA
MGV

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=408, Percent_Identity=65.1960784313726, Blast_Score=558, Evalue=1e-159,
Organism=Homo sapiens, GI28178825, Length=410, Percent_Identity=64.6341463414634, Blast_Score=555, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17550822, Length=407, Percent_Identity=64.8648648648649, Blast_Score=558, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17540874, Length=397, Percent_Identity=66.2468513853904, Blast_Score=552, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6320137, Length=405, Percent_Identity=62.4691358024691, Blast_Score=531, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6323203, Length=404, Percent_Identity=62.8712871287129, Blast_Score=528, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6324319, Length=407, Percent_Identity=60.6879606879607, Blast_Score=527, Evalue=1e-151,
Organism=Drosophila melanogaster, GI21356561, Length=409, Percent_Identity=62.1026894865526, Blast_Score=550, Evalue=1e-157,
Organism=Drosophila melanogaster, GI221330987, Length=409, Percent_Identity=62.1026894865526, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI221330985, Length=409, Percent_Identity=62.1026894865526, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI28574947, Length=409, Percent_Identity=62.1026894865526, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24660849, Length=409, Percent_Identity=62.1026894865526, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24660856, Length=409, Percent_Identity=62.1026894865526, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI221330983, Length=409, Percent_Identity=62.1026894865526, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24660868, Length=409, Percent_Identity=62.1026894865526, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24660860, Length=409, Percent_Identity=62.1026894865526, Blast_Score=548, Evalue=1e-156,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45237; Mature: 45106

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVANPVVELDGDEMTRIIWAEIKNKLIHPYLDVDLEYYDLGVEHRDATNDKVTVDA
CCEEEECCCEEEECCCHHHHHHHHHHHHHHCCCHHCCCEEEEECCCCCCCCCCCEEEEEH
AEAIKRHGVGVKCATITPDEQRVQEFGLKEMWRSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHCCCCEEEEEECCCHHHHHHCCHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPFVIGRHAYGDQYRATDFKVPGKGRLTIKFEGDDGTVIEKEVFKFPEAGVAMSM
CCCCCCCEEEEECCCCCCCCCCCEECCCCCEEEEEEECCCCCEEHHHHHHCCCCCCEEEH
YNLDQSIIDFARASMNYGLARKYPVYLSTKNTILKAYDGRFKDLFQKVYEDEFEAKFKAL
HHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHC
GITYEHRLIDDMVASCLKWSGGYVWACKNYDGDVQSDTAAQGFGSLGLMTSVLMTPDGRT
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHCCCHHHHHHHHEECCCCCE
VEAEAAHGTVTRHYREHQKGRETSTNSIASIFAWTRGLSHRAKLDGNDDLAKFSATLEKV
EEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
CVDTVEAGYMTKDLALLVGPDQKWLSTTGFLDKVDQNLKTAMGV
HHHHHHCCCEEECEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKIKVANPVVELDGDEMTRIIWAEIKNKLIHPYLDVDLEYYDLGVEHRDATNDKVTVDA
CEEEECCCEEEECCCHHHHHHHHHHHHHHCCCHHCCCEEEEECCCCCCCCCCCEEEEEH
AEAIKRHGVGVKCATITPDEQRVQEFGLKEMWRSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHCCCCEEEEEECCCHHHHHHCCHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPFVIGRHAYGDQYRATDFKVPGKGRLTIKFEGDDGTVIEKEVFKFPEAGVAMSM
CCCCCCCEEEEECCCCCCCCCCCEECCCCCEEEEEEECCCCCEEHHHHHHCCCCCCEEEH
YNLDQSIIDFARASMNYGLARKYPVYLSTKNTILKAYDGRFKDLFQKVYEDEFEAKFKAL
HHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHC
GITYEHRLIDDMVASCLKWSGGYVWACKNYDGDVQSDTAAQGFGSLGLMTSVLMTPDGRT
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHCCCHHHHHHHHEECCCCCE
VEAEAAHGTVTRHYREHQKGRETSTNSIASIFAWTRGLSHRAKLDGNDDLAKFSATLEKV
EEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
CVDTVEAGYMTKDLALLVGPDQKWLSTTGFLDKVDQNLKTAMGV
HHHHHHCCCEEECEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]