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The map label for this gene is degP [H]

Identifier: 170751798

GI number: 170751798

Start: 5732888

End: 5734414

Strand: Reverse

Name: degP [H]

Synonym: Mrad2831_5428

Alternate gene names: 170751798

Gene position: 5734414-5732888 (Counterclockwise)

Preceding gene: 170751800

Following gene: 170751791

Centisome position: 94.35

GC content: 71.51

Gene sequence:

>1527_bases
ATGACCGAGACCCGTCCCACTGGCCGCACCTCGCGCCGCGCCCTCGCCTCCGTGGCGGCCGCCGCGCTGATCGCCGGCGG
TGCCGTCGGCAGCGGCTATCTGCCGGCCGCGACCCCGGCCTACGCGCAGGCGCTGCCCAAGTCGCCGATCGAGGCTCCCG
AGCACCCGCCGGGCTCGTTCGCCGGCATCGTCAGCAAGGTGAAGCCGGGCGTCGTCTCGGTGAAGGTGAAGCTCGACGAC
TCGGCGAGCAGCGACGACGACGACGGCCCGAGCCAGGGGCGCAACCTCCAGAACGTGCCGCCGCAGCTGCGCGAGTTCTT
CAAGCGCTTCGGCCAGAACGGCCCGGGCGGCATGCAGCCCCAGCATCAGGGCCCGCGCGGCGCGGTCGGCTCCGGCTTCA
TCATCTCGGCCGACGGCTACGTGGTCACCAACAACCACGTGGTCGACCATGCCAAGACCGTTCAGGTGACGCTGGACGAC
GGCCGCACCCTCGACGCGAAGGTCATCGGCAAGGATTCCAAGACGGACGTCGCGCTCCTGAAGATCACCGAGGGCTCGAA
CTTCCCGTACGTGCAGTTCGGCAAGGCCGCGCCGCAGGTCGGCGACTGGGTCGTGGCGATCGGTAACCCGTTCGGTCTCG
GCGGCACCGTGACCGCCGGCATCGTCTCGGCCCGCGGCCGCGACATCGGCGCCGGCCCCTACGACGACTTCCTGCAGATC
GACGCGCCCATCAACAAGGGCAATTCGGGCGGGCCGACCTTCAACGTCAACGGCGAGGTGGTCGGCATGAACACCGCCAT
CGCGTCCCCGTCGGGCGGCAGCGTCGGCCTCGCCTTCGCGATTCCCGCCGAGACCGTCCAGGCGGTCGTCGACCAGCTCC
GCACCGACGGCAAGGTCGCCCGCGGCTACCTGGGCGTCCAGATCCAGCCCGTGACGCAGGATATCGCCGAGGGTCTGGGC
CTCGACAAGGCCAAGGGCGCCCTGGTCGACCACGCCGAGAACGGCACCCCGGCGGCCAAGGCCGGCCTGAAGGCGGGCGA
CGTGATCGAGAAGGTCAACGGCGACACGGTGGACAGCGCCCGCGAGCTATCGCGCAAGATCGCCGGCCTGAAGCCCGGCG
CCAAGGTCGAGCTGAGCTACCTGCGCGGCGGCAAGACCGACACCGCCACGGTGACGCTGGGCACGATGCCGACCGACGGC
ACCAAGATGGCGAGCCGCGACGACGACTCGGGCAACGGCCAGCCGCGGCTCGGCCTGCAGCTCGCCCCGGCCGGCGATGT
CGGCCTGTCGGATCAGGGCGTCGCGGTGGTCCAAGTCGATCCCGACGGCCCGGCGGCCGCCAAGGGCATCGAGGCCGGCG
ACGTGATCCTCGACGTGGGTGGCCAGAGCGTGTCCCGCCCGGCGGACGTGGCGACGCAGATCCGGGCGGCCGAGACGAGC
GGGCGCAAGGCCGTGCTGATGCGGGTGAAGAGCGGCAAGGGCCAGACCCGGTTCGTGGCGGTCTCGCTCAACAAGAAGGC
CGGCTGA

Upstream 100 bases:

>100_bases
ATCGCCACGCCCGGGTCAGGCGCCCCCCCTTAGACAGATCCCATCGACGGCCGCGACCGCCGGCGTCGTCCCGATCAGTC
CCGAGAGGTTGAGACCCCCC

Downstream 100 bases:

>100_bases
GGCCGGTTCCTCCCGGCGCGGGGTCCGCCCCGCGCCGTCTCGTGGTGACCTCCGACTCGCGCCGGCCGTGCAGGCCGGCG
CTTTTTCGTGGCCCCCCTCA

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MTETRPTGRTSRRALASVAAAALIAGGAVGSGYLPAATPAYAQALPKSPIEAPEHPPGSFAGIVSKVKPGVVSVKVKLDD
SASSDDDDGPSQGRNLQNVPPQLREFFKRFGQNGPGGMQPQHQGPRGAVGSGFIISADGYVVTNNHVVDHAKTVQVTLDD
GRTLDAKVIGKDSKTDVALLKITEGSNFPYVQFGKAAPQVGDWVVAIGNPFGLGGTVTAGIVSARGRDIGAGPYDDFLQI
DAPINKGNSGGPTFNVNGEVVGMNTAIASPSGGSVGLAFAIPAETVQAVVDQLRTDGKVARGYLGVQIQPVTQDIAEGLG
LDKAKGALVDHAENGTPAAKAGLKAGDVIEKVNGDTVDSARELSRKIAGLKPGAKVELSYLRGGKTDTATVTLGTMPTDG
TKMASRDDDSGNGQPRLGLQLAPAGDVGLSDQGVAVVQVDPDGPAAAKGIEAGDVILDVGGQSVSRPADVATQIRAAETS
GRKAVLMRVKSGKGQTRFVAVSLNKKAG

Sequences:

>Translated_508_residues
MTETRPTGRTSRRALASVAAAALIAGGAVGSGYLPAATPAYAQALPKSPIEAPEHPPGSFAGIVSKVKPGVVSVKVKLDD
SASSDDDDGPSQGRNLQNVPPQLREFFKRFGQNGPGGMQPQHQGPRGAVGSGFIISADGYVVTNNHVVDHAKTVQVTLDD
GRTLDAKVIGKDSKTDVALLKITEGSNFPYVQFGKAAPQVGDWVVAIGNPFGLGGTVTAGIVSARGRDIGAGPYDDFLQI
DAPINKGNSGGPTFNVNGEVVGMNTAIASPSGGSVGLAFAIPAETVQAVVDQLRTDGKVARGYLGVQIQPVTQDIAEGLG
LDKAKGALVDHAENGTPAAKAGLKAGDVIEKVNGDTVDSARELSRKIAGLKPGAKVELSYLRGGKTDTATVTLGTMPTDG
TKMASRDDDSGNGQPRLGLQLAPAGDVGLSDQGVAVVQVDPDGPAAAKGIEAGDVILDVGGQSVSRPADVATQIRAAETS
GRKAVLMRVKSGKGQTRFVAVSLNKKAG
>Mature_507_residues
TETRPTGRTSRRALASVAAAALIAGGAVGSGYLPAATPAYAQALPKSPIEAPEHPPGSFAGIVSKVKPGVVSVKVKLDDS
ASSDDDDGPSQGRNLQNVPPQLREFFKRFGQNGPGGMQPQHQGPRGAVGSGFIISADGYVVTNNHVVDHAKTVQVTLDDG
RTLDAKVIGKDSKTDVALLKITEGSNFPYVQFGKAAPQVGDWVVAIGNPFGLGGTVTAGIVSARGRDIGAGPYDDFLQID
APINKGNSGGPTFNVNGEVVGMNTAIASPSGGSVGLAFAIPAETVQAVVDQLRTDGKVARGYLGVQIQPVTQDIAEGLGL
DKAKGALVDHAENGTPAAKAGLKAGDVIEKVNGDTVDSARELSRKIAGLKPGAKVELSYLRGGKTDTATVTLGTMPTDGT
KMASRDDDSGNGQPRLGLQLAPAGDVGLSDQGVAVVQVDPDGPAAAKGIEAGDVILDVGGQSVSRPADVATQIRAAETSG
RKAVLMRVKSGKGQTRFVAVSLNKKAG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=253, Percent_Identity=38.7351778656126, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI24308541, Length=254, Percent_Identity=35.0393700787402, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI22129776, Length=291, Percent_Identity=32.3024054982818, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI7019477, Length=280, Percent_Identity=33.9285714285714, Blast_Score=132, Evalue=1e-30,
Organism=Escherichia coli, GI1786356, Length=453, Percent_Identity=37.7483443708609, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI1789629, Length=446, Percent_Identity=39.237668161435, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1789630, Length=278, Percent_Identity=39.568345323741, Blast_Score=184, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324206, Length=295, Percent_Identity=27.1186440677966, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24646839, Length=287, Percent_Identity=32.7526132404181, Blast_Score=135, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 51655; Mature: 51523

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETRPTGRTSRRALASVAAAALIAGGAVGSGYLPAATPAYAQALPKSPIEAPEHPPGSF
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHH
AGIVSKVKPGVVSVKVKLDDSASSDDDDGPSQGRNLQNVPPQLREFFKRFGQNGPGGMQP
HHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCC
QHQGPRGAVGSGFIISADGYVVTNNHVVDHAKTVQVTLDDGRTLDAKVIGKDSKTDVALL
CCCCCCCCCCCCEEEECCCEEEECCEEECCCEEEEEEECCCCEEEEEEECCCCCCCEEEE
KITEGSNFPYVQFGKAAPQVGDWVVAIGNPFGLGGTVTAGIVSARGRDIGAGPYDDFLQI
EEECCCCCCEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEE
DAPINKGNSGGPTFNVNGEVVGMNTAIASPSGGSVGLAFAIPAETVQAVVDQLRTDGKVA
ECCCCCCCCCCCEEECCCEEEEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCC
RGYLGVQIQPVTQDIAEGLGLDKAKGALVDHAENGTPAAKAGLKAGDVIEKVNGDTVDSA
CCEEEEEEEHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHCCCHHHHHHHCCCCCHHHH
RELSRKIAGLKPGAKVELSYLRGGKTDTATVTLGTMPTDGTKMASRDDDSGNGQPRLGLQ
HHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEE
LAPAGDVGLSDQGVAVVQVDPDGPAAAKGIEAGDVILDVGGQSVSRPADVATQIRAAETS
ECCCCCCCCCCCCEEEEEECCCCCHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCC
GRKAVLMRVKSGKGQTRFVAVSLNKKAG
CCEEEEEEEECCCCCEEEEEEEECCCCC
>Mature Secondary Structure 
TETRPTGRTSRRALASVAAAALIAGGAVGSGYLPAATPAYAQALPKSPIEAPEHPPGSF
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHH
AGIVSKVKPGVVSVKVKLDDSASSDDDDGPSQGRNLQNVPPQLREFFKRFGQNGPGGMQP
HHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCC
QHQGPRGAVGSGFIISADGYVVTNNHVVDHAKTVQVTLDDGRTLDAKVIGKDSKTDVALL
CCCCCCCCCCCCEEEECCCEEEECCEEECCCEEEEEEECCCCEEEEEEECCCCCCCEEEE
KITEGSNFPYVQFGKAAPQVGDWVVAIGNPFGLGGTVTAGIVSARGRDIGAGPYDDFLQI
EEECCCCCCEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEE
DAPINKGNSGGPTFNVNGEVVGMNTAIASPSGGSVGLAFAIPAETVQAVVDQLRTDGKVA
ECCCCCCCCCCCEEECCCEEEEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCC
RGYLGVQIQPVTQDIAEGLGLDKAKGALVDHAENGTPAAKAGLKAGDVIEKVNGDTVDSA
CCEEEEEEEHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHCCCHHHHHHHCCCCCHHHH
RELSRKIAGLKPGAKVELSYLRGGKTDTATVTLGTMPTDGTKMASRDDDSGNGQPRLGLQ
HHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEE
LAPAGDVGLSDQGVAVVQVDPDGPAAAKGIEAGDVILDVGGQSVSRPADVATQIRAAETS
ECCCCCCCCCCCCEEEEEECCCCCHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCC
GRKAVLMRVKSGKGQTRFVAVSLNKKAG
CCEEEEEEEECCCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]