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The map label for this gene is lon2 [H]

Identifier: 170751675

GI number: 170751675

Start: 5620183

End: 5621838

Strand: Reverse

Name: lon2 [H]

Synonym: Mrad2831_5305

Alternate gene names: 170751675

Gene position: 5621838-5620183 (Counterclockwise)

Preceding gene: 170751676

Following gene: 170751674

Centisome position: 92.5

GC content: 71.56

Gene sequence:

>1656_bases
ATGACGAAGCGCGTCCCCGTTCACGGGGCTCCCCCGACCTTGCGCGAACTCCTCTGCGGCGCGGCGCCCTACGGCGGCTC
CGCCCACCGCGACCTCTACGCGCATCTCCCCCACACGTGGCCCAGCTTTCTCGATGGCGACCGGAAGTCGCTGTGGGAGG
ACCTCGGCGGGTCCTGGGTCATGGTCGAGCTCCTCGAAGGTGTCTGGGTCGCGGCCGAGAAGGTGATCGACAGTAGAGGC
GCGAACGGCGCCCTCGACACAAGGGTGTTCCAGACGCAGTTGCTGGTCGCTTGGTCGGAGCTCGGACGCCTCCTCGACGG
GCGGCCGGCCGCCGACATCGAGCTTGACCGCCTGTACAATCTCCCGAGCCTCCTCGACGAACTCCGGGACCGAATGACCG
TCCTGCTCGCCATGCTGGCGGAGCGGACGGCGGTCGACAGGATGCCCGACGTCCTGTGGCGGTACGCCCGGCGCGCCACG
CCCGATGCGGGGCTGCTTCAACTGTACGCGGCCGCTTTCGGCGTCTCGCACGACGAGTGCAGCTACACCCCGCGGCACAT
CCCGGGGACACGGCTGCTCGACGTCCTGGGCCACTGGCGCGAGACGGGCATGCAGGCCATTGCGGACGCCGCCCTTCTGG
CTCGAGGCCAGATCCGCGACGCCGTCACCGATGCCGTCGCGGAACGGCAGGCGCCGGCCCGTCCGGAGCCCTCCCTCCAT
CAGTTGCTGAACAGCGCCCACGCCAAGCCCGAGCAGGCCGACCCGGAGCCGGAGGCGGGCCCGGGCGTCGTGGTCGTGCC
CCGCATCGGGGGCGGCACGAAGGGCCAAGGCAACAAGGACGCGACCTCCGAGCTCGGGGACATCCTCGGGCGCCGGCTCC
CGCTCTACGAGGTCCCGTCCGACCGGCACGCCCTCGTCGAGGAGGCTGCCGCGGAGGCCCCGCACGCACGCCGGTTCTTC
GAGCGCCTCGTCGCGCTTCAGGACACCCGGGAGCATTGGGCCCTGCCGCCGATCCTCGCCCTGGGCGACCCGGGCGGGGG
CAAGACGACGGCGGTGGACGCGTTCTTCCGGCGGTACGGGCTGCACGTCGAGCGCTACGCATGCGACGGGTCGTCAGATT
CGGCGGCGGCAGGGACGCCCAGGAGATGGGCGAGCGGCGAGGTGTCCCTGCCCCTGCGGGCTTCGATGACCGCTGGGTAC
GCGAATCCCGTCATCCTGTGGGATGAGGTCAACCGCGCCGGCGGCCAACGGCAGGGTTCGGGAGGGACGCTTAGGGACGC
CTTGACCAGCTTCCTGGAGCCTCAGAACGCGTGCCGATACCGGGACCCCCTAGTCGAGGCCGAGGTGGACATCAGCCACG
TCCTGCATGTGGCGACCGCGAACAGCCAGGACGGTATCGCCCCCCAAGTATTGGACCGGCTCGTCGTGCTGGAGTTCCCC
CTGCCGACGCGGGAGCACCTGCCGGTCCTCGCCCGGCGCATGGCGCGCGAGATCGCCCGTCGCCAGGGGCTGCCCGACGA
CCACGGCGAGCTCGACAGGGCCGAGCTCCAGGCGCTTGCCGAGAACTGGGCGGGGGGCAGCCTGCGCGGCCTCAAGCGGC
TCGTCGAGGTCGCCATGCGGGTGCGCATGACGGCCCCGTGGGCCACTCGGCACTGA

Upstream 100 bases:

>100_bases
GGGCTGCCCGTTAACTCTTTCGTGGGCCGGCCCTGATAGAACGGGGGCTCCCTAGCGCTGAGAGGCTCATGCCGCTCGCG
CCGACCCGGAAGTACCGACG

Downstream 100 bases:

>100_bases
TGGGGGTGATCATGCACGACACCCCTCAGGCCGCTCTGTCCCGCATCCGCCTGGCGTGGTCCTCGCGCCGGTCATGCGGT
CTCGTCGCCGCCGCCATGGG

Product: ATP-dependent Lon protease-like protein

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MTKRVPVHGAPPTLRELLCGAAPYGGSAHRDLYAHLPHTWPSFLDGDRKSLWEDLGGSWVMVELLEGVWVAAEKVIDSRG
ANGALDTRVFQTQLLVAWSELGRLLDGRPAADIELDRLYNLPSLLDELRDRMTVLLAMLAERTAVDRMPDVLWRYARRAT
PDAGLLQLYAAAFGVSHDECSYTPRHIPGTRLLDVLGHWRETGMQAIADAALLARGQIRDAVTDAVAERQAPARPEPSLH
QLLNSAHAKPEQADPEPEAGPGVVVVPRIGGGTKGQGNKDATSELGDILGRRLPLYEVPSDRHALVEEAAAEAPHARRFF
ERLVALQDTREHWALPPILALGDPGGGKTTAVDAFFRRYGLHVERYACDGSSDSAAAGTPRRWASGEVSLPLRASMTAGY
ANPVILWDEVNRAGGQRQGSGGTLRDALTSFLEPQNACRYRDPLVEAEVDISHVLHVATANSQDGIAPQVLDRLVVLEFP
LPTREHLPVLARRMAREIARRQGLPDDHGELDRAELQALAENWAGGSLRGLKRLVEVAMRVRMTAPWATRH

Sequences:

>Translated_551_residues
MTKRVPVHGAPPTLRELLCGAAPYGGSAHRDLYAHLPHTWPSFLDGDRKSLWEDLGGSWVMVELLEGVWVAAEKVIDSRG
ANGALDTRVFQTQLLVAWSELGRLLDGRPAADIELDRLYNLPSLLDELRDRMTVLLAMLAERTAVDRMPDVLWRYARRAT
PDAGLLQLYAAAFGVSHDECSYTPRHIPGTRLLDVLGHWRETGMQAIADAALLARGQIRDAVTDAVAERQAPARPEPSLH
QLLNSAHAKPEQADPEPEAGPGVVVVPRIGGGTKGQGNKDATSELGDILGRRLPLYEVPSDRHALVEEAAAEAPHARRFF
ERLVALQDTREHWALPPILALGDPGGGKTTAVDAFFRRYGLHVERYACDGSSDSAAAGTPRRWASGEVSLPLRASMTAGY
ANPVILWDEVNRAGGQRQGSGGTLRDALTSFLEPQNACRYRDPLVEAEVDISHVLHVATANSQDGIAPQVLDRLVVLEFP
LPTREHLPVLARRMAREIARRQGLPDDHGELDRAELQALAENWAGGSLRGLKRLVEVAMRVRMTAPWATRH
>Mature_550_residues
TKRVPVHGAPPTLRELLCGAAPYGGSAHRDLYAHLPHTWPSFLDGDRKSLWEDLGGSWVMVELLEGVWVAAEKVIDSRGA
NGALDTRVFQTQLLVAWSELGRLLDGRPAADIELDRLYNLPSLLDELRDRMTVLLAMLAERTAVDRMPDVLWRYARRATP
DAGLLQLYAAAFGVSHDECSYTPRHIPGTRLLDVLGHWRETGMQAIADAALLARGQIRDAVTDAVAERQAPARPEPSLHQ
LLNSAHAKPEQADPEPEAGPGVVVVPRIGGGTKGQGNKDATSELGDILGRRLPLYEVPSDRHALVEEAAAEAPHARRFFE
RLVALQDTREHWALPPILALGDPGGGKTTAVDAFFRRYGLHVERYACDGSSDSAAAGTPRRWASGEVSLPLRASMTAGYA
NPVILWDEVNRAGGQRQGSGGTLRDALTSFLEPQNACRYRDPLVEAEVDISHVLHVATANSQDGIAPQVLDRLVVLEFPL
PTREHLPVLARRMAREIARRQGLPDDHGELDRAELQALAENWAGGSLRGLKRLVEVAMRVRMTAPWATRH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=199, Percent_Identity=30.1507537688442, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI21396489, Length=244, Percent_Identity=25.4098360655738, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1786643, Length=201, Percent_Identity=29.3532338308458, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17556486, Length=197, Percent_Identity=26.9035532994924, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319449, Length=208, Percent_Identity=27.8846153846154, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221513036, Length=204, Percent_Identity=27.4509803921569, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24666867, Length=204, Percent_Identity=27.4509803921569, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 60335; Mature: 60204

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRVPVHGAPPTLRELLCGAAPYGGSAHRDLYAHLPHTWPSFLDGDRKSLWEDLGGSWV
CCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHCCHHHHHHHHCCCCEE
MVELLEGVWVAAEKVIDSRGANGALDTRVFQTQLLVAWSELGRLLDGRPAADIELDRLYN
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHC
LPSLLDELRDRMTVLLAMLAERTAVDRMPDVLWRYARRATPDAGLLQLYAAAFGVSHDEC
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
SYTPRHIPGTRLLDVLGHWRETGMQAIADAALLARGQIRDAVTDAVAERQAPARPEPSLH
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
QLLNSAHAKPEQADPEPEAGPGVVVVPRIGGGTKGQGNKDATSELGDILGRRLPLYEVPS
HHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCC
DRHALVEEAAAEAPHARRFFERLVALQDTREHWALPPILALGDPGGGKTTAVDAFFRRYG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHC
LHVERYACDGSSDSAAAGTPRRWASGEVSLPLRASMTAGYANPVILWDEVNRAGGQRQGS
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEECHHHCCCCCCCC
GGTLRDALTSFLEPQNACRYRDPLVEAEVDISHVLHVATANSQDGIAPQVLDRLVVLEFP
CCHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEECC
LPTREHLPVLARRMAREIARRQGLPDDHGELDRAELQALAENWAGGSLRGLKRLVEVAMR
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VRMTAPWATRH
HHCCCCCCCCC
>Mature Secondary Structure 
TKRVPVHGAPPTLRELLCGAAPYGGSAHRDLYAHLPHTWPSFLDGDRKSLWEDLGGSWV
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHCCHHHHHHHHCCCCEE
MVELLEGVWVAAEKVIDSRGANGALDTRVFQTQLLVAWSELGRLLDGRPAADIELDRLYN
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHC
LPSLLDELRDRMTVLLAMLAERTAVDRMPDVLWRYARRATPDAGLLQLYAAAFGVSHDEC
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
SYTPRHIPGTRLLDVLGHWRETGMQAIADAALLARGQIRDAVTDAVAERQAPARPEPSLH
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
QLLNSAHAKPEQADPEPEAGPGVVVVPRIGGGTKGQGNKDATSELGDILGRRLPLYEVPS
HHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCC
DRHALVEEAAAEAPHARRFFERLVALQDTREHWALPPILALGDPGGGKTTAVDAFFRRYG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHC
LHVERYACDGSSDSAAAGTPRRWASGEVSLPLRASMTAGYANPVILWDEVNRAGGQRQGS
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEECHHHCCCCCCCC
GGTLRDALTSFLEPQNACRYRDPLVEAEVDISHVLHVATANSQDGIAPQVLDRLVVLEFP
CCHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEECC
LPTREHLPVLARRMAREIARRQGLPDDHGELDRAELQALAENWAGGSLRGLKRLVEVAMR
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VRMTAPWATRH
HHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA