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The map label for this gene is nodT [H]

Identifier: 170751619

GI number: 170751619

Start: 5564406

End: 5566019

Strand: Reverse

Name: nodT [H]

Synonym: Mrad2831_5243

Alternate gene names: 170751619

Gene position: 5566019-5564406 (Counterclockwise)

Preceding gene: 170751620

Following gene: 170751618

Centisome position: 91.58

GC content: 69.21

Gene sequence:

>1614_bases
ATGACGCTCTCCCGATACCTCGGCCGACGCGGCCGAGCGATGATCACGGCCGGCCTGCTCGGCCTTGCCGGATGCACGGT
CGGGCCCGACTTCGCCCCGCTTGCGACGCCGCTCGCAGACGCGGGCGACTATCTCGACACCGGCCTCGTCGCGCCGACGC
CACGGCGACTCCTGGCACGCACCATCGACGCCGAACCGGACGTTGCGTGGTGGCTCGCCTTCCGCGATCCCGTGCTGGCG
CAACTTGAGGACCGTCTGGCGGCCCAGAACCTCGACGTTCAGACCACCACCGCGCGGCTGTTCCAGAGCCGGTCCCAGAT
CAATACCGCCGCTGCCGCGGGCCTGCCGACCCTCAACGGGCAAGGCAGCGCCTACCGGCAGCAGTTCAGCAAGAACGGCA
CCATCGGCCTCCTCTCCAACTCGCTCGGCAGCCTGACGGGCGGAAGCAGCGGCGCTTCCAGCGGCAACCTGACGGCGCCG
CTGACCAACGGCTTCGAGAGCTACACGCTGGGCTTCGACGCCTCCTGGGAACTCGACCTCTGGGGCAAGGTCCGGCGCTC
GGTCGAGTCCGCAGAGGCCCAGGCGGACGCCTCCGCGGAAGCGAGGCGCGACGCGCTGATCTCCGGCCAGGCCGAACTCG
CGCGAGCCTACGTGCAGTTGCGGGGCACCCAGGAGCTCATCCGGATCGACCTCGCCAACATCCGGGTCAACGAGCAGATC
CTCGACGTCGTCCGGGTGCGTCAGCAGAAGGGATTGGTCACCGGACTCGATACGTCCAGTGCGGCACAGCAGGTCGAGGC
GATCAAAGCGCAGCTGCCGCAGCTCCAGCAGCAGGAGATCCAGCAAATCAACGCGATCTCTCTGCTGCTCGGCGAACCGC
CGCTGGCGCTCTCGCAGGAACTCGTCGCCGGCCCCTCGATCCCGCCCGTGCCCCCGCGCATACCCATCGGTGTGCCGTCG
AGCCTGGTCATGCGCCGGCCCGACATCCGCAGGGCCGAGGCCAACCTGCATTCGGCCGTGGCCGAGATCGGTGTCGCGGA
AGCGCAGTTCTTCCCAAGCGTTACGCTGACCGGAAGCCCGACCGTGAATTCGGTCGACCCGGGCAAGCTCTTCCGGGGCT
CGTCGCTCCAGTACATGAACATCGGCCCTTCGATCTCCATCCCGCTGTTCGAGGGCGGGCGGCTCAAGTCGAACCTAGTG
CTCCAGCGCGCCCGGCAACAGGAGGCGGCCATTGCCTACCAGAAGGCGGTGCTCCAGGGCTGGCACGACGTCGTCAACGC
CCTCGCCGCTCTACGCGGTGACGAGGCCCGCCGAGCGCGTCTGGCCAGGCAGGTGGCCGATGCGCGCCAAGCCCTCGCCC
TGTCGCGGGCGCGATACGTCCAGGGCGTCGAAATCTTCACGACCGTCCTCCAGGCTTCACAGACGGTGCTCCAAGCCGAG
ACCAGCCTGTCCCAGGCGACGGCCGCTATCTCGACCGACTTCGTCGCGCTGTCGAAGGCGCTCGGCGGCGGCTGGGAGAC
GACCTTCCCGGTCGGACGGACGCCGCCCCTGTCCCTGGCCAAGGTGGGCATCCCGCTCACGGACGTCGTGCACGACGGGG
CCCTCGGCCGATGA

Upstream 100 bases:

>100_bases
GTGTACCAGTACGCGGCGGTCCTGGCGTTCCTCGTCGTACCCCTATGCCTGTTGATCTCGGCCAAGACCGCGCAAGGCGA
AGGCGGCGGGGGACACTGAC

Downstream 100 bases:

>100_bases
GGGACCGGGGAACATCGACGAGCTGGCTGCATGCGCGGGACGGCCCTGCGTCACCCGTGAAGGCAGTCGGCGTCACGCCT
GAGGGGGCGCGACCATACAG

Product: RND efflux system outer membrane lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MTLSRYLGRRGRAMITAGLLGLAGCTVGPDFAPLATPLADAGDYLDTGLVAPTPRRLLARTIDAEPDVAWWLAFRDPVLA
QLEDRLAAQNLDVQTTTARLFQSRSQINTAAAAGLPTLNGQGSAYRQQFSKNGTIGLLSNSLGSLTGGSSGASSGNLTAP
LTNGFESYTLGFDASWELDLWGKVRRSVESAEAQADASAEARRDALISGQAELARAYVQLRGTQELIRIDLANIRVNEQI
LDVVRVRQQKGLVTGLDTSSAAQQVEAIKAQLPQLQQQEIQQINAISLLLGEPPLALSQELVAGPSIPPVPPRIPIGVPS
SLVMRRPDIRRAEANLHSAVAEIGVAEAQFFPSVTLTGSPTVNSVDPGKLFRGSSLQYMNIGPSISIPLFEGGRLKSNLV
LQRARQQEAAIAYQKAVLQGWHDVVNALAALRGDEARRARLARQVADARQALALSRARYVQGVEIFTTVLQASQTVLQAE
TSLSQATAAISTDFVALSKALGGGWETTFPVGRTPPLSLAKVGIPLTDVVHDGALGR

Sequences:

>Translated_537_residues
MTLSRYLGRRGRAMITAGLLGLAGCTVGPDFAPLATPLADAGDYLDTGLVAPTPRRLLARTIDAEPDVAWWLAFRDPVLA
QLEDRLAAQNLDVQTTTARLFQSRSQINTAAAAGLPTLNGQGSAYRQQFSKNGTIGLLSNSLGSLTGGSSGASSGNLTAP
LTNGFESYTLGFDASWELDLWGKVRRSVESAEAQADASAEARRDALISGQAELARAYVQLRGTQELIRIDLANIRVNEQI
LDVVRVRQQKGLVTGLDTSSAAQQVEAIKAQLPQLQQQEIQQINAISLLLGEPPLALSQELVAGPSIPPVPPRIPIGVPS
SLVMRRPDIRRAEANLHSAVAEIGVAEAQFFPSVTLTGSPTVNSVDPGKLFRGSSLQYMNIGPSISIPLFEGGRLKSNLV
LQRARQQEAAIAYQKAVLQGWHDVVNALAALRGDEARRARLARQVADARQALALSRARYVQGVEIFTTVLQASQTVLQAE
TSLSQATAAISTDFVALSKALGGGWETTFPVGRTPPLSLAKVGIPLTDVVHDGALGR
>Mature_536_residues
TLSRYLGRRGRAMITAGLLGLAGCTVGPDFAPLATPLADAGDYLDTGLVAPTPRRLLARTIDAEPDVAWWLAFRDPVLAQ
LEDRLAAQNLDVQTTTARLFQSRSQINTAAAAGLPTLNGQGSAYRQQFSKNGTIGLLSNSLGSLTGGSSGASSGNLTAPL
TNGFESYTLGFDASWELDLWGKVRRSVESAEAQADASAEARRDALISGQAELARAYVQLRGTQELIRIDLANIRVNEQIL
DVVRVRQQKGLVTGLDTSSAAQQVEAIKAQLPQLQQQEIQQINAISLLLGEPPLALSQELVAGPSIPPVPPRIPIGVPSS
LVMRRPDIRRAEANLHSAVAEIGVAEAQFFPSVTLTGSPTVNSVDPGKLFRGSSLQYMNIGPSISIPLFEGGRLKSNLVL
QRARQQEAAIAYQKAVLQGWHDVVNALAALRGDEARRARLARQVADARQALALSRARYVQGVEIFTTVLQASQTVLQAET
SLSQATAAISTDFVALSKALGGGWETTFPVGRTPPLSLAKVGIPLTDVVHDGALGR

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=489, Percent_Identity=27.4028629856851, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI2367348, Length=456, Percent_Identity=25, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 57063; Mature: 56931

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSRYLGRRGRAMITAGLLGLAGCTVGPDFAPLATPLADAGDYLDTGLVAPTPRRLLAR
CCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHCCCCCCCHHHHHHH
TIDAEPDVAWWLAFRDPVLAQLEDRLAAQNLDVQTTTARLFQSRSQINTAAAAGLPTLNG
HCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
QGSAYRQQFSKNGTIGLLSNSLGSLTGGSSGASSGNLTAPLTNGFESYTLGFDASWELDL
CCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCEEECCCCCCCCHH
WGKVRRSVESAEAQADASAEARRDALISGQAELARAYVQLRGTQELIRIDLANIRVNEQI
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCEECHHH
LDVVRVRQQKGLVTGLDTSSAAQQVEAIKAQLPQLQQQEIQQINAISLLLGEPPLALSQE
HHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEECCCCHHHHHH
LVAGPSIPPVPPRIPIGVPSSLVMRRPDIRRAEANLHSAVAEIGVAEAQFFPSVTLTGSP
HHCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCC
TVNSVDPGKLFRGSSLQYMNIGPSISIPLFEGGRLKSNLVLQRARQQEAAIAYQKAVLQG
CCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
WHDVVNALAALRGDEARRARLARQVADARQALALSRARYVQGVEIFTTVLQASQTVLQAE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSLSQATAAISTDFVALSKALGGGWETTFPVGRTPPLSLAKVGIPLTDVVHDGALGR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCHHHHHCCCCCCC
>Mature Secondary Structure 
TLSRYLGRRGRAMITAGLLGLAGCTVGPDFAPLATPLADAGDYLDTGLVAPTPRRLLAR
CHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHCCCCCCCHHHHHHH
TIDAEPDVAWWLAFRDPVLAQLEDRLAAQNLDVQTTTARLFQSRSQINTAAAAGLPTLNG
HCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
QGSAYRQQFSKNGTIGLLSNSLGSLTGGSSGASSGNLTAPLTNGFESYTLGFDASWELDL
CCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCEEECCCCCCCCHH
WGKVRRSVESAEAQADASAEARRDALISGQAELARAYVQLRGTQELIRIDLANIRVNEQI
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCEECHHH
LDVVRVRQQKGLVTGLDTSSAAQQVEAIKAQLPQLQQQEIQQINAISLLLGEPPLALSQE
HHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEECCCCHHHHHH
LVAGPSIPPVPPRIPIGVPSSLVMRRPDIRRAEANLHSAVAEIGVAEAQFFPSVTLTGSP
HHCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCC
TVNSVDPGKLFRGSSLQYMNIGPSISIPLFEGGRLKSNLVLQRARQQEAAIAYQKAVLQG
CCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
WHDVVNALAALRGDEARRARLARQVADARQALALSRARYVQGVEIFTTVLQASQTVLQAE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSLSQATAAISTDFVALSKALGGGWETTFPVGRTPPLSLAKVGIPLTDVVHDGALGR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2303029; 2338917 [H]