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The map label for this gene is phoP [H]

Identifier: 170751369

GI number: 170751369

Start: 5307990

End: 5308667

Strand: Direct

Name: phoP [H]

Synonym: Mrad2831_4988

Alternate gene names: 170751369

Gene position: 5307990-5308667 (Clockwise)

Preceding gene: 170751368

Following gene: 170751370

Centisome position: 87.33

GC content: 69.03

Gene sequence:

>678_bases
GTGCGTCTGCTGGTCGTGGAGGATGACAAGGACATCAACCGGCAGGTCGTGGCCGCGCTGGAGGAGGCCGGCTACGTCGC
CGACAAGGCCTATGACGGCGAGGAGGGCGGCTATCTCGGCGAGAGCGAGCCCTACGACGCCATCATCCTCGACATGGGCC
TGCCCAAGGCCGACGGCGTCACGGTGCTGCAGAAGTGGCGCCGGGCCGGCGTGAAGACCCCGGTGATCATCCTCACGGCC
CGCGACCGCTGGTCCGACAAGGTCGACGGCTTCGACGCCGGCGCCGACGACTACGTCACCAAGCCCTTCCACATGGAGGA
GCTGATGGCCCGGGTGCGCGCCCTGCTGCGCCGCGCCGCCGGCCACGCCACCAGCCAGATCGCCTGCGGGCCGGTGACCC
TCGACACGCGCTCCGGCAAGGTCTTCGTCGACGGCGCCCAGGTGAAGCTGACGAGCCACGAGTACCGGCTGCTCTCCTAC
CTGATGCACCATACCGGCCGGGTCGTGTCCCGCGCCGAACTCACCGAGCACCTCTACGACCAGGATTTCGACCGCGACTC
GAACACGATCGAGGTGTTCGTCGGCCGCCTGCGCAAGAAGCTCGCGGTGGACCTGATCCAGACCGTGCGCGGCCTCGGCT
ACCTCGTGGATCCCAACCAGCCGCCGGCGCGGATGTGA

Upstream 100 bases:

>100_bases
GGGACGGGCATTTCGTGCACGTGATTGTCGACGCGCGCACCGGCACCGTGGCGGGACAGTATTGAGCGGGCGCCGGAACC
GTTTCGGAAGGGAGTGAGCC

Downstream 100 bases:

>100_bases
GCGCGGCTCCGCGTTCCGGCACGCTGCCGGCCGTGTTCATGCGCGGCGGCACCAGCAAGGCGCTGATGCTGCACCGCCGG
GACGTGCCGGGGGATCTCGC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MRLLVVEDDKDINRQVVAALEEAGYVADKAYDGEEGGYLGESEPYDAIILDMGLPKADGVTVLQKWRRAGVKTPVIILTA
RDRWSDKVDGFDAGADDYVTKPFHMEELMARVRALLRRAAGHATSQIACGPVTLDTRSGKVFVDGAQVKLTSHEYRLLSY
LMHHTGRVVSRAELTEHLYDQDFDRDSNTIEVFVGRLRKKLAVDLIQTVRGLGYLVDPNQPPARM

Sequences:

>Translated_225_residues
MRLLVVEDDKDINRQVVAALEEAGYVADKAYDGEEGGYLGESEPYDAIILDMGLPKADGVTVLQKWRRAGVKTPVIILTA
RDRWSDKVDGFDAGADDYVTKPFHMEELMARVRALLRRAAGHATSQIACGPVTLDTRSGKVFVDGAQVKLTSHEYRLLSY
LMHHTGRVVSRAELTEHLYDQDFDRDSNTIEVFVGRLRKKLAVDLIQTVRGLGYLVDPNQPPARM
>Mature_225_residues
MRLLVVEDDKDINRQVVAALEEAGYVADKAYDGEEGGYLGESEPYDAIILDMGLPKADGVTVLQKWRRAGVKTPVIILTA
RDRWSDKVDGFDAGADDYVTKPFHMEELMARVRALLRRAAGHATSQIACGPVTLDTRSGKVFVDGAQVKLTSHEYRLLSY
LMHHTGRVVSRAELTEHLYDQDFDRDSNTIEVFVGRLRKKLAVDLIQTVRGLGYLVDPNQPPARM

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=42.7927927927928, Blast_Score=183, Evalue=7e-48,
Organism=Escherichia coli, GI1789402, Length=214, Percent_Identity=42.5233644859813, Blast_Score=171, Evalue=4e-44,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=41.8918918918919, Blast_Score=167, Evalue=7e-43,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=40, Blast_Score=163, Evalue=9e-42,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=41.5525114155251, Blast_Score=158, Evalue=2e-40,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=36.1990950226244, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=32.6086956521739, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=34.2465753424658, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=33.1818181818182, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=32.4561403508772, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1790860, Length=217, Percent_Identity=33.1797235023041, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=30.5309734513274, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=30.3571428571429, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=24.7863247863248, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=31.7757009345794, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25130; Mature: 25130

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLVVEDDKDINRQVVAALEEAGYVADKAYDGEEGGYLGESEPYDAIILDMGLPKADGV
CEEEEECCCCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCH
TVLQKWRRAGVKTPVIILTARDRWSDKVDGFDAGADDYVTKPFHMEELMARVRALLRRAA
HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GHATSQIACGPVTLDTRSGKVFVDGAQVKLTSHEYRLLSYLMHHTGRVVSRAELTEHLYD
CCCCCCEECCCEEEECCCCEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFVGRLRKKLAVDLIQTVRGLGYLVDPNQPPARM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCC
>Mature Secondary Structure
MRLLVVEDDKDINRQVVAALEEAGYVADKAYDGEEGGYLGESEPYDAIILDMGLPKADGV
CEEEEECCCCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCH
TVLQKWRRAGVKTPVIILTARDRWSDKVDGFDAGADDYVTKPFHMEELMARVRALLRRAA
HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GHATSQIACGPVTLDTRSGKVFVDGAQVKLTSHEYRLLSYLMHHTGRVVSRAELTEHLYD
CCCCCCEECCCEEEECCCCEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFVGRLRKKLAVDLIQTVRGLGYLVDPNQPPARM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA