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The map label for this gene is hsaA [H]

Identifier: 170751164

GI number: 170751164

Start: 5096909

End: 5098120

Strand: Direct

Name: hsaA [H]

Synonym: Mrad2831_4780

Alternate gene names: 170751164

Gene position: 5096909-5098120 (Clockwise)

Preceding gene: 170751163

Following gene: 170751167

Centisome position: 83.86

GC content: 69.72

Gene sequence:

>1212_bases
ATGAACGTCGTAGCATCCTCGCCTGCCCCTGCCGCGAGGGCCGGAGATCCGGACGCGGCGCTGCTCGCGACTGTCGAGAC
ACTTCGGCCTCTGATCGCGGAGCACCGGTCGGCCTTGGCTGTCGGACCGGACCTGCCGGAGCCGGTCGCGGAGGCGCTCA
TCGACGCCGGTCTCACACAACTCTGGCTCCCCCGGGGCCTGGGCGGTCCTGAGACCCATCCGCTGCGCGTTCTCGCCGCC
ATCGAGGCCTTGGCGGAACTCGACGGTTCGGTTGCCTGGTGCGCCGCGATCTCGTCCGGGGGCGCGTCACGCTTCGCCGA
CCTCATCGATCGGGACGCGATGCGCGCGCTCATGCCCGCCGGCAAGAAGTTCGCGGGCAGCGGCAGCGGCCAGCCGACGG
GAACGGCGGTTCGCGACGGGGCCGGCTGGCGGATCAACGGACGCTGGTCCTGGGCGAGCTTCTGCCGCTTCAGCTCGGTC
TCGGCACTGATGTGTCTCGAGATCGAAGGGGGACAACCGAAACTCGACGCGCACGGGCGGCCGTCTGTGCGGGGCGTCTT
CATGGCCTCGAGGGACGTCGAGGTCGTCGGCAACTGGAACGCCGGTGGGCTGCGGTCCAGCGGGAGTCACGACGTCGTCT
GCACCGACATCTGGGTGCCGGACGCGCGGACAGTCGACGGCGCGCGCATCATGATGCCGCACGATAGGGAGCCGCTCTAC
ATGCTGCCGATGGCATCGGCGGCCGCGATTGCCGCCGCCGGCGTTCCGCTGGGACTCGCTCGGGCCTCGATCGACGCGTT
GATCGATCTCGCGCAGACGAAGACGCCGCATGGCGGCAAGGTGCCCTTGCGACTTCGCGAGGACGTTCAGGTCGCGGTCG
CGCGCGCGGAGACGAGTCTCGGCGCCGCCCGCGCCTTCGCCCGCGATACGGTCTCCGGTCTCTGGTCTGAAGCCGAGAAC
GGCCGCCCGGTCACCCCCGCGTGGCAGGCCAAGATTCGGCAGGCCTGCTGGTACGCAGGCCACGTCGGGAAGCAGGTGGT
CACGAGCATGTACGAAGCGGCGGGCAGTTCCGCCGTTCTCGAGGCGCTGCCGTTCGCGCGCCAGTTGCGCGATGTGTACG
CGACCTGCCAGCACATGCAGTATCAGGACCGCATGCTCGTGCCGCCTGGCCGTATCCTCCTGAGCCTCGAGGCCGACGCA
CCTTTCATCTAG

Upstream 100 bases:

>100_bases
AATTCCAGGTTACAACCGTAACCGAATGATCTTCCGAATGACACGAAATAGATCGATTGCCGAATCTAATATGCATCTCG
GACGGATGAGAGGTCTGAGA

Downstream 100 bases:

>100_bases
ATAGAAGCGACAGATCCTTTCTGAATAGTGGGAAGACGCGCGGCTTTCGGCGGCGCCGGGAGCGCGCGGTCCCCTTTTCC
CGTCGCGGCATCCGCGCCGG

Product: acyl-CoA dehydrogenase type 2

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MNVVASSPAPAARAGDPDAALLATVETLRPLIAEHRSALAVGPDLPEPVAEALIDAGLTQLWLPRGLGGPETHPLRVLAA
IEALAELDGSVAWCAAISSGGASRFADLIDRDAMRALMPAGKKFAGSGSGQPTGTAVRDGAGWRINGRWSWASFCRFSSV
SALMCLEIEGGQPKLDAHGRPSVRGVFMASRDVEVVGNWNAGGLRSSGSHDVVCTDIWVPDARTVDGARIMMPHDREPLY
MLPMASAAAIAAAGVPLGLARASIDALIDLAQTKTPHGGKVPLRLREDVQVAVARAETSLGAARAFARDTVSGLWSEAEN
GRPVTPAWQAKIRQACWYAGHVGKQVVTSMYEAAGSSAVLEALPFARQLRDVYATCQHMQYQDRMLVPPGRILLSLEADA
PFI

Sequences:

>Translated_403_residues
MNVVASSPAPAARAGDPDAALLATVETLRPLIAEHRSALAVGPDLPEPVAEALIDAGLTQLWLPRGLGGPETHPLRVLAA
IEALAELDGSVAWCAAISSGGASRFADLIDRDAMRALMPAGKKFAGSGSGQPTGTAVRDGAGWRINGRWSWASFCRFSSV
SALMCLEIEGGQPKLDAHGRPSVRGVFMASRDVEVVGNWNAGGLRSSGSHDVVCTDIWVPDARTVDGARIMMPHDREPLY
MLPMASAAAIAAAGVPLGLARASIDALIDLAQTKTPHGGKVPLRLREDVQVAVARAETSLGAARAFARDTVSGLWSEAEN
GRPVTPAWQAKIRQACWYAGHVGKQVVTSMYEAAGSSAVLEALPFARQLRDVYATCQHMQYQDRMLVPPGRILLSLEADA
PFI
>Mature_403_residues
MNVVASSPAPAARAGDPDAALLATVETLRPLIAEHRSALAVGPDLPEPVAEALIDAGLTQLWLPRGLGGPETHPLRVLAA
IEALAELDGSVAWCAAISSGGASRFADLIDRDAMRALMPAGKKFAGSGSGQPTGTAVRDGAGWRINGRWSWASFCRFSSV
SALMCLEIEGGQPKLDAHGRPSVRGVFMASRDVEVVGNWNAGGLRSSGSHDVVCTDIWVPDARTVDGARIMMPHDREPLY
MLPMASAAAIAAAGVPLGLARASIDALIDLAQTKTPHGGKVPLRLREDVQVAVARAETSLGAARAFARDTVSGLWSEAEN
GRPVTPAWQAKIRQACWYAGHVGKQVVTSMYEAAGSSAVLEALPFARQLRDVYATCQHMQYQDRMLVPPGRILLSLEADA
PFI

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol. Also catalyzes the o-hydroxylation of a range of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 42503; Mature: 42503

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVVASSPAPAARAGDPDAALLATVETLRPLIAEHRSALAVGPDLPEPVAEALIDAGLTQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCHHH
LWLPRGLGGPETHPLRVLAAIEALAELDGSVAWCAAISSGGASRFADLIDRDAMRALMPA
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHCC
GKKFAGSGSGQPTGTAVRDGAGWRINGRWSWASFCRFSSVSALMCLEIEGGQPKLDAHGR
CCCCCCCCCCCCCCCEEECCCCEEECCEECHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
PSVRGVFMASRDVEVVGNWNAGGLRSSGSHDVVCTDIWVPDARTVDGARIMMPHDREPLY
CCEEEEEEECCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEECCCCCCCEE
MLPMASAAAIAAAGVPLGLARASIDALIDLAQTKTPHGGKVPLRLREDVQVAVARAETSL
EECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHH
GAARAFARDTVSGLWSEAENGRPVTPAWQAKIRQACWYAGHVGKQVVTSMYEAAGSSAVL
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
EALPFARQLRDVYATCQHMQYQDRMLVPPGRILLSLEADAPFI
HHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEEECCCCCCC
>Mature Secondary Structure
MNVVASSPAPAARAGDPDAALLATVETLRPLIAEHRSALAVGPDLPEPVAEALIDAGLTQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCHHH
LWLPRGLGGPETHPLRVLAAIEALAELDGSVAWCAAISSGGASRFADLIDRDAMRALMPA
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHCC
GKKFAGSGSGQPTGTAVRDGAGWRINGRWSWASFCRFSSVSALMCLEIEGGQPKLDAHGR
CCCCCCCCCCCCCCCEEECCCCEEECCEECHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
PSVRGVFMASRDVEVVGNWNAGGLRSSGSHDVVCTDIWVPDARTVDGARIMMPHDREPLY
CCEEEEEEECCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEECCCCCCCEE
MLPMASAAAIAAAGVPLGLARASIDALIDLAQTKTPHGGKVPLRLREDVQVAVARAETSL
EECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHH
GAARAFARDTVSGLWSEAENGRPVTPAWQAKIRQACWYAGHVGKQVVTSMYEAAGSSAVL
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
EALPFARQLRDVYATCQHMQYQDRMLVPPGRILLSLEADAPFI
HHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]