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The map label for this gene is hemF [H]

Identifier: 170751060

GI number: 170751060

Start: 4969962

End: 4970894

Strand: Direct

Name: hemF [H]

Synonym: Mrad2831_4671

Alternate gene names: 170751060

Gene position: 4969962-4970894 (Clockwise)

Preceding gene: 170751059

Following gene: 170751061

Centisome position: 81.77

GC content: 71.7

Gene sequence:

>933_bases
ATGACGATGCCGGACGACGCGCGCGCAGCCCTGGCTGCGCCTCCCTCCGAGGCCGACGTGACGGCCATGAAGTCCGAGGC
CGCGGCGTGGTTCGAGACGCTGCGCGACCGGATCGTCGCCGCCTTGGAGACCCTCGAGGCGGAGGCGGCGGGTCCGTTCC
ACCCCGACGCGCCCGAGGCCCCGGGGACGTTCGAGAAGACGCCGTGGAACCGGACCGACCATACCGGGCGGCCGGGCGGC
GGCGGCGTCATGGCGATGCTGCGGGGCCGCGTCTTCGAGAAGGCCGGCGTGCACATCTCGACGGTGCACGGCGAGTTCGC
GCCGGAATTCCGCGCCCAGATGCCCGGCGCCGCCGAGGATCCGCGCTTCTTCGCCACCGGCATCTCGCTGATCGCCCATC
CGTGGAACCCGCACGTGCCGACGGTGCACATGAACACCCGGTTCGTCGCCACGACGCGGGCGTGGTTCGGGGGCGGGGCC
GATCTGACGCCGGTGCTCGACCGGCGCCGCACGCAGGAGGATCCCGACAGCCGCCACTTCCACGCCTGCCTGGAGCGGGC
CTGCGCGGCGCACGGCATCGATCACGCCCGCTACAAGGCGTGGTGCGACGAGTACTTCCACCTCAAGCACCGGAACGAGC
CGCGCGGCATCGGCGGGATCTTCTACGATTACCTCTGGAGCGGGACGCCGCAGGCCGACCTCGCCTACACCCGCGACGTG
GGCCGGGCCTTCCTGGAGGCCTACCCGAAGATCGTGCGCGACAATCTCGGCACGCCCTGGACCGAGGCGGACCGCCACGA
GCAGCAGGTGCGGCGGGGCCGCTACGTGGAGTTCAACCTGCTCTACGACCGGGGCACGATCTTCGGCCTGAAGACGGGCG
GCAACGTCGCCTCCATCCTCTCCTCGATGCCGCCGACTGTGCGCTGGCCGTGA

Upstream 100 bases:

>100_bases
AGCGGTCGGCGCCCGCGTAGGCCGGCGCGGGAGCCCCGCGCGGTCACGCGGGGTCGCGACCGCATTGACGTGCGCCCGGC
AGGGTGGAAAAGCCTGTGCC

Downstream 100 bases:

>100_bases
GTGCGGGTCTGCCGGCCGCCTACGCGCCGCAGCAGGACGCGGCGCTGAAGGCGATCGCCGCGTGGCGGCGGGACGGGGGA
TCGCAGGTGTTCCGGCTGTT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTMPDDARAALAAPPSEADVTAMKSEAAAWFETLRDRIVAALETLEAEAAGPFHPDAPEAPGTFEKTPWNRTDHTGRPGG
GGVMAMLRGRVFEKAGVHISTVHGEFAPEFRAQMPGAAEDPRFFATGISLIAHPWNPHVPTVHMNTRFVATTRAWFGGGA
DLTPVLDRRRTQEDPDSRHFHACLERACAAHGIDHARYKAWCDEYFHLKHRNEPRGIGGIFYDYLWSGTPQADLAYTRDV
GRAFLEAYPKIVRDNLGTPWTEADRHEQQVRRGRYVEFNLLYDRGTIFGLKTGGNVASILSSMPPTVRWP

Sequences:

>Translated_310_residues
MTMPDDARAALAAPPSEADVTAMKSEAAAWFETLRDRIVAALETLEAEAAGPFHPDAPEAPGTFEKTPWNRTDHTGRPGG
GGVMAMLRGRVFEKAGVHISTVHGEFAPEFRAQMPGAAEDPRFFATGISLIAHPWNPHVPTVHMNTRFVATTRAWFGGGA
DLTPVLDRRRTQEDPDSRHFHACLERACAAHGIDHARYKAWCDEYFHLKHRNEPRGIGGIFYDYLWSGTPQADLAYTRDV
GRAFLEAYPKIVRDNLGTPWTEADRHEQQVRRGRYVEFNLLYDRGTIFGLKTGGNVASILSSMPPTVRWP
>Mature_309_residues
TMPDDARAALAAPPSEADVTAMKSEAAAWFETLRDRIVAALETLEAEAAGPFHPDAPEAPGTFEKTPWNRTDHTGRPGGG
GVMAMLRGRVFEKAGVHISTVHGEFAPEFRAQMPGAAEDPRFFATGISLIAHPWNPHVPTVHMNTRFVATTRAWFGGGAD
LTPVLDRRRTQEDPDSRHFHACLERACAAHGIDHARYKAWCDEYFHLKHRNEPRGIGGIFYDYLWSGTPQADLAYTRDVG
RAFLEAYPKIVRDNLGTPWTEADRHEQQVRRGRYVEFNLLYDRGTIFGLKTGGNVASILSSMPPTVRWP

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=263, Percent_Identity=43.7262357414449, Blast_Score=199, Evalue=4e-51,
Organism=Escherichia coli, GI1788777, Length=260, Percent_Identity=46.5384615384615, Blast_Score=200, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6320249, Length=302, Percent_Identity=39.0728476821192, Blast_Score=190, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17864388, Length=294, Percent_Identity=41.156462585034, Blast_Score=204, Evalue=6e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34504; Mature: 34373

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMPDDARAALAAPPSEADVTAMKSEAAAWFETLRDRIVAALETLEAEAAGPFHPDAPEA
CCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PGTFEKTPWNRTDHTGRPGGGGVMAMLRGRVFEKAGVHISTVHGEFAPEFRAQMPGAAED
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHCCCCCCC
PRFFATGISLIAHPWNPHVPTVHMNTRFVATTRAWFGGGADLTPVLDRRRTQEDPDSRHF
CHHHHHHHHHHCCCCCCCCCEEECCCEEEEEEHHHHCCCCCCCHHHHHHCCCCCCCHHHH
HACLERACAAHGIDHARYKAWCDEYFHLKHRNEPRGIGGIFYDYLWSGTPQADLAYTRDV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
GRAFLEAYPKIVRDNLGTPWTEADRHEQQVRRGRYVEFNLLYDRGTIFGLKTGGNVASIL
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCEEEEECCCCHHHHHH
SSMPPTVRWP
HHCCCCCCCC
>Mature Secondary Structure 
TMPDDARAALAAPPSEADVTAMKSEAAAWFETLRDRIVAALETLEAEAAGPFHPDAPEA
CCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PGTFEKTPWNRTDHTGRPGGGGVMAMLRGRVFEKAGVHISTVHGEFAPEFRAQMPGAAED
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHCCCCCCC
PRFFATGISLIAHPWNPHVPTVHMNTRFVATTRAWFGGGADLTPVLDRRRTQEDPDSRHF
CHHHHHHHHHHCCCCCCCCCEEECCCEEEEEEHHHHCCCCCCCHHHHHHCCCCCCCHHHH
HACLERACAAHGIDHARYKAWCDEYFHLKHRNEPRGIGGIFYDYLWSGTPQADLAYTRDV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
GRAFLEAYPKIVRDNLGTPWTEADRHEQQVRRGRYVEFNLLYDRGTIFGLKTGGNVASIL
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCEEEEECCCCHHHHHH
SSMPPTVRWP
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]