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The map label for this gene is evgS [C]

Identifier: 170751052

GI number: 170751052

Start: 4963295

End: 4965187

Strand: Reverse

Name: evgS [C]

Synonym: Mrad2831_4663

Alternate gene names: 170751052

Gene position: 4965187-4963295 (Counterclockwise)

Preceding gene: 170751054

Following gene: 170751051

Centisome position: 81.69

GC content: 75.28

Gene sequence:

>1893_bases
GTGCCAACCTTGACCATCAAGACTGTCCTGACGTCTCTGATCGACGACCGGCTCGCGGGTCTCGTCCACGAATCCGTGGC
CGACAATCCGGCCGCCCGTGCGCGCCACCAGCGCTTCCTGGTGTCGCGGCTGGCGACCGGCGCCGTGATGATGGCCGGGC
TGCCGCCCTACCTGCTCTGGCGGGGGGTGCCGTCGGGCTTCGAGGTCCTGGCGATCGCGAGCCTGCTGCTGCCGGTCCTC
GCCGCCGTCCTCCTCACCCGCACCGGCTCCCTCTGGGTCGCCCACGCGGTCTCGTCGGCGGGCCTGACCGGCCTCGTCGT
CGCCCTGGCGGGCGTCACCGGCGGCGTCACCTCGCCCGCCGCGGTCTGGCTCGTGGCGATCCCCCTGGAGGCGCTGGTCT
CCGGCTCGCTCCGCGCGACGATCGCGGCCGCCGCGATGGCGGTCCTCGGCGTGCTGGCCGTGGTGGCCCTCGGGGCCTGG
GCCGGCTCCCTGCCGGTCATGGACATCTCGGCCGCGATCGCCCTGCCGGCCTTCGCGATCACGGCGATCGGCCACGTCGC
CGCCCAGGCCCTGGAGCACATGCGCAACGAGGGCGTCTGGCGCGAGCGGCTGCGCGACAACGAGGCCCGCGACCGGCTGC
TGCTCTCGGCGATCGACGACCTCGTGACCTGGCACGACCGCAACGGCCGCGTCCTGGAGGCCTCGGTCTCGGCCGTGCGG
CTCCTCGGCAGCGACCCGGCCCGGCTGCGCGGCCACGGCCTGCTGGAGCGCGTCCACGTCGCCGACCGTCCGGCCTTCCT
CAAGGCGGTGAGCGACGTCGCCGCGACCGGGCGCCCCGCGACGCTGCCCCTGCGCCTGCACGTCGAGCCCGAGACCGGCC
GCGCCGACGGCGCGAGCCTGATCTACGCCGAGATGCGCGCCCACCGGATCGAGCACGGCCCGCACGACGCCGCCATGGCG
GTCGTGGCGGTCACCCGCGACATGACCGAGCACCACCGGCACGCCGCGGAACTGGAGCGCGCCCGCGCCGAGGCCGAGCG
GGCCGACGCGATCAAGGGCCGGTTCCTGGCCAACGTCACCCACGAGTTGCGCACGCCGCTCAACGCGATCATCGGCTTCT
CCGAGGTCCTGGCGGGCGAAGGCGCCGTCAGCCTCGGGCCGGTCCAGGCGCGGGAATATGCCGGCATCATCGGCGCCTCC
GGCCACCACCTGCTCGGCGTTGTCAACACGCTGCTCGACATGAGCCGGATCCAGAGCGGCAACTTCGACTGCGCGCCCGA
GACCTTCGACGTCGCGGACCTGCTCCGGGGCTGCTGCGACCTGATGCGGCTGAAGGCCGACGCCGCCGGCGTCGCCCTCA
CCGCCGCCCCGTCGGGACCGGTGGAGATCACGGCCGATCCCGCCGCCTGCCGGCAGGTCCTGATCAACCTCATCTCGAAC
GCCGTGAAGTTCACCCCGTCGGGCGGCCGCATCGACCTCTCCCTGCGGCGCGGCGCGGGCAGCCTGGACATCGTCGTGGC
CGATACCGGCGTCGGCATCGGCGCGGACGACCTGCCCAAGCTCGGCACCCCGTTCTTCCAGGCCGGGAGCGGCGGCTACA
AGCGGCAGCACGAGGGCACCGGCCTCGGCCTGTCGGTGGTCCAGGGCCTCGTCGGCCTCCACGGCGGCTCCCTGCTGATC
GAGAGCGCCCCGCAGGCCGGGACCGTGGTGACCGTCACCCTGCCCCTCGTCTGCCAGGCCCCCGCGACCGCGCACGGCCC
GGCCCCGATCCGCACGGCCGTGCGGGGCGCCCCGGCGCCGCGCCGCGTGGTGCGCCTGCCGCTCGGCCTGTTCGACGCGG
AGCCGGGCCCCGCCGCGGCCCCGGCCGAGCCGGTCCTGCGCCGCACCGGCTGA

Upstream 100 bases:

>100_bases
GTCCCGCAACACTCGTTTAAGCCGGCTCTGCGACCGTCCGGTAGTCGTTCGAAGTCGAACCGGAGGCGCGACGGATGCGG
GAACGCAGCCAGCGCGACGC

Downstream 100 bases:

>100_bases
CCCGAAGATCCCCGGAAGGAGACATGATGTCAGGCTACCGCGAGATCACCGTACCGGGCGAACCCGGCCGCGCCCGCCGG
TCCGCGCCGCGCCGCGCCGC

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 630; Mature: 629

Protein sequence:

>630_residues
MPTLTIKTVLTSLIDDRLAGLVHESVADNPAARARHQRFLVSRLATGAVMMAGLPPYLLWRGVPSGFEVLAIASLLLPVL
AAVLLTRTGSLWVAHAVSSAGLTGLVVALAGVTGGVTSPAAVWLVAIPLEALVSGSLRATIAAAAMAVLGVLAVVALGAW
AGSLPVMDISAAIALPAFAITAIGHVAAQALEHMRNEGVWRERLRDNEARDRLLLSAIDDLVTWHDRNGRVLEASVSAVR
LLGSDPARLRGHGLLERVHVADRPAFLKAVSDVAATGRPATLPLRLHVEPETGRADGASLIYAEMRAHRIEHGPHDAAMA
VVAVTRDMTEHHRHAAELERARAEAERADAIKGRFLANVTHELRTPLNAIIGFSEVLAGEGAVSLGPVQAREYAGIIGAS
GHHLLGVVNTLLDMSRIQSGNFDCAPETFDVADLLRGCCDLMRLKADAAGVALTAAPSGPVEITADPAACRQVLINLISN
AVKFTPSGGRIDLSLRRGAGSLDIVVADTGVGIGADDLPKLGTPFFQAGSGGYKRQHEGTGLGLSVVQGLVGLHGGSLLI
ESAPQAGTVVTVTLPLVCQAPATAHGPAPIRTAVRGAPAPRRVVRLPLGLFDAEPGPAAAPAEPVLRRTG

Sequences:

>Translated_630_residues
MPTLTIKTVLTSLIDDRLAGLVHESVADNPAARARHQRFLVSRLATGAVMMAGLPPYLLWRGVPSGFEVLAIASLLLPVL
AAVLLTRTGSLWVAHAVSSAGLTGLVVALAGVTGGVTSPAAVWLVAIPLEALVSGSLRATIAAAAMAVLGVLAVVALGAW
AGSLPVMDISAAIALPAFAITAIGHVAAQALEHMRNEGVWRERLRDNEARDRLLLSAIDDLVTWHDRNGRVLEASVSAVR
LLGSDPARLRGHGLLERVHVADRPAFLKAVSDVAATGRPATLPLRLHVEPETGRADGASLIYAEMRAHRIEHGPHDAAMA
VVAVTRDMTEHHRHAAELERARAEAERADAIKGRFLANVTHELRTPLNAIIGFSEVLAGEGAVSLGPVQAREYAGIIGAS
GHHLLGVVNTLLDMSRIQSGNFDCAPETFDVADLLRGCCDLMRLKADAAGVALTAAPSGPVEITADPAACRQVLINLISN
AVKFTPSGGRIDLSLRRGAGSLDIVVADTGVGIGADDLPKLGTPFFQAGSGGYKRQHEGTGLGLSVVQGLVGLHGGSLLI
ESAPQAGTVVTVTLPLVCQAPATAHGPAPIRTAVRGAPAPRRVVRLPLGLFDAEPGPAAAPAEPVLRRTG
>Mature_629_residues
PTLTIKTVLTSLIDDRLAGLVHESVADNPAARARHQRFLVSRLATGAVMMAGLPPYLLWRGVPSGFEVLAIASLLLPVLA
AVLLTRTGSLWVAHAVSSAGLTGLVVALAGVTGGVTSPAAVWLVAIPLEALVSGSLRATIAAAAMAVLGVLAVVALGAWA
GSLPVMDISAAIALPAFAITAIGHVAAQALEHMRNEGVWRERLRDNEARDRLLLSAIDDLVTWHDRNGRVLEASVSAVRL
LGSDPARLRGHGLLERVHVADRPAFLKAVSDVAATGRPATLPLRLHVEPETGRADGASLIYAEMRAHRIEHGPHDAAMAV
VAVTRDMTEHHRHAAELERARAEAERADAIKGRFLANVTHELRTPLNAIIGFSEVLAGEGAVSLGPVQAREYAGIIGASG
HHLLGVVNTLLDMSRIQSGNFDCAPETFDVADLLRGCCDLMRLKADAAGVALTAAPSGPVEITADPAACRQVLINLISNA
VKFTPSGGRIDLSLRRGAGSLDIVVADTGVGIGADDLPKLGTPFFQAGSGGYKRQHEGTGLGLSVVQGLVGLHGGSLLIE
SAPQAGTVVTVTLPLVCQAPATAHGPAPIRTAVRGAPAPRRVVRLPLGLFDAEPGPAAAPAEPVLRRTG

Specific function: Member Of The Two-Component Regulatory System Evgs/Evga. Phosphorylates Evga Via A Four-Step Phosphorelay In Response To Environmental Signals. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=270, Percent_Identity=33.7037037037037, Blast_Score=149, Evalue=8e-37,
Organism=Escherichia coli, GI145693157, Length=267, Percent_Identity=32.9588014981273, Blast_Score=137, Evalue=3e-33,
Organism=Escherichia coli, GI1789149, Length=285, Percent_Identity=31.2280701754386, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI87081816, Length=296, Percent_Identity=35.472972972973, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI48994928, Length=263, Percent_Identity=30.7984790874525, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI1790436, Length=226, Percent_Identity=32.7433628318584, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1786600, Length=260, Percent_Identity=29.6153846153846, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1786912, Length=242, Percent_Identity=32.2314049586777, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788549, Length=382, Percent_Identity=25.6544502617801, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1790346, Length=242, Percent_Identity=28.099173553719, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1788393, Length=242, Percent_Identity=26.0330578512397, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786783, Length=227, Percent_Identity=27.7533039647577, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790861, Length=246, Percent_Identity=27.6422764227642, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082128, Length=235, Percent_Identity=28.936170212766, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1788279, Length=250, Percent_Identity=25.6, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790551, Length=217, Percent_Identity=26.7281105990783, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1789403, Length=223, Percent_Identity=28.6995515695067, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000700
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 65336; Mature: 65205

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLTIKTVLTSLIDDRLAGLVHESVADNPAARARHQRFLVSRLATGAVMMAGLPPYLLW
CCCEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RGVPSGFEVLAIASLLLPVLAAVLLTRTGSLWVAHAVSSAGLTGLVVALAGVTGGVTSPA
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCHH
AVWLVAIPLEALVSGSLRATIAAAAMAVLGVLAVVALGAWAGSLPVMDISAAIALPAFAI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
TAIGHVAAQALEHMRNEGVWRERLRDNEARDRLLLSAIDDLVTWHDRNGRVLEASVSAVR
HHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCEEEHHHHHHH
LLGSDPARLRGHGLLERVHVADRPAFLKAVSDVAATGRPATLPLRLHVEPETGRADGASL
HHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHH
IYAEMRAHRIEHGPHDAAMAVVAVTRDMTEHHRHAAELERARAEAERADAIKGRFLANVT
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HELRTPLNAIIGFSEVLAGEGAVSLGPVQAREYAGIIGASGHHLLGVVNTLLDMSRIQSG
HHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHCCEECCCCHHHHHHHHHHHHHHHHCCC
NFDCAPETFDVADLLRGCCDLMRLKADAAGVALTAAPSGPVEITADPAACRQVLINLISN
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHH
AVKFTPSGGRIDLSLRRGAGSLDIVVADTGVGIGADDLPKLGTPFFQAGSGGYKRQHEGT
HEEECCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GLGLSVVQGLVGLHGGSLLIESAPQAGTVVTVTLPLVCQAPATAHGPAPIRTAVRGAPAP
CCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECEEECCCCCCCCCCHHHHHHCCCCCC
RRVVRLPLGLFDAEPGPAAAPAEPVLRRTG
HHHHCCCCHHCCCCCCCCCCCCCHHHHCCC
>Mature Secondary Structure 
PTLTIKTVLTSLIDDRLAGLVHESVADNPAARARHQRFLVSRLATGAVMMAGLPPYLLW
CCEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RGVPSGFEVLAIASLLLPVLAAVLLTRTGSLWVAHAVSSAGLTGLVVALAGVTGGVTSPA
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCHH
AVWLVAIPLEALVSGSLRATIAAAAMAVLGVLAVVALGAWAGSLPVMDISAAIALPAFAI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
TAIGHVAAQALEHMRNEGVWRERLRDNEARDRLLLSAIDDLVTWHDRNGRVLEASVSAVR
HHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCEEEHHHHHHH
LLGSDPARLRGHGLLERVHVADRPAFLKAVSDVAATGRPATLPLRLHVEPETGRADGASL
HHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHH
IYAEMRAHRIEHGPHDAAMAVVAVTRDMTEHHRHAAELERARAEAERADAIKGRFLANVT
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HELRTPLNAIIGFSEVLAGEGAVSLGPVQAREYAGIIGASGHHLLGVVNTLLDMSRIQSG
HHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHCCEECCCCHHHHHHHHHHHHHHHHCCC
NFDCAPETFDVADLLRGCCDLMRLKADAAGVALTAAPSGPVEITADPAACRQVLINLISN
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHH
AVKFTPSGGRIDLSLRRGAGSLDIVVADTGVGIGADDLPKLGTPFFQAGSGGYKRQHEGT
HEEECCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GLGLSVVQGLVGLHGGSLLIESAPQAGTVVTVTLPLVCQAPATAHGPAPIRTAVRGAPAP
CCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECEEECCCCCCCCCCHHHHHHCCCCCC
RRVVRLPLGLFDAEPGPAAAPAEPVLRRTG
HHHHCCCCHHCCCCCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430; 7756693 [H]