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The map label for this gene is galE [C]

Identifier: 170751004

GI number: 170751004

Start: 4910512

End: 4911543

Strand: Direct

Name: galE [C]

Synonym: Mrad2831_4615

Alternate gene names: 170751004

Gene position: 4910512-4911543 (Clockwise)

Preceding gene: 170751003

Following gene: 170751005

Centisome position: 80.79

GC content: 69.77

Gene sequence:

>1032_bases
ATGCCCAAGCTGCGTGAGGTCACCAAGGGAAGCCGGTTCAGCGGCGACCTGCGCGGGACCCGGATCCTGGTCACCGGCGG
ATCGGGCTTCATCGGCTCCCACATCATCGACCTGCTGGTCGAGGCCGGCTGCGACGAGATCGTGGCCATCGACAACATGA
TCCGCGGCCGCCCCGAGAATCTCGGGGACGCCCTCGGCTCCGGCCGCGTCCGCCTCGTCCAGGGCGACATCCGCGACCGC
GCCCTGATGGACACGCTGATCAAGGGCACCGACGTGGTGTTCCACCAGGCGGCCCTGCGGATCACGCAGTGCGCCGCGGA
GCCGCGCCACGCCTTCGAGGTGATGGCCGCCGCGACCTTCAACCTGCTGGAGAACTGCGTCGAGGCCGGCGTCGCCAAGG
TGGTGATGGCCTCCTCGGCCTCGGTCTACGGGATGGCGGAGGTCTTCCCGACGACCGAGAAGCACCACCCCTACGACAAC
CGGACCCTGTACGGCGCCGCCAAGTCCTTCGGCGAAGGTCTGCTGCGCTCGTTCAACGACATGCACGGGCTCGACTACGT
CGCGCTCCGGTACTTCAACGCCTACGGCCCGCGGATGGACCTGACCGGCCGCTACACCGAGGTCATGGTCCGCTGGATGC
AGCGCCTGGCCGAGGGCCAGTCGCCGATCGTCTTCGGCGACGGCCTGCAGACCATGGACCTCGTCCATGTCCGCGACATC
GCCCGGGCCAACATCCTGTCGGCGATCTCGCCGGCCACCGACGTGGTGCTCAACGTCGGCACCGGCGTCGAGACCTCGCT
GGTCGACCTCGCCGGCCACCTCACCCGGATCATGGGCCGGGACGGCACGCCGCTGATCCACGAGGCCGAGCGGGCCGTGA
ACCCGGTGCCCCGGCGTCTCTGCGACACGAGCCTCGCCAAGGAGCTGATCGGCTTCGAGGCGAAGATCGGGGCCGCCGAG
GGCCTCGCCGACCTCGTCGCCTGGTGGCAGGACGAGTCCCGCTCCGAGCATCTGCGGCGGGCGATGGCATGA

Upstream 100 bases:

>100_bases
CTGGCCGCCCGGACTCTGTCCCTCCCGATGTTCCCCGAGATGACGTCCGCGCAGATCGACACCGTCTGCCGGGCCGTCAC
CAGCTACTGCGAGGTCGCCG

Downstream 100 bases:

>100_bases
TCCCGATCGCCAAGCCCGAAGTCGGCGACCCCGAGGCCGAGGCCGCCGCCGCCGTCGTCCGCTCCGGATGGCTGACCCAG
GGGCCGCAGGTCGCGGCCTT

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MPKLREVTKGSRFSGDLRGTRILVTGGSGFIGSHIIDLLVEAGCDEIVAIDNMIRGRPENLGDALGSGRVRLVQGDIRDR
ALMDTLIKGTDVVFHQAALRITQCAAEPRHAFEVMAAATFNLLENCVEAGVAKVVMASSASVYGMAEVFPTTEKHHPYDN
RTLYGAAKSFGEGLLRSFNDMHGLDYVALRYFNAYGPRMDLTGRYTEVMVRWMQRLAEGQSPIVFGDGLQTMDLVHVRDI
ARANILSAISPATDVVLNVGTGVETSLVDLAGHLTRIMGRDGTPLIHEAERAVNPVPRRLCDTSLAKELIGFEAKIGAAE
GLADLVAWWQDESRSEHLRRAMA

Sequences:

>Translated_343_residues
MPKLREVTKGSRFSGDLRGTRILVTGGSGFIGSHIIDLLVEAGCDEIVAIDNMIRGRPENLGDALGSGRVRLVQGDIRDR
ALMDTLIKGTDVVFHQAALRITQCAAEPRHAFEVMAAATFNLLENCVEAGVAKVVMASSASVYGMAEVFPTTEKHHPYDN
RTLYGAAKSFGEGLLRSFNDMHGLDYVALRYFNAYGPRMDLTGRYTEVMVRWMQRLAEGQSPIVFGDGLQTMDLVHVRDI
ARANILSAISPATDVVLNVGTGVETSLVDLAGHLTRIMGRDGTPLIHEAERAVNPVPRRLCDTSLAKELIGFEAKIGAAE
GLADLVAWWQDESRSEHLRRAMA
>Mature_342_residues
PKLREVTKGSRFSGDLRGTRILVTGGSGFIGSHIIDLLVEAGCDEIVAIDNMIRGRPENLGDALGSGRVRLVQGDIRDRA
LMDTLIKGTDVVFHQAALRITQCAAEPRHAFEVMAAATFNLLENCVEAGVAKVVMASSASVYGMAEVFPTTEKHHPYDNR
TLYGAAKSFGEGLLRSFNDMHGLDYVALRYFNAYGPRMDLTGRYTEVMVRWMQRLAEGQSPIVFGDGLQTMDLVHVRDIA
RANILSAISPATDVVLNVGTGVETSLVDLAGHLTRIMGRDGTPLIHEAERAVNPVPRRLCDTSLAKELIGFEAKIGAAEG
LADLVAWWQDESRSEHLRRAMA

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=331, Percent_Identity=25.6797583081571, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI7657641, Length=329, Percent_Identity=27.6595744680851, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI56237023, Length=345, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI56118217, Length=345, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI189083684, Length=345, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI193211614, Length=252, Percent_Identity=25.7936507936508, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI8393516, Length=252, Percent_Identity=25.7936507936508, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786974, Length=331, Percent_Identity=27.7945619335347, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790049, Length=263, Percent_Identity=28.5171102661597, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788365, Length=228, Percent_Identity=28.0701754385965, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI48994969, Length=275, Percent_Identity=26.5454545454545, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788589, Length=251, Percent_Identity=24.7011952191235, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71982035, Length=340, Percent_Identity=29.7058823529412, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71982038, Length=342, Percent_Identity=29.5321637426901, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17539532, Length=331, Percent_Identity=25.0755287009063, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17568069, Length=332, Percent_Identity=25.6024096385542, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115532424, Length=327, Percent_Identity=25.3822629969419, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=351, Percent_Identity=26.4957264957265, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356223, Length=332, Percent_Identity=28.0120481927711, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19923002, Length=354, Percent_Identity=27.4011299435028, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 37405; Mature: 37274

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLREVTKGSRFSGDLRGTRILVTGGSGFIGSHIIDLLVEAGCDEIVAIDNMIRGRPEN
CCCHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCHH
LGDALGSGRVRLVQGDIRDRALMDTLIKGTDVVFHQAALRITQCAAEPRHAFEVMAAATF
HHHHHCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
NLLENCVEAGVAKVVMASSASVYGMAEVFPTTEKHHPYDNRTLYGAAKSFGEGLLRSFND
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHH
MHGLDYVALRYFNAYGPRMDLTGRYTEVMVRWMQRLAEGQSPIVFGDGLQTMDLVHVRDI
HCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHH
ARANILSAISPATDVVLNVGTGVETSLVDLAGHLTRIMGRDGTPLIHEAERAVNPVPRRL
HHHHHHHHHCCHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHH
CDTSLAKELIGFEAKIGAAEGLADLVAWWQDESRSEHLRRAMA
HHHHHHHHHHCCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
PKLREVTKGSRFSGDLRGTRILVTGGSGFIGSHIIDLLVEAGCDEIVAIDNMIRGRPEN
CCHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCHH
LGDALGSGRVRLVQGDIRDRALMDTLIKGTDVVFHQAALRITQCAAEPRHAFEVMAAATF
HHHHHCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
NLLENCVEAGVAKVVMASSASVYGMAEVFPTTEKHHPYDNRTLYGAAKSFGEGLLRSFND
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHH
MHGLDYVALRYFNAYGPRMDLTGRYTEVMVRWMQRLAEGQSPIVFGDGLQTMDLVHVRDI
HCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHH
ARANILSAISPATDVVLNVGTGVETSLVDLAGHLTRIMGRDGTPLIHEAERAVNPVPRRL
HHHHHHHHHCCHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHH
CDTSLAKELIGFEAKIGAAEGLADLVAWWQDESRSEHLRRAMA
HHHHHHHHHHCCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]