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The map label for this gene is argH

Identifier: 170750893

GI number: 170750893

Start: 4786251

End: 4787630

Strand: Direct

Name: argH

Synonym: Mrad2831_4504

Alternate gene names: 170750893

Gene position: 4786251-4787630 (Clockwise)

Preceding gene: 170750889

Following gene: 170750894

Centisome position: 78.75

GC content: 71.3

Gene sequence:

>1380_bases
ATGAGCAACCGGATGTGGGGCGGCCGCTTCGCGAGCGGCCCGGCGGAGATCATGGAGGAGATCAACGCCTCCATCGGATT
CGACAAGCGCCTCGCGCCCCAGGACATCCGCGGCTCGCTGGCGCATGTGGCGATGCTGGGCAAAGCCGGCATCCTGCCGG
CGGAGGATGTGGCCGCAATCGAGGCCGGGCTCAAGTCCGTGCGCGACGAGATCGAGGCCGGGACCTTCGCGTTCAAGCGC
GAGCTCGAGGACATTCACATGTCGGTGGAGAGCCGGCTGACCGAGATCGTCGGCCCGGCCGCCGGCCGCCTGCACACGGC
GCGCTCGCGCAACGACCAGGTCGCCACCGACATGAAGCTCTGGGTGCGCGACACCCTCGATTCCCTCGACCAGCAGGCCG
CCGACCTGCAGCGGGCACTCGCCGACAAGGCGCTGAAGCATGCCGACACGGTGATGCCGGGCTTCACCCATCTGCAATCG
GCCCAGCCGGTGACCTTCGGCCACCATTGCCTCGCCTATGTCGAGATGCTGGCCCGCGACCGCGGCCGGTTCCGCGACGC
CCGGGCGCGGCTCAACGAATCGCCGCTCGGCGCCGCGGCGCTGGCCGGCACCTCCTTCCCGATCGACCGGCACGCCACCG
CAGCGGCCCTCGGCTTCGACCGGCCGACCGCCAACTCGCTCGATTCGGTCGCCGACCGCGACTTCGCCCTGGAGGCGCTG
GCGGCGGCCTCGATCTGCGCCGTGCACCTGTCGCGCTTCGCCGAGGAGCTGGTGGTCTGGACCTCGGCCCAGTTCAACTT
CGTGCGGCTGTCCGACGGGTTCACCACCGGCTCGTCGATCATGCCGCAGAAGCGCAATCCCGACGCCGCCGAGCTGGTGC
GGGCCAAGAGCGGCCGGATCATCGGCGCGCTCACCGGCCTGCTCATCGTCATGAAGGGCCTGCCGCTCGCCTATTCGAAG
GACATGCAGGAGGACAAGGAGGGCACGTTCGACGCCCTCCAGGCCCTGTCCCTGTGCCTCGCCGCCATGACCGGCATGGT
GAAGGATCTCGAGCCCAACGCCGAGGTGCTCGCCCGGGCCGCCGGCTCCGGCTACGCCACCGCCACCGACCTCGCCGACT
GGCTGGTGCGCGAGCTCGGCCTGCCGTTCCGGCAGGCGCACCACGTCACCGGTCGCCTCGTCGGCGTCGCCTCGGCCAAG
GGGGTCGGGCTCGAGGCGCTGTCGCTGCCCGAGATGCAGGAGGCGGAGCCGCGGATCACCGAGGCGGTCTACGCGGTGCT
GGGGGTCGAGAACTCGGTGGCGAGCCGCACCAGCTACGGCGGCACCGCGCCCGACAACGTCCGGCGCCAGGCGCAGGCCT
GGATCGAGCGGCTGGGCTGA

Upstream 100 bases:

>100_bases
CGAGGACGGCGAGCGCGGCGACGCCCGCGCCGGCCAGGATGGGTGTGCGGCCGGGCATCAGCTTTGCCTGCCGGGGCGTT
CAGGGCGCGGAAGGATCGAC

Downstream 100 bases:

>100_bases
GCCGCGCCCTCGGCGACCGGCGCCCTCGGTGACCGGTGCCCTTGGCGGCGGCGCCCGGCGGATGGCAGGGTGGGACCATG
ACCCTGCCGGTTCACGGCGC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSNRMWGGRFASGPAEIMEEINASIGFDKRLAPQDIRGSLAHVAMLGKAGILPAEDVAAIEAGLKSVRDEIEAGTFAFKR
ELEDIHMSVESRLTEIVGPAAGRLHTARSRNDQVATDMKLWVRDTLDSLDQQAADLQRALADKALKHADTVMPGFTHLQS
AQPVTFGHHCLAYVEMLARDRGRFRDARARLNESPLGAAALAGTSFPIDRHATAAALGFDRPTANSLDSVADRDFALEAL
AAASICAVHLSRFAEELVVWTSAQFNFVRLSDGFTTGSSIMPQKRNPDAAELVRAKSGRIIGALTGLLIVMKGLPLAYSK
DMQEDKEGTFDALQALSLCLAAMTGMVKDLEPNAEVLARAAGSGYATATDLADWLVRELGLPFRQAHHVTGRLVGVASAK
GVGLEALSLPEMQEAEPRITEAVYAVLGVENSVASRTSYGGTAPDNVRRQAQAWIERLG

Sequences:

>Translated_459_residues
MSNRMWGGRFASGPAEIMEEINASIGFDKRLAPQDIRGSLAHVAMLGKAGILPAEDVAAIEAGLKSVRDEIEAGTFAFKR
ELEDIHMSVESRLTEIVGPAAGRLHTARSRNDQVATDMKLWVRDTLDSLDQQAADLQRALADKALKHADTVMPGFTHLQS
AQPVTFGHHCLAYVEMLARDRGRFRDARARLNESPLGAAALAGTSFPIDRHATAAALGFDRPTANSLDSVADRDFALEAL
AAASICAVHLSRFAEELVVWTSAQFNFVRLSDGFTTGSSIMPQKRNPDAAELVRAKSGRIIGALTGLLIVMKGLPLAYSK
DMQEDKEGTFDALQALSLCLAAMTGMVKDLEPNAEVLARAAGSGYATATDLADWLVRELGLPFRQAHHVTGRLVGVASAK
GVGLEALSLPEMQEAEPRITEAVYAVLGVENSVASRTSYGGTAPDNVRRQAQAWIERLG
>Mature_458_residues
SNRMWGGRFASGPAEIMEEINASIGFDKRLAPQDIRGSLAHVAMLGKAGILPAEDVAAIEAGLKSVRDEIEAGTFAFKRE
LEDIHMSVESRLTEIVGPAAGRLHTARSRNDQVATDMKLWVRDTLDSLDQQAADLQRALADKALKHADTVMPGFTHLQSA
QPVTFGHHCLAYVEMLARDRGRFRDARARLNESPLGAAALAGTSFPIDRHATAAALGFDRPTANSLDSVADRDFALEALA
AASICAVHLSRFAEELVVWTSAQFNFVRLSDGFTTGSSIMPQKRNPDAAELVRAKSGRIIGALTGLLIVMKGLPLAYSKD
MQEDKEGTFDALQALSLCLAAMTGMVKDLEPNAEVLARAAGSGYATATDLADWLVRELGLPFRQAHHVTGRLVGVASAKG
VGLEALSLPEMQEAEPRITEAVYAVLGVENSVASRTSYGGTAPDNVRRQAQAWIERLG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=449, Percent_Identity=44.3207126948775, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI68303542, Length=449, Percent_Identity=44.3207126948775, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI68303549, Length=449, Percent_Identity=42.0935412026726, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI68303547, Length=449, Percent_Identity=41.8708240534521, Blast_Score=349, Evalue=3e-96,
Organism=Escherichia coli, GI1790398, Length=444, Percent_Identity=50, Blast_Score=422, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6321806, Length=452, Percent_Identity=41.3716814159292, Blast_Score=359, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221473854, Length=447, Percent_Identity=39.8210290827741, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI78706858, Length=447, Percent_Identity=39.8210290827741, Blast_Score=337, Evalue=1e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_METRJ (B1M509)

Other databases:

- EMBL:   CP001001
- RefSeq:   YP_001757153.1
- ProteinModelPortal:   B1M509
- SMR:   B1M509
- GeneID:   6140570
- GenomeReviews:   CP001001_GR
- KEGG:   mrd:Mrad2831_4504
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   CLSK2541638
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 49269; Mature: 49137

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRMWGGRFASGPAEIMEEINASIGFDKRLAPQDIRGSLAHVAMLGKAGILPAEDVAAI
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHH
EAGLKSVRDEIEAGTFAFKRELEDIHMSVESRLTEIVGPAAGRLHTARSRNDQVATDMKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHH
WVRDTLDSLDQQAADLQRALADKALKHADTVMPGFTHLQSAQPVTFGHHCLAYVEMLARD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHH
RGRFRDARARLNESPLGAAALAGTSFPIDRHATAAALGFDRPTANSLDSVADRDFALEAL
HHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
AAASICAVHLSRFAEELVVWTSAQFNFVRLSDGFTTGSSIMPQKRNPDAAELVRAKSGRI
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCH
IGALTGLLIVMKGLPLAYSKDMQEDKEGTFDALQALSLCLAAMTGMVKDLEPNAEVLARA
HHHHHHHHHHHHCCCCHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AGSGYATATDLADWLVRELGLPFRQAHHVTGRLVGVASAKGVGLEALSLPEMQEAEPRIT
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHEEECCCCCCCCHHCCCCCHHHCCHHHH
EAVYAVLGVENSVASRTSYGGTAPDNVRRQAQAWIERLG
HHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNRMWGGRFASGPAEIMEEINASIGFDKRLAPQDIRGSLAHVAMLGKAGILPAEDVAAI
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHH
EAGLKSVRDEIEAGTFAFKRELEDIHMSVESRLTEIVGPAAGRLHTARSRNDQVATDMKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHH
WVRDTLDSLDQQAADLQRALADKALKHADTVMPGFTHLQSAQPVTFGHHCLAYVEMLARD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHH
RGRFRDARARLNESPLGAAALAGTSFPIDRHATAAALGFDRPTANSLDSVADRDFALEAL
HHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
AAASICAVHLSRFAEELVVWTSAQFNFVRLSDGFTTGSSIMPQKRNPDAAELVRAKSGRI
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCH
IGALTGLLIVMKGLPLAYSKDMQEDKEGTFDALQALSLCLAAMTGMVKDLEPNAEVLARA
HHHHHHHHHHHHCCCCHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AGSGYATATDLADWLVRELGLPFRQAHHVTGRLVGVASAKGVGLEALSLPEMQEAEPRIT
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHEEECCCCCCCCHHCCCCCHHHCCHHHH
EAVYAVLGVENSVASRTSYGGTAPDNVRRQAQAWIERLG
HHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA