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The map label for this gene is thlA [H]

Identifier: 170750840

GI number: 170750840

Start: 4733531

End: 4734709

Strand: Direct

Name: thlA [H]

Synonym: Mrad2831_4451

Alternate gene names: 170750840

Gene position: 4733531-4734709 (Clockwise)

Preceding gene: 170750839

Following gene: 170750841

Centisome position: 77.88

GC content: 75.57

Gene sequence:

>1179_bases
ATGACCGAGGTCGTGATCACAGGCGCGGTGCGCACCGCCATCGGCACGTTCGGCGGCGCGCTGGCCGGCACGCCCCCCTC
CGTCCTCGCCGCAAGCTGCGTCGCGGAGGCGCTGCGCCGCGCCGGGACCGCGCCCGAGGCGGTCGGCCACGTGGTCCTCG
GCAACGTCATCCCGACCGAGCCCCGGGACGCCTACATCGCCCGGGTCGCGGCGATGGAGGGTGGCATCCCCGAGGAGGTG
CCGGCCATGACGGTCAACCGCCTCTGCGGCAGCGGCCTGCAGGCGGTCGTCTCGGCCGCGCAGTCCATCCTGCTCGGCGA
CGCCGAGACGGCCCTGGCCGGCGGCGCCGAGAGCATGAGCCGCGCCCCCCACCTCCTGACCACCGGGCGGACCGGGTCGC
GCATGGGCGACGCCGTGCTGGTCGACTACATGCTCGGCGCGCTGACCGACCCGTTCGGCAACGGCCACATGGGCGTCACC
GCCGAGAACGTGGCCGCGCGCTACGCCGTCCCCCGCGACGTGCAGGACGCCTTCGCGGCCGAGAGCCAGGCCCGCGCCGC
GCGGGCGATCCGCGAGGGCCGGTTCCGGGAGCAGATCCTGCCGATCGAGGTCCAGCGCCGGCGCGAGACGGTGGCCTTCG
ACACCGACGAGCACCCGAAGGCCACGAGCGCCGAGGACCTCGCCAAGCTGCGCCCGGCCTTCTCCAAGACCGGCAGCGTC
ACGGCCGGCAACGCCTCGGGGCTGAACGACGGCGCCGCGGCCCTCGTCCTGTCGAGCGCCGCGCGGGCGGAGCGCGACGG
CGCGACGCCGCTCGCCCGGATCGTCGGCTACGCCCACGCGGGCGTGGACCCGTCCGAGATGGGCATGGGCCCGGTGCCGG
CGGTGCGGCGCCTGCTGGAGCGGACCGGCCTGCGGGCCGCGGATTTCGACGTCGTCGAGTCGAACGAGGCCTTCGCGGCG
CAGGCCTGCGCGGTCTCCCGCGAACTTGACCTCGATCCCGACAGGGTCAACCCGAACGGCGGCGCCATCGCCCTCGGCCA
CCCGATCGGCGCCACGGGGGCGATCATCACCGTGAAGGCCCTCTACGAGCTGGCCCGGACCGGCGGCCGCTACGGGCTCG
TGACCATGTGCATCGGCGGCGGCCAGGGGATCGCCATGGCCCTCGAGCGCGTCCCGTGA

Upstream 100 bases:

>100_bases
CCTTCTGGTCGTGGGGCGTCGGGGCCTGAGCGGCGCCGACACCGTCCATCCGCCGCGCGGGGCACGCCGGCAGGCTGAGT
CAGGCATGGAGGCCGAGAGT

Downstream 100 bases:

>100_bases
CGCGGCCCTGAGGCACCATGCTGGACGCGGATCAGAGAACGGCGCTCTGCGCCTGGATCGGCCGGACCCTGGAGGCCGGG
ACGGTCACGCTCGACGACGC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTEVVITGAVRTAIGTFGGALAGTPPSVLAASCVAEALRRAGTAPEAVGHVVLGNVIPTEPRDAYIARVAAMEGGIPEEV
PAMTVNRLCGSGLQAVVSAAQSILLGDAETALAGGAESMSRAPHLLTTGRTGSRMGDAVLVDYMLGALTDPFGNGHMGVT
AENVAARYAVPRDVQDAFAAESQARAARAIREGRFREQILPIEVQRRRETVAFDTDEHPKATSAEDLAKLRPAFSKTGSV
TAGNASGLNDGAAALVLSSAARAERDGATPLARIVGYAHAGVDPSEMGMGPVPAVRRLLERTGLRAADFDVVESNEAFAA
QACAVSRELDLDPDRVNPNGGAIALGHPIGATGAIITVKALYELARTGGRYGLVTMCIGGGQGIAMALERVP

Sequences:

>Translated_392_residues
MTEVVITGAVRTAIGTFGGALAGTPPSVLAASCVAEALRRAGTAPEAVGHVVLGNVIPTEPRDAYIARVAAMEGGIPEEV
PAMTVNRLCGSGLQAVVSAAQSILLGDAETALAGGAESMSRAPHLLTTGRTGSRMGDAVLVDYMLGALTDPFGNGHMGVT
AENVAARYAVPRDVQDAFAAESQARAARAIREGRFREQILPIEVQRRRETVAFDTDEHPKATSAEDLAKLRPAFSKTGSV
TAGNASGLNDGAAALVLSSAARAERDGATPLARIVGYAHAGVDPSEMGMGPVPAVRRLLERTGLRAADFDVVESNEAFAA
QACAVSRELDLDPDRVNPNGGAIALGHPIGATGAIITVKALYELARTGGRYGLVTMCIGGGQGIAMALERVP
>Mature_391_residues
TEVVITGAVRTAIGTFGGALAGTPPSVLAASCVAEALRRAGTAPEAVGHVVLGNVIPTEPRDAYIARVAAMEGGIPEEVP
AMTVNRLCGSGLQAVVSAAQSILLGDAETALAGGAESMSRAPHLLTTGRTGSRMGDAVLVDYMLGALTDPFGNGHMGVTA
ENVAARYAVPRDVQDAFAAESQARAARAIREGRFREQILPIEVQRRRETVAFDTDEHPKATSAEDLAKLRPAFSKTGSVT
AGNASGLNDGAAALVLSSAARAERDGATPLARIVGYAHAGVDPSEMGMGPVPAVRRLLERTGLRAADFDVVESNEAFAAQ
ACAVSRELDLDPDRVNPNGGAIALGHPIGATGAIITVKALYELARTGGRYGLVTMCIGGGQGIAMALERVP

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=46.8030690537084, Blast_Score=341, Evalue=5e-94,
Organism=Homo sapiens, GI167614485, Length=388, Percent_Identity=44.5876288659794, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI4557237, Length=403, Percent_Identity=38.4615384615385, Blast_Score=265, Evalue=6e-71,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=41.8136020151133, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=32.1596244131455, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI194353979, Length=397, Percent_Identity=32.7455919395466, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=49.7448979591837, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1788554, Length=399, Percent_Identity=50.125313283208, Blast_Score=342, Evalue=3e-95,
Organism=Escherichia coli, GI1787663, Length=403, Percent_Identity=46.8982630272953, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=41.8952618453865, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1788683, Length=422, Percent_Identity=33.6492890995261, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=46.2724935732648, Blast_Score=353, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI25147385, Length=389, Percent_Identity=34.1902313624679, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=35.7868020304569, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=28.7058823529412, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=27.7777777777778, Blast_Score=144, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=35.3535353535354, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6322031, Length=393, Percent_Identity=37.9134860050891, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=48.0916030534351, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=43.7340153452685, Blast_Score=314, Evalue=8e-86,
Organism=Drosophila melanogaster, GI24640423, Length=396, Percent_Identity=38.8888888888889, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=31.924882629108, Blast_Score=181, Evalue=7e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40181; Mature: 40050

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVVITGAVRTAIGTFGGALAGTPPSVLAASCVAEALRRAGTAPEAVGHVVLGNVIPTE
CCEEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCC
PRDAYIARVAAMEGGIPEEVPAMTVNRLCGSGLQAVVSAAQSILLGDAETALAGGAESMS
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHCCHHHHH
RAPHLLTTGRTGSRMGDAVLVDYMLGALTDPFGNGHMGVTAENVAARYAVPRDVQDAFAA
CCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHCCCCCHHHHHHH
ESQARAARAIREGRFREQILPIEVQRRRETVAFDTDEHPKATSAEDLAKLRPAFSKTGSV
HHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCE
TAGNASGLNDGAAALVLSSAARAERDGATPLARIVGYAHAGVDPSEMGMGPVPAVRRLLE
ECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHH
RTGLRAADFDVVESNEAFAAQACAVSRELDLDPDRVNPNGGAIALGHPIGATGAIITVKA
HCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHH
LYELARTGGRYGLVTMCIGGGQGIAMALERVP
HHHHHHCCCCEEEEEEEEECCCCHHHHHHCCC
>Mature Secondary Structure 
TEVVITGAVRTAIGTFGGALAGTPPSVLAASCVAEALRRAGTAPEAVGHVVLGNVIPTE
CEEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCC
PRDAYIARVAAMEGGIPEEVPAMTVNRLCGSGLQAVVSAAQSILLGDAETALAGGAESMS
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHCCHHHHH
RAPHLLTTGRTGSRMGDAVLVDYMLGALTDPFGNGHMGVTAENVAARYAVPRDVQDAFAA
CCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHCCCCCHHHHHHH
ESQARAARAIREGRFREQILPIEVQRRRETVAFDTDEHPKATSAEDLAKLRPAFSKTGSV
HHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCE
TAGNASGLNDGAAALVLSSAARAERDGATPLARIVGYAHAGVDPSEMGMGPVPAVRRLLE
ECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHH
RTGLRAADFDVVESNEAFAAQACAVSRELDLDPDRVNPNGGAIALGHPIGATGAIITVKA
HCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHH
LYELARTGGRYGLVTMCIGGGQGIAMALERVP
HHHHHHCCCCEEEEEEEEECCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]