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The map label for this gene is iorA [H]

Identifier: 170750831

GI number: 170750831

Start: 4724838

End: 4725284

Strand: Direct

Name: iorA [H]

Synonym: Mrad2831_4442

Alternate gene names: 170750831

Gene position: 4724838-4725284 (Clockwise)

Preceding gene: 170750830

Following gene: 170750832

Centisome position: 77.74

GC content: 70.92

Gene sequence:

>447_bases
ATGGTGAACCTGACGATCAATGGCCAGCCGCGCGCGGTCGAGGCCGAGCCCGACACGCCGCTCCTCTTCGTCCTGCGCGA
CACACTCGGGATGACCGGCACCAAGTACGGCTGCGGGATCGCCCAGTGCGGGGCCTGCACGGTGCTCCTCGACGGGCAGG
CGACGCGCTCCTGCCAGGTGCCGCTGGAGAGCGTCGGCAGCCAGGCCGTCACCACCATCGAGGCGATCGAGCAGGACGCC
GTCGGCCGGAAAGTCGTCGAGGCCTGGGTCTCCGTGCAGGTGCCCCAGTGCGGCTACTGCCAGTCGGGCCAGGTCATGGC
CGCCACGGCCCTCCTCAAGCAGACGCCCAAGCCCACCGATTCCGAGATCGCCGAGGCGATGACCAACCTGTGCCGGTGCG
GGACCTACAACGCCATCGCCGCCGCCGTGCGGCAGGCCGCCGCCTGA

Upstream 100 bases:

>100_bases
CGGACATGGCCGGAAACGTGGCTTTTTTGACGTAGGCCGATCCCGGGGGACGACCGTAAGCATGGCCGGGGGCTCAGCCG
ATCCTCGGAGAAACGCGGCC

Downstream 100 bases:

>100_bases
GGAGGCCGCCATGGACCAGCTCCTGGATTCCGCCCGTCACGGCGCGACCCTCGTCGATCCCGTCCCCGCCGCCCCGGCCC
GCCGGCCTTCCCCCTCCCGC

Product: 2Fe-2S iron-sulfur cluster binding domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MVNLTINGQPRAVEAEPDTPLLFVLRDTLGMTGTKYGCGIAQCGACTVLLDGQATRSCQVPLESVGSQAVTTIEAIEQDA
VGRKVVEAWVSVQVPQCGYCQSGQVMAATALLKQTPKPTDSEIAEAMTNLCRCGTYNAIAAAVRQAAA

Sequences:

>Translated_148_residues
MVNLTINGQPRAVEAEPDTPLLFVLRDTLGMTGTKYGCGIAQCGACTVLLDGQATRSCQVPLESVGSQAVTTIEAIEQDA
VGRKVVEAWVSVQVPQCGYCQSGQVMAATALLKQTPKPTDSEIAEAMTNLCRCGTYNAIAAAVRQAAA
>Mature_148_residues
MVNLTINGQPRAVEAEPDTPLLFVLRDTLGMTGTKYGCGIAQCGACTVLLDGQATRSCQVPLESVGSQAVTTIEAIEQDA
VGRKVVEAWVSVQVPQCGYCQSGQVMAATALLKQTPKPTDSEIAEAMTNLCRCGTYNAIAAAVRQAAA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=158, Percent_Identity=38.6075949367089, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1786480, Length=162, Percent_Identity=35.8024691358025, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1789232, Length=145, Percent_Identity=38.6206896551724, Blast_Score=87, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17540638, Length=140, Percent_Identity=40, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17539860, Length=152, Percent_Identity=34.8684210526316, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI32566215, Length=152, Percent_Identity=35.5263157894737, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737937, Length=149, Percent_Identity=35.5704697986577, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24647197, Length=162, Percent_Identity=30.8641975308642, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24647195, Length=162, Percent_Identity=30.8641975308642, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24647201, Length=154, Percent_Identity=31.1688311688312, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 15449; Mature: 15449

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
8.1 %Cys+Met (Translated Protein)
5.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
8.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNLTINGQPRAVEAEPDTPLLFVLRDTLGMTGTKYGCGIAQCGACTVLLDGQATRSCQV
CEEEEECCCCCEEECCCCCCEEEEEEHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
PLESVGSQAVTTIEAIEQDAVGRKVVEAWVSVQVPQCGYCQSGQVMAATALLKQTPKPTD
CHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCH
SEIAEAMTNLCRCGTYNAIAAAVRQAAA
HHHHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MVNLTINGQPRAVEAEPDTPLLFVLRDTLGMTGTKYGCGIAQCGACTVLLDGQATRSCQV
CEEEEECCCCCEEECCCCCCEEEEEEHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
PLESVGSQAVTTIEAIEQDAVGRKVVEAWVSVQVPQCGYCQSGQVMAATALLKQTPKPTD
CHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCH
SEIAEAMTNLCRCGTYNAIAAAVRQAAA
HHHHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]