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The map label for this gene is serA [H]

Identifier: 170750794

GI number: 170750794

Start: 4671878

End: 4672858

Strand: Reverse

Name: serA [H]

Synonym: Mrad2831_4405

Alternate gene names: 170750794

Gene position: 4672858-4671878 (Counterclockwise)

Preceding gene: 170750797

Following gene: 170750793

Centisome position: 76.88

GC content: 76.55

Gene sequence:

>981_bases
GTGATCACCGGTCCGTGCCTCATCGTCCAGCCGATCCACGCGGCGGGCCTCGACCGGTTGCGCGCGGCCGGGCTGGAGCC
GCGCCCGGCGAGCGGGACCGATTCCGAGACGCTGGCCCGCGAGGTCGCCGACTGCGTCGCCGTCATCACCCGCAACACCG
GCTTCCCGGCACGCGCCATCGCGGCGGCGCCGGCCCTGCGGGTGATCGGCGTGCACGGCACCGGCACCGACCACGTCGCC
ACCGCCGAGGCGACCGCGGCCGGGATCGTGGTGGTCAACACGCCCGGCGCGAACGCCGTCTCGGTGGCCGAGCAGACGCT
GGCGCTGATCTTCGCCCTGGCCAAGGCCCTGCCGGAGGCCGACCGCTCGGTCCGGACCGGCGACGACAGCTTCAAGTTCA
CCGCCCGGCTGATCGAGCTCGCCGGGCTGACGCTGGGTCTCGTCGGCTTCGGGGCGATCGGGCAGGCGACCGCCCGGCTC
GCCGCCGCCCTGGGGCTGCGGGTGCTGGCCTACGGCCCGAGCCGCCCGGACGCCGATTTCGCCAATGCCGGCGCCCTGCG
GGCCGCCTCGGTCGACGCGCTCCTGGCGGAGGCGGACATCGTCTCCCTGCACGTGCCGCTGACCCCGGGCACCCGCGGCC
TGATCGGTCGGGACCAGCTCGCCCGGATGAAGCGGGAGGCCTTCCTGATCAACACCAGCCGCGGCGGCCTGATCGACGAG
GCGGCCCTGGTGGAGGCGCTGGAGGCCGGCACGATCGCGGGCGCCGGGCTCGACGTCTTCGCCCAGGAGCCGCTGCCGGT
CGACCACCCGCTGGCCCGCCAGCCCCGGGCGATCCTGACGCCCCATGTCGGCGGCTCCACCGGCGCGGCCCTGATCCGCA
CCGCCGAGACCGCCGCGACCCGCGTGGTCGACGTCCTCGCCGGCCGGCGGCCGGGCGGGCTGGTCAACCCGGATGTCTGG
GAGCGGCGCCGCGCGCCGTGA

Upstream 100 bases:

>100_bases
CGGGGACCGGGGCGCCCGGTTGCCAGGGTTGCTAACCCCGCCTAGACGGGCCCGGCGCGAAACTTGCCCGTCACCCCTCC
TCTTGTGCAGAGGTTTTCCC

Downstream 100 bases:

>100_bases
CACCCTGAGACCGGGGACCGCCGCGGGCCGCGCGACGGGCCTCCGACCAACAGCCTCATCCTGAGGTGCCCGCCTCGGCG
GGCCTCGGAGGGGAGGCTCC

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MITGPCLIVQPIHAAGLDRLRAAGLEPRPASGTDSETLAREVADCVAVITRNTGFPARAIAAAPALRVIGVHGTGTDHVA
TAEATAAGIVVVNTPGANAVSVAEQTLALIFALAKALPEADRSVRTGDDSFKFTARLIELAGLTLGLVGFGAIGQATARL
AAALGLRVLAYGPSRPDADFANAGALRAASVDALLAEADIVSLHVPLTPGTRGLIGRDQLARMKREAFLINTSRGGLIDE
AALVEALEAGTIAGAGLDVFAQEPLPVDHPLARQPRAILTPHVGGSTGAALIRTAETAATRVVDVLAGRRPGGLVNPDVW
ERRRAP

Sequences:

>Translated_326_residues
MITGPCLIVQPIHAAGLDRLRAAGLEPRPASGTDSETLAREVADCVAVITRNTGFPARAIAAAPALRVIGVHGTGTDHVA
TAEATAAGIVVVNTPGANAVSVAEQTLALIFALAKALPEADRSVRTGDDSFKFTARLIELAGLTLGLVGFGAIGQATARL
AAALGLRVLAYGPSRPDADFANAGALRAASVDALLAEADIVSLHVPLTPGTRGLIGRDQLARMKREAFLINTSRGGLIDE
AALVEALEAGTIAGAGLDVFAQEPLPVDHPLARQPRAILTPHVGGSTGAALIRTAETAATRVVDVLAGRRPGGLVNPDVW
ERRRAP
>Mature_326_residues
MITGPCLIVQPIHAAGLDRLRAAGLEPRPASGTDSETLAREVADCVAVITRNTGFPARAIAAAPALRVIGVHGTGTDHVA
TAEATAAGIVVVNTPGANAVSVAEQTLALIFALAKALPEADRSVRTGDDSFKFTARLIELAGLTLGLVGFGAIGQATARL
AAALGLRVLAYGPSRPDADFANAGALRAASVDALLAEADIVSLHVPLTPGTRGLIGRDQLARMKREAFLINTSRGGLIDE
AALVEALEAGTIAGAGLDVFAQEPLPVDHPLARQPRAILTPHVGGSTGAALIRTAETAATRVVDVLAGRRPGGLVNPDVW
ERRRAP

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=299, Percent_Identity=36.7892976588629, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI145580578, Length=260, Percent_Identity=36.9230769230769, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI4557499, Length=260, Percent_Identity=36.9230769230769, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI61743967, Length=260, Percent_Identity=36.1538461538462, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI4557497, Length=260, Percent_Identity=36.1538461538462, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI145580575, Length=260, Percent_Identity=37.3076923076923, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI6912396, Length=232, Percent_Identity=34.9137931034483, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI87082289, Length=275, Percent_Identity=34.1818181818182, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789279, Length=295, Percent_Identity=35.2542372881356, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1787645, Length=206, Percent_Identity=32.0388349514563, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081824, Length=174, Percent_Identity=30.4597701149425, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788660, Length=228, Percent_Identity=30.2631578947368, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=314, Percent_Identity=35.3503184713376, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI25147481, Length=262, Percent_Identity=32.4427480916031, Blast_Score=114, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=273, Percent_Identity=37.7289377289377, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322116, Length=303, Percent_Identity=34.3234323432343, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324964, Length=309, Percent_Identity=29.126213592233, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=299, Percent_Identity=26.7558528428094, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6325144, Length=197, Percent_Identity=27.9187817258883, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6324980, Length=115, Percent_Identity=31.304347826087, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=169, Percent_Identity=30.1775147928994, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19921140, Length=321, Percent_Identity=33.6448598130841, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24646446, Length=271, Percent_Identity=37.2693726937269, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646448, Length=271, Percent_Identity=37.2693726937269, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646452, Length=271, Percent_Identity=37.2693726937269, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646450, Length=271, Percent_Identity=37.2693726937269, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI62472511, Length=262, Percent_Identity=37.0229007633588, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28574286, Length=255, Percent_Identity=31.7647058823529, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24585516, Length=254, Percent_Identity=29.9212598425197, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28571528, Length=254, Percent_Identity=33.4645669291339, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45552429, Length=251, Percent_Identity=29.8804780876494, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24585514, Length=252, Percent_Identity=29.7619047619048, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28574282, Length=252, Percent_Identity=29.7619047619048, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45551003, Length=251, Percent_Identity=29.8804780876494, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28574284, Length=251, Percent_Identity=29.8804780876494, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 33329; Mature: 33329

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITGPCLIVQPIHAAGLDRLRAAGLEPRPASGTDSETLAREVADCVAVITRNTGFPARAI
CCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
AAAPALRVIGVHGTGTDHVATAEATAAGIVVVNTPGANAVSVAEQTLALIFALAKALPEA
HHCCCEEEEEECCCCCCCEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHH
DRSVRTGDDSFKFTARLIELAGLTLGLVGFGAIGQATARLAAALGLRVLAYGPSRPDADF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEEECCCCCCCCC
ANAGALRAASVDALLAEADIVSLHVPLTPGTRGLIGRDQLARMKREAFLINTSRGGLIDE
CCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHEEEEECCCCCCCHH
AALVEALEAGTIAGAGLDVFAQEPLPVDHPLARQPRAILTPHVGGSTGAALIRTAETAAT
HHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCEEECCCCCCCCCHHHEEHHHHHHH
RVVDVLAGRRPGGLVNPDVWERRRAP
HHHHHHHCCCCCCCCCCCHHHHCCCC
>Mature Secondary Structure
MITGPCLIVQPIHAAGLDRLRAAGLEPRPASGTDSETLAREVADCVAVITRNTGFPARAI
CCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
AAAPALRVIGVHGTGTDHVATAEATAAGIVVVNTPGANAVSVAEQTLALIFALAKALPEA
HHCCCEEEEEECCCCCCCEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHH
DRSVRTGDDSFKFTARLIELAGLTLGLVGFGAIGQATARLAAALGLRVLAYGPSRPDADF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEEECCCCCCCCC
ANAGALRAASVDALLAEADIVSLHVPLTPGTRGLIGRDQLARMKREAFLINTSRGGLIDE
CCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHEEEEECCCCCCCHH
AALVEALEAGTIAGAGLDVFAQEPLPVDHPLARQPRAILTPHVGGSTGAALIRTAETAAT
HHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCEEECCCCCCCCCHHHEEHHHHHHH
RVVDVLAGRRPGGLVNPDVWERRRAP
HHHHHHHCCCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]