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The map label for this gene is cynR [H]

Identifier: 170750771

GI number: 170750771

Start: 4648197

End: 4649099

Strand: Direct

Name: cynR [H]

Synonym: Mrad2831_4382

Alternate gene names: 170750771

Gene position: 4648197-4649099 (Clockwise)

Preceding gene: 170750764

Following gene: 170750772

Centisome position: 76.48

GC content: 73.31

Gene sequence:

>903_bases
ATGCAGAGTACGGGCCTGCGCTACTTCCTGGCCGTGGCCCGCACCGGCTCGATCGCGGCGGCCTCGGCCCAGCTCAACGT
CGCGGCCTCGGCGATCAGCCGGCAGATCGCCAACCTCGAGGCCGAACTCGACTGCGTGCTGTTCGAGCGGCGCCCGCGCG
GCATGGTGCCGAGCCCGGCCGGGGAACTCCTGGCGCAGCACGCCCATCAGGTGCTGATCCGCTCCGAGCAGGTGGTCACC
GAGATCCGGGAGCTCGAAGGGCTCGCCCGCGGGCTGATCCGGGTCGCCTGCTCAGAGGGCTTCTCCCTCGACATCGTGCC
GAACGCGATCGCGGCCTTCCACGCCGACCATCCCGGCATCCGCTTCGAGGTCACGGTCCAGCCCCCGGCCCAGGTCACCC
AGACGGTCGCGGCGGGGGATGCCGATCTCGGGATCACCTTCGCGCTGACGCCAACCGCGCAGGTCGAGGTTCTCTACGAC
GGGCAGGTCGACATGCTGGCGCTGGCCGCCCCCGACCACCCCCTCGCGCGGGCACCGGTCCTGCGCCTCGTCGACCTGCT
GCACTATCCCGTCGCCCTGCCGACCCGGGACACGACCCTGCGGCAGGTCTTCGACGCCGCCTGCGCGCACGAGGGCCTCA
CGGTCGAGCCCGTGCTGACCGCCAACAAGCTCTCGGCGCTGCTGCCCTTCGTGCGGCGGTCGCGCGGGCTGGCGCTGATG
TCGGCCCTGTCGGTCCGGACGCCCCTGCGCCTCAACGAGCTGGTCAGCCTGCCGATCCAGTCCCGGGCGAGCCTCGCCCG
CGGCATCAAGGTCCAGGCCATGCGCGACCGGCGGCTGCCCCGGGCGGTGCGGGCGTTCCTGCGCCAGCTGCTCGACGCGC
TGCCGCCGCCGCGGTCGCCGTGA

Upstream 100 bases:

>100_bases
TGGTGTTGTGCATCTGGGATCGCAACAAGTAGAATTTGGCGAGTGCTGCGTTGCCGTATCGGCAATGTGCGCGGCACCAT
ACAGCGTATCGAGCACGATA

Downstream 100 bases:

>100_bases
CGCCGCCGTGACGCCGCCGTGACCCTCGACGCGCTCGGCCCGCGGCTCTGCATCCTGGGACCGTCGAACAGCGGCAAGTC
CACCCTGGCGGTCGCCGTCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MQSTGLRYFLAVARTGSIAAASAQLNVAASAISRQIANLEAELDCVLFERRPRGMVPSPAGELLAQHAHQVLIRSEQVVT
EIRELEGLARGLIRVACSEGFSLDIVPNAIAAFHADHPGIRFEVTVQPPAQVTQTVAAGDADLGITFALTPTAQVEVLYD
GQVDMLALAAPDHPLARAPVLRLVDLLHYPVALPTRDTTLRQVFDAACAHEGLTVEPVLTANKLSALLPFVRRSRGLALM
SALSVRTPLRLNELVSLPIQSRASLARGIKVQAMRDRRLPRAVRAFLRQLLDALPPPRSP

Sequences:

>Translated_300_residues
MQSTGLRYFLAVARTGSIAAASAQLNVAASAISRQIANLEAELDCVLFERRPRGMVPSPAGELLAQHAHQVLIRSEQVVT
EIRELEGLARGLIRVACSEGFSLDIVPNAIAAFHADHPGIRFEVTVQPPAQVTQTVAAGDADLGITFALTPTAQVEVLYD
GQVDMLALAAPDHPLARAPVLRLVDLLHYPVALPTRDTTLRQVFDAACAHEGLTVEPVLTANKLSALLPFVRRSRGLALM
SALSVRTPLRLNELVSLPIQSRASLARGIKVQAMRDRRLPRAVRAFLRQLLDALPPPRSP
>Mature_300_residues
MQSTGLRYFLAVARTGSIAAASAQLNVAASAISRQIANLEAELDCVLFERRPRGMVPSPAGELLAQHAHQVLIRSEQVVT
EIRELEGLARGLIRVACSEGFSLDIVPNAIAAFHADHPGIRFEVTVQPPAQVTQTVAAGDADLGITFALTPTAQVEVLYD
GQVDMLALAAPDHPLARAPVLRLVDLLHYPVALPTRDTTLRQVFDAACAHEGLTVEPVLTANKLSALLPFVRRSRGLALM
SALSVRTPLRLNELVSLPIQSRASLARGIKVQAMRDRRLPRAVRAFLRQLLDALPPPRSP

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=234, Percent_Identity=29.4871794871795, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787601, Length=258, Percent_Identity=27.5193798449612, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI145693105, Length=242, Percent_Identity=21.4876033057851, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787530, Length=248, Percent_Identity=25.8064516129032, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1788481, Length=286, Percent_Identity=29.020979020979, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788748, Length=243, Percent_Identity=25.1028806584362, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081904, Length=262, Percent_Identity=27.0992366412214, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789204, Length=300, Percent_Identity=24, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790262, Length=177, Percent_Identity=30.5084745762712, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788297, Length=236, Percent_Identity=23.3050847457627, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32371; Mature: 32371

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSTGLRYFLAVARTGSIAAASAQLNVAASAISRQIANLEAELDCVLFERRPRGMVPSPA
CCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHCCHHHHEEEEEECCCCCCCCCCH
GELLAQHAHQVLIRSEQVVTEIRELEGLARGLIRVACSEGFSLDIVPNAIAAFHADHPGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHCCCCCCE
RFEVTVQPPAQVTQTVAAGDADLGITFALTPTAQVEVLYDGQVDMLALAAPDHPLARAPV
EEEEEECCHHHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCEEEEEEECCCCCCHHHHH
LRLVDLLHYPVALPTRDTTLRQVFDAACAHEGLTVEPVLTANKLSALLPFVRRSRGLALM
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHCCCHHHH
SALSVRTPLRLNELVSLPIQSRASLARGIKVQAMRDRRLPRAVRAFLRQLLDALPPPRSP
HHHHHCCCCCHHHHHHCCCHHHHHHHHCCEEEHHHHCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQSTGLRYFLAVARTGSIAAASAQLNVAASAISRQIANLEAELDCVLFERRPRGMVPSPA
CCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHCCHHHHEEEEEECCCCCCCCCCH
GELLAQHAHQVLIRSEQVVTEIRELEGLARGLIRVACSEGFSLDIVPNAIAAFHADHPGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHCCCCCCE
RFEVTVQPPAQVTQTVAAGDADLGITFALTPTAQVEVLYDGQVDMLALAAPDHPLARAPV
EEEEEECCHHHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCEEEEEEECCCCCCHHHHH
LRLVDLLHYPVALPTRDTTLRQVFDAACAHEGLTVEPVLTANKLSALLPFVRRSRGLALM
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHCCCHHHH
SALSVRTPLRLNELVSLPIQSRASLARGIKVQAMRDRRLPRAVRAFLRQLLDALPPPRSP
HHHHHCCCCCHHHHHHCCCHHHHHHHHCCEEEHHHHCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]