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The map label for this gene is purQ [H]

Identifier: 170750749

GI number: 170750749

Start: 4624340

End: 4625020

Strand: Reverse

Name: purQ [H]

Synonym: Mrad2831_4360

Alternate gene names: 170750749

Gene position: 4625020-4624340 (Counterclockwise)

Preceding gene: 170750750

Following gene: 170750743

Centisome position: 76.1

GC content: 71.95

Gene sequence:

>681_bases
ATGCACGCCGCGGTCGTCGTCTTCCCGGGTTCCAACCGCGAGTCGGACGTCGTCCGGGCCCTGCGGCGCTCCGGCGCGCA
GGTGAGCCTCGTGTGGCACGCGGACCACGCGCTCCCCGCCGGCACCGACCTCGCCGTCCTGCCGGGTGGCTTCTCGTACG
GCGACTACCTGCGCTGCGGCGCCATCGCCGGCCGGGCCGCCGCCATGGACGCGGTCCGGGCCCACGCCGCCCGCGGCGGC
CTCGTGCTCGGCATCTGCAACGGCTTCCAGATCCTGTGCGAATCGGGGCTCCTGCCGGGCGTTCTGATGCGCAACATCGA
CCGGCGCTTCATCTGCCATCGGCAGACGCTCCGGGTCGAGCGCACCGACACCCGCTTCACCAGCGCCTACCGGCAGGGTC
AGGTCATCGACGTCTGCGTGGCCCACGGCGAAGGCAACTACTTCGCCGATCCCGAGACCCTGGCGCGGATCGAGGGCGAG
GGCCGGGTCGCCTTCCGCTACTGCGACGCGACCGGCGCGATCACCGTGGAGGCCAACCGCAACGGCTCCCTCAACGCCAT
CGCGGGCGTCCTGTCGGAGACCGGGAACGTCCTCGGGATGATGCCGCACCCGGAGAACTTCGTCGAGGACCTGATCGGCG
GGACCGACGGGCGCGGTCTGTTCGACAGTCTGGCGGCCTGA

Upstream 100 bases:

>100_bases
CGGCGGTCGACAGCGCCGCCGCCGAGGCGACCCTGCGCGCGGCCTGCGAGAAGCTCCTGGCCAACACCGTCGTCGAGAAC
TACGCGATCGAGATCCTCTG

Downstream 100 bases:

>100_bases
GATCGCCGGGCGAGAACCTGCCTTAACTCCGCATTAAGGTTTTCGAGGCATAAACAGGCATCCAGTGATCTGGATGTCGA
GTTGGACATATCCGTCCGCT

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MHAAVVVFPGSNRESDVVRALRRSGAQVSLVWHADHALPAGTDLAVLPGGFSYGDYLRCGAIAGRAAAMDAVRAHAARGG
LVLGICNGFQILCESGLLPGVLMRNIDRRFICHRQTLRVERTDTRFTSAYRQGQVIDVCVAHGEGNYFADPETLARIEGE
GRVAFRYCDATGAITVEANRNGSLNAIAGVLSETGNVLGMMPHPENFVEDLIGGTDGRGLFDSLAA

Sequences:

>Translated_226_residues
MHAAVVVFPGSNRESDVVRALRRSGAQVSLVWHADHALPAGTDLAVLPGGFSYGDYLRCGAIAGRAAAMDAVRAHAARGG
LVLGICNGFQILCESGLLPGVLMRNIDRRFICHRQTLRVERTDTRFTSAYRQGQVIDVCVAHGEGNYFADPETLARIEGE
GRVAFRYCDATGAITVEANRNGSLNAIAGVLSETGNVLGMMPHPENFVEDLIGGTDGRGLFDSLAA
>Mature_226_residues
MHAAVVVFPGSNRESDVVRALRRSGAQVSLVWHADHALPAGTDLAVLPGGFSYGDYLRCGAIAGRAAAMDAVRAHAARGG
LVLGICNGFQILCESGLLPGVLMRNIDRRFICHRQTLRVERTDTRFTSAYRQGQVIDVCVAHGEGNYFADPETLARIEGE
GRVAFRYCDATGAITVEANRNGSLNAIAGVLSETGNVLGMMPHPENFVEDLIGGTDGRGLFDSLAA

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=191, Percent_Identity=32.4607329842932, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI48994899, Length=177, Percent_Identity=39.5480225988701, Blast_Score=83, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17553022, Length=234, Percent_Identity=26.4957264957265, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321498, Length=182, Percent_Identity=34.6153846153846, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24582111, Length=233, Percent_Identity=31.7596566523605, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24582109, Length=233, Percent_Identity=31.7596566523605, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17137292, Length=233, Percent_Identity=31.7596566523605, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR011698
- InterPro:   IPR010075 [H]

Pfam domain/function: PF07685 GATase_3 [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 24042; Mature: 24042

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAAVVVFPGSNRESDVVRALRRSGAQVSLVWHADHALPAGTDLAVLPGGFSYGDYLRCG
CCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEECCCCCCCCHHHHH
AIAGRAAAMDAVRAHAARGGLVLGICNGFQILCESGLLPGVLMRNIDRRFICHRQTLRVE
HHCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCHHHHHHHCHHHHHHHHHHEEEE
RTDTRFTSAYRQGQVIDVCVAHGEGNYFADPETLARIEGEGRVAFRYCDATGAITVEANR
CCCHHHHHHHHCCCEEEEEEEECCCCEECCHHHHEEECCCCEEEEEEECCCCEEEEEECC
NGSLNAIAGVLSETGNVLGMMPHPENFVEDLIGGTDGRGLFDSLAA
CCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCCCHHHHHCC
>Mature Secondary Structure
MHAAVVVFPGSNRESDVVRALRRSGAQVSLVWHADHALPAGTDLAVLPGGFSYGDYLRCG
CCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEECCCCCCCCHHHHH
AIAGRAAAMDAVRAHAARGGLVLGICNGFQILCESGLLPGVLMRNIDRRFICHRQTLRVE
HHCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCHHHHHHHCHHHHHHHHHHEEEE
RTDTRFTSAYRQGQVIDVCVAHGEGNYFADPETLARIEGEGRVAFRYCDATGAITVEANR
CCCHHHHHHHHCCCEEEEEEEECCCCEECCHHHHEEECCCCEEEEEEECCCCEEEEEECC
NGSLNAIAGVLSETGNVLGMMPHPENFVEDLIGGTDGRGLFDSLAA
CCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]