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The map label for this gene is mdtA [H]

Identifier: 170750708

GI number: 170750708

Start: 4574607

End: 4575989

Strand: Reverse

Name: mdtA [H]

Synonym: Mrad2831_4319

Alternate gene names: 170750708

Gene position: 4575989-4574607 (Counterclockwise)

Preceding gene: 170750709

Following gene: 170750707

Centisome position: 75.29

GC content: 71.66

Gene sequence:

>1383_bases
ATGAACGAGAGTTCACCGATCCGGACCGACACGGCCCGCGCCTACCAGCCCGGCGAGGCGCCCGCGCGCGAGGTCCGGAC
GCGGCGCTTCCGGCCGATCCGCTGGCTCGTGATCCTGGTGCTGCTCGCCGGCGCCGGGGCGATCGGGCACCGCTGGTACG
AGGCCCGCACCGACAGGGGTGCCGAGCCCGCGACGGCGCACCGGACCGGCGGCCGCGGCGGCCGGCACGGCGGCTCCGAC
ATGCCGCAGGCGGTGGGTATCGCCAGCGTCACGACCGGCGACATGCCGGTGGTGCTGCAGGGCCTCGGCACCGTGACGCC
GCTCGCCACCGTGACGGTGAAGTCGCAGATCAGCGGCTACCTCACGCAGGTGCAGTTCCGGGAGGGCCAGACCGTGAAGG
CGGGCGACGAGCTCGCCCGGATCGATGCCCGCCCCTACGAGGCGCTGCTCGCCCAGTATCAGGGCCAGCTCGCCCGCGAT
CAGGCGCTGCTCCAGAACTCGAAGCTCGACCTGCAGCGCTATCAGACGCTGAACCGGCAGGACTCGATCTCGAAGCAGAA
CGTCGACACGCAGGCCGCGCTGGTGAAGCAGAACGAGGGCACGGTCGCGGCCGACCAGGCGCTCGTCGACCAGCAGAGGC
TCAACATCGCCTACACGCACATCACGTCGCCCGTGGACGGCCGGGTCGGCCTGCGCCAGGTCGACCAGGGCAACTACATC
TCGGCCGCCTCCACGGCGATCGTGGTGGTGACCCAGCTCCACCCGATCTCGGTGGTCTTCACCCTGCCGGAGGACGACGT
GTCGCGGGTGATGCGGCAGGTGCGGGCGGGCGCGAAGCTCACCGTGCGGGCCTACGACCGCGGCGACGCCCACGAGATCG
CCACCGGCCGCCTCGACACGGTCGACAACCAGATCGACACGACCACCGGCACGGTGAAGCTGCGCGCGCTGTTCGACAAC
GCCGACGAGGAGCTGTTCCCGAACCAGTTCGTCAACGCCAAGCTGACCGTCGACACGGTGCGGGGCGCGACGCTGGTGCC
GAATTCCAGCCTGCTCCAGGGCACGCCCGGCACCTACGTCTACCTGATGGACGGGGACAGCAAGGTCACGGTCCGGCCGA
TCAAGACCGGCGAGACCGACGGCACCACCACCGTGGTGGTCTCCGGCCTCAAGCCGGGCGACCGGGTCGTCACGGACGGC
ACCGACCGGCTGAAGGACGGCGCGCCGGTGCGGATCACCGAGGGCGCACAGGCGGCTGCGGGTGACGGGAAGGCTGCCGA
GAAGGCTGATGGCCGCCCCGGTGCACCGACCGAGGCTGCGGCGGCGGATTCGCAGGGGACAGCGGAGGGCGGTCGTCGGC
ACCGGCGCCGTCAGGCGCAGTGA

Upstream 100 bases:

>100_bases
CTTCCGGGACGCGGCGTTCCGGAGGCGGCATGGGGGCTTGGACAGCGAGGGATAGGGTGCCGCCGGTCGCGCTGACGACC
GTCCTGTGCTCTAGTCAGGC

Downstream 100 bases:

>100_bases
GGGGATTGGCCGCGCGCGTGTGCGGCTTCCCCCCCTCTCCCCGCACGCGGGGAGAGGGCTCCGGCGACCTCGTCGTCGCC
GGAGCGAGGCGGCAGCCGAA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MNESSPIRTDTARAYQPGEAPAREVRTRRFRPIRWLVILVLLAGAGAIGHRWYEARTDRGAEPATAHRTGGRGGRHGGSD
MPQAVGIASVTTGDMPVVLQGLGTVTPLATVTVKSQISGYLTQVQFREGQTVKAGDELARIDARPYEALLAQYQGQLARD
QALLQNSKLDLQRYQTLNRQDSISKQNVDTQAALVKQNEGTVAADQALVDQQRLNIAYTHITSPVDGRVGLRQVDQGNYI
SAASTAIVVVTQLHPISVVFTLPEDDVSRVMRQVRAGAKLTVRAYDRGDAHEIATGRLDTVDNQIDTTTGTVKLRALFDN
ADEELFPNQFVNAKLTVDTVRGATLVPNSSLLQGTPGTYVYLMDGDSKVTVRPIKTGETDGTTTVVVSGLKPGDRVVTDG
TDRLKDGAPVRITEGAQAAAGDGKAAEKADGRPGAPTEAAAADSQGTAEGGRRHRRRQAQ

Sequences:

>Translated_460_residues
MNESSPIRTDTARAYQPGEAPAREVRTRRFRPIRWLVILVLLAGAGAIGHRWYEARTDRGAEPATAHRTGGRGGRHGGSD
MPQAVGIASVTTGDMPVVLQGLGTVTPLATVTVKSQISGYLTQVQFREGQTVKAGDELARIDARPYEALLAQYQGQLARD
QALLQNSKLDLQRYQTLNRQDSISKQNVDTQAALVKQNEGTVAADQALVDQQRLNIAYTHITSPVDGRVGLRQVDQGNYI
SAASTAIVVVTQLHPISVVFTLPEDDVSRVMRQVRAGAKLTVRAYDRGDAHEIATGRLDTVDNQIDTTTGTVKLRALFDN
ADEELFPNQFVNAKLTVDTVRGATLVPNSSLLQGTPGTYVYLMDGDSKVTVRPIKTGETDGTTTVVVSGLKPGDRVVTDG
TDRLKDGAPVRITEGAQAAAGDGKAAEKADGRPGAPTEAAAADSQGTAEGGRRHRRRQAQ
>Mature_460_residues
MNESSPIRTDTARAYQPGEAPAREVRTRRFRPIRWLVILVLLAGAGAIGHRWYEARTDRGAEPATAHRTGGRGGRHGGSD
MPQAVGIASVTTGDMPVVLQGLGTVTPLATVTVKSQISGYLTQVQFREGQTVKAGDELARIDARPYEALLAQYQGQLARD
QALLQNSKLDLQRYQTLNRQDSISKQNVDTQAALVKQNEGTVAADQALVDQQRLNIAYTHITSPVDGRVGLRQVDQGNYI
SAASTAIVVVTQLHPISVVFTLPEDDVSRVMRQVRAGAKLTVRAYDRGDAHEIATGRLDTVDNQIDTTTGTVKLRALFDN
ADEELFPNQFVNAKLTVDTVRGATLVPNSSLLQGTPGTYVYLMDGDSKVTVRPIKTGETDGTTTVVVSGLKPGDRVVTDG
TDRLKDGAPVRITEGAQAAAGDGKAAEKADGRPGAPTEAAAADSQGTAEGGRRHRRRQAQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=391, Percent_Identity=44.5012787723785, Blast_Score=325, Evalue=3e-90,
Organism=Escherichia coli, GI1786668, Length=365, Percent_Identity=33.6986301369863, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1789929, Length=396, Percent_Identity=29.040404040404, Blast_Score=148, Evalue=9e-37,
Organism=Escherichia coli, GI1789665, Length=310, Percent_Identity=30.9677419354839, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI87081951, Length=252, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 49289; Mature: 49289

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNESSPIRTDTARAYQPGEAPAREVRTRRFRPIRWLVILVLLAGAGAIGHRWYEARTDRG
CCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
AEPATAHRTGGRGGRHGGSDMPQAVGIASVTTGDMPVVLQGLGTVTPLATVTVKSQISGY
CCCCCCCCCCCCCCCCCCCCCCHHHCEEEEECCCCHHHHHHCCCCCCCEEEEEHHHHHHH
LTQVQFREGQTVKAGDELARIDARPYEALLAQYQGQLARDQALLQNSKLDLQRYQTLNRQ
HEEEEECCCCEEECCCHHHHCCCCHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHCCHH
DSISKQNVDTQAALVKQNEGTVAADQALVDQQRLNIAYTHITSPVDGRVGLRQVDQGNYI
HCCHHCCCCCHHHEEECCCCCEEHHHHHHHHHHCEEEEEEECCCCCCCCCCEECCCCCEE
SAASTAIVVVTQLHPISVVFTLPEDDVSRVMRQVRAGAKLTVRAYDRGDAHEIATGRLDT
ECCCEEEEEEEEECEEEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHCCCCCCC
VDNQIDTTTGTVKLRALFDNADEELFPNQFVNAKLTVDTVRGATLVPNSSLLQGTPGTYV
CCCCCCCCCCEEEEEEEECCCCHHHCCCHHCCCEEEEEECCCEEECCCCCCCCCCCCCEE
YLMDGDSKVTVRPIKTGETDGTTTVVVSGLKPGDRVVTDGTDRLKDGAPVRITEGAQAAA
EEEECCCEEEEEEEECCCCCCCEEEEEECCCCCCEEEECCHHHHCCCCCEEEECCCCCCC
GDGKAAEKADGRPGAPTEAAAADSQGTAEGGRRHRRRQAQ
CCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNESSPIRTDTARAYQPGEAPAREVRTRRFRPIRWLVILVLLAGAGAIGHRWYEARTDRG
CCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
AEPATAHRTGGRGGRHGGSDMPQAVGIASVTTGDMPVVLQGLGTVTPLATVTVKSQISGY
CCCCCCCCCCCCCCCCCCCCCCHHHCEEEEECCCCHHHHHHCCCCCCCEEEEEHHHHHHH
LTQVQFREGQTVKAGDELARIDARPYEALLAQYQGQLARDQALLQNSKLDLQRYQTLNRQ
HEEEEECCCCEEECCCHHHHCCCCHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHCCHH
DSISKQNVDTQAALVKQNEGTVAADQALVDQQRLNIAYTHITSPVDGRVGLRQVDQGNYI
HCCHHCCCCCHHHEEECCCCCEEHHHHHHHHHHCEEEEEEECCCCCCCCCCEECCCCCEE
SAASTAIVVVTQLHPISVVFTLPEDDVSRVMRQVRAGAKLTVRAYDRGDAHEIATGRLDT
ECCCEEEEEEEEECEEEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHCCCCCCC
VDNQIDTTTGTVKLRALFDNADEELFPNQFVNAKLTVDTVRGATLVPNSSLLQGTPGTYV
CCCCCCCCCCEEEEEEEECCCCHHHCCCHHCCCEEEEEECCCEEECCCCCCCCCCCCCEE
YLMDGDSKVTVRPIKTGETDGTTTVVVSGLKPGDRVVTDGTDRLKDGAPVRITEGAQAAA
EEEECCCEEEEEEEECCCCCCCEEEEEECCCCCCEEEECCHHHHCCCCCEEEECCCCCCC
GDGKAAEKADGRPGAPTEAAAADSQGTAEGGRRHRRRQAQ
CCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA