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The map label for this gene is mro [H]

Identifier: 170750507

GI number: 170750507

Start: 4368383

End: 4369423

Strand: Direct

Name: mro [H]

Synonym: Mrad2831_4114

Alternate gene names: 170750507

Gene position: 4368383-4369423 (Clockwise)

Preceding gene: 170750506

Following gene: 170750514

Centisome position: 71.87

GC content: 73.68

Gene sequence:

>1041_bases
ATGCCGGCCGAACCGTTCGGCACGACGGCGGACGGCCGATCGGTCAGCCGCCACACCCTGAGCCGGGGCAGCCTGCGCGT
CGCCGTCATCGAGTACGGTGCGGCCGTCACGGCGATCGAGGTGCCCGACCGCGCCGGCCATCCGGCCAACGTCGTGCTCG
GCCTCGGCACCCTGGCGGGCTACGAGACCGTGAGCCCGAGCTTCGGCGCGATCGTCGGCCGCTACGCGAACCGCATCGCG
GGCGGGCGCTTCAGCCTCGACGGGCACGGCTACCGATTGCCGGTGAACGAGGCCCCCAACACCCTCCACGGGGGCCCGGA
GAATTTCGGCCGGCGCCTGTGGCGGGCGGAGCTCTCCGACGCGGCGCGCCTCGTCCTGGTCCGGCGCTCGCCGGACGGGG
AGGAGGGGTTTCCCGGCAATCTCGACGTCCGCGTCACCTACAGCCTGCCCGAGGACGGCGTGCTGCGCGTCGACTACGCC
GCGGTGACCGACCGGCCCACGATCCTGAACCTCACGAATCACAGCTACTTCAACCTCGCCGGCGAGGGGACGGGCAGCGT
CCTCGACCACCTCGTGCAGGTCGAGGCGGACGCCTTCGCGCCGACCGACGCGACCCAGATCCCCACCGGCGCGCTCCTGC
CGGTCGCCGGGACGCCGTTCGACTTCCGCACGCCGCGGGCCCTGGAGGCGCGGATCCGCGCCGGAGACCCGCAGCTCACC
TACGCCAAGGGCTACGACCACACCTTCGCGCTGCGCGGGGCCGCCGGGACGCTGCGGCCGGCCGCCAGCTGCGTCGATCC
CGGAAGCGGGCGGCGGCTCGACGTCTGGACCACCCAGCCGGCGCTGCAGCTCTACAGCGGCAACAACCTCGACGGGCGGC
TGATCGGTCCGTCCGGGCGGATCTACCGCTCGGGCGACGGCGTCTGCTTCGAGACCCAGGGCTTTCCGGACGCGCCGAAC
CAGCCGGGCTTCCCGTCCGCGGTCCTGCGGCCGGGCGAGACCTTCGCGGCCGCCACGGAGTTCCGGTTCTCGGTCGTGTG
A

Upstream 100 bases:

>100_bases
AACGGCGGCGGTCGCGCCTCTCCGGAGGCGAGCCCCGAGCTGGTCGCGGCCGAGGACCACGCCCGGAGCGAGCGGCTCGG
CGTCTGGAAGCGCTAGCCGG

Downstream 100 bases:

>100_bases
CGGCCGCACCGCGCGGGCCTTCCGGGGGCGCGGCGTCGCCACCGGCGGAGGGCCGGACCGGTCGTCCCCGCGCGCTCAGG
CCGCCGCGCGGTCGACCGCC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MPAEPFGTTADGRSVSRHTLSRGSLRVAVIEYGAAVTAIEVPDRAGHPANVVLGLGTLAGYETVSPSFGAIVGRYANRIA
GGRFSLDGHGYRLPVNEAPNTLHGGPENFGRRLWRAELSDAARLVLVRRSPDGEEGFPGNLDVRVTYSLPEDGVLRVDYA
AVTDRPTILNLTNHSYFNLAGEGTGSVLDHLVQVEADAFAPTDATQIPTGALLPVAGTPFDFRTPRALEARIRAGDPQLT
YAKGYDHTFALRGAAGTLRPAASCVDPGSGRRLDVWTTQPALQLYSGNNLDGRLIGPSGRIYRSGDGVCFETQGFPDAPN
QPGFPSAVLRPGETFAAATEFRFSVV

Sequences:

>Translated_346_residues
MPAEPFGTTADGRSVSRHTLSRGSLRVAVIEYGAAVTAIEVPDRAGHPANVVLGLGTLAGYETVSPSFGAIVGRYANRIA
GGRFSLDGHGYRLPVNEAPNTLHGGPENFGRRLWRAELSDAARLVLVRRSPDGEEGFPGNLDVRVTYSLPEDGVLRVDYA
AVTDRPTILNLTNHSYFNLAGEGTGSVLDHLVQVEADAFAPTDATQIPTGALLPVAGTPFDFRTPRALEARIRAGDPQLT
YAKGYDHTFALRGAAGTLRPAASCVDPGSGRRLDVWTTQPALQLYSGNNLDGRLIGPSGRIYRSGDGVCFETQGFPDAPN
QPGFPSAVLRPGETFAAATEFRFSVV
>Mature_345_residues
PAEPFGTTADGRSVSRHTLSRGSLRVAVIEYGAAVTAIEVPDRAGHPANVVLGLGTLAGYETVSPSFGAIVGRYANRIAG
GRFSLDGHGYRLPVNEAPNTLHGGPENFGRRLWRAELSDAARLVLVRRSPDGEEGFPGNLDVRVTYSLPEDGVLRVDYAA
VTDRPTILNLTNHSYFNLAGEGTGSVLDHLVQVEADAFAPTDATQIPTGALLPVAGTPFDFRTPRALEARIRAGDPQLTY
AKGYDHTFALRGAAGTLRPAASCVDPGSGRRLDVWTTQPALQLYSGNNLDGRLIGPSGRIYRSGDGVCFETQGFPDAPNQ
PGFPSAVLRPGETFAAATEFRFSVV

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=335, Percent_Identity=47.1641791044776, Blast_Score=294, Evalue=7e-80,
Organism=Escherichia coli, GI1786971, Length=338, Percent_Identity=37.2781065088757, Blast_Score=220, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17557428, Length=326, Percent_Identity=30.9815950920245, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI115533334, Length=326, Percent_Identity=30.9815950920245, Blast_Score=174, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6324399, Length=310, Percent_Identity=30, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6322004, Length=341, Percent_Identity=30.791788856305, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319493, Length=327, Percent_Identity=27.82874617737, Blast_Score=102, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24659048, Length=355, Percent_Identity=37.1830985915493, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24668278, Length=352, Percent_Identity=35.2272727272727, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24583720, Length=341, Percent_Identity=36.3636363636364, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24668282, Length=343, Percent_Identity=34.9854227405248, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24641876, Length=361, Percent_Identity=29.9168975069252, Blast_Score=170, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 36744; Mature: 36613

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAEPFGTTADGRSVSRHTLSRGSLRVAVIEYGAAVTAIEVPDRAGHPANVVLGLGTLAG
CCCCCCCCCCCCCCHHHHHHCCCCEEEEEEECCCEEEEEECCCCCCCCCEEEEEECCCCC
YETVSPSFGAIVGRYANRIAGGRFSLDGHGYRLPVNEAPNTLHGGPENFGRRLWRAELSD
CCCCCCHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCC
AARLVLVRRSPDGEEGFPGNLDVRVTYSLPEDGVLRVDYAAVTDRPTILNLTNHSYFNLA
CEEEEEEEECCCCCCCCCCCEEEEEEEECCCCCEEEEEEEEECCCCEEEEECCCCEEEEE
GEGTGSVLDHLVQVEADAFAPTDATQIPTGALLPVAGTPFDFRTPRALEARIRAGDPQLT
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHEEECCCCCEE
YAKGYDHTFALRGAAGTLRPAASCVDPGSGRRLDVWTTQPALQLYSGNNLDGRLIGPSGR
EECCCCEEEEEECCCCCCCCHHHHCCCCCCCEEEEEECCCEEEEECCCCCCCEEECCCCC
IYRSGDGVCFETQGFPDAPNQPGFPSAVLRPGETFAAATEFRFSVV
EEECCCCEEEECCCCCCCCCCCCCCHHHCCCCCCEEEEEEEEEEEC
>Mature Secondary Structure 
PAEPFGTTADGRSVSRHTLSRGSLRVAVIEYGAAVTAIEVPDRAGHPANVVLGLGTLAG
CCCCCCCCCCCCCHHHHHHCCCCEEEEEEECCCEEEEEECCCCCCCCCEEEEEECCCCC
YETVSPSFGAIVGRYANRIAGGRFSLDGHGYRLPVNEAPNTLHGGPENFGRRLWRAELSD
CCCCCCHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCC
AARLVLVRRSPDGEEGFPGNLDVRVTYSLPEDGVLRVDYAAVTDRPTILNLTNHSYFNLA
CEEEEEEEECCCCCCCCCCCEEEEEEEECCCCCEEEEEEEEECCCCEEEEECCCCEEEEE
GEGTGSVLDHLVQVEADAFAPTDATQIPTGALLPVAGTPFDFRTPRALEARIRAGDPQLT
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHEEECCCCCEE
YAKGYDHTFALRGAAGTLRPAASCVDPGSGRRLDVWTTQPALQLYSGNNLDGRLIGPSGR
EECCCCEEEEEECCCCCCCCHHHHCCCCCCCEEEEEECCCEEEEECCCCCCCEEECCCCC
IYRSGDGVCFETQGFPDAPNQPGFPSAVLRPGETFAAATEFRFSVV
EEECCCCEEEECCCCCCCCCCCCCCHHHCCCCCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]