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The map label for this gene is mhpD [H]

Identifier: 170750460

GI number: 170750460

Start: 4317446

End: 4318303

Strand: Direct

Name: mhpD [H]

Synonym: Mrad2831_4067

Alternate gene names: 170750460

Gene position: 4317446-4318303 (Clockwise)

Preceding gene: 170750453

Following gene: 170750461

Centisome position: 71.04

GC content: 74.83

Gene sequence:

>858_bases
ATGTCACCCCGTCGGCCCTCACGCCGTTCGCCGATGACCGAGCCGATCTCCGCCGCGGCCCATGCCCGCACGATCCTGGC
CGCGCACGAGCATCGCCGCCCGATCGCGCCGCTGACCGACTGGGATCCGACCCTCGACCTGCCGGCGGCCTACCGGGTCG
CCGAGGCGGTCCGGGTCCTGCGCGGGGAGCGCGGTGAGCGGCCCGTCGGCTACAAGATCGGCTTCACCAACACGACCCTG
TGGGAGCGCTACGGCGTCCGGGCGCCAATCTGGGGGCACGTCTACGACACGACCCTGCGCGACCGGGCCGCGCTGACCGG
GCCGGTCCCGCTCGCCGCCTTCGTCGAGCCGCGGATCGAGCCTGAGATCGTGTTCGGGCTGGCGCGCGCGCCCGAGCCCG
GCATGGATGCCGAGGCGCTGATCGCCTGCCTCGACTGGGCGGCGAGCGGCTTCGAGATCGTGCAGTCGCTCTACCCCGGC
TGGCGCTTCGCGGCGCCCGACACGGTCGCGGCCTTCGGCCTGCACGGGCTGCTGGTGGTGGGCGAGCGGGTGCGGATCTC
CCCGGACGCGCGATCGGCCTGGATCGGCGACCTCGCGGGCTTCACCGTCGACCTGCTCCGGGACGAGGCCGTCGCGGACC
GGGGCGGCGGCCGCTGCGTGCTCGGGACGGGGCCGCTCGCGGCCCTGGCCCACCTCGTCGATGCGCTGGCTAACGATCCT
GTGGCCCCACCGCTCGCGGCCGGGACCGTCGTCACGACGGGCACGCTGACGGACGCGCTTTCCGTCGCCTCCGGTCAGCG
CTGGCGCACGCGCCTCGACGGGCTGCCGCTTCCCGGCATCGACCTTGCCCTGAGCTGA

Upstream 100 bases:

>100_bases
GGGCACCGGCGGCCGGCGAGGCGGGGACAAATCGCGCGTTCACGGCGGTGACGGCCCTGCGTAAGATCGGCGGCGCCGCG
ATCGAGGCGGCCCGACGCGG

Downstream 100 bases:

>100_bases
AAGGCCCGGCACGCGTTATCGTGCCGGGTTCGTGCAGTTTCCCGGCGGCTCCGGGACTCGGGCATTGGTGATGGTTAGCC
GACATGCCAAATGCTGGACC

Product: hydratase/decarboxylase

Products: NA

Alternate protein names: 2-hydroxypentadienoic acid hydratase [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MSPRRPSRRSPMTEPISAAAHARTILAAHEHRRPIAPLTDWDPTLDLPAAYRVAEAVRVLRGERGERPVGYKIGFTNTTL
WERYGVRAPIWGHVYDTTLRDRAALTGPVPLAAFVEPRIEPEIVFGLARAPEPGMDAEALIACLDWAASGFEIVQSLYPG
WRFAAPDTVAAFGLHGLLVVGERVRISPDARSAWIGDLAGFTVDLLRDEAVADRGGGRCVLGTGPLAALAHLVDALANDP
VAPPLAAGTVVTTGTLTDALSVASGQRWRTRLDGLPLPGIDLALS

Sequences:

>Translated_285_residues
MSPRRPSRRSPMTEPISAAAHARTILAAHEHRRPIAPLTDWDPTLDLPAAYRVAEAVRVLRGERGERPVGYKIGFTNTTL
WERYGVRAPIWGHVYDTTLRDRAALTGPVPLAAFVEPRIEPEIVFGLARAPEPGMDAEALIACLDWAASGFEIVQSLYPG
WRFAAPDTVAAFGLHGLLVVGERVRISPDARSAWIGDLAGFTVDLLRDEAVADRGGGRCVLGTGPLAALAHLVDALANDP
VAPPLAAGTVVTTGTLTDALSVASGQRWRTRLDGLPLPGIDLALS
>Mature_284_residues
SPRRPSRRSPMTEPISAAAHARTILAAHEHRRPIAPLTDWDPTLDLPAAYRVAEAVRVLRGERGERPVGYKIGFTNTTLW
ERYGVRAPIWGHVYDTTLRDRAALTGPVPLAAFVEPRIEPEIVFGLARAPEPGMDAEALIACLDWAASGFEIVQSLYPGW
RFAAPDTVAAFGLHGLLVVGERVRISPDARSAWIGDLAGFTVDLLRDEAVADRGGGRCVLGTGPLAALAHLVDALANDPV
APPLAAGTVVTTGTLTDALSVASGQRWRTRLDGLPLPGIDLALS

Specific function: Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid [H]

COG id: COG3971

COG function: function code Q; 2-keto-4-pentenoate hydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hydratase/decarboxylase family. MhpD subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081722, Length=250, Percent_Identity=28.4, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: =4.2.1.80 [H]

Molecular weight: Translated: 30462; Mature: 30331

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPRRPSRRSPMTEPISAAAHARTILAAHEHRRPIAPLTDWDPTLDLPAAYRVAEAVRVL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
RGERGERPVGYKIGFTNTTLWERYGVRAPIWGHVYDTTLRDRAALTGPVPLAAFVEPRIE
HCCCCCCCCCEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCC
PEIVFGLARAPEPGMDAEALIACLDWAASGFEIVQSLYPGWRFAAPDTVAAFGLHGLLVV
HHHEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCEECCCHHHHHHHHHEEEEE
GERVRISPDARSAWIGDLAGFTVDLLRDEAVADRGGGRCVLGTGPLAALAHLVDALANDP
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCC
VAPPLAAGTVVTTGTLTDALSVASGQRWRTRLDGLPLPGIDLALS
CCCCCCCCCEEECCHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SPRRPSRRSPMTEPISAAAHARTILAAHEHRRPIAPLTDWDPTLDLPAAYRVAEAVRVL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
RGERGERPVGYKIGFTNTTLWERYGVRAPIWGHVYDTTLRDRAALTGPVPLAAFVEPRIE
HCCCCCCCCCEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCC
PEIVFGLARAPEPGMDAEALIACLDWAASGFEIVQSLYPGWRFAAPDTVAAFGLHGLLVV
HHHEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCEECCCHHHHHHHHHEEEEE
GERVRISPDARSAWIGDLAGFTVDLLRDEAVADRGGGRCVLGTGPLAALAHLVDALANDP
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCC
VAPPLAAGTVVTTGTLTDALSVASGQRWRTRLDGLPLPGIDLALS
CCCCCCCCCEEECCHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA