Click here to switch to the map view.

The map label for this gene is lysA [H]

Identifier: 170750439

GI number: 170750439

Start: 4289175

End: 4290443

Strand: Direct

Name: lysA [H]

Synonym: Mrad2831_4044

Alternate gene names: 170750439

Gene position: 4289175-4290443 (Clockwise)

Preceding gene: 170750438

Following gene: 170750440

Centisome position: 70.57

GC content: 72.1

Gene sequence:

>1269_bases
ATGCACCACTTCCACTATCGCGACGGCCGCCTGCACGCCGAGGAGGTCGACCTGACCGGCCTCGCCGCGGAGGTCGGCAC
ACCGTTCTACTGCTACAGCACCGCCACGCTGGAGCGGCACTACCGCGTGTTCGCGGAGGCGTTCGCGGCCGACGACGCGC
TGGTCTGCTTCGCCATGAAGGCGAACTCGAACCAGGCCGTCCTGCGGACCCTCGCGGCCCGGGGCGCCGGGATGGATATC
GTCTCCGGCGGCGAGCTGCAGCGGGCGCTGGCCGCCGGCGTGGATCCCGGGAAGATCGTGTTCTCGGGAGTGGGCAAGAG
CCGCGCCGAGATGGAGGCCGCGCTGACGGCCGGCATCTTCTGCTTCAACGTCGAGAGCGAGCCGGAGCTCGCGGTCCTGT
CCGAGGTGGCCGTGGGTCTCGGCCTCCGGGCGCCCGTCTCGGTCCGGGTGAACCCCGACGTGGATGCCGGCACGCACGCC
AAGATCTCCACCGGCAAGTACGAGAACAAGTTCGGCATCCCGATCACCCGGGCGCCGGCGGTCTACGCCGCCGCGGCCGC
CCTGCCGGGGATCGCGGTGCACGGCGTCGACATGCATATCGGCAGCCAGATCACCGATCTGGCGCCCTTCGCCGACGCGG
CCCGGCTGCTGGCCGGCCTCGCCCGGGAGCTGCTGGCGGCCGGCCATCCCCTGCGCCACATCGACTTCGGCGGCGGGCTC
GGGATCCCCTACCGCGACGACAACGCGCCGCCGCCGGACCCGGCGGCGCTGGCCGCGACCCTGCGGCCGCATTTCGCTCC
CCTCGGCCTGCGGCCGGTCTTCGAGATCGGCCGGATGATCGTCGGCAATGCCGGGATCCTGCTGACGCGGGTGCTCTACG
TGAAGCACAGCGAGGGACGGACCTTCGTGATCGTCGACGCGGCGATGAACGACCTGATCCGCCCGACCCTGTACGAGGCC
TATCACGGCCTGCGACCGGTCATCGAGCCGGGCCCCGAGACGTCGCGCCTCGTCGCCGACGTGGTCGGCCCGGTCTGCGA
GAGCGGCGACTATCTCGCGCTCAACCGCGAGATGCCGGAGGTGAGGCCCGGTGACCTGATCGCCGTGATGAGCGCCGGCG
CCTACGGGGCGGTGCAGTCCTGCACCTACAACACCCGGCCGCTGGTGCCGGAGGTTCTGGTGCGGGGCGACCGGGCGGCG
GTGGTCCGTCCGCGCCTCGACGTCGACGCGCTGATCGCCCTCGACCGGGTGCCGGACTGGCTGGCGTGA

Upstream 100 bases:

>100_bases
CCGGTCGGCGGCGCGCCCGCCGCGGCCCGCGGCGGGGTGTTTCACGGGAAACAGCCCGCGCTCCGGCGCGGACGAGACAC
GGCGACGAGACACGGCCGAG

Downstream 100 bases:

>100_bases
GCCGCGCTCCGGCGGGCGCCGCCTCCGCGCCGGCCCCGGGACCCGACGGGCCGCTGCCGCTGTCGGTCTTCATCATCGCC
CACAACGAGGTCGACCGGAT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MHHFHYRDGRLHAEEVDLTGLAAEVGTPFYCYSTATLERHYRVFAEAFAADDALVCFAMKANSNQAVLRTLAARGAGMDI
VSGGELQRALAAGVDPGKIVFSGVGKSRAEMEAALTAGIFCFNVESEPELAVLSEVAVGLGLRAPVSVRVNPDVDAGTHA
KISTGKYENKFGIPITRAPAVYAAAAALPGIAVHGVDMHIGSQITDLAPFADAARLLAGLARELLAAGHPLRHIDFGGGL
GIPYRDDNAPPPDPAALAATLRPHFAPLGLRPVFEIGRMIVGNAGILLTRVLYVKHSEGRTFVIVDAAMNDLIRPTLYEA
YHGLRPVIEPGPETSRLVADVVGPVCESGDYLALNREMPEVRPGDLIAVMSAGAYGAVQSCTYNTRPLVPEVLVRGDRAA
VVRPRLDVDALIALDRVPDWLA

Sequences:

>Translated_422_residues
MHHFHYRDGRLHAEEVDLTGLAAEVGTPFYCYSTATLERHYRVFAEAFAADDALVCFAMKANSNQAVLRTLAARGAGMDI
VSGGELQRALAAGVDPGKIVFSGVGKSRAEMEAALTAGIFCFNVESEPELAVLSEVAVGLGLRAPVSVRVNPDVDAGTHA
KISTGKYENKFGIPITRAPAVYAAAAALPGIAVHGVDMHIGSQITDLAPFADAARLLAGLARELLAAGHPLRHIDFGGGL
GIPYRDDNAPPPDPAALAATLRPHFAPLGLRPVFEIGRMIVGNAGILLTRVLYVKHSEGRTFVIVDAAMNDLIRPTLYEA
YHGLRPVIEPGPETSRLVADVVGPVCESGDYLALNREMPEVRPGDLIAVMSAGAYGAVQSCTYNTRPLVPEVLVRGDRAA
VVRPRLDVDALIALDRVPDWLA
>Mature_422_residues
MHHFHYRDGRLHAEEVDLTGLAAEVGTPFYCYSTATLERHYRVFAEAFAADDALVCFAMKANSNQAVLRTLAARGAGMDI
VSGGELQRALAAGVDPGKIVFSGVGKSRAEMEAALTAGIFCFNVESEPELAVLSEVAVGLGLRAPVSVRVNPDVDAGTHA
KISTGKYENKFGIPITRAPAVYAAAAALPGIAVHGVDMHIGSQITDLAPFADAARLLAGLARELLAAGHPLRHIDFGGGL
GIPYRDDNAPPPDPAALAATLRPHFAPLGLRPVFEIGRMIVGNAGILLTRVLYVKHSEGRTFVIVDAAMNDLIRPTLYEA
YHGLRPVIEPGPETSRLVADVVGPVCESGDYLALNREMPEVRPGDLIAVMSAGAYGAVQSCTYNTRPLVPEVLVRGDRAA
VVRPRLDVDALIALDRVPDWLA

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=361, Percent_Identity=25.7617728531856, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1789203, Length=434, Percent_Identity=33.8709677419355, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17562780, Length=365, Percent_Identity=21.6438356164384, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24586472, Length=369, Percent_Identity=23.3062330623306, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24586474, Length=349, Percent_Identity=23.2091690544413, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44801; Mature: 44801

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHFHYRDGRLHAEEVDLTGLAAEVGTPFYCYSTATLERHYRVFAEAFAADDALVCFAMK
CCCCCCCCCCCCHHHCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEEE
ANSNQAVLRTLAARGAGMDIVSGGELQRALAAGVDPGKIVFSGVGKSRAEMEAALTAGIF
CCCCHHHHHHHHHCCCCCEEECCCHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCEE
CFNVESEPELAVLSEVAVGLGLRAPVSVRVNPDVDAGTHAKISTGKYENKFGIPITRAPA
EEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEECCCH
VYAAAAALPGIAVHGVDMHIGSQITDLAPFADAARLLAGLARELLAAGHPLRHIDFGGGL
HHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GIPYRDDNAPPPDPAALAATLRPHFAPLGLRPVFEIGRMIVGNAGILLTRVLYVKHSEGR
CCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHEEEEEEECCCC
TFVIVDAAMNDLIRPTLYEAYHGLRPVIEPGPETSRLVADVVGPVCESGDYLALNREMPE
EEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCC
VRPGDLIAVMSAGAYGAVQSCTYNTRPLVPEVLVRGDRAAVVRPRLDVDALIALDRVPDW
CCCCCEEEEEECCCCCCHHHCCCCCCCCCHHHHHCCCCEEEECCCCCHHHHHHHHCCCCC
LA
CC
>Mature Secondary Structure
MHHFHYRDGRLHAEEVDLTGLAAEVGTPFYCYSTATLERHYRVFAEAFAADDALVCFAMK
CCCCCCCCCCCCHHHCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEEE
ANSNQAVLRTLAARGAGMDIVSGGELQRALAAGVDPGKIVFSGVGKSRAEMEAALTAGIF
CCCCHHHHHHHHHCCCCCEEECCCHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCEE
CFNVESEPELAVLSEVAVGLGLRAPVSVRVNPDVDAGTHAKISTGKYENKFGIPITRAPA
EEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEECCCH
VYAAAAALPGIAVHGVDMHIGSQITDLAPFADAARLLAGLARELLAAGHPLRHIDFGGGL
HHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GIPYRDDNAPPPDPAALAATLRPHFAPLGLRPVFEIGRMIVGNAGILLTRVLYVKHSEGR
CCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHEEEEEEECCCC
TFVIVDAAMNDLIRPTLYEAYHGLRPVIEPGPETSRLVADVVGPVCESGDYLALNREMPE
EEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCC
VRPGDLIAVMSAGAYGAVQSCTYNTRPLVPEVLVRGDRAAVVRPRLDVDALIALDRVPDW
CCCCCEEEEEECCCCCCHHHCCCCCCCCCHHHHHCCCCEEEECCCCCHHHHHHHHCCCCC
LA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]