| Definition | Methylobacterium radiotolerans JCM 2831 chromosome, complete genome. |
|---|---|
| Accession | NC_010505 |
| Length | 6,077,833 |
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The map label for this gene is fixR [H]
Identifier: 170750379
GI number: 170750379
Start: 4234783
End: 4235538
Strand: Direct
Name: fixR [H]
Synonym: Mrad2831_3982
Alternate gene names: 170750379
Gene position: 4234783-4235538 (Clockwise)
Preceding gene: 170750374
Following gene: 170750380
Centisome position: 69.68
GC content: 71.69
Gene sequence:
>756_bases TTGGCCCTCCCCGTCAACGAACGCCGGCGCATCATGCTGCTCACGGGCGCGAGCCGGGGCATCGGCCACGCCACCGTCAA GCGCTTCTCGGCCGCGGGCTGGCGGGTGATCACCTGCTCGCGCCACGCCTTCCCGGAGAACTGCCCCTGGGAGATGGGGC CCGAGGACCACCTGCAGGTCGACCTCGCCGACGCGCAGGACACGGTCCGCGCCGTCGAGGAGGTGCGGGGCCGGCTCGCC GCCGAGGGCGGGGTGCTGCACGCGCTGGTCAACAATGCCGGCATCTCGCCGAAGGGGCCGGAGGGCGAGCGCCTCGGCGC GCTGGCCACCGAGTTCGACACGTGGCAGCGGGTGTTCCAGGTCAACCTCTTCGCCACGATCCTGCTGGCCCGGGGCCTGC GCGAGGAACTGGCCCGGGCGAAGGGCTCGGTCGTCAACGTGACGTCGATCGCCGGCTCGCGCGTCCACCCCTTCGCGGGG GCAGCCTACGGCACCTCCAAGGCGGCTTTGGCGGGCCTGACCCGCGAGATGGCCGCCGATTTCGGACCGCTCGGCGTGCG GGTGAACGCGATCTCGCCGGGCGAGATCGACACGTCGATCCTGTCGCCCGGCACCGAGAAGCTCGTCGAGCAGATCCCGC AGCGCCGGCTCGGCACGCCGGACGAGGTCGCCAAGGCGATCTACTTCCTGTGCACCGAGGCCTCGTCCTACGTGAACGGG GCCGAACTCCACATCAACGGCGGCCAGCACGTTTGA
Upstream 100 bases:
>100_bases CTGGATTTCCGGTCCCCGTGCGCCTAGACCATTGGGGCTCACCGGCACGCACCGCGCCCGACCGGGCCGCGATCCCTGAA CGCCAGCGAGGCTTACGGCT
Downstream 100 bases:
>100_bases CCAGATCGGACGCTTCCTCGGGCGCGGCGTCCGCGCGCCGGAACCCGGCGGCGCGCCGCGGGCGGCGCGCGCTCGCCCTC AGCCTGCTCGCGTGCGTCGC
Product: short-chain dehydrogenase/reductase SDR
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 251; Mature: 250
Protein sequence:
>251_residues MALPVNERRRIMLLTGASRGIGHATVKRFSAAGWRVITCSRHAFPENCPWEMGPEDHLQVDLADAQDTVRAVEEVRGRLA AEGGVLHALVNNAGISPKGPEGERLGALATEFDTWQRVFQVNLFATILLARGLREELARAKGSVVNVTSIAGSRVHPFAG AAYGTSKAALAGLTREMAADFGPLGVRVNAISPGEIDTSILSPGTEKLVEQIPQRRLGTPDEVAKAIYFLCTEASSYVNG AELHINGGQHV
Sequences:
>Translated_251_residues MALPVNERRRIMLLTGASRGIGHATVKRFSAAGWRVITCSRHAFPENCPWEMGPEDHLQVDLADAQDTVRAVEEVRGRLA AEGGVLHALVNNAGISPKGPEGERLGALATEFDTWQRVFQVNLFATILLARGLREELARAKGSVVNVTSIAGSRVHPFAG AAYGTSKAALAGLTREMAADFGPLGVRVNAISPGEIDTSILSPGTEKLVEQIPQRRLGTPDEVAKAIYFLCTEASSYVNG AELHINGGQHV >Mature_250_residues ALPVNERRRIMLLTGASRGIGHATVKRFSAAGWRVITCSRHAFPENCPWEMGPEDHLQVDLADAQDTVRAVEEVRGRLAA EGGVLHALVNNAGISPKGPEGERLGALATEFDTWQRVFQVNLFATILLARGLREELARAKGSVVNVTSIAGSRVHPFAGA AYGTSKAALAGLTREMAADFGPLGVRVNAISPGEIDTSILSPGTEKLVEQIPQRRLGTPDEVAKAIYFLCTEASSYVNGA ELHINGGQHV
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=259, Percent_Identity=31.2741312741313, Blast_Score=100, Evalue=2e-21, Organism=Homo sapiens, GI32483357, Length=254, Percent_Identity=32.2834645669291, Blast_Score=99, Evalue=4e-21, Organism=Homo sapiens, GI7705925, Length=255, Percent_Identity=33.7254901960784, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI5031737, Length=250, Percent_Identity=32, Blast_Score=91, Evalue=1e-18, Organism=Homo sapiens, GI40254992, Length=244, Percent_Identity=29.5081967213115, Blast_Score=85, Evalue=7e-17, Organism=Homo sapiens, GI59889578, Length=241, Percent_Identity=28.6307053941909, Blast_Score=84, Evalue=2e-16, Organism=Homo sapiens, GI19923817, Length=264, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=1e-15, Organism=Homo sapiens, GI126723750, Length=251, Percent_Identity=29.0836653386454, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI119392083, Length=196, Percent_Identity=32.1428571428571, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI66933014, Length=182, Percent_Identity=29.1208791208791, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI10190704, Length=266, Percent_Identity=27.4436090225564, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI4503301, Length=244, Percent_Identity=28.2786885245902, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI20149619, Length=205, Percent_Identity=29.7560975609756, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI4504503, Length=226, Percent_Identity=30.5309734513274, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI4758504, Length=262, Percent_Identity=25.5725190839695, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI44680136, Length=218, Percent_Identity=28.8990825688073, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI44680133, Length=218, Percent_Identity=28.8990825688073, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI17738292, Length=218, Percent_Identity=28.8990825688073, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI33667109, Length=195, Percent_Identity=32.8205128205128, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI40548397, Length=200, Percent_Identity=25.5, Blast_Score=65, Evalue=5e-11, Organism=Homo sapiens, GI214010158, Length=200, Percent_Identity=25.5, Blast_Score=65, Evalue=5e-11, Organism=Homo sapiens, GI214010156, Length=200, Percent_Identity=25.5, Blast_Score=65, Evalue=5e-11, Organism=Homo sapiens, GI22758144, Length=200, Percent_Identity=25.5, Blast_Score=65, Evalue=5e-11, Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=27.9527559055118, Blast_Score=105, Evalue=3e-24, Organism=Escherichia coli, GI2367365, Length=246, Percent_Identity=33.739837398374, Blast_Score=97, Evalue=8e-22, Organism=Escherichia coli, GI1788459, Length=200, Percent_Identity=32, Blast_Score=92, Evalue=3e-20, Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=30.078125, Blast_Score=92, Evalue=4e-20, Organism=Escherichia coli, GI2367175, Length=257, Percent_Identity=31.9066147859922, Blast_Score=89, Evalue=3e-19, Organism=Escherichia coli, GI1786812, Length=249, Percent_Identity=30.9236947791165, Blast_Score=89, Evalue=4e-19, Organism=Escherichia coli, GI1787905, Length=254, Percent_Identity=30.7086614173228, Blast_Score=84, Evalue=8e-18, Organism=Escherichia coli, GI1790717, Length=254, Percent_Identity=28.3464566929134, Blast_Score=80, Evalue=9e-17, Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=27.2373540856031, Blast_Score=74, Evalue=7e-15, Organism=Escherichia coli, GI1787820, Length=233, Percent_Identity=29.1845493562232, Blast_Score=73, Evalue=2e-14, Organism=Escherichia coli, GI1789208, Length=183, Percent_Identity=30.0546448087432, Blast_Score=72, Evalue=5e-14, Organism=Escherichia coli, GI1789378, Length=271, Percent_Identity=26.5682656826568, Blast_Score=69, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=31.0483870967742, Blast_Score=113, Evalue=8e-26, Organism=Caenorhabditis elegans, GI17560676, Length=256, Percent_Identity=31.640625, Blast_Score=110, Evalue=5e-25, Organism=Caenorhabditis elegans, GI17562906, Length=259, Percent_Identity=33.5907335907336, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17560332, Length=260, Percent_Identity=31.1538461538462, Blast_Score=104, Evalue=4e-23, Organism=Caenorhabditis elegans, GI17562910, Length=258, Percent_Identity=30.2325581395349, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI193204405, Length=258, Percent_Identity=31.3953488372093, Blast_Score=99, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=31.8007662835249, Blast_Score=99, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17531453, Length=258, Percent_Identity=32.1705426356589, Blast_Score=98, Evalue=3e-21, Organism=Caenorhabditis elegans, GI115534694, Length=246, Percent_Identity=30.8943089430894, Blast_Score=95, Evalue=3e-20, Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=30.8880308880309, Blast_Score=94, Evalue=9e-20, Organism=Caenorhabditis elegans, GI17559104, Length=263, Percent_Identity=30.0380228136882, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17561402, Length=264, Percent_Identity=28.030303030303, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17562990, Length=259, Percent_Identity=32.4324324324324, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI72000259, Length=256, Percent_Identity=31.25, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17538480, Length=258, Percent_Identity=27.5193798449612, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17544670, Length=272, Percent_Identity=27.2058823529412, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=29.5454545454545, Blast_Score=87, Evalue=7e-18, Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=28.3464566929134, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=28.735632183908, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=30.0380228136882, Blast_Score=86, Evalue=3e-17, Organism=Caenorhabditis elegans, GI71994604, Length=260, Percent_Identity=29.6153846153846, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI17560220, Length=262, Percent_Identity=29.3893129770992, Blast_Score=84, Evalue=9e-17, Organism=Caenorhabditis elegans, GI17551412, Length=274, Percent_Identity=26.2773722627737, Blast_Score=84, Evalue=9e-17, Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=28.2442748091603, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17538486, Length=270, Percent_Identity=26.6666666666667, Blast_Score=77, Evalue=6e-15, Organism=Caenorhabditis elegans, GI17538182, Length=256, Percent_Identity=29.6875, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17536651, Length=265, Percent_Identity=26.4150943396226, Blast_Score=67, Evalue=9e-12, Organism=Caenorhabditis elegans, GI193207185, Length=144, Percent_Identity=34.0277777777778, Blast_Score=66, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17561272, Length=203, Percent_Identity=27.5862068965517, Blast_Score=65, Evalue=4e-11, Organism=Caenorhabditis elegans, GI17536025, Length=266, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=5e-11, Organism=Caenorhabditis elegans, GI17508651, Length=265, Percent_Identity=26.7924528301887, Blast_Score=64, Evalue=1e-10, Organism=Saccharomyces cerevisiae, GI6322067, Length=213, Percent_Identity=31.924882629108, Blast_Score=80, Evalue=2e-16, Organism=Saccharomyces cerevisiae, GI6324126, Length=142, Percent_Identity=30.9859154929577, Blast_Score=80, Evalue=4e-16, Organism=Saccharomyces cerevisiae, GI6322227, Length=201, Percent_Identity=30.3482587064677, Blast_Score=64, Evalue=2e-11, Organism=Drosophila melanogaster, GI23397609, Length=253, Percent_Identity=32.4110671936759, Blast_Score=116, Evalue=1e-26, Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=31.8897637795276, Blast_Score=113, Evalue=9e-26, Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=31.0756972111554, Blast_Score=104, Evalue=6e-23, Organism=Drosophila melanogaster, GI24643142, Length=256, Percent_Identity=34.375, Blast_Score=101, Evalue=5e-22, Organism=Drosophila melanogaster, GI24644337, Length=178, Percent_Identity=38.7640449438202, Blast_Score=101, Evalue=6e-22, Organism=Drosophila melanogaster, GI28571526, Length=259, Percent_Identity=31.2741312741313, Blast_Score=99, Evalue=3e-21, Organism=Drosophila melanogaster, GI21357041, Length=260, Percent_Identity=31.1538461538462, Blast_Score=97, Evalue=1e-20, Organism=Drosophila melanogaster, GI24644339, Length=257, Percent_Identity=32.6848249027237, Blast_Score=96, Evalue=2e-20, Organism=Drosophila melanogaster, GI17737361, Length=261, Percent_Identity=29.5019157088123, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI116007236, Length=243, Percent_Identity=27.9835390946502, Blast_Score=68, Evalue=6e-12, Organism=Drosophila melanogaster, GI21358495, Length=201, Percent_Identity=27.8606965174129, Blast_Score=64, Evalue=8e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 26813; Mature: 26682
Theoretical pI: Translated: 7.20; Mature: 7.20
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.8 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MALPVNERRRIMLLTGASRGIGHATVKRFSAAGWRVITCSRHAFPENCPWEMGPEDHLQV CCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEEE DLADAQDTVRAVEEVRGRLAAEGGVLHALVNNAGISPKGPEGERLGALATEFDTWQRVFQ EECCHHHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH VNLFATILLARGLREELARAKGSVVNVTSIAGSRVHPFAGAAYGTSKAALAGLTREMAAD HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC FGPLGVRVNAISPGEIDTSILSPGTEKLVEQIPQRRLGTPDEVAKAIYFLCTEASSYVNG CCCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC AELHINGGQHV EEEEECCCCCC >Mature Secondary Structure ALPVNERRRIMLLTGASRGIGHATVKRFSAAGWRVITCSRHAFPENCPWEMGPEDHLQV CCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEEE DLADAQDTVRAVEEVRGRLAAEGGVLHALVNNAGISPKGPEGERLGALATEFDTWQRVFQ EECCHHHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH VNLFATILLARGLREELARAKGSVVNVTSIAGSRVHPFAGAAYGTSKAALAGLTREMAAD HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC FGPLGVRVNAISPGEIDTSILSPGTEKLVEQIPQRRLGTPDEVAKAIYFLCTEASSYVNG CCCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC AELHINGGQHV EEEEECCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 3313281; 11157954; 12597275 [H]