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The map label for this gene is moaA [H]

Identifier: 170750295

GI number: 170750295

Start: 4145916

End: 4146968

Strand: Reverse

Name: moaA [H]

Synonym: Mrad2831_3898

Alternate gene names: 170750295

Gene position: 4146968-4145916 (Counterclockwise)

Preceding gene: 170750298

Following gene: 170750292

Centisome position: 68.23

GC content: 70.75

Gene sequence:

>1053_bases
ATGCTCGATGACAGCTCCCTGACGCCACAGGCGTCCGCGGTCGATGCCCCCGCCGGGCCGGCGCCGCTGATCGACCCGTT
CCAGCGGGCGATCTCGTACCTGCGCATCTCGGTGACGGATCGCTGCGACCTGCGCTGCGCCTACTGCATGTCCGAGCACA
TGGAGTTCCTGCCCAAGCGCGACCTGCTGACCCTGGAGGAGCTGGACCGGCTCTGCGGCGTGTTCATCGCCCGCGGCGTG
CGCAAGCTCCGGATCACCGGCGGCGAGCCGCTCGTGCGCCGCGACATCATGCACCTGTTCCGCCGGCTCTCGCGCCACCT
CGATTCGGGGGCGCTGGAGGAGCTGACGCTCACCACCAACGGCACGCAGCTCACGCGCTACGCCGACGAGCTGGCGAGCC
TCGGCGTGCGCCGGATCAACGTCTCGCTCGACACCCTCGACCCGGACAAGTTCCGGGAGATCACCCGCCGCGGCGACCTC
AAGGTGGTGCTCGACGGCATCGCGGCGGCCCGCGCCGCCGGGATGAAGGTGAAGATCAACGCGGTGGCGCTGCGCGACGT
CAACGCCGACGAGATCCCCGACATGATCGCCTGGGCCCACGGGCTCGGCATGGACATGACGCTGATCGAGGTCATGCCGC
TCGGCGAGATCGAGGCGGACCGGACCGACCAGTTCCTGCCCCTGTCGGTCGCCCGGCAGCGGCTGGAGACCCGCTACACC
CTCACACCCCTCCCCGACCGCACCGGCGGCCCGGCGCGCTACGTCCGCGTCGAGGAGACCGGCGGCAAGCTCGGCTTCAT
CACGCCGCTGACCCACAATTTCTGCGAGAGCTGCAACCGGGTCCGCCTGACCTGCACGGGCCAGCTCTACATGTGCCTGG
GCCAGGAGGATTCGGCCGACCTGCGCGCGGTTCTGCGCGCCTCCCAGGACGATTCGGTGCTGGCCGCGGCGGTGGTCGAG
GCGATCACCCGCAAGCCCAAGGGCCACGACTTCGTCATCGAGCGCCAGCGCCCGGCCGCCGTGCCGCGGCACATGAGCGT
GACGGGGGGGTAG

Upstream 100 bases:

>100_bases
GCCACAGATCCTCGGTCACGGGCCACACTCCTCACGCAATCTGGGGCTGCGGCGCGGGACCTGCTTGCCCGCGACCGCCG
GTGGCATCATATGCCGGACG

Downstream 100 bases:

>100_bases
GCGCCTCGACTGTCCCTGCGAGCGCGGCGAAGCAATCCAGGGCACCGGTCCCTTACGGGCGTAGCGCATCCCTGGGTCGC
TTCGCTGCGCTGGCAAAGAC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MLDDSSLTPQASAVDAPAGPAPLIDPFQRAISYLRISVTDRCDLRCAYCMSEHMEFLPKRDLLTLEELDRLCGVFIARGV
RKLRITGGEPLVRRDIMHLFRRLSRHLDSGALEELTLTTNGTQLTRYADELASLGVRRINVSLDTLDPDKFREITRRGDL
KVVLDGIAAARAAGMKVKINAVALRDVNADEIPDMIAWAHGLGMDMTLIEVMPLGEIEADRTDQFLPLSVARQRLETRYT
LTPLPDRTGGPARYVRVEETGGKLGFITPLTHNFCESCNRVRLTCTGQLYMCLGQEDSADLRAVLRASQDDSVLAAAVVE
AITRKPKGHDFVIERQRPAAVPRHMSVTGG

Sequences:

>Translated_350_residues
MLDDSSLTPQASAVDAPAGPAPLIDPFQRAISYLRISVTDRCDLRCAYCMSEHMEFLPKRDLLTLEELDRLCGVFIARGV
RKLRITGGEPLVRRDIMHLFRRLSRHLDSGALEELTLTTNGTQLTRYADELASLGVRRINVSLDTLDPDKFREITRRGDL
KVVLDGIAAARAAGMKVKINAVALRDVNADEIPDMIAWAHGLGMDMTLIEVMPLGEIEADRTDQFLPLSVARQRLETRYT
LTPLPDRTGGPARYVRVEETGGKLGFITPLTHNFCESCNRVRLTCTGQLYMCLGQEDSADLRAVLRASQDDSVLAAAVVE
AITRKPKGHDFVIERQRPAAVPRHMSVTGG
>Mature_350_residues
MLDDSSLTPQASAVDAPAGPAPLIDPFQRAISYLRISVTDRCDLRCAYCMSEHMEFLPKRDLLTLEELDRLCGVFIARGV
RKLRITGGEPLVRRDIMHLFRRLSRHLDSGALEELTLTTNGTQLTRYADELASLGVRRINVSLDTLDPDKFREITRRGDL
KVVLDGIAAARAAGMKVKINAVALRDVNADEIPDMIAWAHGLGMDMTLIEVMPLGEIEADRTDQFLPLSVARQRLETRYT
LTPLPDRTGGPARYVRVEETGGKLGFITPLTHNFCESCNRVRLTCTGQLYMCLGQEDSADLRAVLRASQDDSVLAAAVVE
AITRKPKGHDFVIERQRPAAVPRHMSVTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=315, Percent_Identity=37.4603174603175, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI22027536, Length=315, Percent_Identity=37.4603174603175, Blast_Score=199, Evalue=4e-51,
Organism=Escherichia coli, GI1786999, Length=333, Percent_Identity=32.1321321321321, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI32566331, Length=319, Percent_Identity=34.1692789968652, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI32566329, Length=323, Percent_Identity=33.7461300309598, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17561210, Length=322, Percent_Identity=34.472049689441, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI28574490, Length=315, Percent_Identity=39.0476190476191, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI28574488, Length=315, Percent_Identity=39.0476190476191, Blast_Score=201, Evalue=7e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38763; Mature: 38763

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDDSSLTPQASAVDAPAGPAPLIDPFQRAISYLRISVTDRCDLRCAYCMSEHMEFLPKR
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCC
DLLTLEELDRLCGVFIARGVRKLRITGGEPLVRRDIMHLFRRLSRHLDSGALEELTLTTN
CCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
GTQLTRYADELASLGVRRINVSLDTLDPDKFREITRRGDLKVVLDGIAAARAAGMKVKIN
CCHHHHHHHHHHHCCEEEEEEEEECCCHHHHHHHHHCCCEEEEEHHHHHHHHCCCEEEEE
AVALRDVNADEIPDMIAWAHGLGMDMTLIEVMPLGEIEADRTDQFLPLSVARQRLETRYT
EEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCEE
LTPLPDRTGGPARYVRVEETGGKLGFITPLTHNFCESCNRVRLTCTGQLYMCLGQEDSAD
ECCCCCCCCCCEEEEEEECCCCCEEEECHHHHHHHHCCCCEEEEEECEEEEEECCCCCHH
LRAVLRASQDDSVLAAAVVEAITRKPKGHDFVIERQRPAAVPRHMSVTGG
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCEECCCC
>Mature Secondary Structure
MLDDSSLTPQASAVDAPAGPAPLIDPFQRAISYLRISVTDRCDLRCAYCMSEHMEFLPKR
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCC
DLLTLEELDRLCGVFIARGVRKLRITGGEPLVRRDIMHLFRRLSRHLDSGALEELTLTTN
CCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
GTQLTRYADELASLGVRRINVSLDTLDPDKFREITRRGDLKVVLDGIAAARAAGMKVKIN
CCHHHHHHHHHHHCCEEEEEEEEECCCHHHHHHHHHCCCEEEEEHHHHHHHHCCCEEEEE
AVALRDVNADEIPDMIAWAHGLGMDMTLIEVMPLGEIEADRTDQFLPLSVARQRLETRYT
EEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCEE
LTPLPDRTGGPARYVRVEETGGKLGFITPLTHNFCESCNRVRLTCTGQLYMCLGQEDSAD
ECCCCCCCCCCEEEEEEECCCCCEEEECHHHHHHHHCCCCEEEEEECEEEEEECCCCCHH
LRAVLRASQDDSVLAAAVVEAITRKPKGHDFVIERQRPAAVPRHMSVTGG
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]