Definition Methylobacterium radiotolerans JCM 2831 chromosome, complete genome.
Accession NC_010505
Length 6,077,833

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The map label for this gene is yciK [H]

Identifier: 170750290

GI number: 170750290

Start: 4139932

End: 4140681

Strand: Reverse

Name: yciK [H]

Synonym: Mrad2831_3893

Alternate gene names: 170750290

Gene position: 4140681-4139932 (Counterclockwise)

Preceding gene: 170750291

Following gene: 170750289

Centisome position: 68.13

GC content: 72.4

Gene sequence:

>750_bases
ATGGCTGAGTCTCAGAGAACCCTGGAAGGCCGCGTCGCGGTCGTCACCGGCGCATCGCGCGGCATCGGGCGCGCCGCCGC
CCTGGCTTTGGCCGGGGCCGGCGCGCACGTCATCGCGGTGGCCCGGACCGTGGGCGCCCTGGAGGAGCTCGACGACGCGA
TCCGCGCCGCCGGCTCCAGCGCCACCCTCGTGCCGTTCGACCTCGCCGATTACGACGCGATCGACCGCCTCGGCGCGGCG
ATCAACGAGCGCTGGAAGCGCCTCGACATCCTGGTCGCCAATGCCGGGATCCTGGGCGCGCTCATGCCGATCGGCCACAT
CACCCCGAAGATCTGGGGGCAGGTGATGGACGTGAACGTCACCGCCAACTGGCGCCTGATCCGCTCCCTCGACCCGCTGC
TGCGCATGTCGGACGCCGGCCGGGCGATCTTCGTCTCGTCGGGGGCCGCCTCGAAGTGTCGGCCCTACTGGGGGCCGTAC
TCGGTCTCGAAGGCGGCGCTGGAGGCCCTGGTGCGGACCTACGCGGCCGAGAACGAGACCACGGCGATCCGGGCCATGCT
GCTCAATCCGGGCCCCCTGCGGACCGGCATGCGCCGCTCGGCCATGCCGGGCGAGGACCCCGAGACCCTCCGGACGCCCG
AGGACCTCGCCCCCCATTTCGTGCGGCTCGCCGCGCCGGACTGGGCCGAGACCGGGAAGCTCTACGATTTCCCCACCGAC
CGGGTGCTGCGTTTCCGCGCGCCCGAGTAA

Upstream 100 bases:

>100_bases
CCGAAGCGCTTCGCCATGCTGGCCGAGGCCGACTGACAGGATCCGGCCGTTGCGCGCGAACGGGCATCCCCTGTGCGCGG
AAATGCGCTAGGTCCTCGCC

Downstream 100 bases:

>100_bases
AGGGGTCCGGGGCCTGCGGCCCCGGCGGGTGGCGGGCGGAGCCCGCCGGGTTTGGGATTTGCGATGATCGACGTCCGCTG
CATCTGCGCGATCGGCCTGC

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MAESQRTLEGRVAVVTGASRGIGRAAALALAGAGAHVIAVARTVGALEELDDAIRAAGSSATLVPFDLADYDAIDRLGAA
INERWKRLDILVANAGILGALMPIGHITPKIWGQVMDVNVTANWRLIRSLDPLLRMSDAGRAIFVSSGAASKCRPYWGPY
SVSKAALEALVRTYAAENETTAIRAMLLNPGPLRTGMRRSAMPGEDPETLRTPEDLAPHFVRLAAPDWAETGKLYDFPTD
RVLRFRAPE

Sequences:

>Translated_249_residues
MAESQRTLEGRVAVVTGASRGIGRAAALALAGAGAHVIAVARTVGALEELDDAIRAAGSSATLVPFDLADYDAIDRLGAA
INERWKRLDILVANAGILGALMPIGHITPKIWGQVMDVNVTANWRLIRSLDPLLRMSDAGRAIFVSSGAASKCRPYWGPY
SVSKAALEALVRTYAAENETTAIRAMLLNPGPLRTGMRRSAMPGEDPETLRTPEDLAPHFVRLAAPDWAETGKLYDFPTD
RVLRFRAPE
>Mature_248_residues
AESQRTLEGRVAVVTGASRGIGRAAALALAGAGAHVIAVARTVGALEELDDAIRAAGSSATLVPFDLADYDAIDRLGAAI
NERWKRLDILVANAGILGALMPIGHITPKIWGQVMDVNVTANWRLIRSLDPLLRMSDAGRAIFVSSGAASKCRPYWGPYS
VSKAALEALVRTYAAENETTAIRAMLLNPGPLRTGMRRSAMPGEDPETLRTPEDLAPHFVRLAAPDWAETGKLYDFPTDR
VLRFRAPE

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=230, Percent_Identity=30.8695652173913, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI109715829, Length=250, Percent_Identity=31.6, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI20149619, Length=206, Percent_Identity=31.0679611650485, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI126723191, Length=196, Percent_Identity=32.1428571428571, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI5031737, Length=231, Percent_Identity=29.8701298701299, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI33667109, Length=188, Percent_Identity=32.9787234042553, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4504505, Length=241, Percent_Identity=27.3858921161826, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI7657478, Length=218, Percent_Identity=27.5229357798165, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI4557649, Length=194, Percent_Identity=28.3505154639175, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI209862901, Length=214, Percent_Identity=30.8411214953271, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI19923983, Length=214, Percent_Identity=30.8411214953271, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI223718074, Length=199, Percent_Identity=28.643216080402, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI7705925, Length=212, Percent_Identity=29.2452830188679, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI126723750, Length=208, Percent_Identity=28.3653846153846, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787526, Length=237, Percent_Identity=37.9746835443038, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI87082100, Length=237, Percent_Identity=30.379746835443, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787335, Length=196, Percent_Identity=30.1020408163265, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI2367175, Length=194, Percent_Identity=30.9278350515464, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87082160, Length=231, Percent_Identity=29.4372294372294, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1789378, Length=233, Percent_Identity=30.9012875536481, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786812, Length=204, Percent_Identity=29.4117647058824, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790717, Length=199, Percent_Identity=27.1356783919598, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787820, Length=217, Percent_Identity=26.2672811059908, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786701, Length=203, Percent_Identity=28.0788177339901, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=241, Percent_Identity=28.6307053941909, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71994604, Length=201, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17551412, Length=222, Percent_Identity=31.5315315315315, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=245, Percent_Identity=30.6122448979592, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=206, Percent_Identity=30.0970873786408, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=214, Percent_Identity=30.8411214953271, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17538480, Length=201, Percent_Identity=32.3383084577114, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=212, Percent_Identity=32.0754716981132, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=222, Percent_Identity=28.3783783783784, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=201, Percent_Identity=34.3283582089552, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=241, Percent_Identity=25.3112033195021, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=201, Percent_Identity=32.3383084577114, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=202, Percent_Identity=31.1881188118812, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=235, Percent_Identity=31.9148936170213, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17536025, Length=191, Percent_Identity=27.7486910994764, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=199, Percent_Identity=32.1608040201005, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=197, Percent_Identity=30.4568527918782, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=224, Percent_Identity=26.7857142857143, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=204, Percent_Identity=27.9411764705882, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=215, Percent_Identity=32.093023255814, Blast_Score=85, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6322226, Length=207, Percent_Identity=29.4685990338164, Blast_Score=79, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322861, Length=227, Percent_Identity=30.3964757709251, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323882, Length=228, Percent_Identity=27.6315789473684, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355319, Length=204, Percent_Identity=30.3921568627451, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21357041, Length=194, Percent_Identity=31.9587628865979, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI23397609, Length=199, Percent_Identity=35.678391959799, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24643142, Length=192, Percent_Identity=36.4583333333333, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21358495, Length=204, Percent_Identity=28.4313725490196, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28571526, Length=204, Percent_Identity=31.3725490196078, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24644339, Length=203, Percent_Identity=29.5566502463054, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356301, Length=222, Percent_Identity=26.5765765765766, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18859837, Length=197, Percent_Identity=30.9644670050761, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281364494, Length=200, Percent_Identity=27.5, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 26712; Mature: 26581

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MAESQRTLEGRVAVVTGASRGIGRAAALALAGAGAHVIAVARTVGALEELDDAIRAAGSS
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
ATLVPFDLADYDAIDRLGAAINERWKRLDILVANAGILGALMPIGHITPKIWGQVMDVNV
CEEEEECCCCHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHCCHHHCCEEEEEEE
TANWRLIRSLDPLLRMSDAGRAIFVSSGAASKCRPYWGPYSVSKAALEALVRTYAAENET
ECCEEEHHHHCHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
TAIRAMLLNPGPLRTGMRRSAMPGEDPETLRTPEDLAPHFVRLAAPDWAETGKLYDFPTD
EEEEEEEECCCCCCCCCHHCCCCCCCHHHCCCCHHHCCCEEEECCCCHHHCCCEEECCCC
RVLRFRAPE
CEEEEECCC
>Mature Secondary Structure 
AESQRTLEGRVAVVTGASRGIGRAAALALAGAGAHVIAVARTVGALEELDDAIRAAGSS
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
ATLVPFDLADYDAIDRLGAAINERWKRLDILVANAGILGALMPIGHITPKIWGQVMDVNV
CEEEEECCCCHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHCCHHHCCEEEEEEE
TANWRLIRSLDPLLRMSDAGRAIFVSSGAASKCRPYWGPYSVSKAALEALVRTYAAENET
ECCEEEHHHHCHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
TAIRAMLLNPGPLRTGMRRSAMPGEDPETLRTPEDLAPHFVRLAAPDWAETGKLYDFPTD
EEEEEEEECCCCCCCCCHHCCCCCCCHHHCCCCHHHCCCEEEECCCCHHHCCCEEECCCC
RVLRFRAPE
CEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on the CH-OH group of donors; With NAD or NADP as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 1885549 [H]