Click here to switch to the map view.

The map label for this gene is fdh [H]

Identifier: 170750278

GI number: 170750278

Start: 4129929

End: 4131104

Strand: Direct

Name: fdh [H]

Synonym: Mrad2831_3881

Alternate gene names: 170750278

Gene position: 4129929-4131104 (Clockwise)

Preceding gene: 170750277

Following gene: 170750279

Centisome position: 67.95

GC content: 66.67

Gene sequence:

>1176_bases
ATGAAGGCACTGTGCTGGCACGGCCGCAACGACATCCGCTGCGACACGGTCCCAGATCCGGTCATCGAGGATTCCCGCGA
CGTCATCATCAAGGTCACGAGCTGCGCGATCTGCGGCTCGGACCTGCACCTGATGGACGGCCTGATGCCGACCATGAAGA
GCGGCGACGTCCTCGGCCACGAGTTCATGGGCGAGGTCGTCGAGGTCGGACAGGGCTTCACCAAGTTCAAGAAGGGCGAC
CGGATCGTCGTGCCCTTCAACATCAATTGCGGCGCGTGCCGCCAGTGCAAGCTCGGCAACTACTCGGTCTGCGAGCGCTC
GAACCGCAACGCCGAGATGGCGGCCGCGCAGTTCGGCTACACGACGGCCGGCCTGTTCGGCTACTCGCACCTCACCGGCG
GCTACGCGGGCGGTCAGGCCGAGTACGTGCGCGTGCCCATGGCGGATGTCGCGCCCATGAAGGTGCCGGACGGCATGGAC
GACGAGTCCGTCCTGTTCCTCACCGACATCCTGCCGACCGGCTGGCAGGGCGCGGAGCACTGCGAGATCCGGGGCGGCGA
GACGATCGCGGTCTGGGGCACCGGCCCTGTCGGCATCTTCGCGATCCAGTCGGCGAAGATCATGGGAGCCGAGCGGATCA
TCGCCATCGAGACCGTGCCCGAGCGGATCGCCCTCGCCCGCAAGGCCGGCGCCACCGACGTCATCGATTTCATGAACGAG
GACGTGTTCGAGCGGATCAAGGAGATCACCAAGGGCCAGGGCGCCGACGGCGTGATCGACTGCGTCGGCATGGAGGCGAG
CGCCGGCCACGGCGGCCTCACCGGCATGCTGTCGACGGTGCAGGAGAAGCTCACCGCCACCGAGCGGCCCTACGCGCTGG
CCGAGGCCATCAAGGCGGTCCGTCCCTGCGGGATCGTCTCGGTGCCCGGCGTCTACGGCGGGCCGATCCCGGTCAACATG
GGCTCGATCGTCCAGAAGGGCCTGACCCTCAAGAGCGGCCAGACCCACGTGAAGCGCTACCTCGAGCCGCTGACCAAGCT
GATCCAGGAGGGCAAGATCGACATGACCTCCCTGATCACACACCGCTCGCAGAACCTCGCGGAGGGGCCAGACCTCTACA
AGACCTTCCGCGACAAGAAGGACGGCTGCGTGAAGGTGGTGTTCCACCTGAACTGA

Upstream 100 bases:

>100_bases
GCGGGGCGCGCCGCCGCCGGAACTTGGCCGCACCGAAGCGGGCTTTACGGGAGAACGGCCGAGTTGGCCGCGACCCCGAG
AGCTTCCGGAGACACGACGC

Downstream 100 bases:

>100_bases
GGCGACGGCGCCCCGGCCACGGATCGGCCGGGGCATTCGCTCCGCCCGGCTGGTCGCGGCGTCCCGGACGCGTGTAGAGC
CGGCGCAGTGCTCACCAACC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MKALCWHGRNDIRCDTVPDPVIEDSRDVIIKVTSCAICGSDLHLMDGLMPTMKSGDVLGHEFMGEVVEVGQGFTKFKKGD
RIVVPFNINCGACRQCKLGNYSVCERSNRNAEMAAAQFGYTTAGLFGYSHLTGGYAGGQAEYVRVPMADVAPMKVPDGMD
DESVLFLTDILPTGWQGAEHCEIRGGETIAVWGTGPVGIFAIQSAKIMGAERIIAIETVPERIALARKAGATDVIDFMNE
DVFERIKEITKGQGADGVIDCVGMEASAGHGGLTGMLSTVQEKLTATERPYALAEAIKAVRPCGIVSVPGVYGGPIPVNM
GSIVQKGLTLKSGQTHVKRYLEPLTKLIQEGKIDMTSLITHRSQNLAEGPDLYKTFRDKKDGCVKVVFHLN

Sequences:

>Translated_391_residues
MKALCWHGRNDIRCDTVPDPVIEDSRDVIIKVTSCAICGSDLHLMDGLMPTMKSGDVLGHEFMGEVVEVGQGFTKFKKGD
RIVVPFNINCGACRQCKLGNYSVCERSNRNAEMAAAQFGYTTAGLFGYSHLTGGYAGGQAEYVRVPMADVAPMKVPDGMD
DESVLFLTDILPTGWQGAEHCEIRGGETIAVWGTGPVGIFAIQSAKIMGAERIIAIETVPERIALARKAGATDVIDFMNE
DVFERIKEITKGQGADGVIDCVGMEASAGHGGLTGMLSTVQEKLTATERPYALAEAIKAVRPCGIVSVPGVYGGPIPVNM
GSIVQKGLTLKSGQTHVKRYLEPLTKLIQEGKIDMTSLITHRSQNLAEGPDLYKTFRDKKDGCVKVVFHLN
>Mature_391_residues
MKALCWHGRNDIRCDTVPDPVIEDSRDVIIKVTSCAICGSDLHLMDGLMPTMKSGDVLGHEFMGEVVEVGQGFTKFKKGD
RIVVPFNINCGACRQCKLGNYSVCERSNRNAEMAAAQFGYTTAGLFGYSHLTGGYAGGQAEYVRVPMADVAPMKVPDGMD
DESVLFLTDILPTGWQGAEHCEIRGGETIAVWGTGPVGIFAIQSAKIMGAERIIAIETVPERIALARKAGATDVIDFMNE
DVFERIKEITKGQGADGVIDCVGMEASAGHGGLTGMLSTVQEKLTATERPYALAEAIKAVRPCGIVSVPGVYGGPIPVNM
GSIVQKGLTLKSGQTHVKRYLEPLTKLIQEGKIDMTSLITHRSQNLAEGPDLYKTFRDKKDGCVKVVFHLN

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501929, Length=245, Percent_Identity=33.0612244897959, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI4501933, Length=245, Percent_Identity=31.0204081632653, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI71565152, Length=249, Percent_Identity=28.9156626506024, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI34577061, Length=244, Percent_Identity=31.1475409836066, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI71565154, Length=243, Percent_Identity=29.2181069958848, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI156523966, Length=380, Percent_Identity=24.7368421052632, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501939, Length=365, Percent_Identity=25.2054794520548, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI262073058, Length=215, Percent_Identity=29.3023255813954, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI71743840, Length=214, Percent_Identity=29.4392523364486, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1786825, Length=393, Percent_Identity=44.0203562340967, Blast_Score=311, Evalue=6e-86,
Organism=Escherichia coli, GI87082125, Length=265, Percent_Identity=32.8301886792453, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788073, Length=340, Percent_Identity=27.6470588235294, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788075, Length=374, Percent_Identity=27.2727272727273, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790045, Length=371, Percent_Identity=27.7628032345013, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI87081918, Length=227, Percent_Identity=36.1233480176211, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1787863, Length=371, Percent_Identity=25.3369272237197, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI226510992, Length=361, Percent_Identity=25.207756232687, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786552, Length=246, Percent_Identity=32.9268292682927, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788407, Length=224, Percent_Identity=28.125, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790718, Length=222, Percent_Identity=23.4234234234234, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=266, Percent_Identity=30.8270676691729, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI25146526, Length=240, Percent_Identity=30.8333333333333, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71997431, Length=242, Percent_Identity=31.404958677686, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=268, Percent_Identity=28.3582089552239, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17565904, Length=207, Percent_Identity=32.3671497584541, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=418, Percent_Identity=26.3157894736842, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319257, Length=297, Percent_Identity=28.6195286195286, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=248, Percent_Identity=28.6290322580645, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=271, Percent_Identity=26.9372693726937, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324486, Length=266, Percent_Identity=28.9473684210526, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=255, Percent_Identity=29.8039215686275, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=300, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=264, Percent_Identity=28.4090909090909, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17137530, Length=392, Percent_Identity=26.2755102040816, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17737897, Length=392, Percent_Identity=25.765306122449, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17737895, Length=297, Percent_Identity=28.6195286195286, Blast_Score=95, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42102; Mature: 42102

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALCWHGRNDIRCDTVPDPVIEDSRDVIIKVTSCAICGSDLHLMDGLMPTMKSGDVLGH
CCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHCCCCCCCCCCCCCH
EFMGEVVEVGQGFTKFKKGDRIVVPFNINCGACRQCKLGNYSVCERSNRNAEMAAAQFGY
HHHHHHHHHCCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCC
TTAGLFGYSHLTGGYAGGQAEYVRVPMADVAPMKVPDGMDDESVLFLTDILPTGWQGAEH
HHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCE
CEIRGGETIAVWGTGPVGIFAIQSAKIMGAERIIAIETVPERIALARKAGATDVIDFMNE
EEECCCCEEEEEECCCEEEEEEECCEEECCCEEEEEECCHHHHHHHHHCCCHHHHHHHHH
DVFERIKEITKGQGADGVIDCVGMEASAGHGGLTGMLSTVQEKLTATERPYALAEAIKAV
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RPCGIVSVPGVYGGPIPVNMGSIVQKGLTLKSGQTHVKRYLEPLTKLIQEGKIDMTSLIT
CCCCEEECCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
HRSQNLAEGPDLYKTFRDKKDGCVKVVFHLN
HHCCCCCCCHHHHHHHHCCCCCEEEEEEEEC
>Mature Secondary Structure
MKALCWHGRNDIRCDTVPDPVIEDSRDVIIKVTSCAICGSDLHLMDGLMPTMKSGDVLGH
CCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHCCCCCCCCCCCCCH
EFMGEVVEVGQGFTKFKKGDRIVVPFNINCGACRQCKLGNYSVCERSNRNAEMAAAQFGY
HHHHHHHHHCCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCC
TTAGLFGYSHLTGGYAGGQAEYVRVPMADVAPMKVPDGMDDESVLFLTDILPTGWQGAEH
HHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCE
CEIRGGETIAVWGTGPVGIFAIQSAKIMGAERIIAIETVPERIALARKAGATDVIDFMNE
EEECCCCEEEEEECCCEEEEEEECCEEECCCEEEEEECCHHHHHHHHHCCCHHHHHHHHH
DVFERIKEITKGQGADGVIDCVGMEASAGHGGLTGMLSTVQEKLTATERPYALAEAIKAV
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RPCGIVSVPGVYGGPIPVNMGSIVQKGLTLKSGQTHVKRYLEPLTKLIQEGKIDMTSLIT
CCCCEEECCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
HRSQNLAEGPDLYKTFRDKKDGCVKVVFHLN
HHCCCCCCCHHHHHHHHCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]