Click here to switch to the map view.

The map label for this gene is acdA [H]

Identifier: 170750182

GI number: 170750182

Start: 4024310

End: 4025455

Strand: Reverse

Name: acdA [H]

Synonym: Mrad2831_3784

Alternate gene names: 170750182

Gene position: 4025455-4024310 (Counterclockwise)

Preceding gene: 170750183

Following gene: 170750181

Centisome position: 66.23

GC content: 71.9

Gene sequence:

>1146_bases
ATGAGTTTCGGGCTCGACGAGGACCGGACCGCGATCCGCGAGATGGCCCTCGGCTTCGCGGCCGAGCACATCGCGCCGCA
CGCCCTCGACTGGGACCGGGACAAGACCTTCCCGGTCGAGACCCTGCGGGCGGCCGCCGCCCTCGGCATGGCGGGTATCT
ACGTCCGCGAGGATGTCGGCGGGTCCGGCCTGTCGCGCCTCGACGCGACGCTGATCTTCGAGGCGCTCAGCGCCGGCTGC
CCGACCGTGGCGGCGTTCCTCTCGATCCACAACATGTGCGCCTGGATGATCGACGCCTACGGCGACGACGACCAGCGCCG
GCGCTGGCTGCCGTCGCTCATGGGCATGGAGCGGATCGCCAGCTACTGCCTCACCGAGCCGGGCTCCGGCTCCGACGCCG
CGGCTTTGCGCACCCGCGCCGAGCGGGACGGCGACCATTACGTGCTCTCCGGCGAGAAGCAGTTCATCTCCGGCGCCGGC
GCCAGCGACCTCTACGTCTGCATGGTCCGCACCGGCGAGGCGGGCCCTTCGGGCATCTCGGCGATCGTGGTGGAGAAGGG
CACGCCCGGCCTCTCCTTCGGGGCCGACGAGCGCAAGATGGGCTGGAACGCCCAGCCGACCCGGGCCGTCCGCTTCGACG
GCTGCCGCGTGCCGGTGGGCAACCGCCTCGGCGCGGAGGGCCAGGGCTTCAAGATCGCCATGAGCGGCCTCGACGGCGGC
CGGCTCAACATCGCCGCCTGCTCGCTCGGCGGCGCGCAGGCGGCCCTCGACAAGGCGCTCGCCTACATGGGCGACCGGCG
CGCGTTCGGGGCCAGGCTCACCGACTTCCAGGCGCTGCAGTTCCGGCTCGCCGACATGGCGACCAGCCTGGAAGTGTCGC
GCACCTTCCTGCGCCACGCGGCCGCCGCGCTCGACGCCAAGGACCCGTCCGCGACCCAGCTCTGCGCCATGGCCAAGCGC
CACGTCACCGACGCGGCCTTCGAGGTGGCCAACCAAGCGCTGCAACTGCACGGCGGCTATGGCTACCTCGCCGAGTACGG
CGTGGAGAAGATCGTCCGGGACCTGCGCGTGCACCAGATCCTCGAAGGGACCAACGAGATCATGCGGCTGATCATCGCCC
GCGGGCTGACCGGGGGGCGCCGATGA

Upstream 100 bases:

>100_bases
CACCCCAACCCTCTCCCGAACGGGAGAGGGTGCACGCCGCGCCCCACGCGCCGGAGGTGCAGGCCCCGGGCGGTTGCGCG
GTGAATCGGAGGGAGTGTCC

Downstream 100 bases:

>100_bases
GCGACGTGATCGTCGAGCGGGTCGGCGCGCTGGGGCGCCTTCGGCTCAACCGGCCGAAGGCCCTGAACGCCTTGACGCAT
GGCATGGTGGGCGAGATCGA

Product: acyl-CoA dehydrogenase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MSFGLDEDRTAIREMALGFAAEHIAPHALDWDRDKTFPVETLRAAAALGMAGIYVREDVGGSGLSRLDATLIFEALSAGC
PTVAAFLSIHNMCAWMIDAYGDDDQRRRWLPSLMGMERIASYCLTEPGSGSDAAALRTRAERDGDHYVLSGEKQFISGAG
ASDLYVCMVRTGEAGPSGISAIVVEKGTPGLSFGADERKMGWNAQPTRAVRFDGCRVPVGNRLGAEGQGFKIAMSGLDGG
RLNIAACSLGGAQAALDKALAYMGDRRAFGARLTDFQALQFRLADMATSLEVSRTFLRHAAAALDAKDPSATQLCAMAKR
HVTDAAFEVANQALQLHGGYGYLAEYGVEKIVRDLRVHQILEGTNEIMRLIIARGLTGGRR

Sequences:

>Translated_381_residues
MSFGLDEDRTAIREMALGFAAEHIAPHALDWDRDKTFPVETLRAAAALGMAGIYVREDVGGSGLSRLDATLIFEALSAGC
PTVAAFLSIHNMCAWMIDAYGDDDQRRRWLPSLMGMERIASYCLTEPGSGSDAAALRTRAERDGDHYVLSGEKQFISGAG
ASDLYVCMVRTGEAGPSGISAIVVEKGTPGLSFGADERKMGWNAQPTRAVRFDGCRVPVGNRLGAEGQGFKIAMSGLDGG
RLNIAACSLGGAQAALDKALAYMGDRRAFGARLTDFQALQFRLADMATSLEVSRTFLRHAAAALDAKDPSATQLCAMAKR
HVTDAAFEVANQALQLHGGYGYLAEYGVEKIVRDLRVHQILEGTNEIMRLIIARGLTGGRR
>Mature_380_residues
SFGLDEDRTAIREMALGFAAEHIAPHALDWDRDKTFPVETLRAAAALGMAGIYVREDVGGSGLSRLDATLIFEALSAGCP
TVAAFLSIHNMCAWMIDAYGDDDQRRRWLPSLMGMERIASYCLTEPGSGSDAAALRTRAERDGDHYVLSGEKQFISGAGA
SDLYVCMVRTGEAGPSGISAIVVEKGTPGLSFGADERKMGWNAQPTRAVRFDGCRVPVGNRLGAEGQGFKIAMSGLDGGR
LNIAACSLGGAQAALDKALAYMGDRRAFGARLTDFQALQFRLADMATSLEVSRTFLRHAAAALDAKDPSATQLCAMAKRH
VTDAAFEVANQALQLHGGYGYLAEYGVEKIVRDLRVHQILEGTNEIMRLIIARGLTGGRR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=58.1333333333333, Blast_Score=473, Evalue=1e-134,
Organism=Homo sapiens, GI187960098, Length=378, Percent_Identity=36.2433862433862, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI4557231, Length=378, Percent_Identity=36.2433862433862, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI4557233, Length=374, Percent_Identity=38.7700534759358, Blast_Score=248, Evalue=5e-66,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=35.8288770053476, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI226958412, Length=380, Percent_Identity=33.9473684210526, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI76496475, Length=342, Percent_Identity=35.3801169590643, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI4557235, Length=342, Percent_Identity=35.3801169590643, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI226958414, Length=342, Percent_Identity=33.9181286549708, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI21361497, Length=357, Percent_Identity=35.5742296918768, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI4501857, Length=370, Percent_Identity=32.1621621621622, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI4503943, Length=383, Percent_Identity=30.8093994778068, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI7669494, Length=356, Percent_Identity=30.8988764044944, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI38505218, Length=323, Percent_Identity=27.8637770897833, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI48976061, Length=287, Percent_Identity=28.2229965156794, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI211971008, Length=287, Percent_Identity=28.2229965156794, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=29.6103896103896, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1786223, Length=383, Percent_Identity=26.8929503916449, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87082384, Length=265, Percent_Identity=27.1698113207547, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17533517, Length=375, Percent_Identity=51.4666666666667, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=37.17277486911, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17534899, Length=380, Percent_Identity=38.4210526315789, Blast_Score=268, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=34.7368421052632, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17506239, Length=376, Percent_Identity=34.8404255319149, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=33.8709677419355, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17538396, Length=381, Percent_Identity=34.1207349081365, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71985184, Length=358, Percent_Identity=33.5195530726257, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI32563615, Length=265, Percent_Identity=36.6037735849057, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI71990804, Length=255, Percent_Identity=36.8627450980392, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71985192, Length=282, Percent_Identity=32.6241134751773, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=30.6569343065693, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=29.8666666666667, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17551932, Length=376, Percent_Identity=29.5212765957447, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17534353, Length=381, Percent_Identity=27.0341207349081, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17562446, Length=320, Percent_Identity=27.5, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17531909, Length=240, Percent_Identity=27.9166666666667, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=37.467018469657, Blast_Score=262, Evalue=3e-70,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=35.8490566037736, Blast_Score=234, Evalue=6e-62,
Organism=Drosophila melanogaster, GI24646207, Length=373, Percent_Identity=38.0697050938338, Blast_Score=225, Evalue=3e-59,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=36.2204724409449, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=33.8709677419355, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI281363737, Length=344, Percent_Identity=34.3023255813954, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI19920834, Length=378, Percent_Identity=28.8359788359788, Blast_Score=132, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 40827; Mature: 40696

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFGLDEDRTAIREMALGFAAEHIAPHALDWDRDKTFPVETLRAAAALGMAGIYVREDVG
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEECCC
GSGLSRLDATLIFEALSAGCPTVAAFLSIHNMCAWMIDAYGDDDQRRRWLPSLMGMERIA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
SYCLTEPGSGSDAAALRTRAERDGDHYVLSGEKQFISGAGASDLYVCMVRTGEAGPSGIS
HHHCCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCEEEEEEEECCCCCCCCE
AIVVEKGTPGLSFGADERKMGWNAQPTRAVRFDGCRVPVGNRLGAEGQGFKIAMSGLDGG
EEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCEECCCCCCCCCCCCCEEEEEECCCCC
RLNIAACSLGGAQAALDKALAYMGDRRAFGARLTDFQALQFRLADMATSLEVSRTFLRHA
EEEEEEECCCCHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAALDAKDPSATQLCAMAKRHVTDAAFEVANQALQLHGGYGYLAEYGVEKIVRDLRVHQI
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LEGTNEIMRLIIARGLTGGRR
HHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SFGLDEDRTAIREMALGFAAEHIAPHALDWDRDKTFPVETLRAAAALGMAGIYVREDVG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEECCC
GSGLSRLDATLIFEALSAGCPTVAAFLSIHNMCAWMIDAYGDDDQRRRWLPSLMGMERIA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
SYCLTEPGSGSDAAALRTRAERDGDHYVLSGEKQFISGAGASDLYVCMVRTGEAGPSGIS
HHHCCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCEEEEEEEECCCCCCCCE
AIVVEKGTPGLSFGADERKMGWNAQPTRAVRFDGCRVPVGNRLGAEGQGFKIAMSGLDGG
EEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCEECCCCCCCCCCCCCEEEEEECCCCC
RLNIAACSLGGAQAALDKALAYMGDRRAFGARLTDFQALQFRLADMATSLEVSRTFLRHA
EEEEEEECCCCHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAALDAKDPSATQLCAMAKRHVTDAAFEVANQALQLHGGYGYLAEYGVEKIVRDLRVHQI
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LEGTNEIMRLIIARGLTGGRR
HHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]