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The map label for this gene is fieF [H]

Identifier: 170750152

GI number: 170750152

Start: 3996177

End: 3997136

Strand: Direct

Name: fieF [H]

Synonym: Mrad2831_3754

Alternate gene names: 170750152

Gene position: 3996177-3997136 (Clockwise)

Preceding gene: 170750150

Following gene: 170750154

Centisome position: 65.75

GC content: 69.9

Gene sequence:

>960_bases
ATGGCGCACGAGAGCACGGGAGCGATCTACGCGGCGGCGGGCGCCAACCTCGCCATCGCGGCGGCGAAGTTCGTGGGCGG
GGCGCTGACAGGCTCGACCGCCATGCTGGCCGAGGGCGTGCACTCGGTGGTCGACACGGCGAACCAGGTGCTGCTCCTCG
TCGGCATGAAGCGGGCCAAGCGCCCGGCCGATGCCCGCCACCCGTTCGGCTACGGACGCGAGATCTACTTCTACGCCTTC
GTGGTGGCGCTGATGATCTTCCTCGGCGGCGGCCTGTTCGCCGTCTACGAGGGGATCGAGCGGGTCCGCCATCCCGAGCC
GGACGTGGATGCCGAGCTGTTCGGCTACCGGCTGCCCGGCCTCTGGGTGAACGTCGCGATCCTGGGCTTCGCCATCGCGG
CGGAAGGCACGTCCTTCTTCGTGGCGATGCGCCAGTTCTGGGCCGAGAAGGGCAAGCACTCGGCCGTGCGGGCGATCCGG
CGCAGCAAGGATCCGACCCTGTTCACGGTGCTCGCGGAGGACACCGCCGCCCTGATCGGCCTGCTGATCGCGCTCGCCGG
TGTGGCCCTGTCCCACCTTCTGGAGATGCCGAGCCTGGACGGCTGGGCGTCGGTCGGCATCGGCCTCGTGCTCATCGGCA
TGGCGGCGTTCCTGATGGTCGAGACCCACGGGTTGCTGATCGGCGAGGCGGCCGATCCCGAGGTCGTCGCGGCCATCTCG
GAGCTGGTCCGCGCCGAGCCGGGCGTTCTCCACGTCAACGAGGTGCTGACCCAGCACCTCGGCCCCTCCGACATCCTGGT
CAATCTCAGCATCGACATGACCGACGATCTCAGCGCCGGCGAGGTCGAGAGCCTCGTCACGCGCCTCGACCGGGCGCTGA
AGGCGCGCAGCCCCGACGTGACCCGGGTGTTCATCGAGATCCAGCAGCAGGGCGATCACACGGTGCGGGCGGCGGCCTGA

Upstream 100 bases:

>100_bases
GGGAACAACCGACCCGCCGCGACGCTTGCATCGCCGCGGCGGCGGCGCCGTGCCGGGGTCCGATGGCCCGGCGTCCCACA
GACCGCGCAGGGAGTTCCGG

Downstream 100 bases:

>100_bases
GCACGCCCGCCTCGCCGGCGAGTGCGGATCTCTGTCAGGCATCCTCCCCGCGCATCGGCGGCGGGCGCACGCCGTCCCAG
GGGGCCGGCGACGGAAACAC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MAHESTGAIYAAAGANLAIAAAKFVGGALTGSTAMLAEGVHSVVDTANQVLLLVGMKRAKRPADARHPFGYGREIYFYAF
VVALMIFLGGGLFAVYEGIERVRHPEPDVDAELFGYRLPGLWVNVAILGFAIAAEGTSFFVAMRQFWAEKGKHSAVRAIR
RSKDPTLFTVLAEDTAALIGLLIALAGVALSHLLEMPSLDGWASVGIGLVLIGMAAFLMVETHGLLIGEAADPEVVAAIS
ELVRAEPGVLHVNEVLTQHLGPSDILVNLSIDMTDDLSAGEVESLVTRLDRALKARSPDVTRVFIEIQQQGDHTVRAAA

Sequences:

>Translated_319_residues
MAHESTGAIYAAAGANLAIAAAKFVGGALTGSTAMLAEGVHSVVDTANQVLLLVGMKRAKRPADARHPFGYGREIYFYAF
VVALMIFLGGGLFAVYEGIERVRHPEPDVDAELFGYRLPGLWVNVAILGFAIAAEGTSFFVAMRQFWAEKGKHSAVRAIR
RSKDPTLFTVLAEDTAALIGLLIALAGVALSHLLEMPSLDGWASVGIGLVLIGMAAFLMVETHGLLIGEAADPEVVAAIS
ELVRAEPGVLHVNEVLTQHLGPSDILVNLSIDMTDDLSAGEVESLVTRLDRALKARSPDVTRVFIEIQQQGDHTVRAAA
>Mature_318_residues
AHESTGAIYAAAGANLAIAAAKFVGGALTGSTAMLAEGVHSVVDTANQVLLLVGMKRAKRPADARHPFGYGREIYFYAFV
VALMIFLGGGLFAVYEGIERVRHPEPDVDAELFGYRLPGLWVNVAILGFAIAAEGTSFFVAMRQFWAEKGKHSAVRAIRR
SKDPTLFTVLAEDTAALIGLLIALAGVALSHLLEMPSLDGWASVGIGLVLIGMAAFLMVETHGLLIGEAADPEVVAAISE
LVRAEPGVLHVNEVLTQHLGPSDILVNLSIDMTDDLSAGEVESLVTRLDRALKARSPDVTRVFIEIQQQGDHTVRAAA

Specific function: Cation-efflux transporter that may have a role in detoxification [H]

COG id: COG0053

COG function: function code P; Predicted Co/Zn/Cd cation transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily [H]

Homologues:

Organism=Homo sapiens, GI57164948, Length=325, Percent_Identity=28.3076923076923, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI115534117, Length=248, Percent_Identity=32.6612903225806, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24653141, Length=224, Percent_Identity=31.25, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24653143, Length=224, Percent_Identity=31.25, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33863; Mature: 33731

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHESTGAIYAAAGANLAIAAAKFVGGALTGSTAMLAEGVHSVVDTANQVLLLVGMKRAK
CCCCCCCCEEEECCCCHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RPADARHPFGYGREIYFYAFVVALMIFLGGGLFAVYEGIERVRHPEPDVDAELFGYRLPG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHCEECCC
LWVNVAILGFAIAAEGTSFFVAMRQFWAEKGKHSAVRAIRRSKDPTLFTVLAEDTAALIG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHH
LLIALAGVALSHLLEMPSLDGWASVGIGLVLIGMAAFLMVETHGLLIGEAADPEVVAAIS
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHH
ELVRAEPGVLHVNEVLTQHLGPSDILVNLSIDMTDDLSAGEVESLVTRLDRALKARSPDV
HHHHCCCCEEEHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCC
TRVFIEIQQQGDHTVRAAA
EEEEEEEECCCCCEEECCC
>Mature Secondary Structure 
AHESTGAIYAAAGANLAIAAAKFVGGALTGSTAMLAEGVHSVVDTANQVLLLVGMKRAK
CCCCCCCEEEECCCCHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RPADARHPFGYGREIYFYAFVVALMIFLGGGLFAVYEGIERVRHPEPDVDAELFGYRLPG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHCEECCC
LWVNVAILGFAIAAEGTSFFVAMRQFWAEKGKHSAVRAIRRSKDPTLFTVLAEDTAALIG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHH
LLIALAGVALSHLLEMPSLDGWASVGIGLVLIGMAAFLMVETHGLLIGEAADPEVVAAIS
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHH
ELVRAEPGVLHVNEVLTQHLGPSDILVNLSIDMTDDLSAGEVESLVTRLDRALKARSPDV
HHHHCCCCEEEHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCC
TRVFIEIQQQGDHTVRAAA
EEEEEEEECCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA