| Definition | Methylobacterium radiotolerans JCM 2831 chromosome, complete genome. |
|---|---|
| Accession | NC_010505 |
| Length | 6,077,833 |
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The map label for this gene is mrcA [H]
Identifier: 170750010
GI number: 170750010
Start: 3835952
End: 3838396
Strand: Reverse
Name: mrcA [H]
Synonym: Mrad2831_3611
Alternate gene names: 170750010
Gene position: 3838396-3835952 (Counterclockwise)
Preceding gene: 170750011
Following gene: 170750008
Centisome position: 63.15
GC content: 74.72
Gene sequence:
>2445_bases ATGACGCCCGACGCGCCGGAACGCGCCCCGGCCGACGGGCCGAAACCGCCGAAGCCGGATCCCGCCGCCGACGCTCCGGA CCCGCGGCTCGCCGCCCGGGAGGCCGGGCGCGCCGCGCGCGACCTCGCGCGCCATCTCCGGACCCTCCTCGCCGCGGCCG GACTCGGCCTCGCGCGGACCGGCCGGGCCCTGTCGGCCCGCGCGGCGGAGCGCGCGGCGCGAGCGCGGGCCGATCTCCCG CCCGCCGCCGAGACGGGCGCGCGCGTCCGGACTCGGCGATTTCGCCCGATCCTCGGCCGCCGGCACCCGGCCGTGATCGC CGCCGCCCTGGTGGTCCTGCTGCCGGCGCTGGCGCTGGCGATCTACCTGTTCGCGGCCTTCGTGAGCCTGCCGCCGCTGG GCGGCGCCGTGGTCGAGACCGGCCAGCGGGCGATCACCGTCGAGGCCGACGACGGCCGGGTCTTCGCCACACGCGGCAGC TTCCGGGGCCAGAAGCTCACCGCGGCCGACCTGCCGCCGCACCTCGCCCAGGCGATCGTGGCGATCGAGGACCGCCGCTT CTACAGTCACTGGGGCATCGACCTGCGCGGCCTCGCCCGGGCGACGTGGCGCAATCTCCGCGGCGGCGGCGTGCGCGAGG GCGGCTCGACCATCACCCAGCAATACGTTCGCCTGACCTCCCTCAACCAGGAGAAGACGCTCTGGCGGAAGGTGCAGGAG GCCTTCCTGGCGCTGCGGGTCGAATCGACGATGAGCAAGGACGCGATCCTGCTCGGCTACCTCGACTCCGCCTATTTCGG CGCCGGCGCCTACGGGGCGGACGCGGCGGCGCGGCGCTACTTCGGCAAGCCCGCCAAGGCGCTGAACCTGCCGGAATCGG CGATGCTGGCCGGGCTGGTGCGGGCGCCCTCGCAGCTCGCCCCGACCCGCAACCTCGGCGGCGCCAAGGAGCGCGCCGAC GTGGTGCTCCAGGCCATGGTCGAGACCGGCGCGATCACGCAAGGAGAGGCCGATGCCGCGCGCAAGCAGAGCGTGACCCT CAAGTCGCCCCCCGAGGCGCCGCCCGGCACCAACTACTTCCTCGACATGATCGCGGGCGACGTGAAGCGCCTCGCCGGCA CGGACGGCGACATGACGGTGCGCTCGACCCTCAACCTCGACCTGCAGAGCCTCGCCGAGGGCGTCGTGGCCCGCCGCCTC GACAAGGACGGCGCCCGCCGCAAGGTCGGCCAGGCCGCCATGGTGGTGCTCTCGAAGGAGGGCGCGATCCTCGCCATGGT CGGCGGCCGCGACTACGAGGACAGCCAGTTCAACCGCGCCGTCCAGGCCAAGCGCCAGCCCGGCTCCCTGTTCAAGCTCC TCGCCTACCTGACGGCCTACGAGAAGGGCTACACGCCGGAATCCGTGATGGTCGACCGCCCGATCCAGATCGGCGACTGG CAGCCCGAGAACGACGACGGCCGCTACCGGGGGGCCGTGCCCCTGCGGACCGCCTTCGCGCTCTCGATCAACACCGTGGC GGCCCAGCTCGGGCAGGATGTCGGCATCCCGGCGGTGATCGCCACCGCCCGCAAGCTCGGGATCCAGTCCGACCTGCCCA ACGTGCCGAGCCTCGTCCTCGGCTCGGGCGCCGTGAGCCTCCTGGAGATGACCCGCGCCTACGGCTCGGTCCTGTCCGGG CGCACCCCGCTCCAGACCTACGGCATCCAGGCGATCCGCGGGGCCGCGCCGCAGCCGCTCTACGTCCGCACCGACGCGGC CCCGGGGCCGATGCTGGCGCAGGAACCGCGCACGATGATGCTCGACTCGCTGCAGGCGGTGGTGGAATCCGGCACCGGCC GCGCAGCGCGGGTGCCGGGCCAGATCATCGGCGGCAAGACCGGCACGAGCCAGGATTTCCGCGACGCGTGGTTCGTCGGC ATGACCCCCGACCTCGTGGTCGGGATCTGGGTCGGCAACGACGACGACAGTCCGATGAACCGCATGTTCGGCGGTGAGAT GCCGGCCGGGATCTTCCACGACTTCGTCCAGCGGGCCACCGAGAAGCTCGCGAAGGGCAGGGCCCGCCCCTCGGCGGAGC GGGCCGAGCCGGCCCGGGCGACGGCACCCGCACCCGAGCCGGCCGCGGTTGGCGAGGTCCGCGGCGTGCCGGAGGTGATC GACACCGGCACCCTCAACCTGCGCGGGCGAGTCGTGCGCCTCCTCGGCGTGGTCGGCGAGCGCGGCCACCTCGCCCGCCA GCTCGCCAGCTACCTGCGCCGTCGCGAGGTCGTCTGCAGCGGCCTGTCCGACGGGGCCACGGCCCGCTGCCGCATCGAGG GCGACGACCTCGCCGGGCTGATCCTGGCGGCGGGCGGCGCCCGCGCCTCGGAGGACGCCCCACCGGACCTCCTGGGCGCG GAGGAGCAGGCCCGGGCCGAGCGGGTCGGCCTGTGGGGCCGGTGA
Upstream 100 bases:
>100_bases CAGCGCCCGTCCCGCGACCCCGCACCGGCGGGACACCGGGACGGATGCGGCTTAGAAGGCTCGGTCGGCCGGATCGACCG GTCCCGGAACACGCACCACG
Downstream 100 bases:
>100_bases CGCCCTAGCCCGCCCCGAGCTTCGCCAGAGTCCGCGGGTCGGGGACGCCGTCGAAGTAGCGCGCGAGCGCGTCGGCGAAG ACCGGCTCCCCCGGCACGGC
Product: 1A family penicillin-binding protein
Products: NA
Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 814; Mature: 813
Protein sequence:
>814_residues MTPDAPERAPADGPKPPKPDPAADAPDPRLAAREAGRAARDLARHLRTLLAAAGLGLARTGRALSARAAERAARARADLP PAAETGARVRTRRFRPILGRRHPAVIAAALVVLLPALALAIYLFAAFVSLPPLGGAVVETGQRAITVEADDGRVFATRGS FRGQKLTAADLPPHLAQAIVAIEDRRFYSHWGIDLRGLARATWRNLRGGGVREGGSTITQQYVRLTSLNQEKTLWRKVQE AFLALRVESTMSKDAILLGYLDSAYFGAGAYGADAAARRYFGKPAKALNLPESAMLAGLVRAPSQLAPTRNLGGAKERAD VVLQAMVETGAITQGEADAARKQSVTLKSPPEAPPGTNYFLDMIAGDVKRLAGTDGDMTVRSTLNLDLQSLAEGVVARRL DKDGARRKVGQAAMVVLSKEGAILAMVGGRDYEDSQFNRAVQAKRQPGSLFKLLAYLTAYEKGYTPESVMVDRPIQIGDW QPENDDGRYRGAVPLRTAFALSINTVAAQLGQDVGIPAVIATARKLGIQSDLPNVPSLVLGSGAVSLLEMTRAYGSVLSG RTPLQTYGIQAIRGAAPQPLYVRTDAAPGPMLAQEPRTMMLDSLQAVVESGTGRAARVPGQIIGGKTGTSQDFRDAWFVG MTPDLVVGIWVGNDDDSPMNRMFGGEMPAGIFHDFVQRATEKLAKGRARPSAERAEPARATAPAPEPAAVGEVRGVPEVI DTGTLNLRGRVVRLLGVVGERGHLARQLASYLRRREVVCSGLSDGATARCRIEGDDLAGLILAAGGARASEDAPPDLLGA EEQARAERVGLWGR
Sequences:
>Translated_814_residues MTPDAPERAPADGPKPPKPDPAADAPDPRLAAREAGRAARDLARHLRTLLAAAGLGLARTGRALSARAAERAARARADLP PAAETGARVRTRRFRPILGRRHPAVIAAALVVLLPALALAIYLFAAFVSLPPLGGAVVETGQRAITVEADDGRVFATRGS FRGQKLTAADLPPHLAQAIVAIEDRRFYSHWGIDLRGLARATWRNLRGGGVREGGSTITQQYVRLTSLNQEKTLWRKVQE AFLALRVESTMSKDAILLGYLDSAYFGAGAYGADAAARRYFGKPAKALNLPESAMLAGLVRAPSQLAPTRNLGGAKERAD VVLQAMVETGAITQGEADAARKQSVTLKSPPEAPPGTNYFLDMIAGDVKRLAGTDGDMTVRSTLNLDLQSLAEGVVARRL DKDGARRKVGQAAMVVLSKEGAILAMVGGRDYEDSQFNRAVQAKRQPGSLFKLLAYLTAYEKGYTPESVMVDRPIQIGDW QPENDDGRYRGAVPLRTAFALSINTVAAQLGQDVGIPAVIATARKLGIQSDLPNVPSLVLGSGAVSLLEMTRAYGSVLSG RTPLQTYGIQAIRGAAPQPLYVRTDAAPGPMLAQEPRTMMLDSLQAVVESGTGRAARVPGQIIGGKTGTSQDFRDAWFVG MTPDLVVGIWVGNDDDSPMNRMFGGEMPAGIFHDFVQRATEKLAKGRARPSAERAEPARATAPAPEPAAVGEVRGVPEVI DTGTLNLRGRVVRLLGVVGERGHLARQLASYLRRREVVCSGLSDGATARCRIEGDDLAGLILAAGGARASEDAPPDLLGA EEQARAERVGLWGR >Mature_813_residues TPDAPERAPADGPKPPKPDPAADAPDPRLAAREAGRAARDLARHLRTLLAAAGLGLARTGRALSARAAERAARARADLPP AAETGARVRTRRFRPILGRRHPAVIAAALVVLLPALALAIYLFAAFVSLPPLGGAVVETGQRAITVEADDGRVFATRGSF RGQKLTAADLPPHLAQAIVAIEDRRFYSHWGIDLRGLARATWRNLRGGGVREGGSTITQQYVRLTSLNQEKTLWRKVQEA FLALRVESTMSKDAILLGYLDSAYFGAGAYGADAAARRYFGKPAKALNLPESAMLAGLVRAPSQLAPTRNLGGAKERADV VLQAMVETGAITQGEADAARKQSVTLKSPPEAPPGTNYFLDMIAGDVKRLAGTDGDMTVRSTLNLDLQSLAEGVVARRLD KDGARRKVGQAAMVVLSKEGAILAMVGGRDYEDSQFNRAVQAKRQPGSLFKLLAYLTAYEKGYTPESVMVDRPIQIGDWQ PENDDGRYRGAVPLRTAFALSINTVAAQLGQDVGIPAVIATARKLGIQSDLPNVPSLVLGSGAVSLLEMTRAYGSVLSGR TPLQTYGIQAIRGAAPQPLYVRTDAAPGPMLAQEPRTMMLDSLQAVVESGTGRAARVPGQIIGGKTGTSQDFRDAWFVGM TPDLVVGIWVGNDDDSPMNRMFGGEMPAGIFHDFVQRATEKLAKGRARPSAERAEPARATAPAPEPAAVGEVRGVPEVID TGTLNLRGRVVRLLGVVGERGHLARQLASYLRRREVVCSGLSDGATARCRIEGDDLAGLILAAGGARASEDAPPDLLGAE EQARAERVGLWGR
Specific function: Cell Wall Formation. Synthesis Of Cross-Linked Peptidoglycan From The Lipid Intermediates. The Enzyme Has A Penicillin-Insensitive Transglycosylase N-Terminal Domain (Formation Of Linear Glycan Strands) And A Penicillin-Sensitive Transpeptidase C-Terminal
COG id: COG0744
COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1786343, Length=557, Percent_Identity=32.1364452423698, Blast_Score=215, Evalue=1e-56, Organism=Escherichia coli, GI1788867, Length=508, Percent_Identity=31.8897637795276, Blast_Score=185, Evalue=1e-47, Organism=Escherichia coli, GI87082258, Length=268, Percent_Identity=36.9402985074627, Blast_Score=157, Evalue=4e-39, Organism=Escherichia coli, GI1789601, Length=177, Percent_Identity=34.4632768361582, Blast_Score=99, Evalue=2e-21,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011816 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.1.129; 3.4.-.- [C]
Molecular weight: Translated: 86402; Mature: 86271
Theoretical pI: Translated: 10.29; Mature: 10.29
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 2.3 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTPDAPERAPADGPKPPKPDPAADAPDPRLAAREAGRAARDLARHLRTLLAAAGLGLART CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHC GRALSARAAERAARARADLPPAAETGARVRTRRFRPILGRRHPAVIAAALVVLLPALALA CCHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH IYLFAAFVSLPPLGGAVVETGQRAITVEADDGRVFATRGSFRGQKLTAADLPPHLAQAIV HHHHHHHHHCCCCCCHHHHCCCEEEEEECCCCEEEEECCCCCCCEEECCCCCHHHHHHHH AIEDRRFYSHWGIDLRGLARATWRNLRGGGVREGGSTITQQYVRLTSLNQEKTLWRKVQE HHHCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH AFLALRVESTMSKDAILLGYLDSAYFGAGAYGADAAARRYFGKPAKALNLPESAMLAGLV HHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCCHHHHHHHHCCCCHHHCCCCHHHHHHHHH RAPSQLAPTRNLGGAKERADVVLQAMVETGAITQGEADAARKQSVTLKSPPEAPPGTNYF HCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEECCCCCCCCCCHHH LDMIAGDVKRLAGTDGDMTVRSTLNLDLQSLAEGVVARRLDKDGARRKVGQAAMVVLSKE HHHHHHHHHHHCCCCCCEEEEHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHEEEEECC GAILAMVGGRDYEDSQFNRAVQAKRQPGSLFKLLAYLTAYEKGYTPESVMVDRPIQIGDW CCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCC QPENDDGRYRGAVPLRTAFALSINTVAAQLGQDVGIPAVIATARKLGIQSDLPNVPSLVL CCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHH GSGAVSLLEMTRAYGSVLSGRTPLQTYGIQAIRGAAPQPLYVRTDAAPGPMLAQEPRTMM CCHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHH LDSLQAVVESGTGRAARVPGQIIGGKTGTSQDFRDAWFVGMTPDLVVGIWVGNDDDSPMN HHHHHHHHHCCCCCEEECCCCEECCCCCCCCCHHHEEEECCCCCCEEEEEECCCCCCHHH RMFGGEMPAGIFHDFVQRATEKLAKGRARPSAERAEPARATAPAPEPAAVGEVRGVPEVI HHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCHHHHCCCCHHH DTGTLNLRGRVVRLLGVVGERGHLARQLASYLRRREVVCSGLSDGATARCRIEGDDLAGL CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEE ILAAGGARASEDAPPDLLGAEEQARAERVGLWGR EEECCCCCCCCCCCCHHCCCHHHHHHHHCCCCCC >Mature Secondary Structure TPDAPERAPADGPKPPKPDPAADAPDPRLAAREAGRAARDLARHLRTLLAAAGLGLART CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHC GRALSARAAERAARARADLPPAAETGARVRTRRFRPILGRRHPAVIAAALVVLLPALALA CCHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH IYLFAAFVSLPPLGGAVVETGQRAITVEADDGRVFATRGSFRGQKLTAADLPPHLAQAIV HHHHHHHHHCCCCCCHHHHCCCEEEEEECCCCEEEEECCCCCCCEEECCCCCHHHHHHHH AIEDRRFYSHWGIDLRGLARATWRNLRGGGVREGGSTITQQYVRLTSLNQEKTLWRKVQE HHHCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH AFLALRVESTMSKDAILLGYLDSAYFGAGAYGADAAARRYFGKPAKALNLPESAMLAGLV HHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCCHHHHHHHHCCCCHHHCCCCHHHHHHHHH RAPSQLAPTRNLGGAKERADVVLQAMVETGAITQGEADAARKQSVTLKSPPEAPPGTNYF HCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEECCCCCCCCCCHHH LDMIAGDVKRLAGTDGDMTVRSTLNLDLQSLAEGVVARRLDKDGARRKVGQAAMVVLSKE HHHHHHHHHHHCCCCCCEEEEHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHEEEEECC GAILAMVGGRDYEDSQFNRAVQAKRQPGSLFKLLAYLTAYEKGYTPESVMVDRPIQIGDW CCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCC QPENDDGRYRGAVPLRTAFALSINTVAAQLGQDVGIPAVIATARKLGIQSDLPNVPSLVL CCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHH GSGAVSLLEMTRAYGSVLSGRTPLQTYGIQAIRGAAPQPLYVRTDAAPGPMLAQEPRTMM CCHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHH LDSLQAVVESGTGRAARVPGQIIGGKTGTSQDFRDAWFVGMTPDLVVGIWVGNDDDSPMN HHHHHHHHHCCCCCEEECCCCEECCCCCCCCCHHHEEEECCCCCCEEEEEECCCCCCHHH RMFGGEMPAGIFHDFVQRATEKLAKGRARPSAERAEPARATAPAPEPAAVGEVRGVPEVI HHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCHHHHCCCCHHH DTGTLNLRGRVVRLLGVVGERGHLARQLASYLRRREVVCSGLSDGATARCRIEGDDLAGL CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEE ILAAGGARASEDAPPDLLGAEEQARAERVGLWGR EEECCCCCCCCCCCCHHCCCHHHHHHHHCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 9537320 [H]