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The map label for this gene is panE [C]

Identifier: 170749968

GI number: 170749968

Start: 3788448

End: 3789338

Strand: Reverse

Name: panE [C]

Synonym: Mrad2831_3569

Alternate gene names: 170749968

Gene position: 3789338-3788448 (Counterclockwise)

Preceding gene: 170749969

Following gene: 170749963

Centisome position: 62.35

GC content: 74.52

Gene sequence:

>891_bases
ATGAACGTCGCGGTCGTGGGGGCCGGCGCGGTCGGCTGTTACTACGGATTTCTCCTGGCGCGGGCCGGCCACGCGGTGAC
GCTGATCGGCCGTCCCGCCCTGGTCGAGGTGGTTGAGAAGGACGGTCTCGTGCTGGAGAGCGCGGCCGGGACGGCCTCGG
TGCCCGTCCGGGCGACCGATGCGGGGGCGGGCGTGTCAGGCGCCGACCTCGTGCTGGTCTGCGTGAAGTCGGGCGACACC
GAGGCGGCGGGCGCGATGATCGCCCCCCACCTCGATCCGGCCGCCACGGTCCTCAGCCTCCAGAACGGCGTCGACAACGC
CGAGCGGCTCGCCGCCGTGCTGGGCCGCCCGGTCGTGCCGGTGGCGGTCTACGTCGCCACCGCGATGGCGGGCCCCGGCC
ACGTCCGGCACAACGGACGCGGCGACCTGATCCTCGGCGCGTCCGAGACGAGCGCGCGCGTCGCCGCCGCGTTCGCGGCG
GCCGGCATCCCGACCACCGTCTCGGCGAAGGCCGTCGACGCGCTCTGGGCGAAGCTGATCATCAACTGCGCCTACAACGC
CCTGTCGGCCCTGACGCAGCTGCCCTACGGCCGCCTGGTGGAGGGCGATGGCGTGGCCGCGGTCATCGCCGACGTCGTCC
AGGAATGCGCGCGCGTCGCCGAGGCCGAGGGCGTGTCGGTGTCGCCCCGCATCCTCGACGACGTGATGGCGCTCAGCGCC
GCCATGGCCGGCCAGCGCTCGTCCACCGCCCAGGACCTGGCCCGCGGCCGGCCGAGCGAGATCGACCACCTCAACGGCAC
GATCGTGCGCAGGGGCGCGGCGCACGGGATCCCGACGCCGGTCAACCGGCTGCTGCACGCGCTGGTCAAGCTCGCCGAGC
GGCGGGACTGA

Upstream 100 bases:

>100_bases
ACCCGGCCCAGGCGCTGCTCGAGCATGTCCGTGCGGCCGCGGCGGCCGCCGCGCCGTTCCATCCCGAGCGCGCCGCGGCG
GTGGCGCCGTGAGCCCCGCC

Downstream 100 bases:

>100_bases
GGCCGTCCTTGCACGGGCATGGACGTCGGCGGCCCGGTCCGCGGCGGGCGGTCACGCCCGCGCGGCGGCGTTGGCCTTGC
GGGTCGCGGCGGCCTTCCGG

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MNVAVVGAGAVGCYYGFLLARAGHAVTLIGRPALVEVVEKDGLVLESAAGTASVPVRATDAGAGVSGADLVLVCVKSGDT
EAAGAMIAPHLDPAATVLSLQNGVDNAERLAAVLGRPVVPVAVYVATAMAGPGHVRHNGRGDLILGASETSARVAAAFAA
AGIPTTVSAKAVDALWAKLIINCAYNALSALTQLPYGRLVEGDGVAAVIADVVQECARVAEAEGVSVSPRILDDVMALSA
AMAGQRSSTAQDLARGRPSEIDHLNGTIVRRGAAHGIPTPVNRLLHALVKLAERRD

Sequences:

>Translated_296_residues
MNVAVVGAGAVGCYYGFLLARAGHAVTLIGRPALVEVVEKDGLVLESAAGTASVPVRATDAGAGVSGADLVLVCVKSGDT
EAAGAMIAPHLDPAATVLSLQNGVDNAERLAAVLGRPVVPVAVYVATAMAGPGHVRHNGRGDLILGASETSARVAAAFAA
AGIPTTVSAKAVDALWAKLIINCAYNALSALTQLPYGRLVEGDGVAAVIADVVQECARVAEAEGVSVSPRILDDVMALSA
AMAGQRSSTAQDLARGRPSEIDHLNGTIVRRGAAHGIPTPVNRLLHALVKLAERRD
>Mature_296_residues
MNVAVVGAGAVGCYYGFLLARAGHAVTLIGRPALVEVVEKDGLVLESAAGTASVPVRATDAGAGVSGADLVLVCVKSGDT
EAAGAMIAPHLDPAATVLSLQNGVDNAERLAAVLGRPVVPVAVYVATAMAGPGHVRHNGRGDLILGASETSARVAAAFAA
AGIPTTVSAKAVDALWAKLIINCAYNALSALTQLPYGRLVEGDGVAAVIADVVQECARVAEAEGVSVSPRILDDVMALSA
AMAGQRSSTAQDLARGRPSEIDHLNGTIVRRGAAHGIPTPVNRLLHALVKLAERRD

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=311, Percent_Identity=29.2604501607717, Blast_Score=92, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 29891; Mature: 29891

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVAVVGAGAVGCYYGFLLARAGHAVTLIGRPALVEVVEKDGLVLESAAGTASVPVRATD
CCEEEEECCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCEEEEECCCCCCCCEEECC
AGAGVSGADLVLVCVKSGDTEAAGAMIAPHLDPAATVLSLQNGVDNAERLAAVLGRPVVP
CCCCCCCCCEEEEEEECCCCCCCCCEECCCCCHHHHHHHHHCCCCHHHHHHHHHCCCHHH
VAVYVATAMAGPGHVRHNGRGDLILGASETSARVAAAFAAAGIPTTVSAKAVDALWAKLI
HHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
INCAYNALSALTQLPYGRLVEGDGVAAVIADVVQECARVAEAEGVSVSPRILDDVMALSA
HHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
AMAGQRSSTAQDLARGRPSEIDHLNGTIVRRGAAHGIPTPVNRLLHALVKLAERRD
HHCCCCCCHHHHHHCCCCCCHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNVAVVGAGAVGCYYGFLLARAGHAVTLIGRPALVEVVEKDGLVLESAAGTASVPVRATD
CCEEEEECCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCEEEEECCCCCCCCEEECC
AGAGVSGADLVLVCVKSGDTEAAGAMIAPHLDPAATVLSLQNGVDNAERLAAVLGRPVVP
CCCCCCCCCEEEEEEECCCCCCCCCEECCCCCHHHHHHHHHCCCCHHHHHHHHHCCCHHH
VAVYVATAMAGPGHVRHNGRGDLILGASETSARVAAAFAAAGIPTTVSAKAVDALWAKLI
HHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
INCAYNALSALTQLPYGRLVEGDGVAAVIADVVQECARVAEAEGVSVSPRILDDVMALSA
HHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
AMAGQRSSTAQDLARGRPSEIDHLNGTIVRRGAAHGIPTPVNRLLHALVKLAERRD
HHCCCCCCHHHHHHCCCCCCHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11016950 [H]