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The map label for this gene is atoS [C]

Identifier: 170749966

GI number: 170749966

Start: 3786445

End: 3788064

Strand: Direct

Name: atoS [C]

Synonym: Mrad2831_3567

Alternate gene names: 170749966

Gene position: 3786445-3788064 (Clockwise)

Preceding gene: 170749965

Following gene: 170749967

Centisome position: 62.3

GC content: 69.2

Gene sequence:

>1620_bases
ATGTCTGAGACGCCAGAAACGCCGCCCTCCGGGCCGAGTCCGCCGATCCGGGACAGCGCCCCGAGCGACATCAGCGACCG
CAAGAGCGACATCTTCTTCGCGGCCGTCGAGACGACGCGGATGCCGATGATCGTCACCGATCCGCGCCAGCCCGACAACC
CGATCATCTTCGCCAACCGGGCATTCCTGGCGATGACCGGCTACACGCCGGAAGAGCTGATCGGGCGCAACTGCCGCTTC
CTCCAGGGTCCCGACACCGATCGCGACAGCGTCGCGCAGGTCCGCGCGGCGATCGCCGAGAAGCGGGAATTCGCCACCGA
GATCCTGAACTACCGCAAGAACGGCTCGACGTTCTGGAACGCCCTGTTCGTCTCTCCGGTCTACAATGCCGACGGCGAGC
TCGTGTACTACTTCGGCTCGCAGCTCGACGTCTCGCGCCGCCGCGACGCCGAGGAGGCGCTGGGTCAGGCCCAGAAGATG
GAGGCGCTCGGCCAGCTCACCGGCGGTATCGCGCACGATTTCAACAACCTGCTGCAGGTGATCGTCGGTTACGTCGACAT
CCTGGCGGCCGGCCTGGAGAAGCCCGACGCCGACCGCGCGCGGCTCGGCCGCGCCACCGAGAACATCCGGCAGGCGGCCG
AGCGCGCCACGACGCTGACGCAGCAATTGCTGGCCTTCGCCCGCAAGCAGCGGCTGGACGGACGCGCGGTCAACCTCAAC
ACCCTGATCGAGGGTATGGGCGAGATGGTCGCCCGCTCGGTGGGCGAGGCCGTGAAGGTCGAACTCGATCTCGCGCCGGA
TCTCTGGAACTGCCGCGTCGACCCGACCCAGGCCGAGGTCGCGATCCTGAACGTCCTGATCAACGCCCGCGACGCGATGC
CGGAGGGCGGCACCGTCCGGATCTCCACCGAGAACAGCGAGGTCGCCTCGCGCGGCCGCGAGATCGGGCCGCTGCGCGAC
GGCCGCTACGTCAGCATCGCCATCAAGGACACCGGCACCGGCATCCCGCCCGCCGTGCTCGCCCGGGTGATGGACCCGTT
CTTCACCACCAAGGAGGAGGGCAAGGGCACGGGCCTCGGCCTGTCGATGGTCTACGGATTCGCCAAGCAGTCGGGGGGCG
CCGCGCAGATCGAGTCGGCGGTGGGGGCCGGCACGACGGTGCGCCTGTCGTTCCCCGCGACCGACGGCGACGTCAACGCG
CCCGCGAAGATCTCGCTGCGGGCCGTGGACCGCCAGGGCACCGAGACGATCCTGATCGTCGACGACCGCGAGGACGTGGC
CGAACTCGCCCGCACGATCCTGCGGGACTTCGGCTACACGACGCTGGTGGCGAGCAACGCCCGCGAGGCCCTGGAGATCC
TGGATTCGAGCGGGAAGGTCGACCTGCTGTTCACCGATCTGATCATGCCGGGGGGCATGAACGGGGTGCTCCTGGCCCGC
GAGGCCCGGCGCCGCCAGCCCAAGCTCAAGGTGCTGCTCGCCACGGGCTACGCGGAGGCGAGCCTGGAACGAACCGATAT
CGGCGGCTCGGAGTTTGATCTCCTGAACAAGCCCTACCGGCGCACGGAGCTAGTCCGCCGCGTCCGCGCGATCCTCGACG
GTCCGACCGGGGTGGGCTGA

Upstream 100 bases:

>100_bases
AGGTCGACTTCGGCCGTCCGGCCGCTAATCTCGCGCACGCATTTCGTGATCGACCGCGCGCAGAGGTCTTTCCCGGCCTG
GAAGGTGACGACCGCCTCGC

Downstream 100 bases:

>100_bases
GCTTCGGGAGACGGCCCATGTCCCAGGGCGACAAGTCGAAATACACCGACAAGCAGAAGCGCAAGGCCGAGCACATCGCC
GAGTCGTACGAGTCCCGCGG

Product: histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MSETPETPPSGPSPPIRDSAPSDISDRKSDIFFAAVETTRMPMIVTDPRQPDNPIIFANRAFLAMTGYTPEELIGRNCRF
LQGPDTDRDSVAQVRAAIAEKREFATEILNYRKNGSTFWNALFVSPVYNADGELVYYFGSQLDVSRRRDAEEALGQAQKM
EALGQLTGGIAHDFNNLLQVIVGYVDILAAGLEKPDADRARLGRATENIRQAAERATTLTQQLLAFARKQRLDGRAVNLN
TLIEGMGEMVARSVGEAVKVELDLAPDLWNCRVDPTQAEVAILNVLINARDAMPEGGTVRISTENSEVASRGREIGPLRD
GRYVSIAIKDTGTGIPPAVLARVMDPFFTTKEEGKGTGLGLSMVYGFAKQSGGAAQIESAVGAGTTVRLSFPATDGDVNA
PAKISLRAVDRQGTETILIVDDREDVAELARTILRDFGYTTLVASNAREALEILDSSGKVDLLFTDLIMPGGMNGVLLAR
EARRRQPKLKVLLATGYAEASLERTDIGGSEFDLLNKPYRRTELVRRVRAILDGPTGVG

Sequences:

>Translated_539_residues
MSETPETPPSGPSPPIRDSAPSDISDRKSDIFFAAVETTRMPMIVTDPRQPDNPIIFANRAFLAMTGYTPEELIGRNCRF
LQGPDTDRDSVAQVRAAIAEKREFATEILNYRKNGSTFWNALFVSPVYNADGELVYYFGSQLDVSRRRDAEEALGQAQKM
EALGQLTGGIAHDFNNLLQVIVGYVDILAAGLEKPDADRARLGRATENIRQAAERATTLTQQLLAFARKQRLDGRAVNLN
TLIEGMGEMVARSVGEAVKVELDLAPDLWNCRVDPTQAEVAILNVLINARDAMPEGGTVRISTENSEVASRGREIGPLRD
GRYVSIAIKDTGTGIPPAVLARVMDPFFTTKEEGKGTGLGLSMVYGFAKQSGGAAQIESAVGAGTTVRLSFPATDGDVNA
PAKISLRAVDRQGTETILIVDDREDVAELARTILRDFGYTTLVASNAREALEILDSSGKVDLLFTDLIMPGGMNGVLLAR
EARRRQPKLKVLLATGYAEASLERTDIGGSEFDLLNKPYRRTELVRRVRAILDGPTGVG
>Mature_538_residues
SETPETPPSGPSPPIRDSAPSDISDRKSDIFFAAVETTRMPMIVTDPRQPDNPIIFANRAFLAMTGYTPEELIGRNCRFL
QGPDTDRDSVAQVRAAIAEKREFATEILNYRKNGSTFWNALFVSPVYNADGELVYYFGSQLDVSRRRDAEEALGQAQKME
ALGQLTGGIAHDFNNLLQVIVGYVDILAAGLEKPDADRARLGRATENIRQAAERATTLTQQLLAFARKQRLDGRAVNLNT
LIEGMGEMVARSVGEAVKVELDLAPDLWNCRVDPTQAEVAILNVLINARDAMPEGGTVRISTENSEVASRGREIGPLRDG
RYVSIAIKDTGTGIPPAVLARVMDPFFTTKEEGKGTGLGLSMVYGFAKQSGGAAQIESAVGAGTTVRLSFPATDGDVNAP
AKISLRAVDRQGTETILIVDDREDVAELARTILRDFGYTTLVASNAREALEILDSSGKVDLLFTDLIMPGGMNGVLLARE
ARRRQPKLKVLLATGYAEASLERTDIGGSEFDLLNKPYRRTELVRRVRAILDGPTGVG

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Homo sapiens, GI38569493, Length=98, Percent_Identity=35.7142857142857, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI27886667, Length=94, Percent_Identity=32.9787234042553, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI6912446, Length=95, Percent_Identity=34.7368421052632, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=340, Percent_Identity=27.9411764705882, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1790436, Length=261, Percent_Identity=28.735632183908, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790300, Length=244, Percent_Identity=29.0983606557377, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788713, Length=440, Percent_Identity=23.6363636363636, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1790861, Length=234, Percent_Identity=28.6324786324786, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI48994928, Length=388, Percent_Identity=24.2268041237113, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=246, Percent_Identity=26.4227642276423, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136946, Length=101, Percent_Identity=29.7029702970297, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 58487; Mature: 58356

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETPETPPSGPSPPIRDSAPSDISDRKSDIFFAAVETTRMPMIVTDPRQPDNPIIFANR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCEEEECC
AFLAMTGYTPEELIGRNCRFLQGPDTDRDSVAQVRAAIAEKREFATEILNYRKNGSTFWN
EEEEEECCCHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
ALFVSPVYNADGELVYYFGSQLDVSRRRDAEEALGQAQKMEALGQLTGGIAHDFNNLLQV
EEEECEEECCCCCEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVGYVDILAAGLEKPDADRARLGRATENIRQAAERATTLTQQLLAFARKQRLDGRAVNLN
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHH
TLIEGMGEMVARSVGEAVKVELDLAPDLWNCRVDPTQAEVAILNVLINARDAMPEGGTVR
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEE
ISTENSEVASRGREIGPLRDGRYVSIAIKDTGTGIPPAVLARVMDPFFTTKEEGKGTGLG
EECCCHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCH
LSMVYGFAKQSGGAAQIESAVGAGTTVRLSFPATDGDVNAPAKISLRAVDRQGTETILIV
HHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEE
DDREDVAELARTILRDFGYTTLVASNAREALEILDSSGKVDLLFTDLIMPGGMNGVLLAR
ECHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCEEEEC
EARRRQPKLKVLLATGYAEASLERTDIGGSEFDLLNKPYRRTELVRRVRAILDGPTGVG
HHHCCCCCEEEEEEECCCHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SETPETPPSGPSPPIRDSAPSDISDRKSDIFFAAVETTRMPMIVTDPRQPDNPIIFANR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCEEEECC
AFLAMTGYTPEELIGRNCRFLQGPDTDRDSVAQVRAAIAEKREFATEILNYRKNGSTFWN
EEEEEECCCHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
ALFVSPVYNADGELVYYFGSQLDVSRRRDAEEALGQAQKMEALGQLTGGIAHDFNNLLQV
EEEECEEECCCCCEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVGYVDILAAGLEKPDADRARLGRATENIRQAAERATTLTQQLLAFARKQRLDGRAVNLN
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHH
TLIEGMGEMVARSVGEAVKVELDLAPDLWNCRVDPTQAEVAILNVLINARDAMPEGGTVR
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEE
ISTENSEVASRGREIGPLRDGRYVSIAIKDTGTGIPPAVLARVMDPFFTTKEEGKGTGLG
EECCCHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCH
LSMVYGFAKQSGGAAQIESAVGAGTTVRLSFPATDGDVNAPAKISLRAVDRQGTETILIV
HHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEE
DDREDVAELARTILRDFGYTTLVASNAREALEILDSSGKVDLLFTDLIMPGGMNGVLLAR
ECHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCEEEEC
EARRRQPKLKVLLATGYAEASLERTDIGGSEFDLLNKPYRRTELVRRVRAILDGPTGVG
HHHCCCCCEEEEEEECCCHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA