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The map label for this gene is hisD [H]

Identifier: 170749912

GI number: 170749912

Start: 3727322

End: 3728617

Strand: Direct

Name: hisD [H]

Synonym: Mrad2831_3512

Alternate gene names: 170749912

Gene position: 3727322-3728617 (Clockwise)

Preceding gene: 170749911

Following gene: 170749913

Centisome position: 61.33

GC content: 73.38

Gene sequence:

>1296_bases
ATGGTCCGGCTCGACAGCAGCGATCCGAATTTTGCCGCCGCCTTCGCGCACCTCCTGACGGTGAAGCGCGAGATCGCCGA
GGACGTGGACGAGGCCGTGCGCGGCATCATCGCCGACGTCGTCGCCCGGGGCGACGACGCGCTGGTCGATTTCACCCGGC
GCTTCGACCGGCTCGGCGCCGATTTCTCGGCGGCGCAGCTGCGGGTCACGGACGCGGAGATGGCCGCGGCCGTCGCGGCC
TGCCCGCCGGATTCCCTGGAGGCGCTGCGCCTCGCCGCCGAGCGGATCGAGAGCTTCCACCGGGCCCAGCGGCCCGAAGA
TCACCGGGCCACGGACGCCCTCGGCGTCACGGCCGGATGGCGCTGGACCGCGCTGGAATCCGTCGGCCTCTACGTACCGG
GCGGCACCGCGAGCTATCCCTCCTCGGTGCTGATGAACGCGCTGCCGGCCCGCGTCGCGGGCGTGCCGCGGCTCGTCATG
GTGGTGCCCACACCGGACGGCCAGATGAACCCGCTGGTCCTGGCCGCCGCGCAGCTCGCCGGCGTCCACGAGGTCTACCG
GGTGGGCGGTGCCCAGGCGGTCGCGGCCCTCGCCTACGGGACCGCCACCATCGCCCCCGTGGCCAAGGTCGTCGGACCGG
GCAATGCCTGGGTGGCGGCGGCCAAGCGCCGGGTCTTCGGCCAGGTCGGGATCGACATGATCGCCGGCCCCTCCGAGGTG
CTGATCCTGGCGGACGGCCACGCCAACCCCGACTGGATCGCCGCCGACCTGCTGGCCCAGGCCGAGCACGACGTGGCCGC
CCAGGCGATCCTGATCACCGACAGCGCCGAACTCGCCGGGGCCGTCGAGGAGGCGGTCGAGCGCGCGCTGACCACCCTGC
CCCGCCAGGAGATCGCCCGGGCGAGCTGGCGCGATTACGGCGCGATCATCCGGGTCCGCACCTTCGACGAGGCCGTGCCG
CTGGTGGACCGCCTCGCACCCGAGCACCTGGAGATCGAGACGCAGGACGCGGAGGCGCTCGCCGCCAAGGTGCGCAATGC
CGGCGCGATCTTCCTCGGCTCGCACACGCCGGAGGCGATCGGCGACTATGTCGGCGGCCCCAACCACGTCCTGCCGACGG
CCCGCTCGGCCCGGTTCTCGTCCGGGCTGGGCGTGCTCGACTTCATGAAGCGGACGACGATCCTCGCCTGCACGCCGGAG
AGCTTGCGGGCGCTCGGCCCGGCGGCGATAAACCTCGGCCGGTCCGAGGGCCTGGAGGGGCATGCCCGCTCCGTCGCGAT
CCGGTTGAACCTGTGA

Upstream 100 bases:

>100_bases
TCTCGGCCCGGTCTGGGAATCGGCCACCCGTCCCGGACACGACATCGACACCGATACGGCCGCCGGCCCGGCGGCCTGAC
GCGAGACAGAAGGCTTCCCG

Downstream 100 bases:

>100_bases
GGTTTTGGGGATGGCGGAGAAGCAGCGCGGGCCGAACCGCCTCGCGAAGGTGAGCCTGGACGAGGCGTCCATCGCCCGCG
GCAATCCGGATCAGGAGCAC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MVRLDSSDPNFAAAFAHLLTVKREIAEDVDEAVRGIIADVVARGDDALVDFTRRFDRLGADFSAAQLRVTDAEMAAAVAA
CPPDSLEALRLAAERIESFHRAQRPEDHRATDALGVTAGWRWTALESVGLYVPGGTASYPSSVLMNALPARVAGVPRLVM
VVPTPDGQMNPLVLAAAQLAGVHEVYRVGGAQAVAALAYGTATIAPVAKVVGPGNAWVAAAKRRVFGQVGIDMIAGPSEV
LILADGHANPDWIAADLLAQAEHDVAAQAILITDSAELAGAVEEAVERALTTLPRQEIARASWRDYGAIIRVRTFDEAVP
LVDRLAPEHLEIETQDAEALAAKVRNAGAIFLGSHTPEAIGDYVGGPNHVLPTARSARFSSGLGVLDFMKRTTILACTPE
SLRALGPAAINLGRSEGLEGHARSVAIRLNL

Sequences:

>Translated_431_residues
MVRLDSSDPNFAAAFAHLLTVKREIAEDVDEAVRGIIADVVARGDDALVDFTRRFDRLGADFSAAQLRVTDAEMAAAVAA
CPPDSLEALRLAAERIESFHRAQRPEDHRATDALGVTAGWRWTALESVGLYVPGGTASYPSSVLMNALPARVAGVPRLVM
VVPTPDGQMNPLVLAAAQLAGVHEVYRVGGAQAVAALAYGTATIAPVAKVVGPGNAWVAAAKRRVFGQVGIDMIAGPSEV
LILADGHANPDWIAADLLAQAEHDVAAQAILITDSAELAGAVEEAVERALTTLPRQEIARASWRDYGAIIRVRTFDEAVP
LVDRLAPEHLEIETQDAEALAAKVRNAGAIFLGSHTPEAIGDYVGGPNHVLPTARSARFSSGLGVLDFMKRTTILACTPE
SLRALGPAAINLGRSEGLEGHARSVAIRLNL
>Mature_431_residues
MVRLDSSDPNFAAAFAHLLTVKREIAEDVDEAVRGIIADVVARGDDALVDFTRRFDRLGADFSAAQLRVTDAEMAAAVAA
CPPDSLEALRLAAERIESFHRAQRPEDHRATDALGVTAGWRWTALESVGLYVPGGTASYPSSVLMNALPARVAGVPRLVM
VVPTPDGQMNPLVLAAAQLAGVHEVYRVGGAQAVAALAYGTATIAPVAKVVGPGNAWVAAAKRRVFGQVGIDMIAGPSEV
LILADGHANPDWIAADLLAQAEHDVAAQAILITDSAELAGAVEEAVERALTTLPRQEIARASWRDYGAIIRVRTFDEAVP
LVDRLAPEHLEIETQDAEALAAKVRNAGAIFLGSHTPEAIGDYVGGPNHVLPTARSARFSSGLGVLDFMKRTTILACTPE
SLRALGPAAINLGRSEGLEGHARSVAIRLNL

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=408, Percent_Identity=41.1764705882353, Blast_Score=291, Evalue=6e-80,
Organism=Saccharomyces cerevisiae, GI6319819, Length=407, Percent_Identity=38.8206388206388, Blast_Score=261, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45398; Mature: 45398

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRLDSSDPNFAAAFAHLLTVKREIAEDVDEAVRGIIADVVARGDDALVDFTRRFDRLGA
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
DFSAAQLRVTDAEMAAAVAACPPDSLEALRLAAERIESFHRAQRPEDHRATDALGVTAGW
CCCHHEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCC
RWTALESVGLYVPGGTASYPSSVLMNALPARVAGVPRLVMVVPTPDGQMNPLVLAAAQLA
EEEEHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHH
GVHEVYRVGGAQAVAALAYGTATIAPVAKVVGPGNAWVAAAKRRVFGQVGIDMIAGPSEV
HHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEECCCCEE
LILADGHANPDWIAADLLAQAEHDVAAQAILITDSAELAGAVEEAVERALTTLPRQEIAR
EEEECCCCCCCHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHH
ASWRDYGAIIRVRTFDEAVPLVDRLAPEHLEIETQDAEALAAKVRNAGAIFLGSHTPEAI
HHHCCCCCEEEEEECHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCEEEECCCCHHHH
GDYVGGPNHVLPTARSARFSSGLGVLDFMKRTTILACTPESLRALGPAAINLGRSEGLEG
HHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHCEEEEECHHHHHHCCHHHHCCCCCCCCCC
HARSVAIRLNL
CCEEEEEEEEC
>Mature Secondary Structure
MVRLDSSDPNFAAAFAHLLTVKREIAEDVDEAVRGIIADVVARGDDALVDFTRRFDRLGA
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
DFSAAQLRVTDAEMAAAVAACPPDSLEALRLAAERIESFHRAQRPEDHRATDALGVTAGW
CCCHHEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCC
RWTALESVGLYVPGGTASYPSSVLMNALPARVAGVPRLVMVVPTPDGQMNPLVLAAAQLA
EEEEHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHH
GVHEVYRVGGAQAVAALAYGTATIAPVAKVVGPGNAWVAAAKRRVFGQVGIDMIAGPSEV
HHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEECCCCEE
LILADGHANPDWIAADLLAQAEHDVAAQAILITDSAELAGAVEEAVERALTTLPRQEIAR
EEEECCCCCCCHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHH
ASWRDYGAIIRVRTFDEAVPLVDRLAPEHLEIETQDAEALAAKVRNAGAIFLGSHTPEAI
HHHCCCCCEEEEEECHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCEEEECCCCHHHH
GDYVGGPNHVLPTARSARFSSGLGVLDFMKRTTILACTPESLRALGPAAINLGRSEGLEG
HHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHCEEEEECHHHHHHCCHHHHCCCCCCCCCC
HARSVAIRLNL
CCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA