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The map label for this gene is envZ [H]

Identifier: 170749871

GI number: 170749871

Start: 3684228

End: 3685622

Strand: Direct

Name: envZ [H]

Synonym: Mrad2831_3471

Alternate gene names: 170749871

Gene position: 3684228-3685622 (Clockwise)

Preceding gene: 170749866

Following gene: 170749873

Centisome position: 60.62

GC content: 71.11

Gene sequence:

>1395_bases
ATGAACGCCCCGGATCCCGCCCTCGCCCGGGCGCTCCGGAAGGACCCGCCGCGCTCGGGCCCGCGCCGCCTGTGGAAGCG
CGTCAGCCGGGCGATCGGCGACGTCCTGCCGAAGGGCCTCTACGCCCGCTCGCTGATCATCATCATCGCGCCGGTCGTCC
TGCTCCAGTCGGTGATCGCCTACACCTTCATGGAGCGGCACTGGCAGCTCGTGACCAAGCGGCTGTCGGCGGCGGTGACC
GCGGACGTCGCGGCGCTGATCGACATCTACGAGAGCTACCCGCAGGACAAGGACGCCGAGACCCTCTCGCGCATCGCCGG
GGAGCGGCTGAACCTCGACCTCGACATCCTCAAGGGCGCCAAGCTGCCGCCCCCGGGCCCGCGGCCGTTCTTCTCGATCC
TCGACGAGGCCCTGTCCGACGAGATCAAGCGCCAGATCCGCAGACCCTTCTGGATCGACACGGTCGGCCGCTCGAACCTG
ATCGAGATCCGCGTGGCGATCCCCGACGGGGTGATGCGCATCACCGCCCGGCGCAGCCAGGCCTACGCGTCGAACTCGCA
CATCTTCCTCGTGTGGATGATCGGCTCGTCGCTGGTGCTGCTCGGCGTCGCGATCCTGTTCCTGCGCAACCAGATCAAGC
CGATCCTGCGGCTCGCCGCCGTGGCGGAGGGCTTCGGCAAGGGGCGGGAGATCGAGTTCCGGCCCCGCGGCGCCCGCGAG
GTGCGTCAGGCCGGTCACGCCTTCATCGAGATGAAGCGGCGCATCGAGCGGGCGATGGAGCAGCGCACCACGATGCTGAA
CGGCGTCAGCCACGACCTGCGCACCATCCTGACCCGCTTCCGCCTGTCCCTGGCGCTGATCGAGCAGACCGAGGAGATCG
AGGATCTCAGCCGCGACGTCGACGAGATGAGCCGGATGCTGGAGGGCTACCTCGCCTTCGCGCGGGGCGATTCGGCCGAG
CCCGCGACCCCCACCGACATGCGCGCCCTGCTGGAGGACCTGCGGACCGACGTCGAGCGCCTCGGTGCCCACGTCTCCGC
GGTCGATCTCGTCGGCGCGCCCGAGGTCACGGTCCGGCCGGGCGCCTTCCAGCGGTGCCTGTTCAATCTCGCGGCCAACG
CCGTCCGCTACGGCGAGACGGTGGCGATCTCCGGCCGGCTGGAGGCCCGCGCCTTCCTCGTCTCGATCGACGATGACGGG
CCCGGCATCCCGGCGGAGAGCCGCGAGGACGTGTTCAAGCCGTTCGTGCGGCTCGACGACGCCCGCCAGGATGCCGGCGG
CTCCGGGCTGGGCCTGTCGATCGCCCGGGACATCGCCCGCGCCCACGGCGGCGACATAACCCTGCACGACAGCCCGCTCG
GCGGCCTGCGGGCCACCGTCCGGGTTCCGGCCTGA

Upstream 100 bases:

>100_bases
GGCTTTCCGCGCCCGCTCGAGCCATGTCCGCCGCCGTTGAACGGATCCTCCGTCGACCGACCTGCCACCGCGCCCGCGGG
ACGGACGGGCGCGCGATGTC

Downstream 100 bases:

>100_bases
GCCGGATTAGGCGGGCCGGATCACGGGAACCGGCTCAGGTATCGGCGGGCCGTCGCAGGCGCAGGAACTCGGCCTGCACG
TTCCGGAGCAGGTGATCGAT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MNAPDPALARALRKDPPRSGPRRLWKRVSRAIGDVLPKGLYARSLIIIIAPVVLLQSVIAYTFMERHWQLVTKRLSAAVT
ADVAALIDIYESYPQDKDAETLSRIAGERLNLDLDILKGAKLPPPGPRPFFSILDEALSDEIKRQIRRPFWIDTVGRSNL
IEIRVAIPDGVMRITARRSQAYASNSHIFLVWMIGSSLVLLGVAILFLRNQIKPILRLAAVAEGFGKGREIEFRPRGARE
VRQAGHAFIEMKRRIERAMEQRTTMLNGVSHDLRTILTRFRLSLALIEQTEEIEDLSRDVDEMSRMLEGYLAFARGDSAE
PATPTDMRALLEDLRTDVERLGAHVSAVDLVGAPEVTVRPGAFQRCLFNLAANAVRYGETVAISGRLEARAFLVSIDDDG
PGIPAESREDVFKPFVRLDDARQDAGGSGLGLSIARDIARAHGGDITLHDSPLGGLRATVRVPA

Sequences:

>Translated_464_residues
MNAPDPALARALRKDPPRSGPRRLWKRVSRAIGDVLPKGLYARSLIIIIAPVVLLQSVIAYTFMERHWQLVTKRLSAAVT
ADVAALIDIYESYPQDKDAETLSRIAGERLNLDLDILKGAKLPPPGPRPFFSILDEALSDEIKRQIRRPFWIDTVGRSNL
IEIRVAIPDGVMRITARRSQAYASNSHIFLVWMIGSSLVLLGVAILFLRNQIKPILRLAAVAEGFGKGREIEFRPRGARE
VRQAGHAFIEMKRRIERAMEQRTTMLNGVSHDLRTILTRFRLSLALIEQTEEIEDLSRDVDEMSRMLEGYLAFARGDSAE
PATPTDMRALLEDLRTDVERLGAHVSAVDLVGAPEVTVRPGAFQRCLFNLAANAVRYGETVAISGRLEARAFLVSIDDDG
PGIPAESREDVFKPFVRLDDARQDAGGSGLGLSIARDIARAHGGDITLHDSPLGGLRATVRVPA
>Mature_464_residues
MNAPDPALARALRKDPPRSGPRRLWKRVSRAIGDVLPKGLYARSLIIIIAPVVLLQSVIAYTFMERHWQLVTKRLSAAVT
ADVAALIDIYESYPQDKDAETLSRIAGERLNLDLDILKGAKLPPPGPRPFFSILDEALSDEIKRQIRRPFWIDTVGRSNL
IEIRVAIPDGVMRITARRSQAYASNSHIFLVWMIGSSLVLLGVAILFLRNQIKPILRLAAVAEGFGKGREIEFRPRGARE
VRQAGHAFIEMKRRIERAMEQRTTMLNGVSHDLRTILTRFRLSLALIEQTEEIEDLSRDVDEMSRMLEGYLAFARGDSAE
PATPTDMRALLEDLRTDVERLGAHVSAVDLVGAPEVTVRPGAFQRCLFNLAANAVRYGETVAISGRLEARAFLVSIDDDG
PGIPAESREDVFKPFVRLDDARQDAGGSGLGLSIARDIARAHGGDITLHDSPLGGLRATVRVPA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=272, Percent_Identity=34.1911764705882, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=30.188679245283, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1787894, Length=281, Percent_Identity=32.3843416370107, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI87082128, Length=301, Percent_Identity=27.5747508305648, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1788279, Length=331, Percent_Identity=26.2839879154079, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788393, Length=367, Percent_Identity=24.7956403269755, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=29.004329004329, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786783, Length=244, Percent_Identity=29.5081967213115, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787374, Length=297, Percent_Identity=28.956228956229, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789149, Length=225, Percent_Identity=26.2222222222222, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI48994928, Length=250, Percent_Identity=24.4, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=235, Percent_Identity=24.2553191489362, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790861, Length=294, Percent_Identity=22.7891156462585, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1790551, Length=237, Percent_Identity=28.2700421940928, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081816, Length=106, Percent_Identity=31.1320754716981, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1789403, Length=319, Percent_Identity=24.7648902821317, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51336; Mature: 51336

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPDPALARALRKDPPRSGPRRLWKRVSRAIGDVLPKGLYARSLIIIIAPVVLLQSVIA
CCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
YTFMERHWQLVTKRLSAAVTADVAALIDIYESYPQDKDAETLSRIAGERLNLDLDILKGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHCCC
KLPPPGPRPFFSILDEALSDEIKRQIRRPFWIDTVGRSNLIEIRVAIPDGVMRITARRSQ
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEECCCCHHHHHHHHHH
AYASNSHIFLVWMIGSSLVLLGVAILFLRNQIKPILRLAAVAEGFGKGREIEFRPRGARE
HHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHH
VRQAGHAFIEMKRRIERAMEQRTTMLNGVSHDLRTILTRFRLSLALIEQTEEIEDLSRDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEMSRMLEGYLAFARGDSAEPATPTDMRALLEDLRTDVERLGAHVSAVDLVGAPEVTVRP
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEECC
GAFQRCLFNLAANAVRYGETVAISGRLEARAFLVSIDDDGPGIPAESREDVFKPFVRLDD
CHHHHHHHHHHHHHHHCCCEEEEECCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
ARQDAGGSGLGLSIARDIARAHGGDITLHDSPLGGLRATVRVPA
HHCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCC
>Mature Secondary Structure
MNAPDPALARALRKDPPRSGPRRLWKRVSRAIGDVLPKGLYARSLIIIIAPVVLLQSVIA
CCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
YTFMERHWQLVTKRLSAAVTADVAALIDIYESYPQDKDAETLSRIAGERLNLDLDILKGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHCCC
KLPPPGPRPFFSILDEALSDEIKRQIRRPFWIDTVGRSNLIEIRVAIPDGVMRITARRSQ
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEECCCCHHHHHHHHHH
AYASNSHIFLVWMIGSSLVLLGVAILFLRNQIKPILRLAAVAEGFGKGREIEFRPRGARE
HHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHH
VRQAGHAFIEMKRRIERAMEQRTTMLNGVSHDLRTILTRFRLSLALIEQTEEIEDLSRDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEMSRMLEGYLAFARGDSAEPATPTDMRALLEDLRTDVERLGAHVSAVDLVGAPEVTVRP
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEECC
GAFQRCLFNLAANAVRYGETVAISGRLEARAFLVSIDDDGPGIPAESREDVFKPFVRLDD
CHHHHHHHHHHHHHHHCCCEEEEECCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
ARQDAGGSGLGLSIARDIARAHGGDITLHDSPLGGLRATVRVPA
HHCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]