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The map label for this gene is lpxB [H]

Identifier: 170749834

GI number: 170749834

Start: 3647964

End: 3649142

Strand: Reverse

Name: lpxB [H]

Synonym: Mrad2831_3434

Alternate gene names: 170749834

Gene position: 3649142-3647964 (Counterclockwise)

Preceding gene: 170749835

Following gene: 170749831

Centisome position: 60.04

GC content: 76.25

Gene sequence:

>1179_bases
GTGACCGGCCGGCCCCGGACGATCTGGCTCGTCGCCGGCGAGGATTCCGGCGACCAGCTCGGCGCCAAGCTGATGCGTGC
CCTGCGCGAGGCCGCGCCCGACACCGTCTTCGGCGGCGTCGGCGGCGAGGCCATGGCGGAGGCGGGGTTCGCGTCGCTGT
TCCCGCTCGATGACGTGGCGGTGATGGGCTACCTGCCGGTTCTCGCCCGCGCCCGGACGCTGCTCCGCCGCATCCGCGAG
ACGGTGTCGGCGACGATCCGCGCCCGGCCGGACGTGCTGGTGATCATCGACAGCCCGGGCTTCACCCACGCGGTGGCCCG
GCGGGTGCGCAGGGCGGCCCCCGGCATCCCGATCATCGACTACGTGTCGCCGAGCGTCTGGGCGTGGCGGCCCTGGCGGG
CGAAGGGCATGCGTCCGTTCATCGACCACGTCCTGGCCCTGCTCCCCTTCGAGCCCGACGCGCATCTGCGGCTCGGCGGC
CCCCCCTGCACCTATGTCGGGCACCCGCTGATCGAGCGCCTCCCGGAGCTGCGCCCCGGCGCGGACGAGCGGGGGCGGCG
CGACGCCGTGCCCTACAGCCTCGTGGTCCTGCCGGGCTCCCGTCGGTCCGAGATCGAGCGGCTGATGCCGGTCTTCGGCG
CGGCCCTGGCACGCGTGGCCGAGGGCCTCGCGGTCGAGGCGGTGCTGCCCGCCGTGACCCGGCACAGGGCCCTGATCGAG
CGGCTCTCGGCCGACTGGGCGGTGCCGGTCCGCATCGTGACCGGCGAGGCGCCGAAATACGCCGCCTTCCGGGAGGCCCG
GGCGGCGCTCGCCGCCTCCGGCACGGTCACGCTGGAGCTGGCGCTCGCCGGCGTGCCGATGGTCGTCGCCTACAAGGTCT
CGCGGGCGGAGGAGTTCATCGCCCGCCGGCTGATCCAGGTCCCGAGCATCGTGCTGCCGAACCTGATCCTCGCCGAGAAC
GCGATGCCGGAATTCGTCCAGGCCGACTGCACCCCGGAGCGCCTCGCGGGCGCCCTGCGGCCGCTCCTGGCCGGCGGTGC
CGACCGCGACGTCCAGCTCGCCGCCCTCGGCCGCATCGACGGGCGGATGCGGCTCGCCGCGGCGGACACGCCGAGCCGCG
CGGCGGCGCGGATCGTCCTGCGCGCGGCCGAGGGGCGGGGGCCGGGTCCGGCGGCGTGA

Upstream 100 bases:

>100_bases
TCGCCCTGGAGGCGGGCGGGACCCTGGTCATCGACCGGGCGGCCACGGCCGCGGAGGCCGATCGCCTCGGCCTCTTCGTG
GTCGGGTACGGAGGCGCGCC

Downstream 100 bases:

>100_bases
CGGTCCCCCTCAGCCGGCGCGGCGGCCGCAGCGGATGTAGGTCGAGGTCCCGCGGCTGCTCGACCAGGTCAGATGCTCGC
CGTCCACCTGCAGGCGGACC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTGRPRTIWLVAGEDSGDQLGAKLMRALREAAPDTVFGGVGGEAMAEAGFASLFPLDDVAVMGYLPVLARARTLLRRIRE
TVSATIRARPDVLVIIDSPGFTHAVARRVRRAAPGIPIIDYVSPSVWAWRPWRAKGMRPFIDHVLALLPFEPDAHLRLGG
PPCTYVGHPLIERLPELRPGADERGRRDAVPYSLVVLPGSRRSEIERLMPVFGAALARVAEGLAVEAVLPAVTRHRALIE
RLSADWAVPVRIVTGEAPKYAAFREARAALAASGTVTLELALAGVPMVVAYKVSRAEEFIARRLIQVPSIVLPNLILAEN
AMPEFVQADCTPERLAGALRPLLAGGADRDVQLAALGRIDGRMRLAAADTPSRAAARIVLRAAEGRGPGPAA

Sequences:

>Translated_392_residues
MTGRPRTIWLVAGEDSGDQLGAKLMRALREAAPDTVFGGVGGEAMAEAGFASLFPLDDVAVMGYLPVLARARTLLRRIRE
TVSATIRARPDVLVIIDSPGFTHAVARRVRRAAPGIPIIDYVSPSVWAWRPWRAKGMRPFIDHVLALLPFEPDAHLRLGG
PPCTYVGHPLIERLPELRPGADERGRRDAVPYSLVVLPGSRRSEIERLMPVFGAALARVAEGLAVEAVLPAVTRHRALIE
RLSADWAVPVRIVTGEAPKYAAFREARAALAASGTVTLELALAGVPMVVAYKVSRAEEFIARRLIQVPSIVLPNLILAEN
AMPEFVQADCTPERLAGALRPLLAGGADRDVQLAALGRIDGRMRLAAADTPSRAAARIVLRAAEGRGPGPAA
>Mature_391_residues
TGRPRTIWLVAGEDSGDQLGAKLMRALREAAPDTVFGGVGGEAMAEAGFASLFPLDDVAVMGYLPVLARARTLLRRIRET
VSATIRARPDVLVIIDSPGFTHAVARRVRRAAPGIPIIDYVSPSVWAWRPWRAKGMRPFIDHVLALLPFEPDAHLRLGGP
PCTYVGHPLIERLPELRPGADERGRRDAVPYSLVVLPGSRRSEIERLMPVFGAALARVAEGLAVEAVLPAVTRHRALIER
LSADWAVPVRIVTGEAPKYAAFREARAALAASGTVTLELALAGVPMVVAYKVSRAEEFIARRLIQVPSIVLPNLILAENA
MPEFVQADCTPERLAGALRPLLAGGADRDVQLAALGRIDGRMRLAAADTPSRAAARIVLRAAEGRGPGPAA

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=383, Percent_Identity=36.5535248041775, Blast_Score=184, Evalue=8e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42050; Mature: 41918

Theoretical pI: Translated: 10.65; Mature: 10.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRPRTIWLVAGEDSGDQLGAKLMRALREAAPDTVFGGVGGEAMAEAGFASLFPLDDVA
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEECCCCCHHHHHCCCHHCCCCHHHH
VMGYLPVLARARTLLRRIRETVSATIRARPDVLVIIDSPGFTHAVARRVRRAAPGIPIID
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEC
YVSPSVWAWRPWRAKGMRPFIDHVLALLPFEPDAHLRLGGPPCTYVGHPLIERLPELRPG
CCCCCCEEECCHHCCCCCHHHHHHHHHCCCCCCCCEEECCCCCHHCCCHHHHHCCCCCCC
ADERGRRDAVPYSLVVLPGSRRSEIERLMPVFGAALARVAEGLAVEAVLPAVTRHRALIE
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
RLSADWAVPVRIVTGEAPKYAAFREARAALAASGTVTLELALAGVPMVVAYKVSRAEEFI
HHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEHHHHHHHHHHH
ARRLIQVPSIVLPNLILAENAMPEFVQADCTPERLAGALRPLLAGGADRDVQLAALGRID
HHHHHHCCHHHHCCHHHHCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCC
GRMRLAAADTPSRAAARIVLRAAEGRGPGPAA
CCEEEEECCCCHHHHHHHHEEECCCCCCCCCC
>Mature Secondary Structure 
TGRPRTIWLVAGEDSGDQLGAKLMRALREAAPDTVFGGVGGEAMAEAGFASLFPLDDVA
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEECCCCCHHHHHCCCHHCCCCHHHH
VMGYLPVLARARTLLRRIRETVSATIRARPDVLVIIDSPGFTHAVARRVRRAAPGIPIID
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEC
YVSPSVWAWRPWRAKGMRPFIDHVLALLPFEPDAHLRLGGPPCTYVGHPLIERLPELRPG
CCCCCCEEECCHHCCCCCHHHHHHHHHCCCCCCCCEEECCCCCHHCCCHHHHHCCCCCCC
ADERGRRDAVPYSLVVLPGSRRSEIERLMPVFGAALARVAEGLAVEAVLPAVTRHRALIE
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
RLSADWAVPVRIVTGEAPKYAAFREARAALAASGTVTLELALAGVPMVVAYKVSRAEEFI
HHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEHHHHHHHHHHH
ARRLIQVPSIVLPNLILAENAMPEFVQADCTPERLAGALRPLLAGGADRDVQLAALGRID
HHHHHHCCHHHHCCHHHHCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCC
GRMRLAAADTPSRAAARIVLRAAEGRGPGPAA
CCEEEEECCCCHHHHHHHHEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA