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The map label for this gene is ygbM [H]

Identifier: 170749808

GI number: 170749808

Start: 3618032

End: 3618841

Strand: Reverse

Name: ygbM [H]

Synonym: Mrad2831_3407

Alternate gene names: 170749808

Gene position: 3618841-3618032 (Counterclockwise)

Preceding gene: 170749809

Following gene: 170749804

Centisome position: 59.54

GC content: 72.59

Gene sequence:

>810_bases
ATGACGCGACCCATGAAGCTCGGGGCCTACAAGGATCGTCTCAGCGGCCATTGCGGCTTCCTGTTCACGGAGCTGCCGCT
GGCCGAGCGCTTCGCGGCGGCGGCCCGGGCAGGGTTCCGCGCCGTCGAGCACCCCAACCTGTTCGCGACGCCGGCCCGCG
AGGTCGCGGGCTGGCTGGAGCGGGCCGGCGTTCCGCTGGTCCAGACCGGCTTCCCGGCGGGGGACGCCGCCAAGGGCGAG
AAGGGGTTCGCGGCCCTGCCCGACCGGATCGACTACTACCGCTCCACGATCGAGCCGACCCTGGACTACGTCGCGCAGCT
CGGCTGCCGGATGGTTCACCCGATGGCGGGCGTCCGGCCTGCCGGGGTCGAGCGGGCGCGGCTCTGGGACACCTACCTCG
ACAACCTCGCCTTCGCGGCCGACGCCGCCGGCGCGCGGGGCATGACGGTGATCGTCGAGCCGATCGGCCCCGGCTCGATC
GCCGACTACGTGATCGACGACCCGCTGGTTGCGGTCGAGGCGATCCGGGCGATCGGTCGCGACAACGTCAAGCTCCTGTT
CGACGCCTATCACTGCGTCTGCCTCGGCCACGATCCGGCGGCGCTGATCCGGGCGCACGCGCCGCTCATCGCCCATGTCC
AGATCGCCGACGACCCCGGGCGGCACGAGCCCGGGACCGGCACGATCGCCTTCGACCCGATCTTCGCCGCCCTGGAGGAG
GTCGGCTATTCCGGCTTCGTCGGCTGCGAGTACCATCCCGCGGCCGGCACCGAGGCGGGGCTCGGCTGGATGAGGGCGGA
CGCGGCGTAG

Upstream 100 bases:

>100_bases
GGCCGTGCGGAAGGCCGTCGACATCCCGGTGCTGACCGCGCCCCACGCGGCGGTGGACCGGATGCGGGCGATGATCGAGA
CCGGCGGGAGCGCCTGAGCC

Downstream 100 bases:

>100_bases
GCCGGGGGCTCAGAACCGGGCCGCGACGCCGCCGATGATCGTGCGCGGCTGCCCCGGCGTCGCGTAGCGGTTCTGGAATG
CCCGGTCGTAGAACGTCGCG

Product: hydroxypyruvate isomerase

Products: 2-hydroxy-3-oxopropanoate

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MTRPMKLGAYKDRLSGHCGFLFTELPLAERFAAAARAGFRAVEHPNLFATPAREVAGWLERAGVPLVQTGFPAGDAAKGE
KGFAALPDRIDYYRSTIEPTLDYVAQLGCRMVHPMAGVRPAGVERARLWDTYLDNLAFAADAAGARGMTVIVEPIGPGSI
ADYVIDDPLVAVEAIRAIGRDNVKLLFDAYHCVCLGHDPAALIRAHAPLIAHVQIADDPGRHEPGTGTIAFDPIFAALEE
VGYSGFVGCEYHPAAGTEAGLGWMRADAA

Sequences:

>Translated_269_residues
MTRPMKLGAYKDRLSGHCGFLFTELPLAERFAAAARAGFRAVEHPNLFATPAREVAGWLERAGVPLVQTGFPAGDAAKGE
KGFAALPDRIDYYRSTIEPTLDYVAQLGCRMVHPMAGVRPAGVERARLWDTYLDNLAFAADAAGARGMTVIVEPIGPGSI
ADYVIDDPLVAVEAIRAIGRDNVKLLFDAYHCVCLGHDPAALIRAHAPLIAHVQIADDPGRHEPGTGTIAFDPIFAALEE
VGYSGFVGCEYHPAAGTEAGLGWMRADAA
>Mature_268_residues
TRPMKLGAYKDRLSGHCGFLFTELPLAERFAAAARAGFRAVEHPNLFATPAREVAGWLERAGVPLVQTGFPAGDAAKGEK
GFAALPDRIDYYRSTIEPTLDYVAQLGCRMVHPMAGVRPAGVERARLWDTYLDNLAFAADAAGARGMTVIVEPIGPGSIA
DYVIDDPLVAVEAIRAIGRDNVKLLFDAYHCVCLGHDPAALIRAHAPLIAHVQIADDPGRHEPGTGTIAFDPIFAALEEV
GYSGFVGCEYHPAAGTEAGLGWMRADAA

Specific function: Unknown

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=262, Percent_Identity=37.0229007633588, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI300068964, Length=244, Percent_Identity=36.0655737704918, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1789095, Length=254, Percent_Identity=38.1889763779528, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1786718, Length=252, Percent_Identity=33.7301587301587, Blast_Score=154, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17552022, Length=241, Percent_Identity=27.8008298755187, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17530883, Length=257, Percent_Identity=33.852140077821, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: 5.3.1.22

Molecular weight: Translated: 28681; Mature: 28550

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPMKLGAYKDRLSGHCGFLFTELPLAERFAAAARAGFRAVEHPNLFATPAREVAGWLE
CCCCCCCCCHHHHHCCCCCEEEECCCHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHH
RAGVPLVQTGFPAGDAAKGEKGFAALPDRIDYYRSTIEPTLDYVAQLGCRMVHPMAGVRP
HCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AGVERARLWDTYLDNLAFAADAAGARGMTVIVEPIGPGSIADYVIDDPLVAVEAIRAIGR
CCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHCCHHHHHHHHHHHCC
DNVKLLFDAYHCVCLGHDPAALIRAHAPLIAHVQIADDPGRHEPGTGTIAFDPIFAALEE
CCEEEEEEEEEEEEECCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEHHHHHHHHHH
VGYSGFVGCEYHPAAGTEAGLGWMRADAA
CCCCCEECCEECCCCCCCCCCCCEECCCC
>Mature Secondary Structure 
TRPMKLGAYKDRLSGHCGFLFTELPLAERFAAAARAGFRAVEHPNLFATPAREVAGWLE
CCCCCCCCHHHHHCCCCCEEEECCCHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHH
RAGVPLVQTGFPAGDAAKGEKGFAALPDRIDYYRSTIEPTLDYVAQLGCRMVHPMAGVRP
HCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AGVERARLWDTYLDNLAFAADAAGARGMTVIVEPIGPGSIADYVIDDPLVAVEAIRAIGR
CCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHCCHHHHHHHHHHHCC
DNVKLLFDAYHCVCLGHDPAALIRAHAPLIAHVQIADDPGRHEPGTGTIAFDPIFAALEE
CCEEEEEEEEEEEEECCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEHHHHHHHHHH
VGYSGFVGCEYHPAAGTEAGLGWMRADAA
CCCCCEECCEECCCCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxypyruvate

Specific reaction: hydroxypyruvate = 2-hydroxy-3-oxopropanoate; Other Name(s): hydroxypyruvate ketol-isomerase

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]