Click here to switch to the map view.

The map label for this gene is livH [H]

Identifier: 170749705

GI number: 170749705

Start: 3504528

End: 3505397

Strand: Direct

Name: livH [H]

Synonym: Mrad2831_3304

Alternate gene names: 170749705

Gene position: 3504528-3505397 (Clockwise)

Preceding gene: 170749704

Following gene: 170749706

Centisome position: 57.66

GC content: 72.41

Gene sequence:

>870_bases
ATGCTGACCTCCATCCTCGTCAGCGGCCTCGGCCTCGGCAGCATGTACGGGCTCGTGGCCCTCGGCTTCCACGTGACCTA
CGCGGTGTCGGGGACCGTGAACTTCGCGCAGGGCAGCGTCGTCACCCTGGGCGCGGTCCTGGCCTACGCGCTCGGCGTCA
CCCTCGGCTGGCCGATGCCGGCGGCGATCGTCCTGGCGCTCGCCGGCTGCGCCCTGTTCGGCCTCGTGGTCGAGCGGGCG
CTGGTCCGCCCGTTCGTGGCCCGCGGCTCGGATGCGTGGCTGCTCGCGACGGTGGCGGGCGGCATCGTCCTCGACAACAC
CGTGCTGTTCACCTTCGGCAAGGAGCCGCGCAGCCTGCCCTCGCCGCTGGCGACCAAGCCGGTGGAGATCCTCGGGACCG
GCATCTACCCGCTCCAGCTCGCAATCCCGGTGGTCGGGATCGCGCTCGCCTTCGCGATCCGCACGGTGTTCCGCCGGACC
GATCTCGGCCGCGTCCTGCTCGCCGTGGCGCAGAACGCCGACGCCGCCCGCCTGATGGGGATCGACGTGCGCCGCACCGT
GGCCTGCGCCTTCGCGCTCTCGGCGGTGCTGGCCGGCATCGCGGGCCTCCTGATCGCGCCGCTGTTCTCGGTCTCGGCCG
AACTCGGCACGCTGTTCGGCATCAAGGCCTTCGCGGTCGCGATCCTCGGCGGGATCGGCTCGGCCACCGGGGTGATCCTG
GCGGGGCTGCTCTACGGCCTCGTCGAGGCCGGCGTCACCGCGACCCTCGGCTCGACCTACACGCAGCTCGTGGTGTTCTC
GGTGATCATCCTGGCCCTCACCCTGCGCCCCGACGGCCTGCTCGGCCGCGCCGCGGTCAACAAGGTCTGA

Upstream 100 bases:

>100_bases
CCTTCGCCCCCGGCCAGCACGACGCGCTGGGACCGAACGATTACGTGTTCACCCGCTTCAAGGACGGTGAGATCGTCGCG
GTGACCAACTGAGCCCGGCG

Downstream 100 bases:

>100_bases
CGCGATGCACCGTCTGCGCTCGGCCCCGGCGATGCGGCTCGGCATTGCCGGCCTCACCGCCGCCGCGCTCGGCCTCGTCG
CGCTGACTGCCGGCTACAGC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MLTSILVSGLGLGSMYGLVALGFHVTYAVSGTVNFAQGSVVTLGAVLAYALGVTLGWPMPAAIVLALAGCALFGLVVERA
LVRPFVARGSDAWLLATVAGGIVLDNTVLFTFGKEPRSLPSPLATKPVEILGTGIYPLQLAIPVVGIALAFAIRTVFRRT
DLGRVLLAVAQNADAARLMGIDVRRTVACAFALSAVLAGIAGLLIAPLFSVSAELGTLFGIKAFAVAILGGIGSATGVIL
AGLLYGLVEAGVTATLGSTYTQLVVFSVIILALTLRPDGLLGRAAVNKV

Sequences:

>Translated_289_residues
MLTSILVSGLGLGSMYGLVALGFHVTYAVSGTVNFAQGSVVTLGAVLAYALGVTLGWPMPAAIVLALAGCALFGLVVERA
LVRPFVARGSDAWLLATVAGGIVLDNTVLFTFGKEPRSLPSPLATKPVEILGTGIYPLQLAIPVVGIALAFAIRTVFRRT
DLGRVLLAVAQNADAARLMGIDVRRTVACAFALSAVLAGIAGLLIAPLFSVSAELGTLFGIKAFAVAILGGIGSATGVIL
AGLLYGLVEAGVTATLGSTYTQLVVFSVIILALTLRPDGLLGRAAVNKV
>Mature_289_residues
MLTSILVSGLGLGSMYGLVALGFHVTYAVSGTVNFAQGSVVTLGAVLAYALGVTLGWPMPAAIVLALAGCALFGLVVERA
LVRPFVARGSDAWLLATVAGGIVLDNTVLFTFGKEPRSLPSPLATKPVEILGTGIYPLQLAIPVVGIALAFAIRTVFRRT
DLGRVLLAVAQNADAARLMGIDVRRTVACAFALSAVLAGIAGLLIAPLFSVSAELGTLFGIKAFAVAILGGIGSATGVIL
AGLLYGLVEAGVTATLGSTYTQLVVFSVIILALTLRPDGLLGRAAVNKV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=297, Percent_Identity=32.6599326599327, Blast_Score=132, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 29357; Mature: 29357

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTSILVSGLGLGSMYGLVALGFHVTYAVSGTVNFAQGSVVTLGAVLAYALGVTLGWPMP
CHHHHHHHHCCHHHHHHHHHHHHHHEEEEECEEEECCCCHHHHHHHHHHHHHHHCCCCHH
AAIVLALAGCALFGLVVERALVRPFVARGSDAWLLATVAGGIVLDNTVLFTFGKEPRSLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCEEECCEEEEEECCCCCCCC
SPLATKPVEILGTGIYPLQLAIPVVGIALAFAIRTVFRRTDLGRVLLAVAQNADAARLMG
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHC
IDVRRTVACAFALSAVLAGIAGLLIAPLFSVSAELGTLFGIKAFAVAILGGIGSATGVIL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AGLLYGLVEAGVTATLGSTYTQLVVFSVIILALTLRPDGLLGRAAVNKV
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCC
>Mature Secondary Structure
MLTSILVSGLGLGSMYGLVALGFHVTYAVSGTVNFAQGSVVTLGAVLAYALGVTLGWPMP
CHHHHHHHHCCHHHHHHHHHHHHHHEEEEECEEEECCCCHHHHHHHHHHHHHHHCCCCHH
AAIVLALAGCALFGLVVERALVRPFVARGSDAWLLATVAGGIVLDNTVLFTFGKEPRSLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCEEECCEEEEEECCCCCCCC
SPLATKPVEILGTGIYPLQLAIPVVGIALAFAIRTVFRRTDLGRVLLAVAQNADAARLMG
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHC
IDVRRTVACAFALSAVLAGIAGLLIAPLFSVSAELGTLFGIKAFAVAILGGIGSATGVIL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AGLLYGLVEAGVTATLGSTYTQLVVFSVIILALTLRPDGLLGRAAVNKV
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]