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The map label for this gene is appC [H]

Identifier: 170749622

GI number: 170749622

Start: 3406106

End: 3406945

Strand: Reverse

Name: appC [H]

Synonym: Mrad2831_3219

Alternate gene names: 170749622

Gene position: 3406945-3406106 (Counterclockwise)

Preceding gene: 170749623

Following gene: 170749621

Centisome position: 56.06

GC content: 71.07

Gene sequence:

>840_bases
ATGACGGCGTTCTGGGCCCGATACGCCCGCAACCGCGGCGCGGTGGTGGGAATCGTCATCCTCGTCCTGGTGCTCGTCCT
GGCGATCGCGGCGCCGGCGCTCTACCCGCGCTCCCCCTGGGCGATGGTGCAGCGCCCGTTCCTGCCGCCCTTCACCAACG
GCGGCTACCCGCTGGGCACCGACACGATGGGCCGGGATATCGCCTCCGCGGTGGCCCACGGGGCCGGGGTGTCGCTGCTG
GTCGGCTTCGTCTCGACCCTCGCGGCCCTGCTGATCGGCATCCCGATCGGGGCCGTCGCGGGCTACTTCGGTGGCCGGGT
CGACGACCTGCTGATGCGCTTCACCGAGTTCTTCCAGAGCGTGCCGAACTTCGCCCTGGCGGTGGTGCTGGTGGCGATCT
TCCGGCCGAGCCTCGTCTCGATCGTCACGGCCATCGCGATCGTGAGCTGGCCGCCGGTGGCCCGGCTCCTGCGCGGCGAG
GTGATGGCGCTGCGCGGGCGGGAATTCGTGCAGGCCGCGGTGCTGTCGGGCCAGCGCAGCGGCCCGATCATCCTGCGGCA
GATCCTGCCCAACACGCTCTCGCCGGTCATCGTCCTCGGGACCATGATGGTGGCGGCCGCCATCCTGCTGGAGAGCGCCC
TGTCGTTCATGGGGCTCGGCGACCCCAACATCATGTCGTGGGGCTACGTCATCGGCGCCGGGCGCACGGTGATCCGGCAG
GCGTGGTGGGTGAGTCTCTTCCCCGGCGTCGCGATCCTCCTGACGGTGCTCGCCCTGAACCTCGTCGGCGAGGGGCTGAA
CGACGCCCTCAACCCGCGCCTGTCGCGCAGGACGCGATGA

Upstream 100 bases:

>100_bases
TCCTCGGCATCTTCGTCGTCTCCGCCGCGATGGTGCTGGCCTTCAACCTCATCACCGACATCCTCTACCGGCTGGTGGAT
CCCCGTATCGGAGCTGCGGC

Downstream 100 bases:

>100_bases
GGGGCGCAGCCATGACCGTCGCCCCCCGAAACCACGCGCCCCAAAACCACGCCGCCGGCGCGCCGGTCCTCGTCGTCGAG
AAGCTCGCCATCGCCCTGCC

Product: binding-protein-dependent transport systems inner membrane component

Products: ADP; phosphate; oligopeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MTAFWARYARNRGAVVGIVILVLVLVLAIAAPALYPRSPWAMVQRPFLPPFTNGGYPLGTDTMGRDIASAVAHGAGVSLL
VGFVSTLAALLIGIPIGAVAGYFGGRVDDLLMRFTEFFQSVPNFALAVVLVAIFRPSLVSIVTAIAIVSWPPVARLLRGE
VMALRGREFVQAAVLSGQRSGPIILRQILPNTLSPVIVLGTMMVAAAILLESALSFMGLGDPNIMSWGYVIGAGRTVIRQ
AWWVSLFPGVAILLTVLALNLVGEGLNDALNPRLSRRTR

Sequences:

>Translated_279_residues
MTAFWARYARNRGAVVGIVILVLVLVLAIAAPALYPRSPWAMVQRPFLPPFTNGGYPLGTDTMGRDIASAVAHGAGVSLL
VGFVSTLAALLIGIPIGAVAGYFGGRVDDLLMRFTEFFQSVPNFALAVVLVAIFRPSLVSIVTAIAIVSWPPVARLLRGE
VMALRGREFVQAAVLSGQRSGPIILRQILPNTLSPVIVLGTMMVAAAILLESALSFMGLGDPNIMSWGYVIGAGRTVIRQ
AWWVSLFPGVAILLTVLALNLVGEGLNDALNPRLSRRTR
>Mature_278_residues
TAFWARYARNRGAVVGIVILVLVLVLAIAAPALYPRSPWAMVQRPFLPPFTNGGYPLGTDTMGRDIASAVAHGAGVSLLV
GFVSTLAALLIGIPIGAVAGYFGGRVDDLLMRFTEFFQSVPNFALAVVLVAIFRPSLVSIVTAIAIVSWPPVARLLRGEV
MALRGREFVQAAVLSGQRSGPIILRQILPNTLSPVIVLGTMMVAAAILLESALSFMGLGDPNIMSWGYVIGAGRTVIRQA
WWVSLFPGVAILLTVLALNLVGEGLNDALNPRLSRRTR

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787498, Length=272, Percent_Identity=37.1323529411765, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1787054, Length=273, Percent_Identity=35.1648351648352, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1787760, Length=261, Percent_Identity=37.9310344827586, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI1789964, Length=282, Percent_Identity=40.7801418439716, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1789889, Length=223, Percent_Identity=34.5291479820628, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1788505, Length=233, Percent_Identity=28.755364806867, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787549, Length=278, Percent_Identity=29.4964028776978, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 29698; Mature: 29567

Theoretical pI: Translated: 11.88; Mature: 11.88

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFWARYARNRGAVVGIVILVLVLVLAIAAPALYPRSPWAMVQRPFLPPFTNGGYPLGT
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCC
DTMGRDIASAVAHGAGVSLLVGFVSTLAALLIGIPIGAVAGYFGGRVDDLLMRFTEFFQS
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
VPNFALAVVLVAIFRPSLVSIVTAIAIVSWPPVARLLRGEVMALRGREFVQAAVLSGQRS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GPIILRQILPNTLSPVIVLGTMMVAAAILLESALSFMGLGDPNIMSWGYVIGAGRTVIRQ
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHH
AWWVSLFPGVAILLTVLALNLVGEGLNDALNPRLSRRTR
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHCCCC
>Mature Secondary Structure 
TAFWARYARNRGAVVGIVILVLVLVLAIAAPALYPRSPWAMVQRPFLPPFTNGGYPLGT
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCC
DTMGRDIASAVAHGAGVSLLVGFVSTLAALLIGIPIGAVAGYFGGRVDDLLMRFTEFFQS
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
VPNFALAVVLVAIFRPSLVSIVTAIAIVSWPPVARLLRGEVMALRGREFVQAAVLSGQRS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GPIILRQILPNTLSPVIVLGTMMVAAAILLESALSFMGLGDPNIMSWGYVIGAGRTVIRQ
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHH
AWWVSLFPGVAILLTVLALNLVGEGLNDALNPRLSRRTR
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; oligopeptides [Periplasm]; H2O [C]

Specific reaction: ATP + oligopeptides [Periplasm] + H2O = ADP + phosphate + oligopeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]